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Getting physical with medical education:Exercise based virtual anatomy review classes for medical students

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World Journal of Methodology 2025年第1期15卷 20-25页

作者： Nadeesha R Samarasinghe Taniya S Nagpal michele l Barbeau Charys M Martin Division of General Surgery Faculty of MedicineUniversity of British ColumbiaVancouver V6T 1Z3BCCanada Faculty of Kinesiology Sport and RecreationUniversity of AlbertaEdmonton T6G 2R3ABCanada Anatomy and Cell Biology University of Western OntarioLondon N6A 3K7ONCanada Department of Anatomy and Cell Biology Schulich School of Medicine and DentistryThe University of Western OntarioLondon N6A 3K7ONCanada

The benefits of regular physical activity are well ***,few studies have examined the effectiveness of integrating physical activity(PA)into curricula within a post-secondary *** investigate the incorporation of PA into medical curriculum,we developed a series of optional exercise-based review sessions designed to reinforce musculoskeletal(MSK)anatomy course *** synchronous sessions were co-taught by a group fitness instructor and an anatomy *** fitness instructor would lead students through both strength and yoga style exercises,while the anatomy instructor asked questions about relevant anatomical structures related to course material previously *** the sessions,participants were asked to evaluate the classes on their self-reported exam preparedness in improving MSK anatomy knowledge,PA levels,and mental *** participants completed surveys;a majority agreed that the classes increased understanding of MSK concepts(90.0%)and activity levels(97.7%).Many(70.0%)felt that the classes helped reduce *** majority of respondents(90.0%)agreed that the classes contributed to increased feelings of social ***,medical students saw benefit in PA based interventions to supplement MSK course *** with increasing activity levels and promoting health behaviours,integrating PA into medical curriculum may improve comprehension of learning material,alleviate stress and foster social connectivity among medical students.

关键词： Medical education Musculoskeletal Anatomy Exercise Online learning

PHASE DIFFERENCE BETWEEN lOW-FREQUENCY OSCIllATIONS OF CEREBRAl DEOXY-AND OXY-HEMOGlOBIN CONCENTRATIONS DURING A MENTAl TASK

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Journal of Innovative Optical Health Sciences 2011年第2期4卷 151-158页

作者： ANGElO SASSAROlI FENG ZHENG michele pierro PETER R.BERGETHON SERGIO FANTINI Department of Biomedical Engineering Tufts University 4 Colby StreetMedfordMA 02155USA

Hemodynamic low-frequency(~0.1 Hz)spontaneous oscillations as detected in the brain by nearinfrared spectroscopy have potential applications in the study of brain activation,cerebral autoregulation,and functional *** this work,we have investigated the phase lag between oscillations of cerebral deoxy-and oxy-hemoglobin concentrations in the frequency range 0.05-0.10 Hz in a human subject during a mental workload *** have obtained a measure of such phase lag using two different methods:(1)phase synchronization analysis as used in the theory of chaotic oscillators and(2)a novel cross-correlation phasor *** two methods yielded comparable initial results of a larger phase lag between low-frequency oscillations of deoxy-and oxyhemoglobin concentrations during mental workload with respect to a control,rest condition.

关键词： Phase lag oxyhemoglobin deoxyhemoglobin phase synchronization cross-correlation phasor lFO

Thermodynamics and dielectric response of BaTiO_(3)by data-driven modeling

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npj Computational Materials 2022年第1期8卷 1998-2014页

作者： lorenzo Gigli Max Veit michele Kotiuga Giovanni Pizzi Nicola Marzari michele Ceriotti laboratory of Computational Science and Modeling(COSMO) Institute of MaterialsÉcole Polytechnique Fédérale de LausanneCH-1015LausanneSwitzerland Theory and Simulation of Materials(THEOS)and National Centre for Computational Design and Discovery of Novel Materials(MARVEl) École Polytechnique Fédérale de LausanneCH-1015LausanneSwitzerland

Modeling ferroelectric materials from first principles is one of the successes of density-functional theory and the driver of much development effort,requiring an accurate description of the electronic processes and the thermodynamic equilibrium that drive the spontaneous symmetry breaking and the emergence of macroscopic *** demonstrate the development and application of an integrated machine learning model that describes on the same footing structural,energetic,and functional properties of barium titanate(BaTiO_(3)),a prototypical *** model uses ab initio calculations as a reference and achieves accurate yet inexpensive predictions of energy and polarization on time and length scales that are not accessible to direct ab initio *** predictions allow us to assess the microscopic mechanism of the ferroelectric *** presence of an order-disorder transition for the Ti off-centered states is the main driver of the ferroelectric transition,even though the coupling between symmetry breaking and cell distortions determines the presence of intermediate,partly-ordered ***,we thoroughly probe the static and dynamical behavior of BaTiO_(3)across its phase diagram without the need to introduce a coarse-grained description of the ferroelectric ***,we apply the polarization model to calculate the dielectric response properties of the material in a full ab initio manner,again reproducing the correct qualitative experimental behavior.

