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Roles of neuronal lysosomes in the etiology of Parkinson’s disease

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Neural Regeneration Research 2024年第9期19卷 1981-1983页

作者： mattia Volta Institute for Biomedicine Eurac ResearchBolzanoItaly

Therapeutic progress in neurodegenerative conditions such as Parkinson’s disease has been hampered by a lack of detailed knowledge of its molecular *** advancements in genetics and genomics have provided fundamental insights into specific protein players and the cellular processes involved in the onset of *** this respect,the autophagy-lysosome system has emerged in recent years as a strong point of convergence for genetics,genomics,and pathologic indications,spanning both familial and idiopathic Parkinson’s ***,if not all,genes linked to familial disease are involved,in a regulatory capacity,in lysosome function(e.g.,LRRK2,alpha-synuclein,VPS35,Parkin,and PINK1).Moreover,the majority of genomic loci associated with increased risk of idiopathic Parkinson’s cluster in lysosome biology and regulation(GBA as the prime example).Lastly,neuropathologic evidence showed alterations in lysosome markers in autoptic material that,coupled to the alpha-synuclein proteinopathy that defines the disease,strongly indicate an alteration in *** this Brief Review article,I present a personal perspective on the molecular and cellular involvement of lysosome biology in Parkinson’s pathogenesis,aiming at a larger vision on the events underlying the onset of the *** attempts at targeting autophagy for therapeutic purposes in Parkinson’s have been mostly aimed at“indiscriminately”enhancing its activity to promote the degradation and elimination of aggregate protein accumulations,such as alpha-synuclein Lewy ***,this approach is based on the assumption that protein pathology is the root cause of disease,while pre-pathology and pre-degeneration dysfunctions have been largely observed in clinical and pre-clinical *** addition,it has been reported that unspecific boosting of autophagy can be ***,it is important to understand the mechanisms of specific autophagy forms and,even more,the adjustment of specific lysosome f

关键词： alpha-synuclein autophagy LRRK2 lysosome neuroprotection neurotransmission Parkinson’s disease Rit2 synapse

Current trends on the use of deep learning methods for image analysis in energy applications

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Energy and AI 2024年第1期15卷 342-355页

作者： mattia Casini Paolo De Angelis Eliodoro Chiavazzo Luca Bergamasco Department of Energy Politecnico di TorinoCorso Duca degli Abruzzi 24Turin10129Italy

Deep learning methods for image analysis are attracting increasing interest for application in a wide range of different research *** we aim to systematically analyze and discuss the most relevant examples for the energy *** this,we perform a comprehensive literature screening on applications of deep learning methods for image analysis,classify the results in application macro-areas,and discuss the emerging trends on the available energy-related *** results of the analysis show that,while the exploitation of these methods for energy applications still appears to be at an early stage,the interest during the last years,in terms of number of published works,has considerably *** provide a systematic overview on the available energy-related examples,we present a schematic correlation chart mapping algorithms,tasks,and *** reported analysis is intended to provide an up-to-date overview on the current application trends and potential developments for energy applications in the next future.

关键词： Deep learning Image analysis Convolutional neural networks Energy applications

Dislocation of primary total hip arthroplasty:Analysis of risk factors and preventive options

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World Journal of Orthopedics 2024年第6期15卷 501-511页

作者： Dario Regis mattia Cason Bruno Magnan Department of Orthopedic and Trauma Surgery Integrated University HospitalVerona 37126VenetoItaly

Total hip arthroplasty(THA)is one of the most successful elective operations in orthopedic surgery for improving pain and functional disability in patients with end-stage joint ***,dislocation continues to be a troublesome complication after THA,as it is a leading cause of revision and is associated with substantial social,health,and economic *** is a relatively rare,usually early occurrence that depends on both the patients’characteristics and the surgical *** most recent and important finding is the special attention to be given preoperatively to spinopelvic mobility,which is closely related to the incidence of ***,clinical and radiographic assessment of the lumbar spine is mandatory to identify an altered pelvic tilt that could suggest a different positioning of the *** spinal fusion is currently considered a risk factor for dislocation and revision regardless of whether it is performed prior to or after *** options for its treatment and prevention include the use of prostheses with large diameter of femoral head size,dual mobility constructs,constrained liners,and modular neck stems.

