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TRIM34 attenuates colon inflammation and tumorigenesis by sustaining barrier integrity

Cellular & Molecular Immunology 2021年第2期18卷 350-362页

作者： Qiaoshi Lian Shanshan Yan Qi yin Chenghua Yan Wanwei Zheng Wangpeng Gu Xinhao Zhao Weiguo Fan xuezhen Li Liyan ma Zhiyang Ling Yaguang zhang jie Liu Jinsong Li Bing Sun State Key Laboratory of Cell Biology CAS Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesUniversity of Chinese Academy of Sciences320 Yueyang RoadShanghai200031China School of Life Sciences University of Science and Technology of ChinaHefei230022China State Key Laboratory of Cell Biology Shanghai Key Laboratory of Molecular AndrologyCAS Center for Excellence in Molecular Cell ScienceShanghai institute of Biochemistry and Cell BiologyChinese Academy of SciencesUniversity of Chinese Academy of Sciences320 Yueyang RoadShanghai200031China Department of Digestive Diseases Huashan HospitalFudan University12 Middle Wulumuqi RoadShanghai200040China Institutes of Biomedical Sciences and Department of Immunology Shanghai Medical SchoolFudan University138 Yi Xue Yuan RoadShanghai200032China

Loss of the colonic inner mucus layer leads to spontaneously severe colitis and colorectal ***,key host factors that may control the generation of the inner mucus layer are rarely ***,we identify a novel function of TRIM34 in goblet cells(GCs)in controlling inner mucus layer *** DSS treatment,TRIM34 deficiency led to a reduction in Muc2 secretion by GCs and subsequent defects in the inner mucus *** outcome rendered TRIM34-deficient mice more susceptible to DSS-induced colitis and colitis-associated colorectal *** experiments demonstrated that TRIM34 controlled TLR signaling-induced Nox/Duox-dependent ROS synthesis,thereby promoting the compound exocytosis of Muc2 by colonic GCs that were exposed to bacterial TLR *** analysis revealed that TRIM34 levels in patient samples were correlated with the outcome of ulcerative colitis(UC)and the prognosis of rectal *** study indicates that TRIM34 expression in GCs plays an essential role in generating the inner mucus layer and preventing excessive colon inflammation and tumorigenesis.

关键词： Colon inflammation Goblet cell Toll-like receptor TRIM34 Muc2

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert maarten Boonekamp marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

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基于聚醚胺(PEA)动态交联网络的多重响应性表面褶皱图案

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高分子学报 2021年第1期52卷 61-68,I0003页

作者：张轶洁李甜甜马晓东印杰姜学松上海交通大学化学化工学院上海200240

刺激响应性表面图案赋予了材料动态可调的表面性能,是智能材料领域研究的热点,然而如何通过简单有效的方法构建这类动态表面图案也是该领域的难点.本文将动态硼酸酯键和光可逆二聚基团引入到聚醚胺(PEA)交联网络中,通过双层褶皱体系构... 详细信息

刺激响应性表面图案赋予了材料动态可调的表面性能,是智能材料领域研究的热点,然而如何通过简单有效的方法构建这类动态表面图案也是该领域的难点.本文将动态硼酸酯键和光可逆二聚基团引入到聚醚胺(PEA)交联网络中,通过双层褶皱体系构建一系列具有光和湿度刺激响应性表面褶皱图案.在365 nm紫外光照和加热的条件下,蒽基团(AN)的光二聚与硼酸键的形成使得上表层聚醚胺模量变大,产生微米级表面褶皱图案;在254 nm紫外光照射或水蒸气作用下,聚醚胺网络解交联,表面褶皱图案消失;利用光化学时空分辨的特性,通过光掩膜板光照还可以制备多层次动态表面褶皱图案.这种多重刺激响应性表面褶皱图案为构建智能聚合物表面提供了新思路,在传感和防伪等领域具有潜在的应用前景.

