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BIOCELL 2021年第1期45卷 17-26页

作者： mervin burnett VITO RODOLICO FAN SHEN ROGER LENG MINGYONG ZHANG DAVID D.EISENSTAT CONSOLATO SERGI Department of Laboratory Medicine and Pathology University of AlbertaEdmontonCanada Department of Sciences for Health Promotion and Mother&Child Care Section of Anatomic PathologyUniversity of PalermoPalermoItaly Department of Orthopedics TianYou HospitalWuhan University of Science and TechnologyWuhanChina Division of Pediatric Hematology/Oncology Stollery Children’s HospitalEdmontonCanada Department of Oncology University of AlbertaEdmontonCanada Department of Pediatrics University of AlbertaEdmontonCanada

MicroRNAs(miRNAs)are small single-stranded,non-coding RNA molecules involved in the pathogenesis and progression of cancer,including *** aimed to clarify the pathways involving miRNAs using new bioinformatics *** applied WikiPathways and PathVisio,two open-source platforms,to analyze miRNAs in osteosarcoma using miRTar and *** as integration *** found 1298 records of osteosarcoma papers associated with the word“miRNA”.In osteosarcoma patients with good response to chemotherapy,miR-92a,miR-99b,miR-193a-5p,and miR-422a expression is increased,while miR-132 is *** identified miRNAs seem to be centered on the TP53 *** is the first application of PathVisio to determine miRNA pathways in *** have the potential to become a useful diagnostic and prognostic tool in the management of *** is a full pathway editor with the potentiality to illustrate the biological events,augment graphical elements,and elucidate all the physical structures and interactions with standard external database identifiers.

关键词： MiRNA Osteosarcoma p53 Carcinogenesis Oncology Cancer Bone tumor Bioinformatics

Stability Analysis and Performance Evaluation of Additive Mixed-Precision Runge-Kutta Methods

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Communications on Applied Mathematics and Computation 2024年第1期6卷 705-738页

作者： Ben burnett Sigal Gottlieb Zachary J.Grant Center for Scientific Computing and Data Science Research UMass DartmouthNorth DartmouthMassachusettsUSA CSME Michigan State UniversityEast LansingMichiganUSA

Additive Runge-Kutta methods designed for preserving highly accurate solutions in mixed-precision computation were previously proposed and *** specially designed methods use reduced precision for the implicit computations and full precision for the explicit *** this work,we analyze the stability properties of these methods and their sensitivity to the low-precision rounding errors,and demonstrate their performance in terms of accuracy and *** develop codes in FORTRAN and Julia to solve nonlinear systems of ODEs and PDEs using the mixed-precision additive Runge-Kutta(MP-ARK)*** convergence,accuracy,and runtime of these methods are *** show that for a given level of accuracy,suitably chosen MP-ARK methods may provide significant reductions in runtime.

关键词： Mixed precision Runge-Kutta methods Additive methods Accuracy

Using Natural Radionuclides to Trace Sources of Suspended Particles in the Lower Reaches of the Yellow River

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Journal of Ocean University of China 2024年第1期23卷 99-108页

作者： ZHANG Han burnett CWilliam ZHANG Xiaojie ZHAO Shibin YANG Disong NAN Haiming YU Zhigang XU Bochao Frontiers Science Center for Deep Ocean Multispheres and Earth System and Key Laboratory of Marine Chemistry Theory and TechnologyMinistry of EducationOcean University of ChinaQingdao 266100China Laboratory for Marine Ecology and Environmental Science Qingdao National Laboratory for Marine Science and TechnologyQingdao 266071China College of Chemistry and Chemical Engineering Ocean University of ChinaQingdao 266100China Department of Earth Ocean and Atmospheric ScienceFlorida State UniversityTallahasseeFL 32306USA North China Sea Environmental Monitoring Center State Oceanic AdministrationKey Laboratory of Ecological Prewarning and Protection of Bohai SeaMNRQingdao 266033China Shandong Provincial Key Laboratory of Marine Ecological Environment and Disaster Prevention and Mitigation Qingdao 266033China

Natural radionuclides are powerful tools for understanding the sources and fate of suspended particulate matter(SPM).Particulate matter with different particle sizes behaves differently with respect to adsorption and *** analyzed the activi-ties and distribution characteristics of multiple natural radionuclides(238U,226Ra,40K,228Ra,7Be and 210Pbex)on size-fractionated SPM at the Lijin Hydrographic Station(Huanghe or Yellow River)every month over a one-year *** showed that medium silt(16–32µm)was the main *** expected,the activity of each radionuclide decreased with an increase of particle *** examined the sources of SPM with different particle sizes using activity ratios of 226Ra/238U,228Ra/226Ra,40K/238U and 7Be/210Pbex,and concluded that SPM with different particle sizes originated from different *** results indicate that fine SPM(32µm)was mainly derived from resuspension of riverbed *** high runoff periods,the concentration of SPM increased significantly,and the pro-portion of fine particles originating upstream *** occurring radioactive isotopes,especially on size-fractionated par-ticles,are therefore seen as useful tracers to understand the sources and behaviors of riverine particles transported from land to sea.