关键词： Dislocation Total hip arthroplasty Revision surgery Review Risk factors Complication

Non-anatomical liver resection for hepatocellular carcinoma:the SegSubTe classification to overcome the problem of heterogeneity

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 265-271页

作者： mattia Garancini Alessandro Fogliati Mauro Alessandro Scotti Cristina Ciulli Francesca Carissimi Antonio Rovere Luca Gianotti Fabrizio Romano Unit of Hepatobiliopancreatic Surgery Department of SurgeryASST-MonzaSan Gerardo HospitalUniversity of Milano-Bicoccavia Pergolesi 33MonzaMB 20052Italy Interventional Radiology Department of RadiologyASST-MonzaSan Gerardo HospitalMilano-Bicocca Universityvia Pergolesi 33MonzaMB 20052Italy

Background:The superiority of anatomical resection(AR)***-anatomical resection(NAR)in the surgical management of hepatocellular carcinoma(HCC)is *** are well-defined procedures,whereas the lack of NAR standardization results in heterogeneous *** study aimed to introduce the SegSubTe classification for NAR detailing the appropriateness of the level of surgical section of the Glissonean pedicles feeding the ***:A single-center retrospective analysis of pre-and postoperative imaging of consecutive patients treated with NAR for single HCC between 2012 and 2020 was *** quality of surgery was assessed classifying the type of vascular supply and the level of surgical section(segmental,subsegmental or terminal next to the tumor)of vascular pedicles feeding the HCCs;then,the population was divided in“SegSubTe-IN”or“SegSubTe-OUT”groups,and the tumor recurrence and survival were ***:Ninety-seven patients who underwent NAR were included;76%were SegSubTe-IN and 24%were *** disease recurrence,local recurrence and cut-edge recurrence in the SegSubTe-IN ***-OUT groups were 50%vs.83%(P=0.006),20%vs.52%(P=0.003)and 16%vs.39%(P=0.020),***-OUT odds ratio for local recurrence was 4.1 at univariate regression ***-,three-,and five-year disease-free survival rates in the SegSubTe-IN ***-OUT groups were 81%,58%and 35%vs.46%,21%and 11%,respectively(P<0.001).Conclusions:The SegSubTe classification is a useful tool to stratify and standardize NAR for HCC,aiming at improving long-term oncological outcomes and reducing the heterogeneity of quality of NAR for HCC.

关键词： Hepatocellular carcinoma Intraoperative ultrasound Liver surgery Computed tomography Surgical procedure

Effects of early postnatal gastric and colonic microbiota transplantation on piglet gut health

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Journal of Animal Science and Biotechnology 2024年第2期15卷 645-658页

作者： Christina Larsen Simone Margaard Offersen Anders Brunse mattia Pirolo Soumya Kanti Kar Luca Guadabassi Thomas Thymann Department of Veterinary and Animal Science University of CopenhagenDyrlagevej 681870 Frederiksberg CDenmark Animal Nutrition Wageningen Livestock ResearchWageningen University&Research1 De Elst6708 WageningenThe Netherlands

Background Diarrhea is a major cause of reduced growth and mortality in piglets during the suckling and weaning periods and poses a major threat to the global pig *** and gut dysbiosis may in part be prevented via improved early postnatal microbial colonization of the *** secure better postnatal gut colonization,we hypothesized that transplantation of colonic or gastric content from healthy donors to newborn recipients would prevent diarrhea in the recipients in the post-weaning *** objective was to examine the impact of transplanting colonic or gastric content on health and growth parameters and paraclinical parameters in recipient single-housed piglets exposed to a weaning transition and challenged with enterotoxigenic Escherichia coli(ETEC).Methods Seventy-two 1-day-old piglets were randomized to four groups:colonic microbiota transplantation(CMT,n=18),colonic content filtrate transplantation(CcFT,n=18),gastric microbiota transplantation(GMT,n=18),or saline(CON,n=18).Inoculations were given on d 2 and 3 of life,and all piglets were milk-fed until weaning(d 20)and shortly after challenged with ETEC(d 24).We assessed growth,diarrhea prevalence,ETEC concentration,organ weight,blood parameters,small intestinal morphology and histology,gut mucosal function,and microbiota composition and *** Episodes of diarrhea were seen in all groups during both the milk-and the solid-feeding phase,possibly due to stress associated with single ***,CcFT showed lower diarrhea prevalence on d 27,28,and 29 compared to CON(all P<0.05).CcFT also showed a lower ETEC prevalence on d 27(P<0.05).CMT showed a higher alpha diversity and a difference in beta diversity compared to CON(P<0.05).Growth and other paraclinical endpoints were similar across *** In conclusion,only CcFT reduced ETEC-related post-weaning ***,the protective effect was marginal,suggesting that higher doses,more effective modalities of administration

关键词： Colonic content filtrate transplantation Colonic microbiota transplantation Gastric microbiota transplantation Gut microbiota Mucosa Neonatal Post-weaning diarrhea

