检索结果-南通市图书馆

World Journal of Gastroenterology 2010年第39期16卷 4958-4967页

作者： Noushin Taghavi Firouzeh Biramijamal Masoud Sotoudeh Omeed Moaven Hooman Khademi mohammad reza abbaszadegan reza Malekzadeh Department of Medical Genetics National Institute of Genetic Engineering and Biotechnology Digestive Disease Research Center Tehran University of Medical SciencesShariati HospitalNorth Karegar Ave Division of Human Genetics Immunology Research CenterAvicenna Research InstituteMashhad University of Medical Sciences

factors,such as cigarette smoking,in esophageal squamous cell carcinoma(ESCC)in northeastern Iran,a region with a high incidence of ***:The expression of p53 and p21 proteins was investigated immunohistochemically in tumor tissue from 80 ESCC patients and in 60 available paraffinembedded blocks of adjacent normal specimens from the cases,along with normal esophageal tissue from 80 healthy ***:Positive expression of p53 protein was detected in 56.2%(45/80)of ESCC cases,and in none of the normal esophageal tissue of the control group(P<0.001).Furthermore,73.8%(59/80)of ESCC cases and 43.8%(35/80)of controls had positive expression of p21 protein(P<0.001).Cigarette smoking was significantly associated with p53 over-expression in ESCC cases(P=0.010,OR=3.64;95%CI:1.32-10.02).p21 over-expression was associated with poorer clinical outcome among the ESCC patients(P=0.009).CONCLUSION:Over-expression of p53 in association with cigarette smoking may play a critical role in ESCC carcinogenesis among this high-risk population of northeastern ***,p21 over-expression was found to be associated with poor prognosis,specifically in the operable ESCC patients.

关键词： Esophageal squamous cell carcinoma p53 p21 Immunohistochemistry Survival Smoking

p16 promoter hypermethylation:A useful serum marker for early detection of gastric cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第13期14卷 2055-2060页

作者： mohammad reza abbaszadegan Omeed Moaven Hamid reza Sima Kamran Ghafarzadegan Azadeh A'rabi mohammad Naser Forghani Hamid reza Raziee Ali Mashhadinejad Mostafa Jafarzadeh Ehsan Esmaili-Shandiz Ezzat Dadkhah Division of Human Genetics Immunology Research Center Avicenna Research Institute Mashhad University of Medical Sciences Mashhad *** Iran Department of Internal Medicine Imam Reza Hospital Mashhad University of Medical Sciences Mashhad *** Iran Department of Pathology Omid Hospital Mashhad University of Medical Sciences Mashhad *** Iran Department of Surgery Omid Hospital Mashhad University of Medical Sciences Mashhad *** Iran Department of Oncology Omid Hospital and Cancer Research Center Mashhad *** Iran Gastroenterology Research Center Mashhad University of Medical Sciences Mashhad *** Iran

AIM： TO determine p15 promoter hypermethylation in gastric tumoral tissue and serum samples, its impact on p16-protein expression, and correlation with clinical and histological features. METHODS： Samples were obtained from 52 histologically confirmed cases of gastric adenocarcinoma. Gastric tissue and serum of 50 age- and sex-matched individuals with normal gastroscopy and biopsy were obtained as control samples. Methylation-specific polymerase chain reaction （MSP） was used to evaluate methylation status of p16 promoter, p16-protein expression was analyzed by immunohistochemical staining on paraffin-embedded sections. RESULTS： Methylation was detected in 44.2% （23/52） of tumoral tissues. 60.9% of them were also methylated in serum, i.e., 26.9% of all patients （14/52）. Methylation was not detected in tissue and sera of control samples. p16-protein expression was decreased in 61.5% of cases （32/52）, and was significantly associated with promoter hypermethylation （P 〈 0.001）. Methylation was significantly more frequent in higher pathological grades （P 〈 0.05）. Methylation was not associated with other clinicopathological features and environmental factors including Hpylori infection and smoking. CONCLUSION： p16 promoter hypermethylation is an important event in gastric carcinogenesis. It is the principle mechanism of p16 gene silencing. It is related to malignant tumor behavior. Detection of DNA methylation in serum may be a biomarker for early detection of gastric cancer.