关键词：褶皱聚醚胺刺激响应硼酸酯光可逆二聚

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Mouse knockout models reveal largely dispensable but context-dependent functions of IncRNAs during development

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Journal of Molecular Cell Biology 2018年第2期10卷 175-178页

作者： xue Han Sai Luo Guangdun Peng Yuyang Lu Guizhong Cui Lichao Liu Pixi Yan Yafei yin Wei Liu Ran Wang jiejie zhang Shanshan Ai Zai Chang jie Na Aibin He Naihe Jing Xiaohua Shen Tsinghua-Peking Center for Life Sciences School of Medicine Tsinghua University Beijing 100084 China State Key Laboratory of Cell Biology CAS Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell Biology Chinese Academy ofSciences University of Chinese Academy ofSciences Shanghai 200031 China Peking Center for Life Sciences Institute of Molecular Medicine Beijing Key Laboratory ofCardiometabolic Molecular Medicine PekingUniversity Beijing 100871 China School of Life Sciences Tsinghua UniversityBeijing 100084 China Program in Cellular and Molecular Medicine Boston Children's Hospital Department of Genetics Harvard Medical School Boston MA 02115 USA

Dear Editor, In mammalian genomes, pervasive transcription produces thousands of long non-coding RNA （IncRNA） transcripts （Olebali et al., 2012; Hon et al., 2017）. Compared to protein-coding mRNAs, IncRNAs are less conserved, and often exhibit low-level, developmental stage-and tissue-specific expression （Pauli et al., 2011; Hu et al., 2012; Lee, 2012; Ulitsky and Bartel, 2013; Cech and Steitz, 2014; Hon et al., 2017）. many IncRNAs are strongly correlated with their neighboring mRNA genes in terms of expression and function, and tend to regulate nearby transcription （Orom et al., 2010; Engreitz et al., 2016; Luo etal., 2016）. It has been implicated that IncRNAs play versatile roles in regulating diverse aspects of cell biology through mechanisms at multiple levels （Pauli et al., 2011; Lee.

关键词：泡利不相容原理上下文编码蛋白质开发模型鼠标 mRNA 哺乳动物

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Safety and immunogenicity of a mosaic vaccine booster against Omicron and other SARS-CoV-2 variants:a randomized phase 2 trial

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Signal Transduction and Targeted Therapy 2023年第2期8卷 672-682页

作者： Nawal Al Kaabi Yun Kai Yang Yu Liang Ke Xu xue Feng zhang Yun Kang Yu qin Jin Jun Wei Hou Jing zhang Tian Yang Salah Hussein Mohamed Saif ElDein Ze Hua Lei Hao zhang Shuai Shao Zhao Ming Liu Ning Liu Xiang Zheng Ji Guo Su Sen Sen Yang Xiangfeng Cong Yao Tan Wenwen Lei xue Jun Gao Zhiwei Jiang Hui Wang Meng Li Hanadi Mekki Mekki Walid Zaher Sally mahmoud xue zhang Chang Qu Dan ying Liu Jing zhang Mengjie Yang Islam Eltantawy Peng Xiao Fu jie Shen Jin Juan Wu Zi Bo Han Li Fang Du Fang Tang Shi Chen Zhi Jing ma Fan Zheng Ya Nan Hou Xin Yu Li Xin Li Zhao Nian Wang Jin Liang yin Xiao Yan mao Jin zhang Liang Qu Yun Tao zhang Xiao Ming Yang Guizhen Wu Qi Ming Li Sheikh Khalifa Medical City SEHAAbu DhabiUAE College of Medicine and Health Sciences Khalifa UniversityAbu DhabiUAE China National Biotec Group Company Limited BeijingChina The Sixth Laboratory National Vaccine and Serum Institute(NVSI)BeijingChina National Engineering Center for New Vaccine Research BeijingChina National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention(China CDC)BeijingChina Clinical Medicine Office National Vaccine and Serum Institute(NVSI)BeijingChina Lanzhou Institute of Biological Products Company Limited LanzhouChina Beijing Key Tech Statistical Consulting Co. LtdBeijingChina Beijing Institute of Biological Products Company Limited BeijingChina Union 71 Abu DhabiUAE G42 Healthcare Abu DhabiUAE

