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Identifying and validating MMP family members(MMP2,MMP9,MMP12,and MMP16)as therapeutic targets and biomarkers in kidney renal clear cell carcinoma(KIRC)

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Oncology Research 2024年第4期32卷 737-752页

作者： KUNLUN LI DANDAN LI BARBOD HAFEZ MOUNIR M.SALEM BEKHIT YOUSEF A.BIN JARDAN FARS KAED ALANAZI EHAB I.TAHA SAYED H.AUDA FAIQAH RAMZAN muhammad jamil The Second Affiliated Hospital of Harbin Medical University Harbin Medical UniversityHarbinChina Department of Pharmaceutical Engineering Jiangsu Ocean UniversityLianyungangChina Department of Biological Engineering University of SalfordSalfordUK Department of Pharmaceutics College of PharmacyKing Saud UniversityRiyadhSaudi Arabia Department of Animal and Poultry Production Faculty of Veterinary and Animal SciencesGomal UniversityDera Ismail KhanPakistan Department of Arid Zone Research PARC instituteDera Ismail KhanPakistan

Kidney Renal Clear Cell Carcinoma(KIRC)is a malignant tumor that carries a substantial risk of morbidity and mortality.The MMP family assumes a crucial role in tumor invasion and metastasis.This study aimed to uncover the mechanistic relevance of the MMP gene family as a therapeutic target and diagnostic biomarker in Kidney Renal Clear Cell Carcinoma(KIRC)through a comprehensive approach encompassing both computational and molecular analyses.STRING,Cytoscape,UALCAN,GEPIA,OncoDB,HPA,cBioPortal,GSEA,TIMER,ENCORI,DrugBank,targeted bisulfite sequencing(bisulfite-seq),conventional PCR,Sanger sequencing,and RT-qPCR based analyses were used in the present study to analyze MMP gene family members to accurately determine a few hub genes that can be utilized as both therapeutic targets and diagnostic biomarkers for KIRC.By performing STRING and Cytohubba analyses of the 24 MMP gene family members,MMP2(matrix metallopeptidase 2),MMP9(matrix metallopeptidase 9),MMP12(matrix metallopeptidase 12),and MMP16(matrix metallopeptidase 16)genes were denoted as hub genes having highest degree scores.After analyzing MMP2,MMP9,MMP12,and MMP16 via various TCGA databases and RT-qPCR technique across clinical samples and KIRC cell lines,interestingly,all these hub genes were found significantly overexpressed at mRNA and protein levels in KIRC samples relative to controls.The notable effect of the up-regulated MMP2,MMP9,MMP12,and MMP16 was also documented on the overall survival(OS)of the KIRC patients.Moreover,targeted bisulfite-sequencing(bisulfite-seq)analysis revealed that promoter hypomethylation pattern was associated with up-regulation of hub genes(MMP2,MMP9,MMP12,and MMP16).In addition to this,hub genes were involved in various diverse oncogenic pathways.The MMP gene family members(MMP2,MMP9,MMP12,and MMP16)may serve as therapeutic targets and prognostic biomarkers in KIRC.

关键词： KIRC MMP gene family Chemotherapy Overall survival

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Effect of Light Emitting Diodes (LEDs) on Growth, Mineral Composition, and Nutritional Value of Wheat & Lentil Sprouts

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Phyton-International Journal of Experimental Botany 2024年第6期93卷 1117-1128页

