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一线EGFR-TKI耐药后接受化疗的晚期非小细胞肺癌患者疗效分析

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实用医学杂志 2016年第2期32卷 228-231页

作者：魏媛马新宇马笛贺川巩平石河子大学医学院第一附属医院肿瘤内科 832002

目的:探讨晚期非小细胞肺癌(NSCLC)获得性耐药的患者进行二线化疗疗效的影响因素。方法:收集EGFR-TKIs获得性耐药后接受化疗的晚期NSCLC患者66例,分析不同化疗方案、EGFR基因状态与化疗疗效及生存之间的关系。结果:接受培美曲塞化疗的... 详细信息

目的:探讨晚期非小细胞肺癌(NSCLC)获得性耐药的患者进行二线化疗疗效的影响因素。方法:收集EGFR-TKIs获得性耐药后接受化疗的晚期NSCLC患者66例,分析不同化疗方案、EGFR基因状态与化疗疗效及生存之间的关系。结果:接受培美曲塞化疗的患者疾病控制率(DCR)明显高于含铂方案化疗的患者(P=0.020)。接受单药培美曲塞方案化疗患者的中位PFS长于含铂方案(P=0.024)。19-del突变患者的PFS及OS均长于21-L858R突变的患者(中位PFS,5.7个月vs.4.6个月,P=0.048;中位OS,14.7个月vs.13.1个月,P=0.032)。Cox多因素分析显示,19-del突变接受培美曲塞方案作为二线治疗的患者在PFS与OS上均长于含铂方案。结论:对于EGFR-TKIs耐药的晚期NSCLC患者,携带19-del突变时使用培美曲塞方案较含铂方案更有优势。

关键词：癌,非小细胞肺 EGFR-TKIs 获得性耐药化疗方案

Trehalose and Sucrose Osmolytes Accumulated by Algae as Potential Raw material for Bioethanol

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Diagnostic Performance of Serial bedside Capillary Lactate, Hemoglobin, and Shock Index for Severe Postpartum

Natural Resources 2011年第3期

作者： ma. del Pilar Bremauntz Luis G. Torres-Bustillos Rosa-Olivia Ca？izares-Villanueva Enrique Duran-Paramo Luis Fernández-Linares

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基于隐藏主题概率模型的图像结构感知SISR重建方法

Advances in Reproductive Sciences 2021年第4期

作者： Roberto Arturo Castillo-Reyther Idelia Natalie Plata-Alcocer Salvador De la maza-Labastida Venance Basil Kway ma.del Pilar Fonseca-Leal

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华南理工大学学报（自然科学版） 2019年第4期47卷 1-9页

作者：马丽红王小娥田菁张宇华南理工大学电子与信息学院广东广州510640 新加坡国立大学系统科学研究所新加坡119615 华南理工大学计算机应用工程研究所广东广州510640

在基于示例学习的单幅图像超分辨率(SISR)重建中,假设从低分辨率(LR)到高分辨率(HR)图像块的映射关系是一对一的,但同一LR块会与多个HR块对应,导致了LR与HR块的匹配误差.为解决HR复原块的失配问题,文中首先导出了LR块主题模式的概率模型... 详细信息

在基于示例学习的单幅图像超分辨率(SISR)重建中,假设从低分辨率(LR)到高分辨率(HR)图像块的映射关系是一对一的,但同一LR块会与多个HR块对应,导致了LR与HR块的匹配误差.为解决HR复原块的失配问题,文中首先导出了LR块主题模式的概率模型,引入信号的隐藏主题这一种新的观察信息.然后提出了一种基于块主题差异和上下文最大概率的结构感知复原机制,通过主题模式与邻域块内容的关联,形成LR块的流形描述;在重构中通过自适应主题决策树选择和节点回归矩阵映射,从相似的LR流形信号中准确区分和复原HR信号.主题模型优化实验结果表明,文中基于主题约束信息的算法比未引入隐藏主题的决策树SISR方法的峰值信噪比(PSNR)值提升了0.25 dB;在5种算法的对比实验中,相对于稀疏字典SISR方法,文中方法的PSNR值平均提升了0.92 dB,表明引入隐藏的主题信息和主题流形结构辨识是可行的.

