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Endogenous formaldehyde as one of important risk factors involving sporadic alzheimer's disease

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Endogenous formaldehyde as one of important risk factors inv...

Formaldehyde induces Tau hyperphosphorylation in vivo

中国生物化学与分子生物学会第十届会员代表大会暨全国学术会议

作者： Rongqiao He Jing Lu junye miao State Key Laboratory of Brain and Cognitive Sciences Institute of BiophysicsChinese Academy of Sciences Department of psychology and psychiatry Beijing Senile Hospital

Formaldehyde is one of the most toxic organic compounds, which is also produced and degraded by human cells at each *** shown in our results,the level of human endogenous formaldehyde is kept at low concentration (0.01-0.1 mM) in urine under physiological condition, but the concentration is getting higher during ***

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Formaldehyde induces Tau hyperphosphorylation in vivo

Dysfunction of dendritic cells in tumor microenvironment and immunotherapy

生命的分子机器及其调控网络——2012年全国生物化学与分子生物学学术大会

作者： junye miao Jing Lu Rongqiao He 中国科学院生物物理研究所

Formaldehyde(FA) is the simplest aldehye,which is widely distributed in environment as well as in *** lab have demonstrated that formaldehyde could promote BSA and protein Tau to aggregation in *** aggregates had cytotoxicity that could in-duce cell apoptosis and *** more,urine formaldehyde concentration of pa-tients with dementia were much higher than control.

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Cancer Communications 2024年第9期44卷 1047-1070页

作者： Jie Chen Yuhang Duan junye Che Jianwei Zhu Jecho Institute Co. LtdShanghaiP.R.China Engineering Research Center of Cell&Therapeutic Antibody Ministry of EducationBeijingP.R.China Shanghai Jiao Tong University School of PharmacyShanghaiP.R.China

Dendritic cells(DCs)comprise diverse cell populations that play critical roles in antigen presentation and triggering immune responses in the ***,several factors impair the immune function of DCs and may promote immune evasion in *** the mechanism of DC dysfunction and the diverse functions of heterogeneous DCs in the tumormicroenvironment(TME)is critical for designing effective strategies for cancer *** applications targeting DCs summarized in this report aim to improve immune infiltration and enhance the biological function of DCs to modulate the TME to prevent cancer cells from evading the immune ***,factors in the TME that induce DC dysfunction,such as cytokines,hypoxic environment,tumor exosomes and metabolites,and co-inhibitory molecules,have been ***,several key signaling pathways involved in DC dysfunction and signal-relevant drugs evaluated in clinical trials were ***,this review provides an overview of current clinical immunotherapies targeting DCs,especially therapies with proven clinical outcomes,and explores future developments in DC immunotherapies.

关键词： DCs immunotherapy dendritic cells dysfunction of DCs tumor microenvironment

Customization of FeNi alloy nanosheet arrays inserted with biomass-derived carbon templates for boosted electromagnetic wave absorption

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International Journal of Minerals,Metallurgy and Materials 2024年第4期31卷 812-824页

作者： Xuanqi Yang Honghan Wang Jing Chen Qingda An Zuoyi Xiao Jingai Hao Shangru Zhai junye Sheng Liaoning Key Lab of Lignocellulose Chemistry and BioMaterials Liaoning Collaborative Innovation Center for Lignocellulosic BiorefineryCollege of Light Industry and Chemical EngineeringDalian Polytechnic UniversityDalian 116034China Qingdao Medical College Qingdao UniversityQingdao 266071China

Electromagnetic wave(EMW)-absorbing materials have considerable capacity in the military field and the prevention of EMW radiation from harming human ***,obtaining lightweight,high-performance,and broadband EMW-absorbing material remains an overwhelming *** dielectric/magnetic composites with customized structures is a strategy with great promise for the development of high-performance EMW-absorbing *** layered double hydroxides as the precursors of bimetallic alloys and combining them with porous biomass-derived carbon materials is a potential way for constructing multi-interface heterostructures as efficient EMW-absorbing materials because they have synergistic losses,low costs,abundant resources,and light ***,FeNi alloy nanosheet array/Lycopodium spore-derived carbon(FeNi/LSC)was prepared through a simple hydrothermal and carbonization ***/LSC presents ideal EMW-absorbing performance by benefiting from the FeNi alloy nanosheet array,sponge-like structure,capability for impedance matching,and improved dielectric/magnetic *** expected,FeNi/LSC exhibited the minimum reflection loss of-58.3 dB at 1.5 mm with 20wt%filler content and a widely effective absorption bandwidth of 4.92 ***/LSC composites with effective EMW-absorbing performance provide new insights into the customization of biomass-derived composites as high-performance and lightweight broadband EMW-absorbing materials.