作者： Abdul Momin Amana Khatoon Wajahat Khan Dilsat Bozdoğan Konuşkan muhammad Mudasar Aslam muhammad jamil Shafiq Ur Rehman Baber Ali Alevcan Kaplan Sana Wahab muhammad Nauman Khan Sezai Ercisli Mohammad Khalid Al-Sadoon Department of Botany Kohat University of Science&TechnologyKohat26000Pakistan Department of Food Engineering Faculty of AgricultureHatay Mustafa Kemal UniversityHatay31000Türkiye Department of Botany University of Science&TechnologyBannu28100Pakistan Department of Biotechnology and Genetic Engineering Kohat University of Science&TechnologyKohat26000Pakistan Department of Biology University of HaripurKhyber Pakhtunkhwa22620Pakistan School of Science Western Sydney UniversityPenrithNew South Wales2151Australia Department of Crop and Animal Production Sason Vocational SchoolBatman UniversityBatman72060Türkiye Department of Plant Sciences Quaid-i-Azam UniversityIslamabad45320Pakistan Department of Botany Islamia College PeshawarPeshawar25120Pakistan Department of Horticulture Agricultural FacultyAtaturk UniversityErzurum25240Türkiye HGF Agro Ata TeknokentErzurumTR-25240Türkiye Department of Zoology College of ScienceKing Saud UniversityRiyadh11451Saudi Arabia

Sprouts are ready-to-eat and are recognized worldwide as functional components of the human diet.Recent advances in innovative agricultural techniques could enable an increase in the production of healthy food.The use of light-emitting diode(LED)in indoor agricultural production could alter the biological feedback loop,increasing the functional beneﬁts of plant foods such as wheat and lentil sprouts and promoting the bioavailability of nutrients.The effects of white(W),red(R),and blue(B)light were investigated on the growth parameters and nutritional value of wheat and lentil sprouts.In the laboratory,seeds were sown under three different LED treat-ments:white,red,and blue light,while normal incandescent light served as a control.Percentage seed germina-tion improved by 18.34%and 12.67%for wheat and 18.34%and 12.67%for lentil sprouts under LED treatments R and B,respectively.An increase in total soluble protein and sugar by 33.4%and 9.23%in wheat and by 31.5%and 5.87%in lentils was observed under the R LED treatment.Vitamin C concentrations in wheat and lentils were signiﬁcantly increased by R LED compared to all other treatments.Other parameters,including potassium and sodium concentrations,were signiﬁcantly increased under red and blue light compared to the control;white light,on the other hand,signiﬁcantly decreased all these parameters.According to the experimental data,red and blue LED light could be beneﬁcial in the production of functional wheat and lentil sprouts with high nutrient concentrations.

关键词： Growth parameters LED nutritional value sprouts total soluble proteins

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Observability of parameter space for charged Higgs boson in its bosonic decays in two Higgs doublet model Type-1

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Chinese Physics C 2024年第2期48卷 57-65页

作者： Ijaz Ahmed Waqas Ahmad M.S.Amjad jamil muhammad Federal Urdu University of Arts Science and TechnologyIslamabad Pakistan Riphah International University Sector I-14Hajj ComplexIslamabad Pakistan National University of Technology Islamabad Pakistan Sang-Ho College and Department of PhysicsKonkuk UniversitySeoul 05029South Korea

This study explores the possibility of discovering H±through its bosonic decays,i.e.,H±→W±φ(whereφ=h or A),within the Type-I two Higgs doublet model(2HDM).The main objective is to demonstrate the available parameter space after applying recent experimental and theoretical exclusion limits.We suggest that mH±=150 GeV is the most probable mass for the H±→W±φdecay channel in pp collisions at s1/2=8,13,and 14 TeV.We also report on the application of a modern machine learning approach to a multivariate technique for heavy charged Higgs production in association with a single top quark through weak interaction to demonstrate its observability in comparison with the most relevant Standard Model backgrounds using the neural networks of boosted decision Tree(BDT),likelihood(LH),and multilayer perceptron(MLP).