An ongoing randomized,double-blind,controlled phase 2 trial was conducted to evaluate the safety and immunogenicity of a mosaic-type recombinant vaccine candidate,named NVSI-06-09,as a booster dose in subjects aged 18 years and older from the United Arab Emirates(UAE),who had administered two or three doses of inactivated vaccine BBIBP-CorV at least 6 months prior to *** participants were randomly assigned with 1:1 to receive a booster dose of NVSI-06-09 or *** primary outcomes were immunogenicity and safety against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)Omicron variant,and the exploratory outcome was cross-immunogenicity against other circulating *** may 25 and 30,2022,516 adults received booster vaccination with 260 in NVSI-06-09 group and 256 in BBIBP-CorV *** results showed a similar safety profile between two booster groups,with low incidence of adverse reactions of grade 1 or *** immunogenicity,by day 14 post-booster,the fold rises in neutralizing antibody geometric mean titers(GMTs)from baseline elicited by NVSI-06-09 were remarkably higher than those by BBIBP-CorV against the prototype strain(19.67 vs 4.47-fold),Omicron BA.1.1(42.35 vs 3.78-fold),BA.2(25.09 vs 2.91-fold),BA.4(22.42 vs 2.69-fold),and BA.5 variants(27.06 vs 4.73-fold).Similarly,the neutralizing GMTs boosted by NVSI-06-09 against Beta and Delta variants were also 6.60-fold and 7.17-fold higher than those by *** findings indicated that a booster dose of NVSI-06-09 was well-tolerated and elicited broad-spectrum neutralizing responses against divergent SARS-CoV-2 variants,including Omicron and its sub-lineages.

关键词： phase neutral spectrum

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基于CdSe/ZnS量子点光转化层的高稳定性白光LED器件

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光谱学与光谱分析 2016年第2期36卷 349-354页

作者：曹进周洁谢婧薇陈安平张雪殷录桥张建华上海大学新型显示技术及应用集成教育部重点实验室上海200072 上海大学材料科学与工程学院上海200072

采用一步法合成了510,550和630nm三种峰值的高稳定性、高量子效率核壳结构CdSe/ZnS量子点材料,其量子产率分别达到82%,98%,97%。将该量子点材料取代传统的荧光粉材料,与硅胶均匀混合后作为光转换层涂覆到蓝色InGaN LED芯片上,制备了白光... 详细信息

采用一步法合成了510,550和630nm三种峰值的高稳定性、高量子效率核壳结构CdSe/ZnS量子点材料,其量子产率分别达到82%,98%,97%。将该量子点材料取代传统的荧光粉材料,与硅胶均匀混合后作为光转换层涂覆到蓝色InGaN LED芯片上,制备了白光LED器件。通过依次添加不同颜色量子点制备的量子点光转换层,考察了510,550和630nm三色CdSe/ZnS量子点在硅胶中的不同配比对白光LED器件性能的影响,研究了不同颜色量子点之间的能量转换机制,利用量子点对白光光谱及其色坐标的影响机制,得到优化的白光器件结果及其三色量子点的配比,结果表明,当绿色、黄绿色、红色三种量子点之间的配比为24∶7∶10时,得到高稳定性、高效率的正白光器件特性,在电流20~200ma范围内,色温变化为4 607~5 920K,色坐标变化为(0.355 1,0.348 3)^(0.323 4,0.336 1),显色指数变化为77.6~84.2,器件最高功率效率达到31.69lm W-1@20ma。另外,为了进一步考察器件性能稳定的原因,研究了时间、温度以及UV处理对CdSe/ZnS QDs/硅胶混合光转换材料稳定性的影响,结果表明,器件的高稳定性可归因于所采用的一步法合成的核壳结构量子点材料本身的稳定性,研究的优化器件结果是一种低能耗的优质白光光源,可使人们真实地感知物体的原貌,在正白光光源领域具有很好的应用前景。

关键词：量子点白光LED 正白光稳定性

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A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV) infected pneumonia(standard version)

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Military Medical Research 2020年第1期7卷 1-22页

