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Genes & Diseases 2024年第4期11卷 90-93页

作者： Yunying Yao Zhizhou Xi min wu Bo Jiao Jiaming Gao Donghe Li Xi Xie Pengfei Xu Jiaoyang Li Lei Yan Ruibao Ren Ping Liu Shanghai Institute of Hematology State Key Laboratory for Medical GenomicsNational Research Center for Translational MedicineCollaborative Innovation Center of HematologyRuijin Hospital affiliated with Shanghai Jiao Tong University School of MedicineShanghai 200025China International Center for Aging and Cancer Hainan Medical UniversityHaikouHainan 570102China

Despite remarkable advances in molecular and cell biology of acute myeloid leukemia(AML),AML patients still frequently relapse and have low 5-year overall survival(OS)rates.1 It is worth noting that a recent study from the registry or clinical trial compilation has reported an improvement in the OS of adult AML patients,especially those under 60 years of age.

关键词： acute myeloid leukemia

Berberine alleviates ovarian tissue damage in mice with hepatolenticular degeneration by suppressing ferroptosis and endoplasmic reticulum stress

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Journal of Integrative Medicine 2024年第4期22卷 493-502页

作者： Qian-zhuo Liu Hui Han Xin-ru Fang Lu-yao Wang Dan Zhao Miao-zhu Yin Nian Zhang Peng-yu Jiang Zhi-hui Ji Li-min wu Department of Neurology the First Affiliated Hospital of Anhui University of Chinese MedicineHefei 230031Anhui ProvinceChina Center for Reproduction and Genetics the First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230031Anhui ProvinceChina

Objective:Hepatolenticular degeneration (HLD) is an autosomal recessive disorder that manifests as multiorgan damage due to impaired copper (Cu) metabolism. Female patients with HLD often experience reproductive impairments. This study investigated the protective effect of berberine against ovarian damage in toxic-milk (TX) mice, a murine model for ***:Mice were categorized into control group, HLD TX group (HLD group), penicillamine (Cu chelator)-treated TX group and berberine-treated TX group. Body weight, ovary weight and the number of ovulated eggs were recorded. Follicular morphology and cellular ultrastructure were examined. Total iron, ferrous iron (Fe2+) and trivalent iron (Fe3+) levels, as well as malondialdehyde (MDA), glutathione(GSH) and oxidized glutathione (GSSG), were measured in the ovaries. Western blot analysis was used to analyze the expression of proteins related to ferroptosis and endoplasmic reticulum (ER) ***:Ovarian tissue damage was evident in the HLD group, with a significant increase in ferroptosis and ER stress compared to the control group. This damage was inhibited by treatment with penicillamine,a Cu chelator. Compared with the HLD group, berberine increased the number of ovulations, and improved ovarian morphology and ultrastructure. Further, we found that berberine reduced total iron,Fe2+, MDA and GSSG levels, elevated GSH levels, decreased the expression of the ferroptosis marker protein prostaglandin-endoperoxide synthase 2 (PTGS2), and increased glutathione peroxidase 4 (GPX4)expression. Furthermore, berberine inhibited the expression of ER stress-associated proteins mediated by the protein kinase RNA-like ER kinase (PERK) ***:Ferroptosis and ER stress are involved in Cu-induced ovarian damage in TX mice. Berberine ameliorates ovarian damage in HLD TX mice by inhibiting ferroptosis and ER stress.

关键词： Berberine Hepatolenticular degeneration Copper deposition Ferroptosis Endoplasmic reticulum stress

Amorphous NiMo_(3)S_(13)/nickel foam integrated anode for lithium-ion batteries

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Tungsten 2024年第2期6卷 438-446页

作者： ming-Xin Shi min wu Shan-Shan Xiao Shan-Ping Liu Rui-Qi Yao Ying-Qi Li Yong-Hui Wang Yang-Guang Li Hua-Qiao Tan Key Laboratory of Polyoxometalate and Reticular Material Chemistry of ministry of Education Faculty of ChemistryNortheast Normal UniversityChangchun 130024China School of Materials Science and Engineering Jilin Jianzhu UniversityChangchun 130118China Institute Charles Gerhardt Montpellier Universite de MontpellierCentre National de la Recherche Scientifi quePlace E.Bataillon34095 Montpellier Cedex 05France

