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Subclinical cardiovascular disease in type 2 diabetes mellitus: To screen or not to screen

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World Journal of Clinical Cases 2014年第9期2卷 415-421页

作者： juan J Chillarón juana A Flores-Le Roux David Benaiges juan Pedro-Botet Department of Endocrinology and nutrition Hospital del Mar Passeig Marítim 25-29 08003 Barcelona Spain Institut Municipal d'Investigacions Mèdiques Passeig Marítim 25-29 08003 Barcelona Spain Departament de Medicina Universitat Autònoma de Barcelona 08193 Cerdanyola (NOT Sarda?ola) del Vallés Barcelona Spain

The prevalence of type 2 diabetes mellitus(T2DM) has risen in recent decades, and cardiovascular disease remains the leading cause of death in this population. Several clinical trials have demonstrated the benefit of tight control of risk factors on the incidence and mortality of cardiovascular disease. However, in clinical practice, few patients achieve the therapeutic goals. The current diagnostic procedures for subclinical cardiovascular disease in T2 DM patients have not been shown to improve prognosis or mortality, probably because they do not categorize cardiovascular risk. Thus, clinical practice guidelines do not systematically recommend screening for subclinical atherosclerosis in these patients, although it is known that patients with extracoronary atherosclerosis, microangiopathy and poorlycontrolled cardiovascular risk factors are at high risk for cardiovascular disease. Improvements in the reliability of diagnostic tests, with fewer side effects and better cost efficiency, may better help to stratify cardiovascular risk in this group of patients, and further evaluation on this topic should be considered.

关键词： Cardiovascular disease Type 2 diabetes mellitus Cardiovascular risk

Habitat use and demography of Mus musculus in a rural landscape of Argentina

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Integrative Zoology 2013年第1期8卷 18-29页

作者： Vanina A.LEÓn Jimena FRASCHInA juan S.GUIDOBOnO Maria BUSCH Department of Ecology Genetics and EvolutionUniversity of Buenos AiresBuenos AiresArgentina

The main goal of the paper was to determine the habitat distribution of the house mouse(Mus musculus)within a rural landscape of Buenos Aires province,*** also studied the seasonal variation in abundance and reproductive *** habitats studied were poultry farms,human houses in a small village,cropfields,pastures,cropfield and pasture edges,riparian habitats(streams),railway embankments and *** captured 817 *** and 690 individuals of 5 native rodent *** was captured in poultry farms,houses,riparian habitats,cropfield and borders,but it showed a significantly higher abundance in poultry farms compared to the other *** presence outside poultry farms was significantly related to the distance to streams and poultry *** mean trapping success index of *** did not show significant variations between periods,but the proportion of active males was significantly higher in the spring-summer period than in the autumn-winter *** captures of *** in cropfields,borders and riparian habitats occurred in the spring-summer *** capture of *** in many types of habitats suggests that it can disperse outside poultry farms,and streams may be used as corridors.

关键词： abundance variation habitat distribution house mice reproductive activity

An Adaptive Lasso Grey Model for Regional FDI Statistics Prediction

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Computers, Materials & Continua 2021年第11期69卷 2111-2121页

作者： juan Huang Bifang Zhou Huajun Huang Jianjiang Liu neal n.Xiong Centre for Innovation Research in Social Governance Changsha University of Science and TechnologyChangsha410114China College of Information Technology and Management Hunan University of Finance and EconomicsChangsha410205China Department of Mathematics and Computer Science Northeastern State UniversityTahlequah74464USA

To overcome the deficiency of traditional mathematical statistics methods,an adaptive Lasso grey model algorithm for regional FDI(foreign direct investment)prediction is proposed in this paper,and its validity is ***,the characteristics of the FDI data in six provinces of Central China are generalized,and the mixture model’s constituent variables of the Lasso grey problem as well as the grey model are ***,based on the influencing factors of regional FDI statistics(mean values of regional FDI and median values of regional FDI),an adaptive Lasso grey model algorithm for regional FDI was ***,an application test in Central China is taken as a case study to illustrate the feasibility of the adaptive Lasso grey model algorithm in regional FDI *** also select RMSE(root mean square error)and MAE(mean absolute error)to demonstrate the convergence and the validity of the ***,we train this proposedal gorithm according to the regional FDI statistical data in six provinces in Central China from 2006 to *** then use it to predict the regional FDI statistical data from 2019 to 2023 and show its changing *** extended work for the adaptive Lasso grey model algorithm and its procedure to other regional economic fields is also discussed.

