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In vitro evaluation of electrospun gelatin-glutaraldehyde nanofibers

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Frontiers of Materials Science 2016年第1期10卷 90-100页

作者： Jianchao ZHAN yosry morsi Hany EI-HAMSHARY Salem S. AL-DEYAB Xiumei MO College of Chemistry Chemical Engineering and Biotechnology Donghua University Shanghai 201620 China College of Materials and Textile Engineering Jiaxing University Jiaxing 314001 China Faculty of Engineering and Industrial Sciences Swinburne University of Technology Hawthorn Vic 3122 Australia Department of Chemistry College of Science King Saud University Riyadh 11451 Saudi Arabia Department of Chemistry Faculty of Science Tanta University Tanta 31527 Egypt

The gelatin-glutaraldehyde （gelatin-GA） nanofibers were electrospun in order to overcome the defects of ex-situ crosslinking process such as complex process, destruction of fiber morphology and decrease of porosity. The morphological structure, porosity, thermal property, moisture absorption and moisture retention performance, hydrolytic resistance, mechanical property and biocompatibiUty of nanofiber scaffolds were tested and characterized. The gelatin-GA nanofiber has nice uniform diameter and more than 80% porosity. The hydrolytic resistance and mechanical property of the gelatin-GA nanofiber scaffolds are greatly improved compared with that of gelatin nanofibers. The contact angle, moisture absorption, hydrolysis resistance, thermal resistance and mechanical property of gelatin-GA nanofiber scaffolds could be adjustable by varying the gelatin solution concentration and GA content. The gelatin- GA nanofibers had excellent properties, which are expected to be an ideal scaffold for biomedical and tissue engineering applications.

关键词： nanofiber electrospinning gelatin tissue engineering

Electrospinning:An emerging technology to construct polymer-based nanofibrous scaffolds for diabetic wound healing

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Frontiers of Materials Science 2021年第1期15卷 10-35页

作者： Atta ur Rehman KHAN yosry morsi Tonghe ZHU Aftab AHMAD Xianrui XIE Fan YU Xiumei MO State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of ChemistryChemical Engineering and BiotechnologyDonghua UniversityShanghai 201620China Faculty of Engineering and Industrial Sciences Swinburne University of TechnologyBoroondaraVIC 3122Australia Multidisciplinary Center for Advanced Materials of Shanghai University of Engineering Science College of Chemistry and Chemical EngineeringShanghai University of Engineering ScienceShanghai 201620China Department of Bioscience cOMSATS Institute of Information TechnologyPakistan

A chronic wound in diabetic patients is a major public health concern withsocioeconomic and clinical *** underlying medical condition of diabeticpatients deteriorates the wound through physiological,metabolic,molecular,and ***,a wound enters a vicious pathological inflammatory *** therapeutic approaches are in practice to manage diabetic wounds hence ensuringthe regeneration ***-based biomaterials have come up with hightherapeutic *** efforts have been devoted,over the years,to build aneffective wound healing material using *** electrospinning technique,although not new,has turned out to be one of the most effective strategies in buildingwound healing biomaterials due to the special structural advantages of electrospunnanofibers over the other *** this review,careful integration of allelectrospinning approaches has been presented which will not only give an insight intothe current updates but also be helpful in the development of new therapeutic materialconsidering pathophysiological conditions of a diabetic wound.

关键词： diabetic wound healing inflammation polymers bioactive substances hydrogel electrospinning nanofibers

A soft tissue adhesive based on aldehyde-sodium alginate and amino-carboxymethyl chitosan preparation through the Schiff reaction

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Frontiers of Materials Science 2017年第3期11卷 215-222页

作者： Yu WU Liu YUAN Nai-an SHENG Zi-qi GU Wen-hao FENG Hai-yue YIN yosry morsi Xiu-mei MO Key Laboratory of Textile Science & Technology (Ministry of Education) College of Chemistry Chemical Engineering and Biotechnology Donghua University Shanghai 201620 China Faculty of Engineering and Industrial Sciences Swinburne University of Technology Hawthorn Vic 3122 Australia Shandong International Biotechnology Park Development Co. Ltd. Yantai 264003 China