关键词： charged Higgs MSSM LHC

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Biological Stability of Water-Based Cutting Fluids:Progress and Application

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Chinese Journal of Mechanical Engineering 2022年第1期35卷 7-30页

作者： Lizhi Tang Yanbin Zhang Changhe Li Zongming Zhou Xiaolin Nie Yun Chen Huajun Cao Bo Liu Naiqing Zhang Zafar Said Sujan Debnath muhammad jamil Hafiz muhammad Ali Shubham Sharma School of Mechanical and Automotive Engineering Qingdao University of TechnologyQingdao 266520China Hanergy(Qingdao)Lubrication Technology Co. Ltd.Qingdao 266200China Nanjing Kerun Lubricants Co. Ltd.Nanjing 211106China Chengdu Tool Research Institute Co. LtdChengdu 610500China School of Mechanical Engineering Chongqing UniversityChongqing 400044China Sichuan Future Aerospace Industry LLC Shifang 618400China Shanghai Jinzhao Energy Saving Technology Co. Ltd.Shanghai 200436China Department of Sustainable and Renewable Energy Engineering University of Sharjah27272 SharjahUnited Arab Emirates Mechanical Engineering Department Curtin University98009 MiriMalaysia College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China Mechanical Engineering Department King Fahd University of Petroleum and MineralsDhahran 31261Saudi Arabia Department of Mechanical Engineering IK Gujral Punjab Technical UniversityKapurthala 144603PunjabIndia

The application of cutting fluid in the field of engineering manufacturing has a history of hundreds of years,and it plays a vital role in the processing efficiency and surface quality of parts.Among them,water-based cutting fluid accounts for more than 90%of the consumption of cutting fluid.However,long-term recycling of water-based cutting fluid could easily cause deterioration,and the breeding of bacteria could cause the cutting fluid to fail,increase manufacturing costs,and even endanger the health of workers.Traditional bactericides could improve the biological stability of cutting fluids,but they are toxic to the environment and do not conform to the development trend of low-carbon manufacturing.Low-carbon manufacturing is inevitable and the direction of sustainable manufacturing.The use of nanomaterials,transition metal complexes,and physical sterilization methods on the bacterial cell membrane and genetic material could effectively solve this problem.In this article,the mechanism of action of additives and microbial metabolites was first analyzed.Then,the denaturation mechanism of traditional bactericides on the target protein and the effect of sterilization efficiency were summarized.Further,the mechanism of nanomaterials disrupting cell membrane potential was discussed.The effects of lipophilicity and the atomic number of transition metal complexes on cell membrane penetration were also summarized,and the effects of ultraviolet rays and ozone on the destruction of bacterial genetic material were reviewed.In other words,the bactericidal performance,hazard,degradability,and economics of various sterilization methods were comprehensively evaluated,and the potential development direction of improving the biological stability of cutting fluid was proposed.

关键词： Cutting fluid Microorganism Bactericide Sterilization

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Lecanemab Unveiled:Exploring Alzheimer’s Treatment Advancements,Assessing Strengths,Limitations,and Its Therapeutic Landscape Position

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Biomedical and Environmental Sciences 2024年第4期37卷 428-431页

作者： VICTOR Abiola Adepoju OKECHUKWU Innocent Onyezue SAFAYET jamil OLALEKAN John Okesanya DON Eliseo Lucero-Prisno Ⅲ Department of HIV and Infectious Diseases Jhpiegoan affiliate of John Hopkins UniversityAbujaNigeria Department of Prevention and Community Directorate APIN Public Health InitiativesAbujaNigeria Department of Public Health Daffodil International UniversityDhaka-1216Bangladesh Department of Public Health and Maritime Transport University of ThessalyVolosGreece Department of Global Health and Development London School of Hygiene and Tropical MedicineLondonUnited Kingdom

In the ever-evolving landscape of Alzheimer’s treatment,lecanemab(Leqembi)has emerged as a promising drug.Unlike conventional therapies that merely alleviate symptoms,lecanemab is a humanized monoclonal antibody with a distinct focus.It targets protofibrils,insoluble fibrils,amyloid oligomers,and soluble amyloid-beta protofibrils,which are known to be especially damaging to neurons,with high accuracy.