关键词： the Yellow River suspended particulate matter size-fractions radionuclides sediment sources water elutriator

Oxide-supported metal catalysts for anaerobic NAD+regeneration with concurrent hydrogen production

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Chinese Chemical Letters 2024年第2期35卷 263-267页

作者： Jianwei Li Joseph W.H.burnett Claudia Martinez Macias Russell F.Howe Xiaodong Wang Chemical Engineering School of EngineeringLancaster UniversityLancaster LA1 4YWUnited Kingdom Chemistry Department University of AberdeenAberdeen AB24 3UEUnited Kingdom

We report SiO_(2)-supported monometallic Pt,Pd,Au,Ni,Cu and Co catalysts for proton-driven NAD+regeneration,co-producing H_(2).All metals are fully selective to NAD+where the order of turnover frequencies(Pt>Pd>Cu>Au,Ni and Co)coincides with those otherwise observed in electrochemical hydrogen evolution *** has revealed that NADH is capable of converting the metal sites into a“cathode”without an external potential and the NADH to NAD+reaction involves transferring electron and hydrogen atom ***-deficient Ptδ+(on CeO_(2))enhances TOF and the heterogeneous Pt/CeO_(2) catalyst is recyclable without losing any activity/selectivity.

关键词： NAD+regeneration Heterogeneous catalyst Hydrogenase mimic Hydrogen binding energy Hydrogen production

NADPH oxidase： recent evidence for its role in erectile dysfunction

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Asian Journal of Andrology 2008年第1期10卷 6-13页

作者： Liming Jin Arthur L.burnett Department of Urology The James Buchanan Brady Urological Institute Johns Hopkins Medical Institutions Baltimore MD 21287 USA

Important roles for reactive oxygen species （ROS） in physiology and pathophysiology have been increasingly recognized. Under normal conditions, ROS serve as signaling molecules in the regulation of cellular functions. However, enhanced ROS production as a result of the activation of nicotinamide adenine dinucleotide phosphate （NADPH） oxidase contributes significantly to the pathogeneses of vascular diseases. Although it has become evident that increased ROS is associated with erectile dysfunction （ED）, the sources of ROS in the penis remain largely unknown. In recent years, emergent evidence suggests the possible role of NADPH oxidase in inducing ED. In this review, we examine the relationship between ROS and ED in different disease models and discuss the current evidence basis for NADPH oxidase-derive＇d ROS in ED.

关键词： reactive oxygen species erectile function superoxide penis nitric oxide

Modified malleable prosthesis with a fixed mesh:case series for the Ghattas technique

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Asian Journal of Andrology 2022年第2期24卷 167-170页

作者： Osama Ghattas Mohamed Fahmy Doheim Hossam Kotb Arthur L burnett Dar-elzokora Center of Andrology Alexandria 21500Egypt Alexandria Faculty of Medicine Alexandria UniversityAlexandria 21131Egypt Department of Urology Johns Hopkins University School of MedicineBaltimoreMD 21287USA

Penile prosthetic implantation represents a cornerstone for patients with organic erectile dysfunction(ED)that is refractory,unsatisfactory,or contra-indicated for other approved medical or mechanical *** this study,we introduce the“Ghattas technique,”wherein we constructed a polypropylene mesh sheath that surrounds and is fixed to a 13-mm malleable prosthesis cylinder,which can increase the cylinder diameter for cases that need a larger *** patients underwent preoperative evaluation and completed the five-item International Index of Erectile Function questionnaire(IIEF-5).Postoperative outcomes were evaluated by IIEF-5 and Erectile Dysfunction Inventory of Treatment Satisfaction(EDITS)questionnaires at final *** mean age of the 23 included patients was 57.9(standard deviation[s.d.]:11.4)years and the mean duration of ED was 8.5(s.d.:7.9)*** improvement was determined by comparing mean preoperative and postoperative IIEF-5 scores(8.3[s.d.:3.9]vs 24.6[s.d.:0.6],P<0.001).High treatment satisfaction was determined according to a mean EDITS score of 94.9(s.d.:9.9).The proposed Ghattas technique was safe and effective in our patients,and provides opportunity for cases that need a diameter larger than 13 *** studies are needed to confirm these results.

关键词： erectile dysfunction mesh penile prosthesis surgical technique

4D imaging of void nucleation,growth,and coalescence from large and small inclusions in steel under tensile deformation

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Journal of Materials Science & Technology 2022年第28期123卷 168-176页

作者： Yi Guo Timothy L.burnett Samuel A.McDonald Michael Daly Andrew H.Sherry Philip J.Withers Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Henry Royce Institute Department of MaterialsUniversity of ManchesterM139PLUK European Synchrotron Radiation Facility(ESRF) 6 rue J Horowitz38000 GrenobleFrance National Nuclear Laboratory Chadwick HouseBirchwood ParkWarringtonWA36AEUK