Sodium alginate and carboxymethyl chitosan have been extensively applied in tissue engineering and other relative fields due to their low price and excellent biocompatibility. In this paper, we oxidized sodium alginate with sodium periodate to convert 1,2-hydroxyl groups into aldehyde groups to get aldehyde-sodium alginate （A- SA）. Carboxymethyl chitosan was modified with ethylenediamine （ED） in the presence of water-soluble N-（3-Dimethylaminopropyl）-N＇-ethylcarbodiimide hydrochloride （EDC） to introduce additional amino groups to get amino-carboxymethyl chitosan （A-CS）. Upon mixing the A-SA and A-CS aqueous solutions together, a gel rapidly formed based on the Schiff＇s base reaction between aldehyde groups in A-SA and amino groups in A-CS. FTIR analysis confirmed the characteristic peak of Schiff＇s base group in the hydrogel. It was confirmed that the gelation time be dependent on the aldehyde group content in A-SA and amino group content in A-CS. The fasted hydrogel formation takes place within 10 min. The data of bonding strength and cytotoxicity measurement also showed that the hydrogel had good adhesion and biocompatibility. All these results support that this gel has the potential as soft tissue adhesive.

关键词： oxidized sodium alginate amino-carboxymethyl chitosan tissue adhesive Schiff's base

Regulation of nerve cells using conductive nanofibrous scaffolds for controlled release of Lycium barbarum polysaccharides and nerve growth factor

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Regenerative Biomaterials 2023年第1期10卷 919-932页

作者： Jing Wang Yuan Liu Minmin Lv Xiaoli Zhao Kwok Fai So Hui Li Mohamed EL-Newehy Hany EL-Hamshary yosry morsi Xiumei Mo Research Center for Human Tissues and Organs Degeneration Institute of Biomedicine and BiotechnologyShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen518055P.R.China Department of Orthopedics Shanghai Sixth People’s HospitalShanghai201306P.R.China University of Hong Kong-Shenzhen Hospital Shenzhen518053P.R.China State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongPokfulamHong KongP.R.China Department of Ophthalmology The University of Hong KongPokfulamHong KongP.R.China Guangdong-Hong Kong-Macao Institute of CNS Regeneration Jinan UniversityGuangzhouP.R.China Department of Chemistry College of ScienceKing Saud UniversityRiyadh 11451P.O.Box 2455Saudi Arabia Faculty of Engineering and Industrial Sciences Swinburne University of TechnologyBoroondaraVIC 3122Australia State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative MedicineCollege of Biological Science and Medical EngineeringDonghua UniversitySongjiangShanghai201600P.R.China

Currently,more and more patients suffer from peripheral nerve injury due to trauma,tumor and other causes ***-based nerve conduits are increasingly recognized as a potential alternative to nerve autografts for the treatment of peripheral nerve ***,an ideal nerve conduit must offer topological guidance and biochemical and electrical signal transduction *** this work,aligned conductive nanofibrous scaffolds comprising polylactic-co-glycolic acid and multiwalled carbon nanotubes(MWCNTs)were fabricated via coaxial electrospinning,and nerve growth factor(NGF)and Lycium barbarum polysaccharides(LBP)purified from the wolfberry were loaded on the core and shell layers of the nanofibers,*** were confirmed to accelerate long-distance axon regeneration after severe peripheral nerve *** addition,the synergistic promotion of LBP and NGF on nerve cell proliferation and neurite outgrowth was *** were introduced into the aligned fibers to further increase the electrical conductivity,which promoted the directional growth and neurite extension of neurons in ***,the combination of conductive fibrous scaffolds with electrical stimulation that mimics endogenous electric fields significantly promoted the differentiation of PC12 cells and the axon outgrowth of *** on robust cell-induced behaviors,conductive composite fibers with optimized fiber alignment may be used for the promotion of nerve recovery.

