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Pedestrian trajectory prediction method based on the Social-LSTM model for vehicle collision

Transportation Safety and Environment 2024年第3期6卷 140-151页

作者： Yong Han Xujie Lin Di Pan Yanting Li Liang Su Robert Thomson koji mizuno School of Mechanical and Automotive Engineering Xiamen University of TechnologyXiamen 361024China Fujian Province Key Laboratory of Advanced Design and Manufacturing of Buses Xiamen 361024China Engineering Research Institute of Xiamen Kinglong United Automobile Industry Co. Ltd.Xiamen 361000China Chalmers University of Technology Gothenburg 41296Sweden Department of Mechanical Systems Engineering Nagoya UniversityNagoya 464-8603Japan

Techniques for predicting the trajectory of vulnerable road users are important to the development of perception systems for autonomous vehicles to avoid *** most effective trajectory prediction methods,such as Social-LSTM,are often used to predict pedestrian trajectories in normal passage ***,they can produce unsatisfactory prediction results and data redundancy,as well as difficulties in predicting trajectories using pixel-based coordinate systems in collision avoidance *** is also a lack of validations using real vehicle-to-pedestrian *** address these issues,some insightful approaches to improve the trajectory prediction scheme of Social-LSTM were proposed,such methods included transforming pedestrian trajectory coordinates and converting image coordinates to world *** YOLOv5 detection model was introduced to reduce target loss and improve prediction *** DeepSORT algorithm was employed to reduce the number of target transformations in the tracking *** Perspective Transformation(IPT)and Direct Linear Transformation(DLT)theories were combined to transform the coordinates to world coordinates,identifying the collision location where the accident could *** performance of the proposed method was validated by training tests using MS COCO(Microsoft Common Objects in Context)and ETH/UCY *** results showed that the target detection accuracy was more than 90%and the prediction loss tends to decrease with increasing training steps,with the final loss value less than 1%.The reliability and effectiveness of the improved method were demonstrated by benchmarking system performance to two video recordings of real pedestrian accidents with different lighting conditions.

关键词： vehicle-to-pedestrian collisions pedestrian trajectory prediction YOLOvB DeepSORT Social-LSTM

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Virtual Reconstruction of Long Bone Fracture in Car-to-pedestrian Collisions Using Multi-body System and Finite Element Method

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Chinese Journal of Mechanical Engineering 2011年第6期24卷 1045-1055页

作者： HAN Yong YANG Jikuang mizuno koji State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body Hunan UniversityChangsha 410082China Department of Applied Mechanics Chalmers University of TechnologyGothenburg 41296Sweden Department of Mechanical Science and Engineering Nagoya UniversityNagoya 464-8601JapanState

Lower limb injures are frequently observed in passenger car traffic *** studies of the injuries focus on long bone fractures by using either cadaver component tests or simulations of the long bone kinematics,which lack in-depth study on the fractures in stress *** paper aims to investigate lower limb impact biomechanics in real-world car to pedestrian accidents and to predict fractures of long bones in term of stress parameter for femur,tibia,and *** the above purposes,a 3D finite element(FE) model of human body lower limb(HBM-LL) is developed based on human *** model consists of the pelvis,femur,tibia,fibula,patella,foot bones,primary tendons,knee joint capsule,meniscus,and *** FE model is validated by comparing the results from a lateral impact between simulations and tests with cadaver lower limb *** real-world accidents are selected from an in-depth accident database with detailed information about the accident scene,car impact speed,damage to the car,and pedestrian ***-body system(MBS) models are used to reconstruct the kinematics of the pedestrians in the two accidents and the impact conditions are calculated for initial impact velocity and orientations of the car and pedestrian during the *** FE model is used to perform injury reconstructions and predict the fractures by using physical parameters,such as von Mises stress of long *** calculated failure level of the long bones is correlated with the injury outcomes observed from the two accident *** reconstruction result shows that the HBM-LL FE model has acceptable biofidelity and can be applied to predict the risk of long bone *** study provides an efficient methodology to investigate the long bone fracture suffered from vehicle traffic collisions.

关键词： passenger car pedestrian accident lower limb FE model long bone fracture impact biomechanics

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Barrier Force Distribution Evaluations in Full-Width Impact Tests

Barrier Force Distribution Evaluations in Full-Width Impact ...

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The 3rd International Forum of Automotive Traffic Safety

作者： koji mizuno Nagoya University

The structural interaction is prerequisite for compatibility in car-to-car crashes. Full- width tests have been proposed to assess the structural ground-height alignment and homogeneity, which are key factors for structural interaction. In the present research, full-width rigid and deformable barrier tests were compared with respect to barrier force distributions, vehicle deformation and dummy responses. The average height of force was similar between full rigid and deformable barrier tests. Further information on force distribution such as structure homogeneity can be obtained in full-width deformable barrier tests because forces from structures can be clearly shown in barrier force distributions compared with rigid barrier. However, force distribution measurements and homogeneity criteria are dependent on load cell height from the ground.