关键词： Gastric cancer p16 Hypermethylation Methylation specific PCR

Stool-based DNA testing,a new noninvasive method for colorectal cancer screening,the first report from Iran

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2007年第10期13卷 1528-1533页

作者： mohammad reza abbaszadegan Alireza Tavasoli Arash Velayati Hamid reza Sima Hassan Vosooghinia Mehdi Farzadnia Hamid Asadzedeh Mehran Gholamin Ezzat Dadkhah Azadeh Aarabi mohammad reza abbaszadegan Division of Human GeneticsImmunology Research CenterBu-Ali Research InstituteMUMSMashhadIran Department of Surgery Ghaem HospitalMashhad University of Medical SciencesMashhadIran Department of Internal Medicine Imam Reza HospitalMUMSMashhadIran Department of Internal Medicine Ghaem HospitalMUMSMashhadIran Department of Pathology Imam Reza HospitalMUMSMashhadIran

AIM： To detect tumor-associated DNA changes in stool samples among Iranian patients with colorectal cancer （CRC） compared to healthy individuals using BAT-26, p16 hypermethylation and long DNA markers. METHODS： Stool DNA was isolated from 45 subjects including 25 CRC patients and 20 healthy individuals using a new, fast and easy extraction method. Long DNA associated with tumor was detected using polymerase chain reaction method. Microsatellite studies were performed utilizing denaturating polyacrylamide gel to determine the instability of BAT-26. Methylation status of p16 promoter was analyzed using methylation-specific PCR （MSP）. RESULTS： The results showed a significant difference in existence of long DNA （16 in patients vs 1 in controls, P 〈 0.001） and p16 （5 in patients vs none in controls, P = 0.043） in the stool samples of two groups. Long DNA was detected in 64% of CRC patients; whereas just one of the healthy individuals was positive for Long DNA. p16 methylation was found in 20% of patients and in none of healthy individuals. Instability of BATo26 was not detected in any of stool samples. CONCLUSION： We could detect colorectal cancer related genetic alterations by analyzing stool DNA with a sensitivity of 64% and 20% and a specificity of 95% and 100% for Long DNA and p16 respectively. A non- invasive molecular stool-based DNA testing can provide a screening strategy in high-risk individuals. However, additional testing on more samples is necessary from Iranian subjects to determine the exact specificity and sensitivity of these markers.

关键词： Stool DNA Colorectal cancer Cancer screening Long DNA BAT-26 p16

PI3K/AKT signaling pathway as a critical regulator of Cisplatin response in tumor cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Oncology Research 2021年第4期29卷 235-250页

作者： ZAHRA NASRPOUR NAVAEI GHAZALEH KHALILI-TANHA AMIR SADRA ZANGOUEI mohammad reza abbaszadegan MEYSAM MOGHBELI Department of Medical Genetics and Molecular Medicine School of MedicineMashhad University of Medical SciencesMashhadIran Student Research Committee Faculty of MedicineMashhad University of Medical SciencesMashhadIran Medical Genetics Research Center Mashhad University of Medical SciencesMashhadIran

Chemotherapy is one of the main therapeutic modalities for cancer ***(CDDP),as one of theﬁrst-line drugs,is of great importance in the chemotherapy of various ***,a signiﬁcant percentage of cancer patients are resistant to CDDP *** to the CDDP side effects on normal tissues,the diagnosis of CDDP resistance is required to suggest the most efﬁcient therapeutic strategies for cancer *** molecular mechanisms and signaling pathways are associated with CDDP *** PI3K/AKT signaling pathway has a pivotal role in the transmission of extracellular signals into the cells to regulate various pathophysiological processes such as cell proliferation,migration,and drug *** the present review,we summarized all of the studies which have been reported on the role of PI3K/AKT pathway in regulation of CDDP *** was shown that the PI3K/AKT pathway is mainly involved in CDDP response in lung,ovarian,and gastrointestinal *** was also observed that the non-coding RNAs have a key role in CDDP response by regulation of PI3K/AKT *** review paves the way for suggesting a PI3K/AKT-related panel marker for the prediction of CDDP response in different cancer patients.

关键词： PI3K/AKT Cancer Chemoresistance Cisplatin Chemotherapy

Movement Trend Alterations in the Periaqueductal Gray(PAG)-Employed Ratbot Navigation Are Correlated with Stimulation Parameters

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Bionic Engineering 2024年第2期21卷 866-876页

作者： Sina Khajei Abed Khorasani mohammad reza Afarinesh Vahid Sheibani Neuroscience Research Center Institute of NeuropharmacologyKerman University of Medical SciencesKerman***Iran Cognitive Neuroscience Research Center Institute of NeuropharmacologyKerman University of Medical SciencesKerman***Iran

