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Increase in neurokinin-1 receptor-mediated colonic motor response in a rat model of irritable bowel syndrome

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World Journal of Gastroenterology 2005年第2期11卷 237-241页

作者： jun-Ho La Tae-Wan Kim Tae-Sik Sung Hyn-ju Kim Jeom-Yong Kim il-Suk Yang Department of Physiology College of Veterinary MedicineSeoul National UniversityRepublic of Korea Department of Physiology College of Veterinary MedicineKyungpuk National UniversityRepublic of Korea Institute of Bioscience and Biotechnology Daewoong Pharm Co.Ltd.Republic of Korea

AIM: Irritable bowel syndrome (IBS) is a functional bowel disorder. Its major symptom is bowel dysmotility, yet the mechanism of the symptom is poorly understood. Since the neurokinin-1 receptor (NK1R)-mediated signaling in the gut is important in the control of normal bowel motor function,we aimed to investigate whether the NK1R-mediated bowel motor function was altered in IBS, using a rat IBS model that was previously reported to show colonic dysmotility in response to restraint ***: IBS symptoms were produced in male SpragueDawley rats by inducing colitis with acetic acid. Rats were left to recover from colitis for 6 d, and used for experiments 7 d post-induction of colitis. Motor activities of distal colon were recorded in ***: The contractile sensitivity of isolated colon to a NK1R agonist [Sar9, Met(O2)11]-substance P (1-30 nmol/L)was higher in IBS rats than that in normal rats. After the enteric neurotransmission was blocked by tetrodotoxin (TTX, 1 μmol/L), the contractile sensitivity to the NK1R agonist was increased in normal colon but not in IBS rat colon. The NK1R agonist-induced contraction was not different between the two groups when the agonist was challenged to the TTX-treated colon or the isolated colonic myocytes. A nitric oxide synthase inhibitor Nω-nitro-L-arginine methyl ester (L-NAME, 100 μmol/L) augmented the NK1R agonist-induced contraction only in normal rat ***: These results suggest that the NK1R-meidated colonic motor response is increased in IBS rats, due to the decrease in the nitrergic inhibitory neural component.

关键词： Irritable bowel syndrome Neurokinin-1 receptor

Comparison of linac-based fractionated stereotactic radiotherapy and tomotherapy treatment plans for intra-cranial tumors

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Chinese Physics C 2010年第11期34卷 1768-1774页

作者： Jang Bo Shim Suk Lee Sam ju Cho Sang Hoon Lee juree Kim Kwang Hwan Cho Chul Kee Min Hyun Do Huh Rena Lee Dae Sik Yang Young Je Park Won Seob Yoon Chul Yong Kim Soo il Kwon Department of Radiation Oncology College of MedicineKorea University Department of Medical Physics Kyonggi University Department of Radiation Oncology College of MedicineEulji University Department of Radiation Oncology Cheil General Hospital & Women's Healthcare CenterKwandong University College of Medicine Department of Radiation Oncology Soonchunhyang University Boocheon Hospital Department of Radiation Oncology Konyang University Hospital Department of Radiation Oncology Inha University Hospital Department of Radiation Oncology School of MedicineEwha Womans University

This study compares and analyzes stereotactic radiotherapy using tomotherapy and linac-based fractionated stereotactic radiotherapy in the treatment of intra-cranial tumors,according to some *** this study,linac-based fractionated stereotactic radiotherapy and tomotherapy treatment were administered to five patients diagnosed with intra-cranial cancer in which the dose of 18–20 Gy was applied on 3–5 separate *** tumor dosing was decided by evaluating the inhomogeneous index （II） and conformity index （CI）.Also,the radiation-sensitive tissue was evaluated using low dose factors V1,V2,V3,V4,V5,and V10,as well as the non-irradiation ratio volume （NIV）.The values of the II for each prescription dose in the linacbased non-coplanar radiotherapy plan and tomotherapy treatment plan were （0.125±0.113） and （0.090±0.180）,respectively,and the values of the CI were （0.899±0.149） and （0.917±0.114）,*** low dose areas,V1,V2,V3,V4,V5,and V10,in radiation-sensitive tissues in the linac-based non-coplanar radiotherapy plan fell into the ranges 0.3%–95.6%,0.1%–87.6%,0.1%–78.8%,38.8%–69.9%,26.6%–65.2%,and 4.2%–39.7%,respectively,and the tomotherapy treatment plan had ranges of 13.6%–100%,3.5%–100%,0.4%–94.9%,0.2%– 82.2%,0.1%–78.5%,and 0.3%–46.3%,*** the NIV for each organ,it is possible to obtain similar values except for the irradiation area of the brain *** percentages of NIV10%,NIV20%,and NIV30%for the brain stem in each patient were 15%–99.8%,33.4%–100%,and 39.8%–100%,respectively,in the fractionated stereotactic treatment plan and 44.2%–96.5%,77.7%–99.8%,and 87.8%–100%,respectively,in the tomotherapy treatment *** order to achieve higher-quality treatment of intra-cranial tumors,treatment plans should be tailored according to the isodose target volume,inhomogeneous index,conformity index,position of the tumor upon fractionated stereotactic radiosurgery,and radiation dosage for radiation-sensitive tissues.