关键词：超分辨率重建主题概率模型结构感知流形约束节点回归映射

Single-cell-resolution transcriptome map revealed novel genes involved in testicular germ cell progression and somatic cells specification in Chinese tongue sole with sex reversal

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Science China(Life Sciences) 2023年第5期66卷 1151-1169页

作者： Hong-Yan Wang Xiang Liu Jian-Yang Chen Yingyi Huang Yifang Lu Fujian Tan Qun Liu Mingming Yang Shuo Li Xianghui Zhang Yating Qin Wenxiu ma Yingming Yang Liang Meng Kaiqiang Liu Qian Wang Guangyi Fan Rafael H.Nóbrega Shanshan Liu Francesc Piferrer Changwei Shao Key Lab of Sustainable Development of marine Fisheries Ministry of Agriculture and Rural AffairsYellow Sea Fisheries Research InstituteChinese Academy of Fishery SciencesQingdao 266072China Laboratory for marine Fisheries Science and Food Production Processes Qingdao National Laboratory for Marine Science and TechnologyQingdao 266071China College of Fisheries and Life Science Shanghai Ocean UniversityShanghai 201306China BGI Research-Qingdao BGIQingdao 266555China BGI-Shenzhen Shenzhen 518083China School of marine Sciences Ningbo UniversityNingbo 315211China College of marine Technology and Environment Dalian Ocean UniversityDalian 116023China Qingdao-Europe Advanced Institute for Life Sciences BGI-ShenzhenQingdao 266555China College of Life Sciences Shandong Normal UniversityJinan 250014China Reproductive and Molecular Biology Group Department of Structural and Functional BiologyInstitute of BiosciencesSão Paulo State University(UNESP)BotucatuSão PauloBrazil Institut de Ciències del mar(ICM) Spanish National Research Council(CSIC)BarcelonaSpain

Female-to-male sex reversals(pseudomales)are common in lower vertebrates and have been found in natural populations,which is a concern under rapid changes in environmental *** can exhibit altered ***,the regulatory mechanisms underlying pseudomale spermatogenesis remain ***,we characterized spermatogenesis in Chinese tongue sole(Cynoglossus semilaevis),a species with genetic and environmental sex determination,based on a highresolution single-cell RNA-seq atlas of cells derived from the testes of genotypic males and *** identified five germ cell types and six somatic cell types and obtained a single-cell atlas of dynamic changes in gene expression during spermatogenesis in Chinese tongue sole,including alterations in *** detected decreased levels of Ca^(2+)signaling pathway-related genes in spermatogonia,insufficient meiotic initiation in spermatocytes,and a malfunction of somatic niche cells in ***,a cluster of CaSR genes and maPK signaling factors were upregulated in undifferentiated spermatogonia of ***,we revealed that Z chromosome-specific genes,such as piwil2,dhx37,and ehmt1,were important for *** results improve our understanding of reproduction after female-to-male sex-reversal and provide new insights into the adaptability of reproductive strategies in lower vertebrates.

关键词： Cynoglossus semilaevis spermatogenesis single-cell transcriptome sex reversal spermatogonia

循环神经网络模型在腹膜透析临床预后预测中的初步应用

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北京大学学报（医学版） 2019年第3期51卷 602-608页

作者：唐雯高峻逸马辛宇张超贺马连韬王亚沙北京大学第三医院肾内科北京100191 北京大学高可信软件技术教育部重点实验室北京100871 北京大学信息科学技术学院北京100871 北京大学软件工程国家工程研究中心北京100871 北京医学会肾脏病学会、北京医学会血液净化学会分会腹膜透析专家组中国计算机学会、普适计算专业委员会、国家大数据标准委员会技术专题组、中国智慧城市产业与技术创新战略联盟