Although crystalline anode materials with long-range ordered lattice structure are in favor of facilitating the electron transfer,their structures are easily disrupted during long-term cycling due to the continuous embedding/de-embedding of lithium *** contrast,the amorphous materials have abundant defects and lithium ion storage sites,refl ecting a superior reaction kinetics and long-term cycling ***,we synthesize an integrated hybrid anode by in-situ loading amorphous NiMo_(3)S_(13)nanosheets on nickel foam *** ting from the introduction of Ni^(2+)that amorphizes the molybdenumsulfur clusters,the assembled lithium ion battery based on the integrated NiMo_(3)S_(13)/nickel foam anode delivers a specifi c capacity up to 1659 mA·h·g^(−1)at a current density of 0.6 A·g^(−1)and exhibits superior rate/cycling performance.

关键词： Molybdenum-sulfur clusters Amorphous Integrated anode Crystalline Lithium-ion batteries

Tunable hexagonal boron nitride topological optical delay line in the visible region

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Chinese Optics Letters 2024年第5期22卷 124-130页

作者：费宏明武敏林瀚杨毅彪肖连团 College of Physics Taiyuan University of TechnologyTaiyuan 030024China College of Information Engineering Shanxi Vocational University of Engineering Science and TechnologyJinzhong 030619China College of Science RMIT UniversityMelbourneVictoria 3000Australia College of Electronic Information and Optical Engineering Taiyuan University of TechnologyTaiyuan 030024China

Tunability,ultracompact design,high group index,low loss,and broad bandwidth are desired properties for integrated optical delay lines(ODLs).However,those properties are challenging to achieve simultaneously in the visible *** paper proposes a tunable hexagonal boron nitride topological optical delay line(ODL)in the visible region based on valley photonic *** topological edge state from the beard-type boundary allows the achievement of an ultralow group velocity close to zero,which results in a large group index of 629 at 645 ***,we demonstrate tuning of the slow-light wavelength and optical delay times with electrically tunable liquid crystals by applying external *** device has an ultracompact size of 5μm×2.7μm with an optical delay distance of 25a(a is the lattice constant)and a delay time of 12 *** design can provide a new possibility for designing ODLs working in the visible region for optical communication and quantum computing systems.

关键词： valley photonic crystal topological edge states optical delay lines

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新形势下管理会计与财务会计的融合思考

Follicle stimulating hormone controls granulosa cell glutamine synthesis to regulate ovulation

中国科技纵横 2024年第7期 159-161页

作者：吴敏华北机电学校山西长治 046000

随着经济发展速度的不断加快,企业会计的职能需要进行及时更新与融合,其中管理会计和财务会计属于需要进行职能改革的岗位.基于此,对新形势下管理会计与财务会计之间的区别和联系进行详细论述,分析管理会计与财务会计融合的必要性,从建... 详细信息

随着经济发展速度的不断加快,企业会计的职能需要进行及时更新与融合,其中管理会计和财务会计属于需要进行职能改革的岗位.基于此,对新形势下管理会计与财务会计之间的区别和联系进行详细论述,分析管理会计与财务会计融合的必要性,从建立统一的会计信息系统、建立协调的会计组织结构、建立完善的会计制度和政策、建立有效的会计监督和评价机制、持续会计学习和创新文化这五个方面提出具体的融合策略,并进行举例论证.希望能够为相关企业提供一定的参考与借鉴,助力会计行业高质量发展.

关键词：新形势管理会计财务会计融合策略

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Protein & Cell 2024年第7期15卷 512-529页

作者： Kai-Hui Zhang Fei-Fei Zhang Zhi-Ling Zhang Ke-Fei Fang Wen-Xing Sun Na Kong min wu Hai-Ou Liu Yan Liu Zhi Li Qing-Qing Cai Yang Wang Quan-Wei Wei Peng-Cheng Lin Yan Lin Wei Xu Cong-Jian Xu Yi-Yuan Yuan Shi-min Zhao The Obstetrics&Gynecology Hospital of Fudan University State Key Laboratory of Genetic EngineeringFudan UniversityShanghai 200090China Shanghai Key Laboratory of Metabolic Remodeling and Children’s Hospital of Fudan UniversityShanghai 200032China School of Life Sciences and Institutes of Biomedical Sciences Fudan UniversityShanghai 200438China Department of Nutrition and Food Hygiene School of Public HealthNantong UniversityNantong 226019China Reproductive Medicine Center The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China Shanghai Fifth People’s Hospital of Fudan University Fudan UniversityShanghai 200240China Department of Animal Science and Technology Nanjing Agricultural UniversityNanjing 210014China Key Laboratory for Tibet Plateau Phytochemistry of Qinghai Province College of PharmacyQinghai University for NationalitiesXining 810007China Pediatric Research Institute Children’s Hospital Affiliated to Shandong University(Jinan Children’s Hospital)Jinan 250022China