Samples of SA508 grade 3 nuclear pressure vessel ferritic steel were subjected to tensile straining whilst being simultaneously imaged in 3D in real time using high resolution,high frame rate time-lapse synchrotron computed tomography(CT).This enabled direct observation of void development from nucleation,through growth to coalescence and final failure validating many inferences made post-mortem or by theoretical models,as well as raising new *** sparse,large inclusions were found to nucleate voids at essentially zero plastic strain(consistent with zero interfacial strength);these became increasingly elongated with *** contrast,a high density of small spherical voids were found to nucleate from the sub-micron cementite particles at larger strains(>200%)only in the centre of the necked(high triaxiality)*** interfacial strength approaching 2100 MPa was inferred and soon after their nucleation,these small voids coalesce to form internal microcracks that lead to the final failure of the *** surprisingly,under these conditions of generally low triaxial constraint the large voids are simply cut across and appear to play no significant role in determining the final *** implications of these results are discussed in terms of ductile fracture behaviour and the Gurson model for ductile fracture.

关键词： Void growth Ductile fracture Synchrotron X-ray tomography 4D imaging Bainitic steel

Postphalloplasty urinary function test:an observational study of novel outcome instrument to capture urinary dysfunction and quality of life after phalloplasty

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Asian Journal of Andrology 2022年第6期24卷 570-574页

作者： James L Liu Lauren Eisenbeis Stephanie Preston Arthur L burnett Heather N DiCarlo Devin Coon The James Buchanan Brady Urological Institute and Department of Urology Johns Hopkins University School of MedicineBaltimoreMD 21287USA Department of Plastic and Reconstructive Surgery Johns Hopkins School of MedicineBaltimoreMD 21287USA Johns Hopkins Center for Transgender Health Johns Hopkins MedicineBaltimoreMD 21287USA Department of Surgery University of Texas SouthwesternDallasTX 75370USA

Due to growing social acceptance,there has been an increasing number of gender-affirmation surgeries performed in North *** research in this patient population focuses on surgical outcomes and advancing ***,little work has been done to study functional *** better evaluate urinary dysfunction in the postphalloplasty trans men patient population,our group developed a novel patient-reported outcome instrument-the postphalloplasty urinary function test(PP UFT)and protocol to measure postvoid urethral volume(PVUR),and we present our preliminary *** conducted a cross-sectional pilot study in a cohort of 15 adult trans men who had undergone phalloplasty with urethral lengthening surgery between 2018 and *** had stable urinary function via the neophallus at the time of *** filled out the PP UFT and were asked to record their PVUR as per our *** average PP UFT score was 8.9 out of 40 and the average quality-of-life(QOL)score was *** dribbling constituted the major complaint and on average comprised 63.2%of the reported PP UFT *** average PVUR was 2.2 ml(range:0.5-5.6 ml).There was a positive correlation between higher PP UFT and worse-reported quality of life(P<0.01;R?=0.4).Current questionnaires accepted in cis-male urology have limitations for accurately capturing urinary dysfunction in this specific patient *** combination of PP UFT and PVUR measurement offers potential for quantifying urinary function and quality of life in patients who undergo *** studies will validate these instruments.

关键词： gender affirmation gender surgery phalloplasty postvoid urethral residual urethral lengthening urinary dysfunction

the EVER-LASTING QUARTET

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英语学习 1998年第12期 25-27页

作者： Whir burnett

Arthur Nilson waited fora bus to ***,alittle old man came upto him."Excuse me,"said the lit-tle old man,"is that a viola underyour arm?""Why yes,"said Arthur Nil-son,"it is a viola.""Ah,I thought so,"said thelittle ma... 详细信息

关键词：作曲家奥地利四重奏 the EVER-LASTING QUARTET 舒伯特

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重载流多芯电缆周围的磁场I.理论模型

上海交通大学学报 2002年第2期36卷 237-242页

作者：傅正财杜亚平 J.burnett 上海交通大学电力学院上海200030 香港理工大学屋宇设备工程学系

多芯电力电缆在低压配电系统中常被用作配电干线 .这种重载流电缆周围的极低频磁场可能干扰附近敏感电子设备的正常运行 ,甚至影响暴露于该场下的人体的健康 .为分析这种磁场的分布特性 ,建立了多芯电缆周围磁场的载流平行螺旋线模型 ,... 详细信息

多芯电力电缆在低压配电系统中常被用作配电干线 .这种重载流电缆周围的极低频磁场可能干扰附近敏感电子设备的正常运行 ,甚至影响暴露于该场下的人体的健康 .为分析这种磁场的分布特性 ,建立了多芯电缆周围磁场的载流平行螺旋线模型 ,并推导了周围磁场的简化计算公式 .基于所提出的理论模型对电缆周围磁场的特性进行了分析 ,发现在电缆的半径方向上磁场随距离衰减的速度大于指数衰减速度 .在平行于电缆轴线的直线上和在电缆的同轴圆周线上 ,磁场的幅值和相角都随观测点的位置周期变化 .理论计算结果表明 ,常用规格的多芯电力电缆在载额定电流的情况下 ,距电缆 2 m外空间中的磁场已小于有关国际标准的限值 .

关键词：重载流理论模型多芯电力电缆极低频磁场电磁兼容低压配电系统