关键词： conductive nanofibrous scaffold LBP NGF nerve cells electrical stimulation

Fabrication and characterization of Antheraea pernyi silk fibroin-blended P（LLA-CL） nanofibrous scaffolds for peripheral nerve tissue engineering

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Frontiers of Materials Science 2017年第1期11卷 22-32页

作者： Juan WANG Binbin SUN Muhammad Aqeel BHUTTO Tonghe ZHU Kui YU Jiayu BAO yosry morsi Hany EL-HAMSHARY Mohamed EL-NEWEHY Xiumei MO State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Chemistry Chemical Engineering and Biotechnology Donghua University Shanghai 201620 China Shandong International Biotechnology Park Development Co. Ltd. Yantai 264670 China College of Materials Science and Engineering Donghua University Shanghai 201620 China Faculty of Engineering and Industrial Sciences Swinburne University of Technology Hawthorn Vic 3122 Australia Department of Chemistry College of Science King Saud University Riyadh 11451 Saudi Arabia Department of Chemistry Faculty of Science Tanta University Tanta 31527 Egypt

Electrospun nanofibers have gained widespreading interest for tissue engineering application. In the present study, ApF/P（LLA-CL） nanofibrous scaffolds were fabricated via electrospinning. The feasibility of the material as tissue engineering nerve scaffold was investigated in vitro. The average diameter increased with decreasing the blend ratio of ApF to P（LLA-CL）. Characterization of 13C NMR and FTIR clarified that there is no obvious chemical bond reaction between ApF and P（LLA-CL）. The tensile strength and elongation at break increased with the content increase of P（LLA-CL）. The surface hydrophilic property of nanofibrous scaffolds enhanced with the increased content of ApF. Cell viability studies with Schwann cells demonstrated that ApFIP（LLA-CL） blended nanofibrous scaffolds significantly promoted cell growth as compare to P（LLA-CL）, especially when the weight ratio of ApF to P（LLA-CL） was 25：75. The present work provides a basis for further studies of this novel nanofibrous material （ApF/P（LLA-CL）） in peripheral nerve tissue repair or regeneration.

关键词： KEYWORDS: ApFIP(LLA-CL) electrospinning nanofibers scaffolds Schwann cells peripheral nerve tissue engineering

Preparation and Characterization of Chitosan Nanofibers Containing Silver Nanoparticles

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Journal of Donghua University(English Edition) 2017年第1期34卷 105-110页

作者：于奎周香香 El-Aassar M R 朱同贺吴俣王娟冯文浩 morsi yosry 莫秀梅 Key Laboratory of Textile Science & Technology College of Materials Science and Engineering Donghua University Shanghai 201620 China College of Chemistry Chemical Engineering and Biotechnology Donghua University Shanghai 201620 China Polymer Materials Research Department Advanced Technology and New Material Institute City of Scientific Research and Technological Applications ( SRTA-City ) New Borg El-Arab City Alexandria 21934 Egypt Faculty of Engineering and Industrial Sciences Swinburne University of Technology Hawthorn Vic 3122 Australia Shandong International Biotechnology Park Development Co. Ltd. Yantai 264670 China

Chitosan(CS)nanofibers containing silver nanoparticles(AgNPs)were prepared by in-situ reducing method.A water soluble carboxymethyl chitosan(CMCT)was applied for the preparation of *** impact factor such as the concentration of CMCT,silver nitrate(AgNO_3)content,temperature and the heating time during the preparation of AgNPs were *** result showed that the proper value of the concentration of CMCT,AgNO_3content,temperature and the heating time were set as0.1%,20μL AgNO_3(1.7 mol/L),90°and 3 h,separately and the maximum concentration of AgNPs could be *** solve the spinnability of chitosan nanofiber,a super high molecular weight polyethylene oxide(PEO)was introduced to the system,and a new mixed solvent system was prepared by adding acetic acid,dimethyl sulfoxide(DMSO)and several drops of Triton X-100TMto distilled ***/PEO(80/20)with the concentration of 3%was dissolved in the mixed solvent to prepare electrospinning solution for CS/PEO(80/20)nanofiber *** CS containing AgNPs electrospun solution could be prepared by replacing the distilled water to silver nanoparticle solution during the preparation of mixed *** visible(UV-Vis)spectra and transmission electron microscope(TEM)results showed that silver nanoparticles were prepared *** membranes with and without AgNPs were acquired via a traditional electrospinning *** two nanofiber membranes were characterized by scanning electron microscope(SEM)images and mechanical *** could be noticed from the SEM images that there was a good morphology and random distribution for the nanofibers with an average fiber diameter of 180 *** mechanical property results showed that the addition of AgNPs decreased the mechanical strength significantly but the mechanical strength could still support wound dressing application.