关键词： fractionated stereotactic radiotherapy tomotherapy treatment plan virtual organ delineation

Optical Probe for Near-Infrared (NIR) Fluorescence Signal Detection with High Optical Performance and Thermal Stability

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Journal of Biomedical Science and Engineering 2014年第10期7卷 792-798页

作者： In Hee Shin Joo Beom Eom Jae Seok Park Hyeong ju Park Byeong-il Lee Bio-Photonics Research Center Korea Photonics Technology Institute Gwangju Korea

We propose a new optical probe for near-infrared (NIR) fluorescence signal detection with high optical performance and thermal stability. The optical probe is composed of an optical source part for efficient excitation of NIR fluorescence signal, a heat dissipation part for stable operation of the NIR fluorescence probe, and an optical detection part for efficient detection of NIR fluorescence signal. From a simulation by use of an optical simulation tool, Light ToolsTM, we could confirm that the optical probe has optical propagation efficiency of 79.6% in case of using a circular detector with 20 cm in diameter located at 20 cm in distance from the optical source. From a measurement of temperature variation of the optical probe, we could also confirm that the optical probe has thermal stability with a standard deviation of 2.19°C under room temperature condition. Finally, from an evaluation of fluorescence image quality, we could confirm that an optical noise which can bring on by overlapped band between optical spectrum of the optical source for fluorescence excitation and optical spectrum of the emitted fluorescence signal decreased effectively in the optical probe.

关键词： Near-Infrared Fluorescence LEDs Liquid Circulation Module

Laboratory investigation on mechanisms of stress wave propagations in porous media

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Science China(Technological Sciences) 2009年第5期52卷 1374-1389页

作者： ju Yang YANG YongMing MAO YanZhe LIU HongBin WANG HuiJie State Key Laboratory of Coal Resources and Safe Mining China University of Mining&TechnologyBeijing 100083China Department of Mechanical and Manufacturing Engineering The University of Calgary2500 University Drive NW CalgaryAB T2N 1N4Canada University of illinois at Urbana-Champaign 1110 West Green StreetUrbanaIL 61801USA Beijing Tongchen Design of Architecture Ltd Beijing 100044China

A number of porous models having the similar statistical characteristics of pores and physical properties with natural sandstones have been produced using reactive powder concrete(RPC) and ***-Hopkinson-Pressure-Bar tests and CT scans have been carried out on the models with the various porosities to probe the performance of wave propagations and the responses of pores and the matrix during wave *** is shown that porosities significantly influence wave *** an identical impact strain rate,the greater the porosity is,the larger the amplitude of the reflected wave appears,the more the peak in the reflected wave presents,and the smaller the amplitude of the trans-mitted wave turns out.A single peak emerges in the reflected wave when the porosity falls down to 5%.The larger the impact strain rate,the much remarkable the *** energy-dissipated ratio of porous models,i.e.,WJ /WI,linearly increases with the increment of *** ratio is sensitive to the impact strain *** in the performance of wave propagations and energy dissipation result from the varied mechanisms that pores response to *** the porosity less than 10%,the mechanism appears to be a process fracturing the matrix to generate new surfaces or *** has primarily been dissipated in creating new surfaces or *** apparent pore deformation takes *** impact strain rate takes little effect on pore *** the porosity of 15% or more,the mechanism works depending on the impact strain *** a low impact strain rate applies,the mechanism still appears to crack the matrix to generate surfaces or pores,but the amount is lower as compared to the case with a low *** a large impact stain rate applies,the mechanism combines both fracturing the matrix and deforming the pores,with the deforming pores *** vast majority of energy has been dissipated to deform *** high porosity and impact strain rate c

关键词： stress wave porous media propagation mechanism sandstones pores CT scan

Isolated MicroGrid’s Voltage and Frequency Characteristic with Induction Generator Based Wind Turbine

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Smart Grid and Renewable Energy 2014年第7期5卷 180-192页