关键词： Alzheimer amyloid Therapeutic

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In silico analysis of a disease-causing mutation in PCDH15 gene in a consanguineous Pakistani family with Usher phenotype

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International Journal of Ophthalmology(English edition) 2016年第5期9卷 662-668页

作者： Shamim Saleha muhammad Ajmal muhammad jamil muhammad Nasir Abdul Hameed Department of Biotechnology and Genetic Engineering Kohat University of Science and Technology Kohat 26000 Khyber Pakhttmkhwa Pakistan Institute of Biomedical and Genetic Engineering (IBGE) Islamabad 44000 Pakistan

AIM： To map Usher phenotype in a consanguineous Pakistani family and identify disease-associated mutation in a causative gene to establish phenotype-genotype correlation.· METHODS： A consanguineous Pakistani family in which Usher phenotype was segregating as an autosomal recessive trait was ascertained. On the basis of results of clinical investigations of affected members of this family disease was diagnosed as Usher syndrome（USH）. To identify the locus responsible for the Usher phenotype in this family, genomic DNA from blood sample of each individual was genotyped using microsatellite Short Tandem Repeat（STR） markers for the known Usher syndrome loci. Then direct sequencing was performed to find out disease associated mutations in the candidate gene.· RESULTS： By genetic linkage analysis, the USH phenotype of this family was mapped to PCDH15 locus on chromosome 10q21.1. Three different point mutations in exon 11 of PCDH15 were identified and one of them,c.1304AC was found to be segregating with the disease phenotype in Pakistani family with Usher phenotype.This, c.1304 A C transversion mutation predicts an amino-acid substitution of aspartic acid with an alanine at residue number 435（p.D435A） of its protein product.Moreover, in silico analysis revealed conservation of aspartic acid at position 435 and predicated this change as pathogenic.·CONCLUSION：Theidentificationofc.1304ACpathogenic mutation in PCDH15 gene and its association with Usher syndrome in a consanguineous Pakistani family is thefirst example of a missense mutation of PCDH15 causing USH1 phenotype. In previous reports, it was hypothesized that severe mutations such as truncated protein of PCDH15 led to the Usher I phenotype and that missense variants are mainly responsible for non-syndromic hearing impairment.

关键词： deafness and blindness Usher syndrome causative gene missense mutation Pakistani family

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Minimum quantity lubrication machining of aeronautical materials using carbon group nanolubricant: From mechanisms to application

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Chinese Journal of Aeronautics 2022年第11期35卷 85-112页

作者： Xin CUI Changhe LI Wenfeng Ding Yun CHEN Cong MAO Xuefeng XU Bo LIU Dazhong WANG Hao Nan LI Yanbin ZHANG Zafar SAID Sujan DEBNATH muhammad jamil Hafiz muhammad ALI Shubham SHARMA School of Mechanical and Automotive Engineering Qingdao University of TechnologyQingdao 266520China College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China Chengdu Tool Research Institute Co. Ltd.Chengdu 610500China College of Automotive and Mechanical Engineering Changsha Universiy of Science and TechnologyChangsha 410ll14China Key Laboratory of Special Purpose Equipment and Advanced Processing Technology Ministry of Education&Zhejiang ProvinceZhejiang University of TechnologyHangzhou 310032China Sichuan Future Aerospace Industry LLC. Shifang 618400China School of Mechanical and Automotive Engineering Shanghai University of Engineering ScienceShanghai 201620China School of Aerospace Universiy of Notingham Ningbo ChinaNingbo 315100China College of Engineering Universityof SharjahSharjah 27272United Arab Emirates Mechanical Engineering Department Curtin UniversityMiri 98009Malaysia Mechanical Engineering Department King Fahd University of Petroleum and MineralsDhahran 31261Saudi Arabia Department of Mechanical Engineering and Advanced Materials Science Council of Scientific and Industrial Research(CSIR)-Central Leather Research Institute(CLRI)Regional Center for Extension and DevelopmentJalandhar 144021India