关键词： transition ferroelectric dielectric

The hypoxia-inducible factor-1α activates ectopic production of fibroblast growth factor 23 in tumor-induced osteomalacia

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Bone Research 2016年第2期4卷 85-90页

作者： Qian Zhang michele Doucet Ryan E Tomlinson Xiaobin Han l Darryl Quarles Michael T Collins Thomas l Clemens Department of Orthopaedic Surgery Johns Hopkins University Baltimore MD USA Department of Medicine University of Tennessee Health Science Center Memphis TN USA Skeletal Clinical Studies Unit craniofacial and Skeletal Diseases Branch National Institutes of HealthBethesda MD USA Baltimore Veterans Administration Medical Center Baltimore MD USA

Tumor-induced osteomalacia （TIO） is a rare paraneoplastic syndrome in which ectopic production of fibroblast growth factor 23 （FGF23） by non-malignant mesenchymal tumors causes phosphate wasting and bone fractures. Recent studies have implicated the hypoxia-inducible factor-la （HIF-la） in other phosphate wasting disorders caused by elevated FGF23, including X-linked hypophosphatemic rickets and autosomal dominant hypophosphatemia. Here we provide evidence that HIF-la mediates aberrant FGF23 in TIO by transcriptionally activating its promoter. Immunohistochemical studies in phosphaturic mesenchymal tumors resected from patients with documented TIO showed that HIF-la and FGF23 were co-localized in spindle- shaped cells adjacent to blood vessels. Cultured tumor tissue produced high levels of intact FGF23 and demonstrated increased expression of HIF-la protein. Transfection of MC3T3-E1 and Saos-2 cells with a HIF-la expression construct induced the activity of a FGF23 reporter construct. Prior treatment of tumor organ cultures with HIF-la inhibitors decreased HIF-la and FGF23 protein accumulation and inhibited HIF-la-induced luciferase reporter activity in transfected cells. Chromatin immunoprecipitation assays confirmed binding to a HIF-la consensus sequence within the proximal FGF23 promoter, which was eliminated by treatment with a HIF-la inhibitor. These results show for the first time that HIF-la is a direct transcriptional activator of FGF23 and suggest that upregulation of HIF-la activity in TIO contributes to the aberrant FGF23 production in these patients.

关键词： The hypoxia-inducible factor-1 activates ectopic production of fibroblast growth factor 23 in tumor-induced osteomalacia HIF

Compact n-Manifolds via(n+l)-Colored Graphs:a New Approach

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Algebra Colloquium 2020年第1期27卷 95-120页

作者： luigi Grasselli michele Mulazzani Dipartimcnto di Scicnze e Metodi dell'Ingegneria Universita di Modena e Reggio Emilia Via Giovanni Amendola2-Pad.Morselli 42122 Reggio EmiliaItaly Dipartimento di Matematica and ARCES Universita di Bologna Piazza di Porta San Donato 540126 BolognaItaly

We introduce a representation via(n+l)-colored graphs of compact n-manifolds with(possibly empty)boundary,which appears to be very convenient for computer aided study and *** construction is a generalization to arbitrary dimension of the one recently given by Cristofori and Mulazzani in dimension three,and it is dual to the one given by Pezzana in the *** this context we establish some results concerning the topology of the represented manifolds:suspensions,fundamental groups,connected sums and moves between graphs representing the same *** results of compact orientable 4-manifolds representable by graphs up to six vertices are obtained,together with some properties of the G-degree of 5-colored graphs relating this approach to tensor models theory.

关键词： compact manifolds colored graphs fundamental groups dipole moves

Covariation between plant biodiversity and soil systems in a European beech forest and a black pine plantation:the case of Mount Faito,(Campania,Southern Italy)

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Journal of Forestry Research 2022年第1期33卷 239-252页

作者： Tiziana Danise michele Innangi Elena Curcio Antonietta Fioretto Department of Environmental Biological and Pharmaceutical Sciences and TechnologiesUniversity of Campania“Luigi Vanvitelli”Via Vivaldi 4381100 CasertaItaly

Both climate and land-use changes,including the introduction and spread of allochthonous species,are forecast to affect forest ***,forests will be affected in terms of species composition as well as their soil chemical and biological *** possible changes in both tree cover and soil system might impact the amount of carbon that is stored in living plants and dead biomass and within the soil ***,such alterations can have a strong impact on the detrital food web that is linked to litter *** there are studies on the infuence of plant diversity on soil physical and chemical characteristics,the effects on soil biological activity and carbon storage processes remain largely *** aim of this study was to investigate and compare chemical and biological variables in covariation with plant communities in an autochthonous beech forest(Fagus sylvatica l.)and a black pine plantation(Pinus nigra *** ***).Our results confirmed that the two communities were considerably different,with the old-growth beech community having a lower number of plant species and the pine community was in development as a consequence of anthropogenic *** aspects of the two communities were also refected in the soil,with the beech soil having higher nitrogen levels and a more specialized microbial community compared to the pine soil,with most extracellular enzymes(such as peroxidase and chitinase)showing lower activity in the pine soil.