关键词： Compatibility Structural interaction Full-width test Average height of force Homogeneity

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Energy modulation of Nonrelativistic Electrons with Infrared Evanescent Waves

Energy modulation of Nonrelativistic Electrons with Infrared...

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2000 25～(th) International Conference on Infrared and Millimeter Waves Conference Digest

作者： Jongsuck Bae Ryo Ishikawa koji mizuno Research Institute of Electrical Communication Tohoku University 2-1-1 KatahiraAoba-kuSendai 980-8577Japan

Optical evanescent waves which are inducedon a metal microslit by illumination of a light have beenutilized to modulate a low-energy electron beam at op-tical frequencies. Experiments performed at the wave-length of 10.6 μm have shown that energy of electronscan be changed more than 10 eV for an electron beamwith an initial energy of 80 keV by using a CO laserbeam with a peak power of 7 kW.

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ISOFIX型儿童座椅正面碰撞台车试验的有限元仿真

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汽车工程 2011年第5期33卷 401-404,400页

作者：胡佳水野幸治上海汽车技术中心上海201804 名古屋大学

建立了ISOFIX型儿童座椅的有限元模型,并应用HybridⅢ3岁儿童假人有限元模型,建立了ISOFIX型儿童座椅正面碰撞台车试验的有限元模型,进行了仿真,对比分析了台车试验与有限元仿真的假人动态举动,头部、胸部和髋部的合成加速度波形及假人... 详细信息

建立了ISOFIX型儿童座椅的有限元模型,并应用HybridⅢ3岁儿童假人有限元模型,建立了ISOFIX型儿童座椅正面碰撞台车试验的有限元模型,进行了仿真,对比分析了台车试验与有限元仿真的假人动态举动,头部、胸部和髋部的合成加速度波形及假人伤害值。接着用有限元模型对儿童座椅上拉带限力效果进行了评价。结果表明,有限元模型仿真结果与试验结果基本吻合,假人伤害值均在法规指标值以内。上拉带限力虽使头部最大前向移动量有所增加,但仍远小于指标值,且其他伤害值都有不同程度的降低。

关键词： ISOFIX型儿童座椅正面碰撞台车试验有限元仿真

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基于转录组测序和网络药理学探究青蒿琥酯干预U87和U251脑胶质瘤细胞的药效差异机制

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药学学报 2023年第6期58卷 1475-1483页

作者：李涛毛霞张彦琼林娜 SATO Takashi mizuno koji OKUYAMA Katsuki 黄丰云南中医药大学中药学院云南昆明650500 中国中医科学院中药研究所北京100700 东京药科大学生物化学系东京都八王子市192-0392

青蒿琥酯具有干预脑胶质瘤的潜能,但其药理作用机制尚不明确。本研究首先基于U87和U251两种人源脑胶质瘤细胞,探究青蒿琥酯对细胞活性、增殖和凋亡的影响,发现青蒿琥酯对U87细胞活性和增殖能力的抑制作用强于对U251细胞;Hoechst和TUNEL... 详细信息

青蒿琥酯具有干预脑胶质瘤的潜能,但其药理作用机制尚不明确。本研究首先基于U87和U251两种人源脑胶质瘤细胞,探究青蒿琥酯对细胞活性、增殖和凋亡的影响,发现青蒿琥酯对U87细胞活性和增殖能力的抑制作用强于对U251细胞;Hoechst和TUNEL细胞凋亡染色实验也发现,青蒿琥酯可以显著促进U87细胞的凋亡(P <0.05),而仅大剂量的青蒿琥酯可促进U251细胞的凋亡(P <0.01)。接着,利用青蒿琥酯处理前后的U87和U251细胞裂解液,通过转录组测序检测和差异数据分析,分别获得青蒿琥酯敏感性和非敏感性细胞株的差异基因集以及青蒿琥酯效应相关基因集,旨在挖掘青蒿琥酯对两类细胞敏感性不一的分子机制。通过构建上述各对比组差异基因互作网络和计算网络拓扑特征值,筛选药效相关的关键网络靶标;生物功能富集分析结果表明,上述关键网络靶标显著富集于多条与脑胶质瘤病理环节相关的信号通路,其中,与细胞凋亡相关的转录激活因子4 (ATF4)-DNA损伤诱导转录因子3 (DDIT3)-聚腺苷二磷酸核糖聚合酶1 (PARP1)信号轴的富集显著性最高。分子对接结果也表明,青蒿琥酯与ATF4和DDIT3均具有较好的结合能力。本研究初步揭示了青蒿琥酯干预U87脑胶质瘤细胞的潜能与其抑制肿瘤细胞内异常活化的ATF4-DDIT3-PARP1信号轴,进而诱导细胞凋亡有关;同时也表明了PARP1可能是U251细胞对青蒿琥酯产生耐药的重要靶标。相关结果为青蒿琥酯治疗脑胶质瘤,以及解决脑胶质瘤治疗药物耐药的现状提供了新的实验依据。

