Mediating Role of Glucose-Lipid Metabolism in the Association between the Increased Risk of Coronary Heart Disease and Exposure to Organophosphate Esters,Phthalates,and Polycyclic Aromatic Hydrocarbons

作     者：Duo Zhang Xiang Liu Jiazichao Tu Qinru Xiao Linjiang Han Jinfeng Fu Junye Bian Ruyue Zhang Jimei Chen Yijia Shao Shaoyou Lu 

作者机构：School of Public Health(Shenzhen)Sun Yatsen UniversityShenzhen 518107China Department of Cardiac SurgeryGuangdong Cardiovascular InstituteGuangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China 

出 版 物：《Environment & Health》 (环境与健康（英文）)

年 卷 期：2024年第2卷第3期

页      面：170-179页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(42077385 42277424 82200435 and 82100451) 

主　　题：Cardiovascular disease Flame retardants Plasticizers Combined exposure analysis Oxidative stress 

摘      要：There is a lack of human evidence concerning the cardiovascular effects of combined exposure to endocrine *** case-control study sought to investigate coronary heart disease(CHD)associations with exposure to organophosphate flame retardants(OFRs),phthalates(PAEs),and polycyclic aromatic hydrocarbons(PAHs)among 148 adults with coronary-angiography-diagnosed CHD and 320 healthy adults from southern *** mediating role of glucose-lipid metabolism was also *** kernel machine regression suggested that when exposure status was fixed to the 75th percentile with the median value as the reference,exposure to OFRs,PAEs,and PAHs was associated with an 84%(95%CI:36%−134%),132%(12%−252%),and 214%(89%−331%)increased risk of developing CHD,*** quantile sum regression indicated urinary bis(2-butoxyethyl)phosphate(BBOEP),dibutyl phosphate(DBP),monoisononyl phthalate(miNP),and metabolites of phenanthrene may be major contributors to the overall effect of *** further analyses on identified chemical risk factors,mediation analyses suggested exposure to phenanthrene may increase the risk of CHD via elevating total cholesterol and blood glucose,while exposure to DiNP mainly associates with serum ***,we observed a slight mediation effect of oxidative DNA damage between urinary BBOEP and risk of *** results provide potential direction for further experimental *** evidence is needed to clarify the causation of the results.