Polycystic ovary syndrome(PCOS)is the leading cause of anovulatory *** understanding of the ovulation drivers hinders PCOS ***,we report that follicle stimulating hormone(FSH)controls follicular fluid(FF)glutamine levels to determine *** ovulation starts from FF-exposing granulosa cell(GC)*** glutamine,which decreases in pre-ovulation porcine FF,elevates in PCOS patients ***-glutamine chow to elevate FF glutamine inhibits mouse GC apoptosis and induces hormonal,metabolic,and morphologic PCOS ***,follicle-development-driving FSH promotes GC glutamine synthesis to elevate FF glutamine,which maintain follicle wall integrity by inhibiting GC apoptosis through inactivating ASK1-JNK apoptotic *** and glutamine inhibit the rapture of cultured murine *** removal or ASK1-JNK pathway activation with metformin or AT-101 reversed PCOS traits in PCOS models that are induced with either glutamine or *** suggest that glutamine,FSH,and ASK1-JNK pathway are targetable to alleviate PCOS.

关键词： ovulation glutamine granulosa cells PCOS FSH

Unveiling the relationship between Fabry-Perot laser structures and optical field distribution via symbolic regression

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Optoelectronics Letters 2024年

作者： LI Wenqiang wu min LI Weijun HAO Meilan YU Lina AnnLab Institute of Semiconductors Chinese Academy of Sciences School of Electronic Electrical and Communication Engineering & School of Integrated Circuits University of Chinese Academy of Sciences Beijing Key Laboratory of Semiconductor Neural Network Intelligent Sensing and Computing Technology

In recent years， machine learning (ML) techniques have been shown to be effective in accelerating the development process of optoelectronic devices. However， as "black box" models， they have limited theoretical interpretability. In this work， we leverage symbolic regression (SR) technique for discovering the explicit symbolic relationship between the structure of the optoelectronic Fabry-Perot (FP) laser and its optical field distribution， which greatly improving model transparency compared to ML. We demonstrated that the expressions explored through SR exhibit lower errors on the test set compared to ML models which suggests that the expressions have better fitting and generalization capabilities.

关键词：

Clovibactin:一种对病原体展现致死效应且低耐药性的革命性抗生素

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Science Bulletin 2024年第5期69卷 570-573页

作者：李翔吴敏帅建伟 Department of Physics and Fujian Provincial Key Lab for Soft Functional Materials ResearchXiamen UniversityXiamen 361005China Joint Research Centre on Medicine The Affiliated Xiangshan Hospital of Wenzhou Medical UniversityNingbo 315700China Wenzhou Institute University of Chinese Academy of SciencesWenzhou 325000China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Wenzhou 325001China

The decades spanning from the 1940s to the 1960s are renowned as the heyday of antibiotic *** was during this era that game-changing antibiotics such as streptomycin,vancomycin,and tetracycline were unearthed,fundamentally reshaping the landscape of modern ***,antibiotic discovery faces alarming challenges and traditional screening has not yielded new drugs in many *** crisis of antimicrobial resistance(AMR)emerges as a consequence of the unintended disruption of the antibiotic discovery pipeline and the subsequent uncontrolled proliferation of resistant pathogens[1].According to the World Health Organization(WHO),in 2019,approximately1.2 million people worldwide died of bacterial infections exacerbated by AMR,surpassing the number of deaths caused by HIV/*** this trend continues,by 2050,AMR could potentially result in over 10 million deaths,surpassing the mortality rate attributed to ***,we are in dire need of new antibiotics to counter the rising resistance of bacteria to most currently employed clinical antibiotics.