It is an inevitable trend of sustainable manufacturing to replace flood and dry machining with minimum quantity lubrication(MQL)technology.Nevertheless,for aeronautical difficult-tomachine materials,MQL couldn’t meet the high demand of cooling and lubrication due to high heat generation during machining.Nano-biolubricants,especially non-toxic carbon group nano-enhancers(CGNs)are used,can solve this technical bottleneck.However,the machining mechanisms under lubrication of CGNs are unclear at complex interface between tool and workpiece,which characterized by high temperature,pressure,and speed,limited its application in factories and necessitates in-depth understanding.To fill this gap,this study concentrates on the comprehensive quantitative assessment of tribological characteristics based on force,tool wear,chip,and surface integrity in titanium alloy and nickel alloy machining and attempts to answer mechanisms systematically.First,to establish evaluation standard,the cutting mechanisms and performance improvement behavior covering antifriction,antiwear,tool failure,material removal,and surface formation of MQL were revealed.Second,the unique film formation and lubrication behaviors of CGNs in MQL turning,milling,and grinding are concluded.The influence law of molecular structure and micromorphology of CGNs was also answered and optimized options were recommended by considering diverse boundary conditions.Finally,in view of CGNs limitations in MQL,the future development direction is proposed,which needs to be improved in thermal stability of lubricant,activity of CGNs,controllable atomization and transportation methods,and intelligent formation of processing technology solutions.

关键词： Aerospace materials Carbon nanoparticles Grinding Lubrication mechanism Milling Minimum quantity lubrication Turning

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Unsteady flow of viscoelastic fluid between two cylinders using fractional Maxwell model

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Acta Mechanica Sinica 2012年第2期28卷 274-280页

作者： muhammad jamil Constantin Fetecau Corina Fetecau Abdus Salam School of Mathematical Sciences GC UniversityLahorePakistan Department of Mathematics NED University of Engineering&TechnologyKarachi-75270Pakistan Department of Mathematics Technical University of IasiIasi-700050Romania Department of Theoretical Mechanics Technical University of IasiIasi-700050Romania

The unsteady flow of an incompressible fractional Maxwell fluid between two infinite coaxial cylinders is studied by means of integral transforms. The motion of the fluid is due to the inner cylinder that applies a time dependent tor- sional shear to the fluid. The exact solutions for velocity and shear stress are presented in series form in terms of some generalized functions. They can easily be particularized to give similar solutions for Maxwell and Newtonian fluids. Fi- nally, the influence of pertinent parameters on the fluid motion, as well as a comparison between models, is highlighted by graphical illustrations.

关键词： Maxwell fluid Fractional derivative Exact so- lutions Velocity field Shear stress Laplace and Hankel transforms

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Nano-enhanced biolubricant in sustainable manufacturing:From processability to mechanisms

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Friction 2022年第6期10卷 803-841页

作者： Yanbin ZHANG Hao Nan LI Changhe LI Chuanzhen HUANG Hafiz muhammad ALI Xuefeng XU Cong MAO Wenfeng DING Xin CUI Min YANG Tianbiao YU muhammad jamil Munish Kumar GUPTA Dongzhou JIA Zafar SAID School of Mechanical and Automotive Engineering Qingdao University of TechnologyQingdao 266520China School of Aerospace University of Nottingham Ningbo ChinaNingbo 315100China School of Mechanical Engineering Yanshan UniversityQinhuangdao 066004China Mechanical Engineering Department King Fahd University of Petroleum and MineralsDhahran 31261Saudi Arabia Key Laboratory of Special Purpose Equipment and Advanced Processing Technology Ministry of Education&Zhejiang ProvinceZhejiang University of TechnologyHangzhou 310032China College of Automotive and Mechanical Engineering Changsha University of Science and TechnologyChangsha 410114China College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China School of Mechanical Engineering&Automation Northeastern UniversityShenyang 110006China Industrial Engineering Department University of Engineering and Technology TaxilaTaxila 47080Pakistan School of Mechanical Engineering Shandong UniversityJinan 250061China College of Mechanical Engineering and Automation Liaoning University of TechnologyJinzhou 121001China College of Engineering University of SharjahSharjah 27272United Arab Emirates

