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Chinese Journal of Natural Medicines 2019年第6期17卷 435-445页

作者： MIAO Lan-Yun CHU Thi Thanh Huyen LI Ping JIANG Yan LI Hui-Jun State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 210009China College of Chemical Engineering Nanjing Forestry UniversityNanjing 210037China

In the market of botanical dietary supplements, Cimicifuga heracleifolia(CH) has always been considered as an adulterated species of Cimicifuga racemosa(CR), a conventional American herb with promising benefits to counteract troubles arising from the menopause. However, the detailed comparison of their therapeutic effects is lacking. In present study, the pharmacological and metabolomics studies were comparatively conducted between CH and CR in ovariectomized(OVX) female rats. Specifically, estrogen-like, anti-hyperlipidemia and anti-osteoporosis effects were evaluated through measuring serum biochemical parameters, histopathological examination and micro computed tomography(Micro-CT) scanning. At the same time, a gas chromatography-mass spectrometry(GC-MS)-based serum metabolomics method was employed to profile the metabolite compositional changes. As a result, both CR and CH displayed anti-osteoporosis and anti-hyperlipemia on menopause syndrome. Meanwhile, their potentials in improving the OVX-induced metabolic disorders were discovered. In conclusion, these results demonstrated that CH is therapeutically similar to CR in relieving menopausal symptoms and CH could be considered as a promising alternative to CR instead of an adulterant in the market of botanical dietary supplements.

关键词： Cimicifuga heracleifolia Black cohosh Menopausal symptoms Metabolomics Substitute

Closing the nitrogen use efficiency gap and reducing the environmental impact of wheat-maize cropping on smallholder farms in the Guanzhong Plain,Northwest China

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Journal of Integrative Agriculture 2019年第1期18卷 169-178页

作者： Lü Feng-lian HOU miao-miao ZHANG Hong-tao Asif Khan Muhammad Ayaz QIANGJIU Ciren HU Chang-lu YANG Xue-yun SUN Ben-hua ZHANG Shu-lan College of Natural Resources and Environment Northwest A&F University/Key Laboratory of Plant Nutrition and the Agro-environment in Northwest ChinaMinistry of Agriculture Agriculture and Husbandry Bureau of Cuona County Agriculture and Husbandry Bureau of Cuona County

A high crop yield with the minimum possible cost to the environment is generally desirable.However,the complicated relationships among crop production,nitrogen(N) use efficiency and environmental impacts must be clearly assessed.We conducted a series of on-farm N application rate experiments to establish the linkage between crop yield and N_2 O emissions in the Guanzhong Plain in Northwest China.We also examined crop yield,partial factor productivity of applied N(PFPN) and reactive N(Nr) losses through a survey of 1 529 and 1 497 smallholder farms that grow wheat and maize,respectively,in the region.The optimum N rates were 175 and 214 kg ha^(-1) for winter wheat and summer maize,respectively,thereby achieving the yields of 6 799 and 7 518 kg ha^(-1),correspondingly,with low N_2 O emissions based on on-farm N rate experiments.Among the smallholder farms,the average N application rates were 215 and 294 kg ha^(-1) season^(-1),thus producing 6 490 and 6 220 kg ha^(-1) of wheat and maize,respectively.The corresponding PFPN values for the two crops were 36.8 and 21.2 kg N kg^(-1),and the total N_2 O emissions were 1.50 and 3.88 kg ha^(-1),respectively.High N balance,large Nr losses and elevated N_2 O emissions could be explained by the overdoses of N application and low grain yields under the current farming practice.The crop yields,N application rates,PFPN and total N_2 O for wheat and maize were 18 and 24% higher,42 and 37% less,75 and 116% higher,and 42 and 47% less,correspondingly,in the high-yield and high-PFPN group than in the average smallholder farms.In conclusion,closing the PFPN gap between the current average and the value for the high-yield and high-PFPN group would increase crop production and reduce Nr losses or the total N_2 O emissions for the investigated cropping system in Northwest China.