关键词： 2B-PlS Plant and soil Vegetation Soil enzymes

Carbon nanostructure morphology templates nanocomposites for phosphoproteomics

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Nano Research 2020年第2期13卷 380-388页

作者： Susy Piovesana Daniel Iglesias Manuel Melle-Franco Slavo Kralj Chiara Cavaliere michele Melchionna Aldo laganà Anna l.Capriotti Silvia Marchesan Piazzale A.Moro 5 Dipartimento di ChimicaSapienza Universitadi RomaRome 00185Italy Via l.Giorgieri 1 Dipartimento di Scienze Chimiche e FarmaceuticheUniversitd di TriesteTrieste 34127Italy CICECO University of AveiroAveiro 3810-193Portugal Jamova 39 Department for Materials SynthesisJozef Stefan InstituteLjubljana 1000Slovenia Via Monteroni Campus Ecotekne CNR NANOTECUniversity of SalentoLecce 73100Italy

Protein and peptide phosphorylation regulate numerous pathological processes,however,their characterization is challenging due to their low abundance and transient ***,nanomaterials are being developed to address this demanding *** particular,carbon nanostructures are attracting interest as scaffolds for functional nanocomposites,yet only isolated studies exist on the topic,and lttle is known on the effect of nanocarbon morphology on templating *** this work,we compared oxidized carbon nanotubes,graphene oxide,oxidized carbon nanohorns and oxidized graphitized carbon black,as scaffolds for magnetized *** nanomaterials were extensively characterized with experimental and in silico ***,they were applied to phosphopeptide enrichment from cancer cell lysates for NanoHPlC-MS/MS,with selectivity as high as nearly 90%and several-thousand identification ***,new insights emerged for the understanding and the design of nanocomposites for phosphoproteomics.

关键词： nanocomposites carbon nanotubes graphene oxide carbon nanohorns proteomics magnetic

Neurotrophic factor-based pharmacological approaches in neurological disorders

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Neural Regeneration Research 2023年第6期18卷 1220-1228页

作者： Margherita Alfonsetti michele d’Angelo Vanessa Castelli Department of life Health and Environmental SciencesUniversity of L’AquilaL’AquilaItaly

Aging is a physiological event dependent on multiple pathways that are linked to lifespan and processes leading to cognitive *** process represents the major risk factor for aging-related diseases such as Alzheimer’s disease,Parkinson’s disease,and ischemic *** incidence of all these pathologies increases exponentially with *** on aging biology has currently focused on elucidating molecular mechanisms leading to the development of those *** deficit and neurodegeneration,common features of aging-related pathologies,are related to the alteration of the activity and levels of neurotrophic factors,such as brain-derived neurotrophic factor,nerve growth factor,and glial cell-derived neurotrophic *** this reason,treatments that modulate neurotrophin levels have acquired a great deal of interest in preventing neurodegeneration and promoting neural regeneration in several neurological *** treatments include both the direct administration of neurotrophic factors and the induced expression with viral vectors,neurotrophins’binding with biomaterials or other molecules to increase their bioavailability but also cell-based *** neurotrophins’crucial role in aging pathologies,here we discuss the involvement of several neurotrophic factors in the most common brain aging-related diseases and the most recent therapeutic approaches that provide direct and sustained neurotrophic support.

关键词： Alzheimer’s disease brain brain-derived neurotrophic factor glial cell-derived neurotrophic factor nerve growth factor neurotrophins neurturin Parkinson’s disease stroke tropomyosin receptor kinase receptors

Selective excitation and imaging of ultraslow phonon polaritons in thin hexagonal boron nitride crystals

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light(Science & Applications) 2018年第1期7卷 808-816页

作者： Antonio Ambrosio michele Tamagnone Kundan Chaudhary luis A.Jauregui Philip Kim William l.Wilson Federico Capasso Center for Nanoscale Systems Harvard UniversityCambridgeMA 02138USA Department of Physics Harvard UniversityCambridgeMA 02138USA Harvard John A.Paulson School of Engineering and Applied Sciences Harvard UniversityCambridgeMA 02138USA

We selectively excite and study two new types of phonon-polariton guided modes that are found in hexagonal boron nitride thin flakes on a gold *** modes show substantially improved confinement and a group velocity that is hundreds of times slower than the speed of light,thereby providing a new way to create slow light in the midinfrared range with a simple structure that does not require *** mode is the fundamental mode in the first Restrahlen band of hexagonal boron nitride thin crystals on a gold substrate;the other mode is equivalent to the second mode of the second Restrahlen band of hexagonal boron nitride flakes that are suspended in *** new modes also couple efficiently with incident light at the hexagonal boron nitride edges,as we demonstrate experimentally using photo-induced force microscopy and scanning near-field optical *** high confinement of these modes allows for Purcell factors that are on the order of tens of thousands directly above boron nitride and a wide band,with new perspectives for enhanced light-matter *** findings demonstrate a new approach to engineering the dispersion of polaritons in 2D materials to improve confinement and light-matter interaction,thereby paving the way for new applications in mid-infrared nano-optics.

关键词： interaction. boron hexagonal