In previous studies,Periaqueductal Gray(PAG)stimulation was used to stop ratbots from *** to the homology between the PAG and the intercollicular nucleus,which has been used for forward movement in birds,we investigated the possibility of PAG application to induce forward locomotion for the first *** a corridor maze,the traveled distances via PAG electrical stimulation were examined in nine Wistar male rats during three sessions.A custom-designed stimulator was developed to apply the *** results showed reductions in responses to stimulation over ***,the traveled distances had negative slopes during the consecutive trials(in 8 out of the 9 rats),and the slope mean was significantly different from *** was a strong correlation between the stimulation parameters(electric Charge per Phase(CPP)and the Number of Pulses(NP))and the observed *** negative Movement Slopes(MS)were highly correlated with the CPP and the NP,as the Pearson's linear correlation coefficients were−0.87 and−0.79,*** MS-CPP coefficients of determination(R-squared)were also between 0.76 and *** addition,the MS-NP coefficients of determination were between 0.63 and ***,it is concluded that the electrical stimulation parameters influence the behavioral outcomes ***,the PAG area may be considered a suitable candidate for forward locomotion control in the future if the area is harnessed effectively to prevent undesirable chaotic behaviors.

关键词： Periaqueductal Gray(PAG) Navigation Ratbot Animal-robot Forward locomotion Movement slope

Interplay between temperature-dependent strengthening mechanisms and mechanical stability in high-performance austenitic stainless steels

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2024年第10期31卷 2182-2188页

作者： mohammad Javad Sohrabi Hamed Mirzadeh Saeed Sadeghpour Milad Zolfipour Aghdam Abdol reza Geranmayeh reza Mahmudi School of Metallurgy and Materials Engineering College of EngineeringUniversity of Tehran14395-515 TehranIran Centre for Advanced Steels Research Materials and Mechanical EngineeringUniversity of Oulu90014 OuluFinland Department of Mechanical Engineering College of EngineeringUniversity of Tehran14395-515 TehranIran

The effects of deformation temperature on the transformation-induced plasticity(TRIP)-aided 304L,twinning-induced plasti-city(TWIP)-assisted 316L,and highly alloyed stable 904L austenitic stainless steels were compared for the first time to tune the mechan-ical properties,strengthening mechanisms,and strength-ductility *** this purpose,the scanning electron microscopy(SEM),electron backscattered diffraction(EBSD),X-ray diffraction(XRD),tensile testing,work-hardening analysis,and thermodynamics calcu-lations were *** induced plasticity effects led to a high temperature-dependency of work-hardening behavior in the 304L and 316L stainless *** the deformation temperature increased,the metastable 304L stainless steel showed the sequence of TRIP,TWIP,and weakening of the induced plasticity mechanism;while the disappearance of the TWIP effect in the 316L stainless steel was also ***,the solid-solution strengthening in the 904L superaustenitic stainless steel maintained the tensile properties over a wide temper-ature range,surpassing the performance of 304L and 316L stainless *** this regard,the dependency of the total elongation on the de-formation temperature was less pronounced for the 904L alloy due to the absence of additional plasticity *** results re-vealed the importance of solid-solution strengthening and the associated high friction stress for superior mechanical behavior over a wide temperature range.

关键词： austenitic stainless steels mechanical behavior stacking fault energy metastability mechanical twinning

Temperature-jump tensile tests to induce optimized TRIP/TWIP effect in a metastable austenitic stainless steel

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2024年第9期31卷 2025-2036页

作者： mohammad Javad Sohrabi Hamed Mirzadeh Saeed Sadeghpour Abdol reza Geranmayeh reza Mahmudi School of Metallurgy and Materials Engineering College of EngineeringUniversity of Tehran14395-515TehranIran Centre for Advanced Steels Research Materials and Mechanical EngineeringUniversity of Oulu90014 OuluFinland

In the present work,plastic deformation mechanisms were initially tailored by adjusting the deformation temperature in the range of 0 to 200℃ in AISI 304L austenitic stainless steel,aiming to optimize the strength-ductility *** was shown that the combined twinning-induced plasticity(TWIP)/transformation-induced plasticity(TRIP)effects and a wider strain range for the TRIP effect up to higher strains by adjusting the deformation temperature are good strategies to improve the strength-ductility synergy of this metastable stainless *** this regard,by consideration of the observed temperature-dependency of plastic deformation,the controlled sequence of TWIP and TRIP effects for archiving superior strength-ductility trade-off was intended by the pre-designed temperature jump tensile ***,the optimum tensile toughness of 846 MJ/m^(3) and total elongation to 133% were obtained by this strategy via exploiting the advantages of the TWIP effect at 100℃ and the TRIP effect at 25℃ at the later stages of the ***,a deformation-temperature-transformation(DTT)diagram was developed for this metastable ***,based on work-hardening analysis,it was found that the main phenomenon constraining further improvement in the ductility and strengthening was the yielding of the deformation-induced α′-martensite.