目的:应用深度学习模型循环神经网络(recurrent neural network,RNN)及其变体门控循环单元(gated recurrent unit,GRU),基于临床真实数据,构建腹膜透析临床预后预测模型,并比较其与医学研究中常用的逻辑回归( logistic regression, LR)... 详细信息

目的:应用深度学习模型循环神经网络(recurrent neural network,RNN)及其变体门控循环单元(gated recurrent unit,GRU),基于临床真实数据,构建腹膜透析临床预后预测模型,并比较其与医学研究中常用的逻辑回归( logistic regression, LR)模型的预测性能,探索预测结果中可能的医学意义。方法:使用北京大学第三医院腹膜透析门诊的常规诊疗数据,基于患者在开始透析时的基线数据、随访数据和预后数据构建RNN和GRU预测模型。使用受试者工作特征曲线下面积(area under the ROC curve,AUROC)、召回率(recall)、F1分数(F1-score)三个指标在测试集上评价比较模型对患者死亡风险的预测效果。结果:共纳入656例患者,其中死亡患者261例,共计 13 091 条诊断记录。经过十折交叉验证调整超参数并在单独的测试集测试结果显示,LR模型、RNN模型、GRU模型的AUROC分别为0.701 4、0.786 0、0.814 7,RNN和GRU模型的预测性能显著优于传统的LR模型。在召回率和F1分数方面,RNN和GRU模型的性能也均显著优于LR模型,且GRU模型表现最好。进一步分析显示GRU模型在不同预测窗口下对于不同死因或相同死因的召回率不尽相同。结论: RNN模型(尤其是GRU模型)相比于传统医学研究所使用的LR模型,对于腹膜透析临床预后预测具有更佳效果,可能有助于医生早期干预,提高医疗质量,具有很强的临床应用价值。

关键词：腹膜透析预后死亡风险预测循环神经网络门控循环单元

Application of Design of Experiments and Simulation to Improve the Deep Drawing Process of Sheet Metal Forming

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材料科学与工程（中英文B版） 2012年第12期2卷 626-633页

作者： Juan Carlos Cisneros Ortega Femando Torres Leza Emilio Royo Vazquez ma Jose Oliveros Colay Aurelio Horacio Heredia Jimenez Department of Engineerings Universidad Popular Aut6noma del Estado de Puebla Puebla 72410 Mdxico Department of Design and manufacturing Engineering University of Zaragoza Zaragoza 50018 Spain

The objective of this work was the planning, simulation and evaluation of the behavior and interactions of diverse factors in the deep drawing process, in order to prevent defects on formed metal sheet parts. The material used is austenitic stainless steel of 0.4 mm of thickness. Due to the potential high number of experiments, a preliminary selection of cylindrical and hemispherical cup drawing geometries was carried out, as well as a parametric analysis of parts and tools. The influence of the punch and die transition radii, as well as the force of the binder, on the maximum thinning suffered by the material, was studied. The tests were planned by means of CAD/CAE and the design of experiments method. After running the simulation with AutoForm, they were evaluated with FLD, Regression, ANOVA, Six Sigma and Pareto analysis. This sequence allowed us to analyze the influence and sensitivity of several tool and process design parameters and to optimize the process. The results of this investigation have also proven to be useful to simplify and accelerate the design of deep drawing tools.

关键词：金属板材成形模拟设计成形过程实验深拉伸工艺应用拉深奥氏体不锈钢

CCL2-2518 A/G and CCR2 190 A/G do not influence the outcome of hepatitis C virus infection in the Spanish population

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World Journal of Gastroenterology 2007年第15期13卷 2187-2192页

作者： ma Montes-Cano JR García-Lozano J Aguilar-Reina M Romero-Gómez N Barroso A Nú(n|~)ez-Roldán MF González-Escribano Servicio de Inmunologia Hospital Universitario Virgen del Rocío Spain Servicio de Digestivo Hospital Universitario Virgen del Rocío Spain Sección Hepatología. Hospital Universitario de Valme. Servicio Andaluz de Salud Seville Spain