To eliminate the negative effect of traditional metal-working fluids and achieve sustainable manufacturing,the usage of nano-enhanced biolubricant(NEBL)is widely researched in minimum quantify lubrication(MQL)machining.It's improved tool wear and surface integrity have been preliminarily verified by experimental studies.The previous review papers also concluded the major influencing factors of processability including nano-enhancer and lubricant types,NEBL concentration,micro droplet size,and so on.Nevertheless,the complex action of NEBL,from preparation,atomization,infiltration to heat transfer and anti-friction,is indistinct which limits preparation of process specifications and popularity in factories.Especially in the complex machining process,in-depth understanding is difficult and meaningful.To fll this gap,this paper concentrates on the comprehensive quantitative assessment of processability based on tribological,thermal,and machined surface quality aspects for NEBL application in turning,milling,and grinding.Then it attempts to answer mechanisms systematically considering multi-factor influence of molecular structure,physicochemical properties,concentration,and dispersion.Firstly,this paper reveals advanced lubrication and heat transfer mechanisms of NEBL by quantitative comparison with biolubricant-based MQL machining.Secondly,the distinctive filmformation,atomization,and infiltration mechanisms of NEBL,as distinguished from metal-working fluid,are clarified combining with its unique molecular structure and physical properties.Furtherly,the process optimization strategy is concluded based on the synergistic relationship analysis among process variables,physicochemical properties,machining mechanisms,and performance of NEBL.Finally,the future development directions are put forward aiming at current performance limitations of NEBL,which requires improvement on preparation and jet methods respects.This paper will help scientists deeply understand effective mechanism,formulate process specifications,and find

关键词： nano-enhanced biolubricant(NEBL) sustainable manufacturing minimum quantity lubrication(MQL) tribological properties machining mechanisms

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C_(f)/SiC复合材料铣削特性的三维有限元分析及试验验证

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Transactions of Nanjing University of Aeronautics and Astronautics 2023年第3期40卷 253-263页

作者： ELLAHI Zohaib 赵国龙年智文 muhammad jamil 何宁南京航空航天大学机电学院南京210016

碳纤维增强碳化硅(C_(f)/SiC)复合材料具有高强度、耐磨损和各向异性等特点,导致材料加工非常困难。本文开展了聚晶金刚石(PCD)刀具铣削C_(f)/SiC复合材料的三维有限元仿真和试验,研究了复合材料的切削特性;研究了加工参数对切削力的影... 详细信息

碳纤维增强碳化硅(C_(f)/SiC)复合材料具有高强度、耐磨损和各向异性等特点,导致材料加工非常困难。本文开展了聚晶金刚石(PCD)刀具铣削C_(f)/SiC复合材料的三维有限元仿真和试验,研究了复合材料的切削特性;研究了加工参数对切削力的影响,以及不同纤维切削角下的材料去除机理。通过用户自定义的子程序在ABAQUS/CAE软件中建立了有限元切削仿真模型,仿真分析了加工参数对切削力的影响,并开展了验证试验。结果表明,有限元仿真和试验得到的X和Y方向的切削力具有良好的一致性。随着切削速度的增加,切削力降低;随着每齿进给量的增加,切削力升高。当沿着纤维方向进行切削时,刀具刃口的应力最小;随着纤维切削角的增大,刃口应力升高。本文可为C_(f)/SiC复合材料切削特性研究提供指导。

关键词：三维有限元仿真 C_(f)/SiC复合材料铣削加工切削力切削加工性

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