作者： Woo-Kyu Chae Hak-ju Lee Sung-Wook Hwang il-Keun Song Jae-Eon Kim Chungbuk National University Chungbuk Korea Research Institute Korea Electric Power Corporation Daejeon-si Korea

To save on the island area's power supply cost and protect the clean environment, the Isolated MicroGrid is being duly considered. Consisting of the Wind Turbine Generator (WT), photovoltaic generator, battery system, back-up diesel generator, etc., Isolated MicroGrid, which usually uses the inverter to maintain voltage and frequency of the system, is very weak in terms of voltage and frequency stability compared to the large-scale electrical power system. If wind turbine generator is applied to this weak power system, it could experience many problems in terms of maintaining its voltage and frequency. In this paper, the measurement result of voltage and frequency is presented for MicroGrid, which consists of the Wind Turbine Generator adopting the induction generator and the battery system. MicroGrid’s voltage waveform distortion and Wind Turbine Generator’s output oscillation problems are analyzed using PSCAD/EMTDC. Based on the analyzed result, the importance of type and capacity choice has been suggested in case the Wind Turbine Generator is applied to the Isolated MicroGrid.

关键词： MicroGrid Wind Turbine Induction Generator Battery Voltage Frequency PSCAD/EMTDC

微炎症状态及肠道菌群与老年2型糖尿病患者并发糖尿病肾病的关系探讨

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中国医刊 2024年第8期59卷 861-865页

作者：赵敏张菊李蓉陈亚明四川省广元市中心医院肾病内科四川广元628000 四川省广元市中心医院老年科四川广元628000

目的探讨微炎症状态及肠道菌群与老年2型糖尿病(T2DM)患者并发糖尿病肾病的关系。方法选取2022年1月至2023年12月四川省广元市中心医院收治的154例老年T2DM患者为研究对象,根据是否并发糖尿病肾病将研究对象分为发生组(并发糖尿病肾病,4... 详细信息

目的探讨微炎症状态及肠道菌群与老年2型糖尿病(T2DM)患者并发糖尿病肾病的关系。方法选取2022年1月至2023年12月四川省广元市中心医院收治的154例老年T2DM患者为研究对象,根据是否并发糖尿病肾病将研究对象分为发生组(并发糖尿病肾病,41例)与未发生组(未并发糖尿病肾病,113例)。比较分析两组患者的微炎症状态[肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、白介素-6(il-6)]及肠道菌群[双歧杆菌、肠球菌、乳杆菌、肠杆菌、双歧杆菌与肠杆菌比值(B/E)]。分析老年T2DM患者并发糖尿病肾病的影响因素以及B/E与微炎症状态的交互作用。结果发生组患者的TNF-α、CRP、il-6、肠杆菌水平均高于未发生组,双歧杆菌、乳杆菌、B/E均低于未发生组,差异均有统计学意义(Pil-6均为老年T2DM患者并发糖尿病肾病的独立危险因素(Pil-6之间不存在相乘交互作用(P>0.05);相加交互作用分析结果显示,相对超额危险度和归因交互效应百分比的可信区间均>0,交互作用指数的可信区间>1,表明B/E与TNF-α、B/E与CRP、B/E与il-6之间均存在相加交互作用。结论老年T2DM患者并发糖尿病肾病后伴有不同程度的微炎症状态及肠道菌群失调,TNF-α、CRP、il-6均为老年T2DM患者并发糖尿病肾病的独立危险因素,B/E为老年T2DM患者并发糖尿病肾病的独立保护因素,且B/E与微炎症状态相关指标存在相加交互作用。

关键词：老年 2型糖尿病微炎症状态肠道菌群糖尿病肾病交互作用

Toughness and characterization of reactive powder concrete with ultra-high strength

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Science China(Technological Sciences) 2009年第4期52卷 1000-1018页

作者： Yang ju HongBin Liu Jian Chen YuDan Jia PeiHuo Peng State Key Laboratory of Coal Resources and Safe Mining China University of Mining & Technology Beijing 100083 China Department of Mechanical & Manufacturing Engineering The University of Calgary 2500 University Drive NW Calgary AB T2N 1N4 Canada The University of illinois at Urbana-Champaign 1110 West Green Street Urbana IL 61801 USA Building Design Division China Nuclear Power Engineering Co. Ltd Beijing 100840 China School of Civil Engineering University of Nottingham University Park Nottingham NG7 2RD UK