关键词： chitosan(CS) silver nanoparticles(AgNPs) electrospinning wound dressing

Multifunctional bioactive core-shell electrospun membrane capable to terminate inflammatory cycle and promote angiogenesis in diabetic wound

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Bioactive Materials 2021年第9期6卷 2783-2800页

作者： Atta ur Rehman Khan Kai Huang Mina Shahriari Khalaji Fan Yu Xianrui Xie Tonghe Zhu yosry morsi Zhao Jinzhong Xiumei Mo State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of ChemistryChemical Engineering and BiotechnologyDonghua UniversityShanghai201620PR China Department of Sports Medicine Department of OrthopedicsShanghai Jiao Tong University Affiliated Sixth People’s HospitalNo.600 Yishan RoadShanghai200233PR China Microbiological Engineering and Industrial Biotechnology Group College of ChemistryChemical Engineering and BiotechnologyDonghua UniversityShanghai201620PR China Multidisciplinary Centre for Advanced Materials of Shanghai University of Engineering Science College of Chemistry and Chemical EngineeringShanghai University of Engineering ScienceNo.333 Longteng RoadShanghai201620PR China Faculty of Engineering and Industrial Sciences Swinburne University of TechnologyBoroondaraVIC3122Australia

Diabetic wound(DW)healing is a major clinical challenge due to multifactorial complications leading to prolonged *** nanofibrous(NF)membranes,due to special structural features,are promising biomaterials capable to promote DW healing through the delivery of active agents in a controlled ***,we report a multifunctional composite NF membrane loaded with ZnO nanoparticles(NP)and oregano essential oil(OEO),employing a new loading strategy,capable to sustainedly co-deliver bioactive *** characterization revealed the successful fabrication of loaded nanofibers with strong in vitro anti-bacterial and anti-oxidant ***,in vivo wound healing confirmed the potential of bioactive NF membranes in epithelialization and granulation tissue *** angiogenesis was greatly prompted by the bioactive NF membranes through expression of vascular endothelial growth factor(VEGF).Moreover,the proposed NF membrane successfully terminated the inflammatory cycle by downregulating the pro-inflammatory cytokines interleukin􀀀6(IL-6)and matrix metalloproteinases-9(MMP-9).In vitro and in vivo studies revealed the proposed NF membrane is a promising dressing material for the healing of DW.

关键词： Bioactive NF membrane Diabetic wound healing Antibacterial Antioxidant Anti-inflammatory Angiogenesis

On the development of modular polyurethane-based bioelastomers for rapid hemostasis and wound healing

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Regenerative Biomaterials 2023年第1期10卷 640-654页

作者： Wanxin Guo Binan Zhao Muhammad Shafiq Xiao Yu Yihong Shen Jie Cui Yujie Chen Pengfei Cai Zhengchao Yuan Mohamed EL-Newehy Hany EL-Hamshary yosry morsi Binbin Sun Jianfeng Pan Xiumei Mo State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative MedicineCollege of Biological Science and Medical EngineeringDonghua UniversitySongjiangShanghai 201620P.R.China Department of Orthopedics Shanghai Tongji HospitalSchool of MedicineTongji UniversityPutuoShanghai 200065China Department of Chemical Engineering Faculty of EngineeringGraduate SchoolKyushu UniversityFukuoka 819-0395Japan Department of Chemistry College of ScienceKing Saud UniversityRiyadh 11451Saudi Arabia Faculty of Engineering and Industrial Sciences Swinburne University of TechnologyBoroondaraVIC 3122Australia Department of Orthopedics Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityJinganShanghai 200072China