AIM： To assess whether CCL2 or interactions between this chemokine and its receptor （CCR2） are associated with outcomes of chronic hepatitis C and with responses to antiviral therapy. METHODS： Two hundred and eighty-four patients with chronic hepatitis C and 193 non-infected matched controls were included in this study. Patients were categorized according to their Scheuer score of hepatic fibrosis as F0-F2 （/7 = 202） or F3-F4 （/7 = 82） and according to their response to anti-Hepatitis C virus （HCV） therapy as sustained response （SR, n = 201） or non-sustained response （NSR, n = 98）. Genotyping of the -2518 （A/G） CCL2 was performed using PCR-RFLP, genotyping of the 190 （A/G） CCR2 using a PCR-ARMS system, and genotyping of the rs3138042 （G/A） CCR2 using Taqman probes. RESULTS： Univariate analyses identified 4 parameters （infection duration time, viral genotype, gender and AST levels） that tended to influence fibrosis and 7 parameters （CCL2G, CCL2ACCR2A, viremia levels, fibrosis stage, viral genotype, infection duration time and AST levels） that significantly influenced or tended to influence response to treatment. Multivariate analysis identified gender and AST levels as parameters that independently influenced fibrosis stage and viral genotype and infection duration time were the two parameters that independently influenced response to treatment. CONCLUSION： Our results indicate that the mutations studied in the gene pair CCL2/CCR2 do not play a major role in the outcome and response to treatment for HCV infection in the Spanish population.

关键词： CCL2 CCR2 Polymorphism Hepatitis C virus Treatment Fibrosis stage

Lymphoepithelial cysts and cystic lymphangiomas: Underrecognized benign cystic lesions of the pancreas

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World Journal of Gastrointestinal Surgery 2014年第7期6卷 136-141页

作者： Ioannis T Konstantinidis Avinash Kambadakone Onofrio A Catalano Dushyant V Sahani Vikram Deshpe David G Forcione Jennifer A Wargo Carlos Fernandez-del Castillo Keith D Lillemoe Andrew L Warshaw Cristina R Ferrone Departments of Surgery Massachusetts General HospitalBoston MA 02114 United States Department of Surgery University of ArizonaTucson AZ 85724 United States Departments of Radiology Massachusetts General Hos-pitalBoston MA 02114 United States Department of Radiology University of Napoli80138 Napoli Italy Departments of Pathology Massachusetts General HospitalBoston MA 02114 United States Departments of Gastroenterology Massachu-setts General HospitalBoston MA 02114 United States

AIM: To identify their diagnostic and prognostic clinical characteristics in a large ***: Retrospective review of clinicopathologic and imaging characteristics of patients diagnosed with lymphoepithelial cysts and cystic lymphangiomas of the pancreas at massachusetts General ***: Twelve patients were identified between 1/1/1997 and 8/1/2007. Their median age was 55.5 years(range 19-78 years), and 6 were females. The le-sion was incidentally discovered in half of the *** enhanced computed tomography demonstrat-ed that the cysts had thin walls, without calcifications, pancreatic duct dilation or pancreatic parenchyma inva-sion. Endoscopic ultrasound with fine needle aspiration(EUS/FNA) confirmed the diagnosis of a lymphoepithe-lial cyst in 3 patients, one of whom was spared an op-eration and continues to do well after 6 years. Eleven patients had a resection: 3 pancreaticoduodenecto-mies, 7 distal pancreatectomies, and 1 enucleation. The median size of the cysts was 3 cm(range 2-20 cm). At a median follow-up of 57 mo no recurrences or other pancreas-related conditions ***: Lymphoepithelial cysts and cystic lymphangiomas of the pancreas can be diagnosed with a combination of contrast-enhanced computed tomog-raphy scans and EUS/FNA. If the lesion is asymptom-atic, an operation might be avoided.

关键词： Lymphoepithelial cysts Cystic lymphangio-mas Pancreas Asymptomatic cysts Benign cystic le-sions of the pancreas