A number of three-point bending and fracture tests of 200 MPa-level reactive powder concrete (RPC) with the various fiber contents have been conducted to probe the nature and characteristics of toughness of RPC200. The contribution of the embedded fibers to improving the crack-resistant capacity, energy absorption capacity and toughness with various deformation mechanisms has been analyzed. Taking account of that the first-crack deformation, peak-load deformation and their improvement varied with the fiber contents and that the deformation mechanism affected differently the performance at the first crack and the peak load, we took the peak-load deformation of plain RPC200 as the reference deformation to measure the toughness of fibered RPC200. Two toughness indices T 2(n−1)(n) and FT 2(n−1)(n) have been formulated based on P-δ responses and P-CMOD responses. The indices quantify the toughness of RPC200 with the various deformation mechanisms relative to perfectly elastoplastic materials by setting the toughness level 2(n−1) as the initial reference. It is shown that the toughness index T 2(n−1)(n) reflects the function of fibers to improve the toughness of RPC with the deformation throughout specimens, but overestimates the contribution to enhancing the toughness in post-peak periods. It underestimates, on other hands, the contribution to improving the toughness in the period from the first crack to the peak load. In contrast, the toughness index FT 2(n−1)(n) properly presents the capability that fibers absorb energy and constrain crack propagation in the matrix when the deformation is concentrated on the open crack. The proposed index unveils the contribution of fibers to toughening RPC200 both in the period from the first-crack to the peak load and in the period of post peak. This characterization method not only reveals the nature of toughness but also levels the toughness of RPC200. I

关键词： reactive powder concrete toughness characterization index deformation mechanism flexure fracture

Emerging roles of ilC2s in antitumor immunity

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Cellular & Molecular Immunology 2022年第11期19卷 1311-1313页

作者： Zhao Li Hanxiao Sun Zhitao Gua ju Qiu CAS Key Laboratory of Tissue Microenvironment and Tumor Shanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai200031China Department of Blood Transfusion Shanghai Tong Ren HospitalShanghai Jiao Tong University School of MedicineShanghai200336China Department of Thoracic Surgery Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghaiChina

Group 2 innate lymphoid cells(ilC2s)are a subset of ilCs that lack T and B-cell antigen receptors[1].ilC2s share similarities with CD4+T helper 2 cells(Th2)in transcription factor GATA3 expression and signature cytoki... 详细信息

关键词： ilC2s GATA3 immunity

基于miR21/PI3K-Akt/SREBP通路研究泽泻汤对高脂血症模型小鼠的调脂作用机制

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南京中医药大学学报 2024年第9期40卷 917-931页

作者：鞠爱霞孙爽王瑞楠韩宇博周育生陈晶刘莉李秋红黑龙江中医药大学附属第一医院黑龙江哈尔滨150040 黑龙江中医药大学药学院黑龙江哈尔滨150040 黑龙江中医药大学基础医学院黑龙江哈尔滨150040

目的探索经典名方泽泻汤对高脂血症模型小鼠的调脂作用机制。方法采用ELISA法检测血清中血脂四项、肝功能指标及胆固醇脂酰转移酶(LCAT)水平。采用HE和油红O染色法判断肝组织病理情况。采用网络药理学预测泽泻汤降脂相关靶点,实现对... 详细信息

目的探索经典名方泽泻汤对高脂血症模型小鼠的调脂作用机制。方法采用ELISA法检测血清中血脂四项、肝功能指标及胆固醇脂酰转移酶(LCAT)水平。采用HE和油红O染色法判断肝组织病理情况。采用网络药理学预测泽泻汤降脂相关靶点,实现对交集靶点GO功能和KEGG通路富集分析。采用PCR芯片技术检测网络药理学筛选的目的基因,应用qPCR和Western blot检测基因和蛋白表达量。结果泽泻汤可显著调节高脂血症模型小鼠的血脂四项水平,改善因高脂引起的肝损伤指标升高,对肝脏组织中脂质代谢关键酶HMGR、CYP7A1及脂质转运体ABCA1、Apo-A1具有反向调节作用。HE和油红O染色显示,泽泻汤可改善肝组织病理形态,减轻肝组织的脂质沉积情况,阳性面积比率显著下降(Pil-6基因表达量(P<0.05,P<0.01),上调ABCG1基因表达量(P<0.05),下调PI3 Kinase p110β、p-AKT(Ser473)及SREBP-1c蛋白表达水平(P<0.01);泽泻汤能够反向调节miR21-5p(P<0.01)。结论泽泻汤对高脂血症模型小鼠脂代谢具有显著的调节作用,能改善高脂血症引起的肝损伤,其调脂作用可能与调节胆固醇在体内代谢、转运有关,与miR21/PI3K-Akt/SREBP通路密切相关,且泽泻汤全方调脂效果优于单味药。

关键词：泽泻汤 miR21/PI3K-Akt/SREBP通路高脂血症