Role of glioma stem cells in promoting tumor chemo- and radioresistance: A systematic review of potential targeted treatments

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World Journal of Stem Cells 2024年第5期16卷 604-614页

作者： Edoardo Agosti Marco Zeppieri mattia Ghidoni Tamara Ius Alessandro Tel Marco Maria Fontanella Pier Paolo Panciani Division of Neurosurgery Department of Medical and Surgical SpecialtiesRadiological Sciences and Public HealthUniversity of BresciaBrescia 25123Italy Department of Ophthalmology University Hospital of UdineUdine 33100Italy Neurosurgery Unit Department of Head-Neck and NeuroScienceUniversity Hospital of UdineUdine 33100Italy Clinic of Maxillofacial Surgery Department of Head-Neck and NeuroScienceUniversity Hospital of UdineUdine 33100Italy

BACKGROUND Gliomas pose a significant challenge to effective treatment despite advancements in chemotherapy and *** stem cells(GSCs),a subset within tumors,contribute to resistance,tumor heterogeneity,and *** studies reveal GSCs’role in therapeutic resistance,driven by DNA repair mechanisms and dynamic transitions between cellular *** mechanisms can involve different cellular pathways,most of which have been recently reported in the *** progress,targeted therapeutic approaches lack consensus due to GSCs’high *** To analyze targeted therapies against GSC-mediated resistance to radio-and chemotherapy in gliomas,focusing on underlying *** A systematic search was conducted across major medical databases(PubMed,Embase,and Cochrane Library)up to September 30,*** search strategy utilized relevant Medical Subject Heading terms and keywords related to including“glioma stem cells”,“radiotherapy”,“chemotherapy”,“resistance”,and“targeted therapies”.Studies included in this review were publications focusing on targeted therapies against the molecular mechanism of GSC-mediated re-sistance to radiotherapy resistance(RTR).RESULTS In a comprehensive review of 66 studies on stem cell therapies for SCI,452 papers were initially identified,with 203 chosen for full-text *** them,201 were deemed eligible after excluding 168 for various *** temporal breakdown of studies illustrates this trend:2005-2010(33.3%),2011-2015(36.4%),and 2016-2022(30.3%).Key GSC models,particularly U87(33.3%),U251(15.2%),and T98G(15.2%),emerge as significant in research,reflecting their representativeness of glioma *** analysis indicates a focus on phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin(mTOR)(27.3%)and Notch(12.1%)pathways,suggesting their crucial roles in resistance *** molecules with mTOR(18.2%),CHK1/2(15.2%),and ATP binding cassette

关键词： Glioma stem cells Chemoresistance Radioresistance Molecular pathways Targeted therapies Systematic review

Stabilized Nickel-Rich-Layered Oxide Electrodes for High-Performance Lithium-Ion Batteries

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Energy & Environmental Materials 2024年第6期7卷 60-73页

作者： Zahra Ahaliabadeh Ville Miikkulainen Miia Mäntymäki mattia Colalongo Seyedabolfazl Mousavihashemi Lide Yao Hua Jiang Jouko Lahtinen Timo Kankaanpää Tanja Kallio Department of Chemistry and Materials Science(CMAT) School of Chemical EngineeringAalto University02150 EspooFinland Department of Chemistry University of Helsinki00014 HelsinkiFinland Department of Applied Physics School of ScienceAalto University02150 EspooFinland Umicore Finland Oy 67101 KokkolaFinland

This work made use of the Aalto University Otanano-Nanomicroscopy Center and RAMI *** support from Business Finland NextGenBat[grant number 211849]is greatly *** tomography experiment was performed at the beamline ID16B of the European Synchrotron Radiation Facility(ESRF),Grenoble,France,in the frame of proposal *** patent titled“Stabilized Positive Electrode Material to Enable High Energy and Power Density Lithium-Ion Batteries”(IPD3173)is pertinent to this *** was filed by Zahra Ahaliabadeh and Tanja Kallio,and the patent rights are held by Aalto University.