Massive hemorrhage may be detrimental to the patients,which necessitates the advent of new materials with high hemostatic efficiency and good *** objective of this research was to screen for the effect of the different types of bio-elastomers as hemostatic dressings.3D loose nanofiber sponges were prepared;PU-TA/Gel showed promising ***(PU)was synthesized and electrospun to afford porous sponges,which were crosslinked with glutaraldehyde(GA).FTIR and 1H-NMR evidenced the successful synthesis of *** prepared PU-TA/Gel sponge had the highest porosity and water absorption ***,PU-TA/Gel sponges exhibited cytocompatibility,negligible hemolysis and the shortest clotting ***-TA/Gel sponge rapidly induced stable blood clots with shorter hemostasis time and less bleeding volume in a liver injury model in ***,PU-TA/Gel sponges also induced good skin regeneration in a full-thickness excisional defect model as revealed by the histological *** results showed that the PU-TA/Gel-based sponges may offer an alternative platform for hemostasis and wound healing.

关键词： polyurethane electrospinning hemostasis material wound healing tissue regeneration regenerative medicine

Multi‑Functional Fibrous Dressings for Burn Injury Treatment with Pain and Swelling Relief and Scarless Wound Healing

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Advanced Fiber Materials 2023年第6期5卷 1963-1985页

作者： Zhengchao Yuan Yue Zhao Muhammad Shafiq Jiahui Song Jing Hou Yuqing Liang Xiao Yu Yujie Chen Fan Yu Mohamed EL‑Newehy Hany EL‑Hamshary yosry morsi Shichao Jiang Hui Zheng Xiumei Mo State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Shanghai Engineering Research Center of Nano‑Biomaterials and Regenerative MedicineCollege of Biological Science and Medical EngineeringDonghua UniversityShanghai 201620People’s Republic of China Department of Chemical Engineering Faculty of EngineeringGraduate SchoolKyushu UniversityFukuoka 819‑0395Japan United Graduate School of Drug Discovery and Medical Information Sciences Gifu University1‑1 YanagidoGifu 501‑1193Japan Department of Orthopedics Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021People’s Republic of China Department of Chemistry College of ScienceKing Saud UniversityP.O.Box 245511451 RiyadhSaudi Arabia Faculty of Engineering and Industrial Sciences Swinburne University of TechnologyBoroondaraVIC 3122Australia Medical Science and Technology Innovation Center Shandong First Medical University&Shandong Academy of Medical SciencesJinan 250117People’s Republic of China Department of Thoracic Surgery Shanghai Pulmonary HospitalTongji University School of MedicineShanghai 200443People’s Republic of China

As one of the most common forms of skin injuries,skin burns are often accompanied by edema pain,suppuration of infection,slow tissue regeneration,and severe scar formation,which significantly delay wound healing as well as affect the quality of *** prepared multifunctional electrospun poly(L-lactide-co-glycolide)/gelatin(P/G)-based dressings to synergistically harness the therapeutic benefits of peppermint essential oil(T),burn ointment(B),and Oregano essential oil(O)(P/G@TBO)for skin regeneration in punch and burn injury *** P/G@TBO can afford the sustained release of bioactive cues for up to 72 h as well as remarkably promote cell migration(ca.P/G@TBO,89%*** group,51%)at 24 *** P/G@TBO membranes also showed significant angiogenic effect as well as antibacterial and anti-inflammatory properties than that of the control group in ***,P/G@TBO dressings enabled fast wound healing(ca.P/G@TBO,100%wound closure *** group,95%)in a full-thickness excisional defect model up to 14 days in *** evaluation of membranes in different animal models,including tail wagging model,facial itch model,and hot burn injury model showed significant pain relieve effect as well as itching and swelling relief functions during earlier stages of wound *** were next transplanted into a scalded wound model in rats and an ear punch wound model in rabbits,which manifested antibacterial and anti-inflammatory properties and promoted re-epithelialization to achieve scarless wound healing percentage wound closure at day 28:P/G@TBO,96%*** group 66%.Taken together our approach of simultaneously harnessing T,B,and O to enable multifunctionality to fibrous dressings may hold great promise for burn wound healing applications and other related disciplines.

关键词： Burn injury Wound healing Skin regeneration Pain and swelling relief Nanofiber membrane