作者： ying-Hui Jin Lin Cai Zhen-Shun Cheng Hong Cheng Tong Deng Yi-Pin Fan Cheng Fang Di Huang Lu-Qi Huang Qiao Huang Yong Han Bo Hu Fen Hu Bing-Hui Li Yi-Rong Li Ke Liang Li-Kai Lin Li-Sha Luo Jing ma Lin-Lu ma Zhi-Yong Peng Yun-Bao Pan Zhen-Yu Pan xue-Qun Ren Hui-Min Sun ying Wang Yun-Yun Wang Hong Weng Chao-jie Wei Dong-Fang Wu Jian Xia Yong Xiong Hai-Bo Xu Xiao-Mei Yao Yu-Feng Yuan Tai-Sheng Ye Xiao-Chun zhang ying-Wen zhang yin-Gao zhang Hua-Min zhang Yan Zhao Ming-Juan Zhao Hao Zi Xian-Tao Zeng Yong-Yan Wang Xing-Huan Wang 无 Center for Evidence-Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Institute of Hospital management Wuhan UniversityWuhan 430071China Department of Respiratory Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Pharmacy Zhongnan Hospital of Wuhan UniversityWuhan 430071China Institute of Evidence-Based Medicine and Knowledge Translation Henan UniversityKaifeng 475000China China Academy of Chinese Medical Sciences Beijing 100700China China Center for Evidence Based Traditional Chinese Medicine(CCEBTCM) Beijing 100700China Department of Critical Care Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Clinical Laboratory Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Infectious Diseases Zhongnan Hospital of Wuhan UniversityWuhan 430071China Division of Medical Affairs Zhongnan Hospital of Wuhan UniversityWuhan 430071China Division of Nursing Affairs Zhongnan Hospital of Wuhan UniversityWuhan 430071China Office of Nosocomial Infection Control Zhongnan Hospital of Wuhan UniversityWuhan 430071China Emergency Center Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Radiology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Health Research Methods Evidenceand ImpactMcMaster UniversityHamiltonON L8S 4L8Canada Department of Traditional Chinese Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Global Health Institute Wuhan UniversityWuhan 430072China the Zhongnan Hospital of Wuhan University Novel Coronavirus management and Research Team Evidence-Based Medicine Chapter of China International Exchange and Promotive Association for Medical and Health Care(CPAM)

In December 2019, a new type viral pneumonia cases occurred in Wuhan, Hubei Province;and then named "2019 novel coronavirus(2019-nCoV)" by the World Health Organization(WHO) on 12 January 2020. For it is a never been experienced respiratory disease before and with infection ability widely and quickly, it attracted the world’s attention but without treatment and control manual. For the request from frontline clinicians and public health professionals of 2019-nCoV infected pneumonia management, an evidence-based guideline urgently needs to be developed. Therefore, we drafted this guideline according to the rapid advice guidelines methodology and general rules of WHO guideline development;we also added the first-hand management data of Zhongnan Hospital of Wuhan University. This guideline includes the guideline methodology, epidemiological characteristics, disease screening and population prevention, diagnosis, treatment and control(including traditional Chinese Medicine), nosocomial infection prevention and control, and disease nursing of the 2019-nCoV. Moreover, we also provide a whole process of a successful treatment case of the severe 2019-nCoV infected pneumonia and experience and lessons of hospital rescue for 2019-nCoV infections. This rapid advice guideline is suitable for the first frontline doctors and nurses, managers of hospitals and healthcare sections, community residents, public health persons, relevant researchers, and all person who are interested in the 2019-nCoV.

关键词： 2019 novel coronavirus 2019-nCoV Respiratory disease Pneumonia Infectious diseases Rapid advice guideline Clinical practice guideline Evidence-based medicine

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Effect of metabolic syndrome on prognosis and clinical characteristics of revascularization in patients with coronary artery disease

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Chinese Medical Journal 2006年第22期119卷 1871-1876页

作者： HU Rong ma Chang-sheng NIE Shao-ping LU Qiang KANG Jun-ping DU Xin zhang yin GAO ying-chun HE Li-qun JIA Chang-qi LIU Xin-min DONG Jian-zeng LIU Xiao-hui CHEN Fang ZHOU Yu-jie LU Shu-zheng WU xue-si Department of Cardiology Beijing Anzhen Hospital Capital University of Medical Sciences Beijing 100029 China