关键词： degradation mechanisms electrolyte decomposition hybrid coatings lithium-ion battery lithium-ion kinetics molecular layer deposition NMC811

Laser-optimized Pt-Y alloy nanoparticles embedded in Pt-Y oxide matrix for high stability and ORR electrocatalytic activity

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Journal of Energy Chemistry 2024年第5期92卷 508-520页

作者： Riccardo Brandiele Andrea Guadagnini mattia Parnigotto Federico Pini Vito Coviello Denis Badocco Paolo Pastore Gian Andrea Rizzi Andrea Vittadini Daniel Forrer Vincenzo Amendola Christian Durante Department of Chemical Sciences University of PaduaVia Marzolo 135131 PadovaItaly Istituto di Chimica della Materia Condensata e di Tecnologie per l’Energia ICMATE-CNR via Marzolo 1 I-35131 PadovaItaly

The development of active yet stable catalysts for oxygen reduction reaction(ORR)is still a major issue for the extensive permeation of fuel cells into everyday *** nanostructured Pt catalysts are to date the best available systems in terms of activity,the same is not true for stability,particularly under operating *** this work,Pt_(Х)Y alloy nanoparticles are proposed as active and durable electrocatalysts for ***_(Х)Y nanoalloys are synthesized and further optimized by laser ablation in liquid followed by laser fragmentation in *** novel integrated laser-assisted methodology succeeded in producing Pt_(Х)Y nanoparticles with the ideal size(1000 A g^(-1).At the same time,the nanoalloys are embedded in a fine Pt oxide matrix,which allows a greater stability of the catalyst than the commercial Pt reference,as directly verified on a gas diffusion electrode.

关键词： Electrocatalysis GDE ORR Pt_(2)Y Pt_(3)Y LAL LFL Oxide support Pto Nanoalloys

Harnessing photosynthetic microorganisms for enhanced bioremediation of microplastics:A comprehensive review

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Environmental Science and Ecotechnology 2024年第4期20卷 63-78页

作者： Giovanni Davide Barone Andres Rodríguez-Seijo mattia Parati Brian Johnston Elif Erdem Tomislav Cernava Zhi Zhu Xufeng Liu Ilka MAxmann Peter Lindblad Iza Radecka Institute of Biology University of GrazUniversitatsplatz 28010GrazAustria Area de Edafoloxía Departamento de Bioloxía Vexetal e Ciencia Do SoloFacultade de CienciasUniversidade de Vigo32004OurenseSpain Agroecology and Food Institute(IAA) University of Vigo e Campus Auga32004OurenseSpain School of Life Sciences Faculty of Science and EngineeringUniversity of WolverhamptonWolverhamptonWV11LYUnited Kingdom FlexSea Ltd. LondonEC2A4NEUnited Kingdom Department of Chemical and Biochemical Engineering Technical University of Denmark2800Kongens LyngbyDenmark Institute of Environmental Biotechnology Graz University of Technology8010GrazAustria The Key Laboratory of Biotechnology for Medicinal Plants of Jiangsu Province School of Life SciencesJiangsu Normal University221116XuzhouChina Department of ChemistrydÅngstrom Laboratory Uppsala UniversitySE-75120UppsalaSweden Synthetic Microbiology Department of BiologyHeinrich Heine University Düsseldorf40225DüsseldorfGermany Cluster of Excellence on Plant Sciences(CEPLAS) Heinrich HeineUniversity DüsseldorfD-40001DüsseldorfGermany

Mismanaged plastics,upon entering the environment,undergo degradation through physicochemical and/or biological *** process often results in the formation of microplastics(MPs),the most prevalent form of plastic debris(<1 mm).MPs pose severe threats to aquatic and terrestrial ecosystems,necessitating innovative strategies for effective *** photosynthetic microorganisms can degrade MPs but there lacks a comprehensive *** we examine the specific role of photoautotrophic microorganisms in water and soil environments for the biodegradation of plastics,focussing on their unique ability to grow persistently on diverse polymers under ***,these cells utilise light and CO_(2) to produce valuable compounds such as carbohydrates,lipids,and proteins,showcasing their multifaceted environmental *** address key scientific questions surrounding the utilisation of photosynthetic microorganisms for MPs and nanoplastics(NPs)bioremediation,discussing potential engineering strategies for enhanced *** review highlights the significance of alternative biomaterials and the exploration of strains expressing enzymes,such as polyethylene terephthalate(PET)hydrolases,in conjunction with microalgal and/or cyanobacterial ***,we delve into the promising potential of photo-biocatalytic approaches,emphasising the coupling of plastic debris degradation with sunlight *** integration of microalgal-bacterial consortia is explored for biotechnological applications against MPs and NPs pollution,showcasing the synergistic effects in wastewater treatment through the absorption of nitrogen,heavy metals,phosphorous,and *** conclusion,this review provides a comprehensive overview of the current state of research on the use of photoautotrophic cells for plastic *** underscores the need for continued investigation into the engineering of these microorganisms and the development of innovative approaches

关键词： Environmental biotechnology Microplastic Nanoplastic Microalgae Cyanobacteria