关键词： passing landscape attributed

The association and underlying mechanism of the digit ratio(2D:4D)in hypospadias

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Asian Journal of Andrology 2024年第4期26卷 356-365页

作者： Yu Ding Zu-Quan Chen Wen-Feng Pan Hao-Jie Chen min wu Yi-Qing Lyu Hua Xie Yi-Chen Huang Zhong-Zhong Chen Fang Chen Department of Urology Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200062China Urogenital Development Research Center Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200062China Clinical Research Center for Hypospadias Pediatric CollegeShanghai Jiao Tong University School of MedicineShanghai 200062China.

The second-to-fourth digit(2D:4D)ratio is thought to be associated with prenatal androgen ***,the relationship between the 2D:4D ratio and hypospadias is poorly understood,and its molecular mechanism is not *** this study,by analyzing the hand digit length of 142 boys with hypospadias(23 distal,68 middle,and 51 proximal)and 196 controls enrolled in Shanghai Children’s Hospital(Shanghai,China)from December 2020 to December 2021,we found that the 2D:4D ratio was significantly increased in boys with hypospadias(P<0.001)and it was positively correlated with the severity of the *** was further verified by the comparison of control mice and prenatal low testosterone mice model obtained by knocking out the risk gene(dynein axonemal heavy chain 8[DNAH8])associated with ***,the discrepancy was mainly caused by a shift in *** characterization of a mouse model validated that low testosterone levels during pregnancy can impair the growth and development of *** mechanistic explorations revealed that during the androgen-sensitive window,the downregulation of the androgen receptor(AR)caused by low testosterone levels,as well as the suppressed expression of chondrocyte proliferation-related genes such as Wnt family member 5a(Wnt5a),Wnt5b,Smad family member 2(Smad2),and Smad3;mitochondrial function-related genes in cartilage such as AMP-activated protein kinase(AMPK)and nuclear respiratory factor 1(Nrf-1);and vascular development-related genes such as myosin light chain(MLC),notch receptor 3(Notch3),and sphingosine kinase 1(Sphk1),are responsible for the limitation of 4D growth,which results in a higher 2D:4D ratio in boys with hypospadias via decreased endochondral *** study indicates that the ratio of 2D:4D is a risk marker of hypospadias and provides a potential molecular mechanism.

关键词： androgen receptor digit ratio(2D:4D) endochondral ossification hypospadias testosterone level

单晶4H-SiC的摩擦诱导化学机械复合加工(FCMM)实验研究

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机械工程学报 2024年第7期60卷 401-410页

作者：张博楠黄辉武民华侨大学脆性材料产品智能制造技术国家地方联合工程研究中心厦门361021 华侨大学制造工程研究院厦门361021

单晶碳化硅(SiC)凭借其优异的材料性能成为下一代电力电子器件和光电子器件的优选衬底材料,但碳化硅的高硬脆性,强化学惰性对其高效精密加工带来了巨大挑战。提出一种基于摩擦诱导化学作用与低硬度磨粒机械作用复合的SiC晶片加工新思路... 详细信息

单晶碳化硅(SiC)凭借其优异的材料性能成为下一代电力电子器件和光电子器件的优选衬底材料,但碳化硅的高硬脆性,强化学惰性对其高效精密加工带来了巨大挑战。提出一种基于摩擦诱导化学作用与低硬度磨粒机械作用复合的SiC晶片加工新思路。跟踪了4H-SiC在不同铁基烧结盘以及不同加工工艺参数下材料去除率随时间的变化;检测了加工后晶片的表面质量及亚表面损伤。实验结果表明摩擦诱导化学机械复合加工方法通过摩擦诱导实现金属与碳化硅的固相化学反应,并利用低硬度磨粒机械去除固相化学反应产物。加工后的亚表面中并未在纳米尺度下观察到晶体变形和晶格缺陷。加工初始阶段的材料去除率最高可达1025nm/min,稳定阶段的材料去除率最高可达385nm/min。工艺参数对加工过程中的固相化学反应速率有着重要的影响,低硬度磨粒实现对化学反应粘附物的机械去除,可以有效提高材料去除率。实验结果证实了本文提出的新型加工思路的可行性,其总体加工效率明显高于现有加工方法,为实现单晶SiC晶片的高效精密加工提供了新的研究思路。

关键词：摩擦诱导固相化学反应化学机械复合加工碳化硅亚表面损伤