关键词： spore-derived carbon FeNi alloy nanosheet array multi-interface heterostructures synergistic effect efficient electromagnet-ic wave absorption

Reasonable Designing of Free-standing MnO_(2)/Graphene Composite Membrane for Lithium-ion Storage

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Chemical Research in Chinese Universities 2024年第3期40卷 508-512页

作者： SHI junye YU Chenxi ZOU Zewei ZHENG Shumin ZHANG Xing WANG Bao Institute of Refrigeration and Cryogenics Shanghai Jiao Tong University Shanghai 200433P.R.China State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190P.R.China Key Laboratory of Biopharmaceutical Preparation and Delivery Institute of Process EngineeringChinese Academy of SciencesBeijing 100190P.R.China CAS Key Laboratory of Molecular Nanostucture and Nanotechnology Institute of ChemistryChinese Academy of SciencesBeijing 100190P.R.China

Free-standing membranes show extraordinary promise in energy storage applications,however are usually limited by low capacity and poor rate ***,we assembled a series of free-standing MnO_(2)/GO composite membranes with ZIF67 particles embedded between two-dimensional(2D)*** particle size of ZIF67 can be adjusted to achieve tunable interlayer *** lithium storage performance of the as-obtained membranes with different interlayer spaces was systematically *** MnO_(2)/GO composite membrane embedded with ZIF67 particles with an average diameter of 30 nm(denoted as MnO_(2)/nZIF67/GO)delivers a good long cycling performance,and it retains a capacity of 340.7 mA·h·g^(−1) after 400 cycles at 0.05 A/*** MnO_(2)/GO composite membrane embedded with ZIF67 particles with an average diameter of 500 nm(denoted as MnO_(2)/mZIF67/GO)exhibits good rate *** of the size of the ZIF67 particles,the performance of the membrane containing ZIF67 is significantly better than that of the membrane without ZIF67,indicating that the ZIF67 particles can enhance the lithium storage performance of the assembled *** work provides a method to fabricate a free-standing membrane for lithium storage with tunable electrochemical performance.

关键词： Lithium-ion battery Membrane Free-standing ZIF67

Hydrophilic polyanionic hydrogel electrolyte for anti-freezing and bending resistant zinc-ion hybrid supercapacitors

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Journal of Materiomics 2024年第6期10卷 1299-1307页

作者： Xuejuan Wan Hangqi Song Zejia Zhao Zuocai Zhang Jingwei Wang junye Cheng Shenzhen Key Laboratory of Polymer Science and Technology Guangdong Research Center for Interfacial Engineering of Functional MaterialsCollege of Materials Science and EngineeringShenzhen UniversityShenzhen518060China Department of Materials Science Shenzhen MSU-BIT UniversityShenzhen517182China Institute of Semiconductor Manufacturing Research College of Mechatronics and Control EngineeringShenzhen UniversityShenzhen518060China

Zinc-ion hybrid supercapacitors(ZHSCs)have been widely considered as promising candidates for flexible electrochemical energy storage *** key challenge is to develop hydrogel electrolytes with high hydrophilicity,anti-freezing,bending resistance,and stable interface with *** study reported a hydrogel electrolyte system that can meet the above functions,in which the zincophilic and negatively charged SO3−,migratable Na+,abundant hydrophilic functional groups,gum xanthan,and porous architecture could effectively promote the electrochemical performance of *** with such hydrogel electrolytes not only exhibited good low-temperature performance but also showed excellent bending resistance ability.A high specific capacitance could be kept after a long air-working lifespan over 10,000 cycles under a wide operation voltage of 1.85 V at−10℃.Furthermore,flexible ZHSCs could maintain the capacitance retention of 93.18%even after continuous 500 bends at an angle of 180°.The designed hydrogel electrolytes could be also used for other electrochemical energy storage devices with anti-freezing and bending resistance by changing electrolyte salt.

关键词： Zn-ion hybrid supercapacitors Polyanionic Anti-freezing Bending resistance Porous architecture

Exciton-harvesting enabled efficient charged particle detection in zero-dimensional halides

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Light(Science & Applications) 2024年第9期13卷 1944-1955页

作者： Qian Wang Chenger Wang Hongliang Shi Jie Chen junye Yang Alena Beitlerova Romana Kucerkova Zhengyang Zhou Yunyun Li Martin Nikl Xilei Sun Xiaoping OuYang Yuntao Wu Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 201899China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China National Engineering Research Center for Rare Earth Grirem Advanced Materials Co.Ltd.and General Research Institute for Nonferrous MetalsBeijing 100088China Department of Physics Beihang UniversityBeijing 100191China Spallation Neutron Source Science Center Dongguan 523803China Department of Optical Materials Institute of Physics of the Czech Academy of SciencesPrague 16200Czech Republic Northwest Institute of Nuclear Technology Xi’an 710024China