关键词： N fertiliser grain yield PFPN N balance reactive nitrogen losses N2O emission

探索性结构方程模型(ESEM)在网络友谊质量问卷中的应用

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基础教育 2019年第5期16卷 93-102页

作者：王小慧苏雪云蓝淼淼华东师范大学教育学部上海200062 上海市信息管理学校上海200030

对435名普通青少年和295名听觉障碍青少年实施了网络友谊质量问卷,运用探索性结构方程模型和验证性因素分析对问卷数据进行了分析。结果表明:(1)探索性结构方程模型的拟合指标优于验证性因素分析,因素相关也有所下降,提高了问卷的区分效... 详细信息

对435名普通青少年和295名听觉障碍青少年实施了网络友谊质量问卷,运用探索性结构方程模型和验证性因素分析对问卷数据进行了分析。结果表明:(1)探索性结构方程模型的拟合指标优于验证性因素分析,因素相关也有所下降,提高了问卷的区分效度;(2)多群组验证性因素证实了弱测量不变性,而强测量不变性和部分不变性都不成立;(3)多群组探索性结构方程模型仅仅检测出构型不变性。最后针对问卷修订提出了一些建议。

关键词：网络友谊质量探索性结构方程模型验证性因素分析测量不变性

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图书馆参与大学生健康素养教育可行性研究

内蒙古科技与经济 2022年第10期 130-132页

作者：崔云苗静蓝晶晶山东农业大学图书馆山东泰安271018

阐述了健康素养的内涵与发展,探讨图书馆参与大学生健康素养教育的可行性和具体策略,为提升大学生的健康素养水平和助力健康中国战略提供依据。结果表明:图书馆在培养大学生健康素养、提供权威可靠的健康资源和强大的服务支持系统方面... 详细信息

阐述了健康素养的内涵与发展,探讨图书馆参与大学生健康素养教育的可行性和具体策略,为提升大学生的健康素养水平和助力健康中国战略提供依据。结果表明:图书馆在培养大学生健康素养、提供权威可靠的健康资源和强大的服务支持系统方面具有独特优势,已经具备了开展健康素养教育的良好条件和信息生态环境。图书馆应该积极参与大学生的健康素养教育,助力健康中国战略的顺利实施。

关键词：健康素养高校图书馆健康中国战略

华北板块南部寒武系底部辛集组遗迹化石及其时代意义

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古生物学报 2014年第3期53卷 274-289页

作者：苗兰云朱茂炎中国科学院大学北京100049 现代古生物学和地层学国家重点实验室中国科学院南京地质古生物研究所南京210008

首次详细描述了河南省石门沟、阳坡和山西省水峪等3条剖面寒武系底部辛集组中的遗迹化石。遗迹化石主要产出于辛集组的近底部层位,以水平管状遗迹化石为主,共计8遗迹属,12遗迹种(含3个未定种),包括Arenicolites sp.,Didymaulichnus lyel... 详细信息

首次详细描述了河南省石门沟、阳坡和山西省水峪等3条剖面寒武系底部辛集组中的遗迹化石。遗迹化石主要产出于辛集组的近底部层位,以水平管状遗迹化石为主,共计8遗迹属,12遗迹种(含3个未定种),包括Arenicolites sp.,Didymaulichnus lyelli,Gordia marina,Helminthopsis abeli,Helminthopsis sp.,Palaeophycus striatus,Palaeophycus tubularis,Phycodes sp.,Planolites beverleyensis,Planolites montanus,Treptichnus pedum与Treptichnus pollardi,此外还有2枚属种未定的遗迹化石。这一遗迹化石组合属非典型的Cruziana遗迹相,形成于盐度正常的潮下带砂质软底环境。通过对寒武纪早期管状遗迹化石Palaeophycus与Planolites直径大小的统计与分析,推测辛集组下部地层的时代不早于沧浪铺期。

关键词：遗迹化石辛集组寒武系华北

Evaluation of anticancer effect of iridium(Ⅲ) complexes on lung carcinoma A549 cells

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Evaluation of anticancer effect of iridium(Ⅲ) complexes on ...

第十一届全国化学生物学学术会议

作者： lan Bai Yi-Ying Gu Fan Du miao He Wen-Yao Zhang yun-Jun Liu School of Pharmacy Guangdong Pharmaceutical University