关键词： metastable stainless steels transformation-induced plasticity twinning-induced plasticity stacking fault energy mechanical properties

Numerical investigation of supercontinuum generation and optical frequency combs in Si N-based PCF with high nonlinear coefficient

在线全文

学校读者我要写书评

暂无评论

Optoelectronics Letters 2024年第3期20卷 163-170页

作者： mohammad reza Alizadeh Mahmood Seifouri Saeed Olyaee Faculty of Electrical Engineering Shahid Rajaee Teacher Training UniversityTehranIran Nano-photonics and Optoelectronics Research Laboratory(NORLab) Shahid Rajaee Teacher Training UniversityTehranIran

In this paper, a photonic crystal fiber(PCF) with a dispersion-engineered and high nonlinear coefficient has been designed for supercontinuum generation(SCG) and frequency comb generation(FCG). The proposed PCF has a Si_(3)N_(4) rod in the core. This rod provides more optical confinement in the core by increasing the refractive index of the core. This high confinement reduces the effective mode area of PCF and thus increases the nonlinear coefficient.

关键词： optical fiber nonlinear

Multidisciplinary design optimization of a dual-spin guided vehicle

在线全文

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2024年第7期37卷 133-148页

作者： Jalal Karimi mohammad reza Rajabi Seyed Hossein Sadati Seyed Mahid Hosseini Department of Aerospace Engineering Malek Ashtar University of TechnologyTehranIran

In this research,a Multidisciplinary Design Optimization approach is proposed for the dual-spin guided flying projectile design considering external and internal parts of the body as design *** this way,a parametric formulation is *** related disciplines,including structure,aerodynamics,guidance,and control are *** total mass,maximum aerodynamic control effectiveness,minimum miss distance,maximum yield stress in all subsystems,controllability and gyroscopic stability constraints are some of objectives/constraints taken into *** problem is formulated in All-At-Ones Multidisciplinary Design Optimization approach structure and solved by Simulated Annealing and minimax *** optimal configurations are evaluated in various *** resulted optimal configurations have met all design objectives and constraints.

关键词： Flying projectile optimal design All-at-ones multidisciplinary optimization Structure discipline Guidance and control discipline Aerodynamic discipline

Improvement of Surface Mechanical and Tribological Characteristics of L-PBF Processed Commercially Pure Titanium through Ultrasonic Impact Treatment

在线全文

学校读者我要写书评

暂无评论

Acta Metallurgica Sinica(English Letters) 2024年第6期37卷 1034-1046页

作者： Iman Ansarian reza Taghiabadi Saeid Amini mohammad Hossein Mosallanejad Luca Iuliano Abdollah Saboori Department of Materials Science and Metallurgy Imam Khomeini International University(IKIU)QazvinIran Department of Mechanical Engineering University of KashanKashanIran Integrated Additive Manufacturing Center Department of Management and Production EngineeringPolitecnico di TorinoCorso Duca Degli Abruzzi 2410129TurinItaly

Multi-pass ultrasonic impact treatment(UIT)was applied to modify the microstructure and improve the mechanical and tribological characteristics at the near-surface region of commercially pure Ti(CP-Ti)specimens produced by the laser powder bed fusion(L-PBF)*** considerably refined the L-PBF process-related acicular martensites(α′-M)and produced a well-homogenized and dense surface microstructure,where the porosity content of 1-,3-,and 5-pass UITed samples was reduced by 43,60,and 67%,*** UITed samples showed an enhancement in their near-surface mechanical properties up to a depth of about 300μ*** nanoindentation results for the 3-pass UITed sample revealed an increase of about 53,45,and 220%in its nanohardness,H/E_(r),and H_(3)/E_(r)^(2)indices,*** stylus profilometry results showed that performing the UIT removed the L-PBF-related features/defects and offered a smooth *** roughness average(R_(a))and the skewness(R_(sk))of the 3-pass UITed sample were found to be lower than those of the L-PBFed sample by 95 and 223%,*** the UIT also enhanced the material ratio,where the maximum load-bearing capacity(~100%)in as-L-PBFed(as-built)and 3-pass UITed samples was obtained at 60-and 10-µm depths,*** tribological investigations showed that applying the UIT resulted in a significant reduction of wear rate and average coefficient of friction(COF)of *** instance,under the normal pressures of 0.05 and 0.2 MPa,the wear rate and COF of the 3-pass UITed sample were lower than those of the L-PBFed sample by 65 and 58%,and 20 and 17%,respectively.

关键词： Laser powder bed fusion Ultrasonic impact treatment Commercially pure Ti(CP-Ti) Surface mechanical properties Tribological properties