Materials for radiation detection are critically important and urgently demanded in diverse fields,starting from fundamental scientific research to medical diagnostics,homeland security,and environmental *** halides(LDHs)exhibiting efficient self-trapped exciton(STE)emission with high photoluminescence quantum yield(PLQY)have recently shown a great potential as ***,an overlooked issue of excitonexciton interaction in LDHs under ionizing radiation hinders the broadening of its radiation detection ***,we demonstrate an exceptional enhancement of exciton-harvesting efficiency in zero-dimensional(0D)Cs3Cu2I5:Tl halide single crystals by forming strongly localized Tl-bound *** of the suppression of nonradiative exciton-exciton interaction,an excellentα/βpulse-shape-discrimination(PSD)figure-of-merit(FoM)factor of 2.64,a superior rejection ratio of 10−9,and a high scintillation yield of 26000 photons MeV−1 under 5.49 MeVα-ray are achieved in Cs3Cu2I5:Tl single crystals,outperforming the commercial ZnS:Ag/PVT composites for charged particle detection ***,a radiation detector prototype based on Cs3Cu2I5:Tl single crystal demonstrates the capability of identifying radioactive 220Rn gas for environmental radiation monitoring *** believe that the exciton-harvesting strategy proposed here can greatly boost the applications of LDHs materials.

关键词： composites particle dimensional

From VIB‑to VB‑Group Transition Metal Disulfides:Structure Engineering Modulation for Superior Electromagnetic Wave Absorption

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Nano-Micro Letters 2024年第2期16卷 218-257页

作者： junye Cheng Yongheng Jin Jinghan Zhao Qi Jing Bailong Gu Jialiang Wei Shenghui Yi Mingming Li Wanli Nie Qinghua Qin Deqing Zhang Guangping Zheng Renchao Che Department of Materials Science Shenzhen MSU-BIT UniversityShenzhen 517182People’s Republic of China School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081People’s Republic of China School of Materials Science and Engineering Qiqihar UniversityQiqihar 161006People’s Republic of China Department of Mechanical Engineering Hong Kong Polytechnic UniversityHung HomKowloonHong KongPeople’s Republic of China Laboratory of Advanced Materials Shanghai Key Lab of Molecular Catalysis and Innovative MaterialsFudan UniversityShanghai 200438People’s Republic of China Zhejiang Laboratory Hangzhou 311100People’s Republic of China

The laminated transition metal disulfides(TMDs),which are well known as typical two-dimensional(2D)semiconductive materials,possess a unique layered structure,leading to their wide-spread applications in various fields,such as catalysis,energy storage,sensing,*** recent years,a lot of research work on TMDs based functional materials in the fields of electromagnetic wave absorption(EMA)has been carried ***,it is of great significance to elaborate the influence of TMDs on EMA in time to speed up the *** this review,recent advances in the development of electromagnetic wave(EMW)absorbers based on TMDs,ranging from the VIB group to the VB group are *** compositions,microstructures,electronic properties,and synthesis methods are presented in ***,the modulation of structure engineering from the aspects of heterostructures,defects,morphologies and phases are systematically summarized,focusing on optimizing impedance matching and increasing dielectric and magnetic losses in the EMA materials with tunable EMW absorption *** as well as the challenges are also identified to guide the design of new TMDs based dielectric EMA materials with high performance.

关键词： Transition metal disulfides Electromagnetic wave absorption Impedance matching Structure engineering modulation

Mediating Role of Glucose-Lipid Metabolism in the Association between the Increased Risk of Coronary Heart Disease and Exposure to Organophosphate Esters,Phthalates,and Polycyclic Aromatic Hydrocarbons

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Environment & Health 2024年第3期2卷 170-179页

作者： Duo Zhang Xiang Liu Jiazichao Tu Qinru Xiao Linjiang Han Jinfeng Fu junye Bian Ruyue Zhang Jimei Chen Yijia Shao Shaoyou Lu School of Public Health(Shenzhen) Sun Yatsen UniversityShenzhen 518107China Department of Cardiac Surgery Guangdong Cardiovascular InstituteGuangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China

There is a lack of human evidence concerning the cardiovascular effects of combined exposure to endocrine *** case-control study sought to investigate coronary heart disease(CHD)associations with exposure to organophosphate flame retardants(OFRs),phthalates(PAEs),and polycyclic aromatic hydrocarbons(PAHs)among 148 adults with coronary-angiography-diagnosed CHD and 320 healthy adults from southern *** mediating role of glucose-lipid metabolism was also *** kernel machine regression suggested that when exposure status was fixed to the 75th percentile with the median value as the reference,exposure to OFRs,PAEs,and PAHs was associated with an 84%(95%CI:36%−134%),132%(12%−252%),and 214%(89%−331%)increased risk of developing CHD,*** quantile sum regression indicated urinary bis(2-butoxyethyl)phosphate(BBOEP),dibutyl phosphate(DBP),monoisononyl phthalate(miNP),and metabolites of phenanthrene may be major contributors to the overall effect of *** further analyses on identified chemical risk factors,mediation analyses suggested exposure to phenanthrene may increase the risk of CHD via elevating total cholesterol and blood glucose,while exposure to DiNP mainly associates with serum ***,we observed a slight mediation effect of oxidative DNA damage between urinary BBOEP and risk of *** results provide potential direction for further experimental *** evidence is needed to clarify the causation of the results.

关键词： Cardiovascular disease Flame retardants Plasticizers Combined exposure analysis Oxidative stress