Chemotherapy remains a common treatment for cancer in humans,but its effects are limited.It has been reported that iridium(Ⅲ) complexes have high antitumor activity and can be used as effective anticancer drugs.In this study,the iridium(Ⅲ) complexes was synthesized and characterized.The in vitro cytotoxicity of the iridium(Ⅲ) complexes on cancer cells and normal cell 3 T3 was assessed by MTT assay.The Ir-1-Ir-3 complexes exhibit significant inhibitory effect on A549 cells growth with an IC value of 5.4 ± 0.28,4.23 ± 0.03 and 3.77 ± 0.18 μM for Ir-1,Ir-2 and Ir-3,respectively.Further studies have shown that iridium(Ⅲ) complexes can induce apoptosis in A549 cells and enhance the levels of ROS,Ca,cyto-c in cells and cause a decrease in mitochondrial membrane potential.It was studied by Image Xpress Micro XLS system and flow cytometry.The effects of iridium(Ⅲ) complexes on DNA damage,autophagy and cell invasion were investigated by Image Xpress Micro XLS system.Flow cytometry was used to assess the proportion of apoptosis and cell cycle arrest.In addition,the effect of the iridium(Ⅲ) complexes on the expression levels of caspase-3 and Bcl-2 family proteins was investigated by Western blot.The results indicate that the iridium(Ⅲ) complexes induce apoptosis of A549 cells via ROS-mediated mitochondrial dysfunction pathway,accompanied by regulation of Bcl-2 family proteins.Therefore,the iridium(Ⅲ) complex may be a potential therapeutic anticancer drug against A549 cells.

关键词： Iridium（Ⅲ） complexes Apoptosis Autophagy Cell cycle arrest

Design,Synthesis,and Anticancer Effect Studies of Iridium(Ⅲ) Polypyridyl Complexes against HeLa Cells

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Design,Synthesis,and Anticancer Effect Studies of Iridium(Ⅲ...

第十一届全国化学生物学学术会议

作者： Yi-Ying Gu lan Bai Wen-Yao Zhang Fan Du miao He yun-Jun Liu School of Pharmacy Guangdong Pharmaceutical University

An iridium(Ⅲ) complex([Ir(PTTP)2(ppy)](PF)(Ir-1) were synthesized and characterized. The cytotoxicity of Ir-1 against cancer cell lines SGC-7901, A549, HeLa, HepG2 and BEL-7402 was investigated using the MTT method. The results showed that the iridium(Ⅲ) complex had moderate in vitro anti-tumor activity toward HeLa cells. Further studies showed that the complex induce cell apoptosis through DNA damage, cell cycle arrest at the G0/G1 phase, ROS elevation, increased levels of Ca, high mitochondrial membrane depolarization, and cellular ATP depletion. Transwell and Colony-Forming assays revealed that Ir-1 can also effectively inhibit the metastasis and proliferation of tumor cells. These results demonstrate that Ir-1 induce apoptosis in HeLa cells through ROS-mediated mitochondrial damage and DNA damage pathways, as well as by inhibiting cell invasion, thereby exerting anti-tumor cell proliferation activity in vitro.

关键词： Iridium complex antitumor activity mitochondrial dysfunction DNA damage

不同氮形态叶面肥对油茶春梢叶片光合生理特性的影响

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南方农业学报 2022年第11期53卷 3165-3173页

作者：李兰兰颜妙珍冯名开赖家业崔芸瑜广西大学林学院广西南宁530004 广西大学农牧产业发展研究院广西南宁530004

【目的】探讨不同氮形态叶面肥处理对油茶春梢叶片光合作用的影响,为油茶林种植经营管理提供参考。【方法】以岑软3号为试验材料,设置4个不同含氮素形态配比的叶面肥处理,即N1~N4处理,分别添加尿素(酰胺态氮)、硫酸铵和硝酸钾按1:1(硝... 详细信息

【目的】探讨不同氮形态叶面肥处理对油茶春梢叶片光合作用的影响,为油茶林种植经营管理提供参考。【方法】以岑软3号为试验材料,设置4个不同含氮素形态配比的叶面肥处理,即N1~N4处理,分别添加尿素(酰胺态氮)、硫酸铵和硝酸钾按1:1(硝铵态氮)、硫酸铵(铵态氮)、硝酸钾(硝态氮),含纯氮量一致均配比中微量元素和生长物质,以只添加中微量元素与生长物质的处理为对照(CK)。测定各处理的油茶叶片光合参数和光合色素含量,并用直角双曲线模型等4种模型对不同处理的光合—光响应曲线进行拟合,评价不同氮形态叶面肥的肥效。【结果】在1000μmol/(m^(2)·s)光强下,不同氮形态叶面肥处理均可提高净光合速率(Pn)、蒸腾速率(Tr)、气孔导度(Gs),降低胞间CO_(2)浓度(C_(i)),其中铵态氮与硝态氮混施处理(N2)的P_(n)、G_(s)和T_(r)值均显著高于其他处理(P<0.05,下同),Ci显著低于其他处理。实测光响应曲线中,随光照强度增加,不同氮形态叶面肥处理均能使G_(s)、T_(r)和P_(n)值上升、Ci值下降,铵态氮与硝态氮混施处理的Gs、T_(r)和P_(n)上升更快,而Ci则表现为下降更快;通过光响应曲线拟合比较,得出最佳模型为直角双曲线修正模型。得出不同氮形态叶面肥处理均提高叶片的表观量子效率(α)和最大净光合速率(P_(n-max))值,其中铵态氮与硝态氮混施处理的α和Pn-max提高幅度最大,分别为0.072和8.5473μmol/(m^(2)·s);同时降低光补偿点(LCP)值,其中铵态氮与硝态氮混施处理的LCP值最小;提高了叶片光合色素含量,其中铵态氮与硝态氮混施处理的含量最高。【结论】不同氮形态叶面肥处理均有利于提高油茶春梢叶片光合作用,效果最佳的是以铵态氮与硝态氮混合配施的叶面肥。