关键词：青蒿琥酯脑胶质瘤转录组测序网络药理学药理机制

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基于DNA甲基化测序技术研究青蒿琥酯干预脑胶质瘤的分子机制

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中草药 2023年第6期54卷 1814-1824页

作者：闫向英毛霞李涛 koji mizuno Katsuki Okuyama 林娜张彦琼 Takashi Sato 中国中医科学院中药研究所北京100700 东京药科大学生物化学系东京192-0392

目的探究青蒿琥酯干预胶质母细胞瘤(glioblastoma,GBM)的药效及其潜在分子机制。方法采用Cell TiterBlue检测青蒿琥酯对U87和U2512种人源胶质母细胞瘤细胞活性和增殖的影响;流式细胞术检测青蒿琥酯对2种细胞周期的调节作用;采用q RT-PCR... 详细信息

目的探究青蒿琥酯干预胶质母细胞瘤(glioblastoma,GBM)的药效及其潜在分子机制。方法采用Cell TiterBlue检测青蒿琥酯对U87和U2512种人源胶质母细胞瘤细胞活性和增殖的影响;流式细胞术检测青蒿琥酯对2种细胞周期的调节作用;采用q RT-PCR和Western blotting检测青蒿琥酯对2种细胞自噬水平的影响。采用DNA甲基化联合网络药理学从表观遗传学层面研究青蒿琥酯干预GBM的靶标基因,并建立蛋白质-蛋白质相互作用网络,通过计算网络中各节点的网络拓扑特征值,筛选出青蒿琥酯干预GBM的核心靶点并进行生物功能富集分析;采用AutoDock v4.2.6和Auto Dock Vina v1.2.0软件开展分子对接虚拟计算,考察青蒿琥酯与其候选关键靶点的结合能力,并采用Western blotting验证青蒿琥酯对2种脑胶质瘤细胞中关键靶点表达的影响。结果青蒿琥酯可显著抑制U87细胞的活性和增殖(P<0.05、0.01、0.001),而对U251细胞的药效不显著;高剂量青蒿琥酯可影响2种细胞周期分布;高剂量青蒿琥酯可显著提高U87细胞中3种自噬标志分子[自噬关键分子酵母Atg6同系物(ATG6 autophagy related 6 homolog,Beclin1)、泛素结合蛋白(ubiquitin-binding protein,p62)、微管相关蛋白1轻链3(microtubule-associated protein 1 light chain 3,LC3)]的m RNA表达水平(P<0.001),而仅高剂量青蒿琥酯升高U251细胞中p62的m RNA表达水平(P<0.05);低、中、高剂量青蒿琥酯可显著提高U87细胞中Beclin1、p62、LC3B蛋白表达水平(P<0.05、0.01),仅中、高剂量青蒿琥酯可以影响U251细胞中Beclin1、p62、LC3B蛋白表达。利用给药前后的U87与U251细胞进行DNA甲基化测序与网络药理学整合分析,在获得青蒿琥酯敏感型和耐药型脑胶质瘤细胞的差异基因集,以及青蒿琥酯干预2种细胞效应基因集的基础上,发现其干预2类脑胶质瘤细胞的关键网络靶标共同参与GBM恶性进展密切相关的血小板衍生生长因子受体α(platelet derived growth factor receptorα,PDGFRA)-大鼠肉瘤基因(rat sarcoma viral oncogene homolog,RAS)-B-Raf原癌基因(B-Raf proto-oncogene,BRAF)-丝裂原活化蛋白激酶激酶(mitogenactivated protein kinase kinase,MEK)-细胞外信号调节激酶(extracellular signal regulated kinase,ERK)通路,且青蒿琥酯与其直接靶标(PDGFRA、BRAF)具有较强的亲和力。Western blotting实验证实青蒿琥酯可以抑制U87和U251细胞中关键靶点PDGFRA和BRAF蛋白的表达(P<0.05、0.01、0.001)。结论青蒿琥酯可能通过靶向调控PDGFRA-RAS-BRAF-MEKERK信号通路,从而抑制GBM细胞的生长和扩散,为青蒿琥酯治疗GBM提供了体外实验依据,也为解决临床抗肿瘤药物的耐药问题提供了新思路和新方法。