关键词： Adaptive lasso grey model algorithm regional FDI statistics mean value of regional FDI median value of regional FDI

BASKETBALL SCORInG In nBA GAMES:An EXAMPLE OF COMPLEXITY

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Journal of Systems Science & Complexity 2013年第1期26卷 94-103页

作者： DE SA GUERRA Yves MARTín GOnZALEZ juan Manuel SARMIEnTO MOnTESDEOCA Samuel RODRIGUEZ RUIZ David ARJOnILLA LóPEZ nieves GARCíA-MAnSO juan Manuel Departament of Phisical Education University of Las Palmas de Gran Canaria Departament of Physics University of Las Palmas de Gran Canaria

Scoring in a basketball game is a highly dynamic, non-linear process. nBA teams try to be more and more competitive each season. For instance, they incorporate into their rosters the best players in the world. This and other mechanisms concur to make the scoring process in nBA games exciting and rarely predictable. This paper is to study the behavior of timing and scoring in basketball gaines. The authors analyze all the games in five nBA regular seasons （2005-06, 2006-07, 2007-08, 2008-09, 2009-10）, for a total of 6150 games. Scoring does not behave uniformly; therefore, the authors also analyze the distributions of the differences in points in the basketball games. To further analyze the behavior of the tail of the distribution, the authors also carry out a semilog-plot and a log-log plot to verify whether this trend approaches a Poisson distribution or a PL. This paper reveals different areas of behavior related to the score, with specific instances of time that could be considered tipping points of the game. The presence of these critical points suggests that there are phase transitions where the dynamic scoring of the games varies significantly.

关键词： Complexity nBA non-linear Poisson power law.

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数字技术驱动下中国民歌变革及应对策略研究

湖北科技学院学报 2025年第1期45卷 80-85页

作者：胡娟方元河南职业技术学院音乐学院河南郑州450046

数字科技的崛起对音乐创作和传播方式带来了革命性的变化,同时也对中国民歌的传承和发展提出了新的课题。本研究旨在深入探讨数字化发展对中国民歌的影响,包括作品表演形式与作品的传承与创新,并详细分析其所面临的挑战和机遇,提出相应... 详细信息

数字科技的崛起对音乐创作和传播方式带来了革命性的变化,同时也对中国民歌的传承和发展提出了新的课题。本研究旨在深入探讨数字化发展对中国民歌的影响,包括作品表演形式与作品的传承与创新,并详细分析其所面临的挑战和机遇,提出相应的对策和建议。通过理论支持和实践指导,期望为传承和创新中国民歌作出积极贡献。

关键词：数字技术中国民歌变革应对

锆基金属有机框架捕获黄连中的生物碱类药物活性成分

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分析测试学报 2025年第1期44卷 188-194页

作者：司甜甜赵薇王慧张红玉刘小烨容蓉冯娟娟山东中医药大学药学院济南大学化学化工学院

采用溶剂热法制备了锆基MOF-808，利用其结构优势实现了中药黄连中生物碱类药物活性成分的富集与捕获，并结合其结构特点探讨了其协同低共熔溶剂捕获生物碱类活性成分过程中的相互作用。通过优化孵育捕获等条件，对黄连粗提液中药根碱... 详细信息

采用溶剂热法制备了锆基MOF-808，利用其结构优势实现了中药黄连中生物碱类药物活性成分的富集与捕获，并结合其结构特点探讨了其协同低共熔溶剂捕获生物碱类活性成分过程中的相互作用。通过优化孵育捕获等条件，对黄连粗提液中药根碱的回收率达到85.78%，结合高效液相色谱技术建立了检测黄连粗提液中5种生物碱类活性成分的方法。方法的线性范围为0.1～300μg·L-1，检出限为0.02～0.05μg·L-1，相对标准偏差为0.40%～4.7%，加标回收率达到69.7%～128%。该研究实现了中药黄连中生物碱类活性成分的高效、快速富集与捕获，为MOFs材料在选择性捕获与富集中药有效成分等领域的研究提供了新思路。

关键词：金属有机框架选择性富集色谱分离生物碱活性成分黄连

Conserved quantities and adiabatic invariants of fractional Birkhoffian system of Herglotz type

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Chinese Physics B 2020年第4期29卷 303-311页

作者： juan-juan Ding Yi Zhang School of Mathematics and Physics Suzhou University of Science and TechnologySuzhou 215009China College of Civil Engineering Suzhou University of Science and TechnologySuzhou 215011China