关键词：油茶春梢氮形态配方叶面肥光合特性光响应曲线模型

Liposomes encapsulated iridium（Ⅲ） polypyridyl complexes for enhanced tumor suppression

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Liposomes encapsulated iridium（Ⅲ） polypyridyl complexes f...

第十一届全国化学生物学学术会议

作者： miao He Wen-Yao Zhang Fan Du Yi-Ying Gu lan Bai Zhi Jia yun-Jun Liu School of Pharmacy Guangdong Pharmaceutical University

A series of novel metal iridium complexes containing phenanthroline derivatives were designed and synthesized by changing the substituent groups on the phenanthroline derivatives [1]. However, its biocompatibility is often unsatisfactory, and we need to find a new way to deal with it. In many drug-loading systems, liposome is a low-toxic, biodegradable common drug-loading material. Due to the hydrophobic nature of phospholipids, liposomes can self-assemble to form vesicles with phospholipid bilayers. And the vesicles can encapsulate hydrophilic or hydrophobic molecules. In addition, when the liposome is modified by polyethylene glycol phospholipid（PEG） or its derivative, the material will greatly improve stability and safety, and can prolong its half-life to achieve the effect of long-circulating preparation. Therefore, the iridium complex was prepared using lecithin and PEG to prepare a long-circulating liposome. In this way, not only the toxicity of the complex to the tumor cells is greatly improved, but also the characteristics of the long-circulating preparation can be utilized, and it is better applied to the vivo [2]. The result shows, Ir-1-Ir-3 complex did not significantly inhibit the growth of BEL-7402 cells（IC50:＞＞ 200）, but Ir-1-lipo, Ir-2-lipo and Ir-3-lipo showed Significant inhibition, IC50 values were 11.0 ± 0.5, 5.8 ± 0.2 and 28.9 ± 3.5, respectively.

关键词： iridium（Ⅲ） complex liposome Apoptosis

Synthesis and Antitumor Activity Studies of Small Molecule Metal Iridium(Ⅲ) Complexes

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Synthesis and Antitumor Activity Studies of Small Molecule M...

第十一届全国化学生物学学术会议

作者： Fan Du miao He Wen-Yao Zhang Yi-Ying Gu lan Bai Zhi Jia yun-Jun Liu School of Pharmacy Guangdong Pharmaceutical University

Malignant tumors have always threatened human health.Among them,platinum metal complexes have been more mature clinical applications,but because they still have some shortcomings,it is the main direction to explore high-efficiency and low-toxic anti-tumor drugs.Three new iridium(Ⅲ) complexes [Ir(ppy)(cdppz)](PF)(Ir-1),[Ir(bzq)2(cdppz)](PF6)(Ir-2) and [Ir(ppy)2(cdppz)](PF6)(Ir-3,Scheme 1) were synthesized and characterized.These three complexes were then evaluated in vitro cytotoxicity by MTT assay.IC values of the complexes toward cancer cells are listed in Table 1.The results showed that SGC-7901 was highly inhibited by the complexes.Flow cytometry was used to detect ROS,mitochondrial membrane potential and cell cycle.The results showed that the level of ROS in the cells increased significantly and the mitochondrial membrane potential decreased,which further proved that the complexes could block the cell cycle at G0/G1 phase to inhibit the cancer cell growth.In addition,cytotoxicity in vivo showed that complex Ir-2 exhibits high antitumor activity(Figure 2).Taken together,the complex induces apoptosis in SGC-7901 cells via ROS-mediated mitochondrial dysfunction pathway.

关键词： Iridium（Ⅲ） complexes Cytotoxic activity in vitro and in vivo Mitochondria