关键词：青蒿琥酯胶质母细胞瘤 DNA甲基化分析耐药 PDGFRA-RAS-BRAF-MEK-ERK信号通路

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Neural plasticity in Parkinson's disease: a neuroimaging perspective

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Neural Regeneration Research 2024年第6期19卷 1203-1205页

作者： Christina Andica koji Kamagata Department of Radiology Juntendo University Graduate School of Medicine Faculty of Health Data Science Juntendo University

Parkinson’s disease(PD) is a progressive neurodegenerative disorder characterized primarily by classical motor signs of bradykinesia,rigidity,tremors,and postural instability usually manifesti ng unilate rally or at least *** disease involves a loss of dopaminergic neurons projecting from the substantia nigra pars compacta to the dorsal striatum,

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Evaluation of excavation damaged zones(EDZs)in Horonobe Underground Research Laboratory(URL)

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第2期16卷 365-378页

作者： koji Hata Sumio Niunoya Kazuhei Aoyagi Nobukatsu Miyara Obayashi Corporation Technology Research InstituteTechnology DivisionKiyoseTokyo204-8558Japan Obayashi Corporation Nuclear Facilities DivisionSinagawaTokyo108-8502Japan Japan Atomic Energy Agency Horonobe Underground Research CenterHoronobeHokkaido098-3224Japan

Excavation of underground caverns,such as mountain tunnels and energy-storage caverns,may cause the damages to the surrounding rock as a result of the stress *** this influenced zone,new cracks and discontinuities are created or propagate in the rock ***,it is effective to measure and evaluate the acoustic emission(AE)events generated by the rocks,which is a small elastic vibration,and permeability *** authors have developed a long-term measurement device that incorporates an optical AE(O-AE)sensor,an optical pore pressure sensor,and an optical temperature sensor in a single multi-optical measurement probe(MOP).Japan Atomic Energy Agency has been conducting R&D activities to enhance the reliability of high-level radioactive waste(HLW)deep geological disposal *** a high-level radioactive disposal project,one of the challenges is the development of methods for long-term monitoring of rock mass ***,in January 2014,the long-term measurements of the hydro-mechanical behavior of the rock mass were launched using the developed MOP in the vicinity of 350 m below the surface at the Horonobe Underground Research *** measurement results show that AEs occur frequently up to 1.5 m from the wall during *** addition,hydraulic conductivity increased by 2e4 orders of *** analysis revealed that the hydraulic behavior of the rock mass affected the pore pressure fluctuations and caused *** on this,a conceptual model is developed to represent the excavation damaged zone(EDZ),which contributes to the safe geological disposal of radioactive waste.

关键词： Excavation damaged zone(EDZ) Optical sensor Long-term monitoring Acoustic emission(AE) Shaft sinking

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台车加速度波形对3岁儿童损伤风险影响的研究

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汽车工程 2017年第6期39卷 661-666页

作者：韩勇李雄黄红武苍安国水野幸治厦门理工学院厦门364024 第三军医大学重庆400038 广东检验检疫技术中心广州510000 名古屋大学

用不同长度的圆形薄壁吸能管和不同质量的台车,采用有限元分析和台车试验进行拟合,获得FMVSS213规定的动态试验台车碰撞加速度波形。将所得的台车加速度波形和已有的ECE R44台车加速度波形,加载到放置有Q3儿童有限元模型的两种(汽车安... 详细信息

用不同长度的圆形薄壁吸能管和不同质量的台车,采用有限元分析和台车试验进行拟合,获得FMVSS213规定的动态试验台车碰撞加速度波形。将所得的台车加速度波形和已有的ECE R44台车加速度波形,加载到放置有Q3儿童有限元模型的两种(汽车安全带和ISOFIX固定式)背带式前向儿童约束系统碰撞仿真模型中,通过仿真,分析了加速度波形对3岁儿童乘员的运动学响应和损伤参数的影响。结果显示,加载FMVSS213加速度波形的儿童乘员的前向运动学响应比加载ECE R44加速度波形约提前20ms。加载FMVSS213加速度波形的头部前向位移、HIC15和头部与胸部的加速度均大于ECE R44工况。两种工况的上颈部轴向力和胸部压缩量无显著差异,但上颈部轴向力均大于法规限值(1 705N),而胸部压缩量均小于法规限值(53mm)。研究结果表明,FMVSS213动态加载试验对儿童约束系统的安全性评价要求更高,可为儿童约束系统的设计提供参考依据。

关键词：儿童约束系统薄壁圆管加速度波形损伤风险

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