In order to further study the dynamical behavior of nonconservative systems,we study the conserved quantities and the adiabatic invariants of fractional Brikhoffian systems with four kinds of different fractional derivatives based on Herglotz differential variational ***,the conserved quantities of Herglotz type for the fractional Brikhoffian systems based on Riemann-Liouville derivatives and their existence conditions are established by using the fractional Pfaff-Birkhoff-d Alembert principle of Herglotz ***,the effects of small perturbations on fractional Birkhoffian systems are studied,the conditions for the existence of adiabatic invariants for the Birkhoffian systems of Herglotz type based on Riemann-Liouville derivatives are established,and the adiabatic invariants of Herglotz type are ***,the conserved quantities and adiabatic invariants for the fractional Birkhoffian systems of Herglotz type under other three kinds of fractional derivatives are established,namely Caputo derivative,Riesz-Riemann-Liouville derivative and Riesz-Caputo ***,an example is given to illustrate the application of the results.

关键词： fractional Birkhoffian system Pfaff-Birkhoff-d’Alembert principle adiabatic invariant Herglotz generalized variational principle

Hepatitis C virus-specific cytotoxic T cell response restoration after treatment-induced hepatitis C virus control

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World Journal of Gastroenterology 2015年第12期21卷 3480-3491页

作者： juan-Ramón Larrubia Elia Moreno-Cubero Joaquín Miquel Eduardo Sanz-de-Villalobos Translational Hepatology Unit Guadalajara University Hospital University of Alcalá Department of Medicine and Medical Specialties University of Alcalá Department of Biology of Systems University of Alcalá

Hepatitis C virus(HCV)-specific cytotoxic T cell(CTL) response plays a major role in viral control during spontaneous infection resolution. These cells develop an exhausted and pro-apoptotic status during chronic onset, being unable to get rid of HCV. The role of this response in contributing to sustained viral response(SVR) after anti-HCV is controversial. Recent studies show that after successful interferon-based anti-HCV treatment, HCV traces are still detectable and this correlates with a peak of HCV-specific CTL response activation, probably responsible for maintaining SVR by subsequent complete HCV clearing. Moreover, SVR patients' serum is still able to induce HCV infection in na?ve chimpanzees, suggesting that the infection could be under the control of the immune system after a successful treatment, being transmissible in absence of this adaptive response. At least theoretically, treatmentinduced viral load decrease could allow an effective HCV-specific CTL response reestablishment. This effect has been recently described with anti-HCV interferonfree regimes, based on direct-acting antivirals. nevertheless, this is to some extent controversial with interferon-based therapies, due to the detrimental immunoregulatory α-interferon effect on T cells. Moreover, HCV-specific CTL response features during anti-HCV treatment could be a predictive factor of SVR that could have clinical implications in patient management. In this review, the recent knowledge about the role of HCV-specific CTL response in the development of SVR after anti-HCV treatment is discussed.

关键词： Hepatitis C virus Chronic hepatitis Hepatitis C vi

Mushroom Production as an Alternative for Rural Development in a Forested Mountainous Area

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Journal of Mountain Science 2014年第2期11卷 535-543页

作者： José *** José R.GOnZáLEZ-OLABARRIA juan MARTínEZ DE ARAGón Departament de Producció Vegetal i Ciència Forestal Universitat de Lleida-Agrotecnio Center (UdL-Agrotecnio).Av. Rovira Roure 191 E-25198 Lleida Spain Centre Tecnològic Forestal de Catalunya (CTFC-CEMFOR). Ctra. de St. Lloren? de Morunys km 2 E-25280 Solsona Spain

Wild mushrooms are recognized as important non-wood forest products in mountainous ecosystems, but their real potential for generating rural economies has not been fully evaluated due to the difficulties in obtaining reliable productivity data, minimizing their true potential as contributor to rural economies. Mushroom yield models based on large data series from Pinus forest ecosystems in the region of Catalonia(Spain), combined with data from the Spanish national Forest Inventory allow us to estimate the potential mushroom productivity by forest ecosystems. The results of 24,500 tons/yr of mushrooms of which 16,300 tons are classified as edible and 7,900 tons are commonly marketed demonstrate the importance of mushroom productions in Catalonian pine forests, mostly located in mountainous areas where the development of agricultural activities is limited. Economic mushroom value is estimated at 48 million € for the edible mushroom and 32 million € for those corresponding to marketable yields, confirming the potential of this non-wood forest product. These production results and corresponding economic values provide a basis for the incorporation of wild mushrooms as significant non-wood forest products in the development of forest policies in mountainous areas.

关键词： non-wood forest products Mushroom models national Forest Inventory Economic value Mushroom potential estimation