Background People with metabolic syndrome are at higher risk for developing coronary artery disease （CAD）. The effect of the metabolic syndrome on outcomes in patients with preexisting CAD has not been well studied. This study was conducted to assess the prevalence, characteristics, in hospital and long term prognosis of CAD with metabolic syndrome and to determine the factors influencing the prognosis of the disease. Methods The DESIRE registry contains data of 3696 patients with CAD between 2001 and 2004. Mean long term followup was （8294±373） days. Diagnosis of metabolic syndrome was based on modified International Diabetes Federation （IDF） Worldwide Definition of the Metabolic Syndrome, using body mass index （BMI） instead of waist circumference. Results Of 2596 patients with complete records of height, weight, and so on, 1280 （49.3%） were identified with metabolic syndrome. The patients with metabolic syndrome had higher level of body mass index, systolic blood pressure, diastolic blood pressure, fasting glucose and disordered blood lipid （all P〈0.0001）, with higher creatinine [（10.5±4.3） mg/L vs （9.9±2.9） mg/L, P〈0.0001] and the number of white blood cells [（7.49±2.86）×10^9/L VS （7.19 ± 2.62） ×10^9/L, P=0.008） compared with those without metabolic syndrome. The patients with metabolic syndrome showed severer coronary angiographic alterations （left main artery and/or ≥2-vessel）（73.6% vs 69.6%, P=0.031）. There were no significant differences of major adverse cardiac and cerebral events （maCCE） or mortality in hospital between the two groups. During followup, the ratio of maCCE in CAD with metabolic syndrome patients increased significantly （11.8% vs 10.0%, P=0.044）. Fasting blood glucose （≥ 1000 mg/L） and triglyceride （TG ≥1500 mg/L） were responsible for most of the increased risk associated with the metabolic syndrome （adjusted OR 1.465, 95% CI 1.037-1.874, P=0.032; OR 1.378, 95% CI 1.01±1.768, P=0.044）. Conclusions The prevalence of metabolic syndrome was very

关键词： coronary artery disease revascularization metabofic syndrome

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Site testing campaign for the Large Optical/infrared Telescope of China:overview

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Research in Astronomy and Astrophysics 2020年第6期20卷 81-95页

作者： Lu Feng Jin-Xin Hao Zi-Huang Cao Jin-Min Bai Ji Yang Xu Zhou Yong-Qiang Yao Jin-Liang Hou Yong-Heng Zhao Yu Liu Teng-Fei Song Li-Yong Liu Jia yin Hua-Lin Chen Chong Pei Ali Esamdin Lu ma Chun-Hai Bai Peng Wei Jing Xu Guang-Xin Pu Guo-jie Feng Xuan zhang Liang Ming Abudusaimaitijiang Yisikandee Jian-Rong Shi Jian Li Yuan Tian Zheng Wang Xia Wang Xiao-Jun Jiang Jian-Feng Wang Jian-Feng Tian Yan-jie xue Jian-Sheng Chen Jing-Yao Hu Zhi-Xia Shen Yun-ying Jiang National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Yunnan Observatories Chinese Academy of SciencesKunming 650216China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Nanjing Institute of Astronomical Optics&Technology Chinese Academy of SciencesNanjing 210042China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210033China University of Chinese Academy of Sciences Beijing 100049China

The Large Optical/infrared Telescope(LOT)is a ground-based 12 m diameter optical/infrared telescope which is proposed to be built in the western part of China in the next *** on satellite remote sensing data,along with geographical,logistical and political considerations,three candidate sites were chosen for ground-based astronomical performance *** sites include:Ali in Tibet,Daocheng in Sichuan and Muztagh-ata in *** until now,all three sites have continuously collected data for two *** this paper,we will introduce this site testing campaign,and present its monitoring results obtained during the period between march 2017 and march 2019.

关键词： techniques telescope-site testing

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基于生物信息学筛选的胰腺癌差异基因及免疫浸润机制预测靶向中药

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天然产物研究与开发 2023年第2期35卷 319-331页

作者：龙思丹季双双陈美池贠张君马银杰薛鹏朱世杰中国中医科学院望京医院肿瘤科北京100102 北京中医药大学研究生院北京100029

本研究首先通过生物信息学方法得到胰腺癌差异基因2653个,进一步筛选得到COL1A2等10个核心差异基因,涉及蛋白质消化与吸收等信号通路。然后生存分析表明核心差异基因对胰腺癌患者的无复发生存率具有显著影响,进一步免疫细胞浸润矩阵分... 详细信息

本研究首先通过生物信息学方法得到胰腺癌差异基因2653个,进一步筛选得到COL1A2等10个核心差异基因,涉及蛋白质消化与吸收等信号通路。然后生存分析表明核心差异基因对胰腺癌患者的无复发生存率具有显著影响,进一步免疫细胞浸润矩阵分析发现胰腺癌组织中CD4^(+)记忆T细胞、M2巨噬细胞、树突状细胞等浸润程度高,而CD8^(+)T细胞浸润程度低,不同免疫细胞的分布之间存在一定相关性。最后,本研究预测的有效中药多属于清热、补益和祛风湿类,归肝经,其中葶苈子、姜黄等中药与核心基因和相关免疫途径最为密切。

关键词：胰腺癌生物信息学免疫浸润生存分析中药预测

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