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环境科学前沿（中英文版） 2014年第2期3卷 75-83页

作者： Xiaohong yu mengsi Zhang Management and Economics Institute/Beijing Institute of Technology Beijing 100081 China

Prognostic tumor microenvironment gene and the relationship with immune infiltration characteristics in metastatic breast cancer

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BIOCELL 2022年第5期46卷 1215-1243页

作者： LU YANG yuN LIU BOKE ZHANG mengsi yu FEN HUANG YANG WEN JIANGZHENG ZENG YANDA LU CHANGCHENG YANG Department of Medical Oncology The First Affiliated Hospital of Hainan Medical UniversityHaikou570102China Clinical Laboratory Center The First Affiliated Hospital of Anhui University of Chinese MedicineHefei230031China Department of Clinical Laboratory The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi830054China

The aim of this study was to reveal genes associated with breast cancer metastasis,to investigate their intrinsic relationship with immune cell infiltration in the tumor microenvironment,and to screen for prognostic *** expression data of breast cancer patients and their metastases were downloaded from the GEO,TCGA database.R language package was used to screen for differentially expressed genes,enrichment analysis of genes,PPI network construction,and also to elucidate key genes for diagnostic and prognostic ***’s r correlation was used to analyze the correlation between key genes and infiltrating immune *** screened 25 hub genes,FN1,CLEC5A,ATP8B4,TLR7,LY86,PTGER3 and other genes were differentially expressed in cancer and paraneoplastic ***,patients with higher expression of CD1C,IL-18 breast cancer had a better prognosis in the 10 years survival period,while patients with high expression of FN1,EIF4EBP1 tumors had a worse *** addition,TP53 and HIF1 genes are closely related to the signaling pathway of breast cancer *** this study,gene expression of ATP8B4 and CD1C were correlated with cancer tissue infiltration of CD8^(+)T lymphocytes,while GSE43816,GSE62327 and TCGA databases showed that CD8^(+)T lymphocytes were closely associated with breast cancer *** enrichment analysis of genes based on expression differences yielded key genes of prognostic value in the breast cancer microenvironment.

关键词： Tumor microenvironment Immune infiltration Prognostic biomarker Metastatic breast cancer

蒸汽发生器倒U型管单相倒流特性RELAP5建模方法研究

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核动力工程 2017年第5期38卷 28-33页

作者：沈梦思于雷郝建立胡高杰海军工程大学武汉430033

利用RALAP5/MOD3.2程序对蒸汽发生器(SG)倒U型管单相倒流实验进行建模计算。计算结果表明,已有的按管长对倒U型管进行分类建模会使得RELAP5计算的4根Ⅰ类倒U型管发生倒流,过大的估计了倒流流量。在此基础上,将未倒流管用集总参数法处理... 详细信息

利用RALAP5/MOD3.2程序对蒸汽发生器(SG)倒U型管单相倒流实验进行建模计算。计算结果表明,已有的按管长对倒U型管进行分类建模会使得RELAP5计算的4根Ⅰ类倒U型管发生倒流,过大的估计了倒流流量。在此基础上,将未倒流管用集总参数法处理,倒流管进行进一步的划分,建立了改进的U型管模型。通过分析比较,新建的模型能比较准确地计算倒流流量。

关键词：蒸汽发生器(SG) 倒流 RALAP5/MOD3.2

血清脂肪酸结合蛋白1、正五聚蛋白3水平与2型糖尿病合并非酒精性脂肪性肝病的关系

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国际检验医学杂志 2021年第24期42卷 3009-3013,3017页

作者：王丽娟关晓燕余梦思秦文沛李蕾新疆医科大学第一附属医院医学检验中心新疆乌鲁木齐830000 新疆医科大学第一附属医院内分泌科新疆乌鲁木齐830000

目的探讨血清脂肪酸结合蛋白1(FABP1)、正五聚蛋白3(PTX3)水平与2型糖尿病(T2DM)合并非酒精性脂肪性肝病(NAFLD)的关系。方法选择79例T2DM合并NAFLD患者(NAFLD组),53例T2DM未合并NAFLD患者(无NAFLD组),61例门诊体检健康志愿者(对照组)... 详细信息

目的探讨血清脂肪酸结合蛋白1(FABP1)、正五聚蛋白3(PTX3)水平与2型糖尿病(T2DM)合并非酒精性脂肪性肝病(NAFLD)的关系。方法选择79例T2DM合并NAFLD患者(NAFLD组),53例T2DM未合并NAFLD患者(无NAFLD组),61例门诊体检健康志愿者(对照组)进行研究。所有受试者均检测血清FABP1、PTX3、糖脂代谢、胰岛素抵抗和肝酶指标水平,并收集临床资料。采用Pearson相关分析血清FABP1、PTX3与糖脂代谢、胰岛素抵抗、肝酶指标的相关性,Logistic回归分析FABP1、PTX3与T2DM合并NAFLD的关系,采用受试者工作特征(ROC)曲线分析血清FABP1、PTX3诊断T2DM合并NAFLD的价值。结果NAFLD组血清FABP1、PTX3水平高于无NAFLD组和对照组,差异有统计学意义(P<0.05)。FABP1、PTX3水平与体质量指数(BMI)、总胆固醇(TC)、胰岛素抵抗指数(HOMA-IR)、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)均呈正相关(P<0.05)。Logistic回归分析显示,高脂血症、高BMI、HOMA-IR及高FABP1、PTX3水平是T2DM合并NAFLD的独立危险因素(P<0.05)。ROC曲线分析显示,FABP1、PTX3诊断T2DM合并NAFLD的AUC(95%CI)分别为0.693(0.598~0.789)、0.700(0.607~0.793)。联合检测AUC(95%CI)为0.894(0.828~0.959),联合检测的AUC明显高于各指标单独检测。结论T2DM合并NAFLD患者血清FABP1、PTX3水平均升高,高水平FABP1、PTX3与T2DM合并NAFLD的发生关系密切,可作为T2DM患者发生NAFLD的潜在诊断指标。

关键词：脂肪酸结合蛋白1 正五聚蛋白3 2型糖尿病非酒精性脂肪性肝病糖脂代谢胰岛素抵抗肝酶

Apoptosis-enhanced ferroptosis therapy of pancreatic carcinoma through PAMAM dendrimer-iron(Ⅲ)complex-based plasmid delivery

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Science China Chemistry 2022年第4期65卷 778-788页

作者： Wenjing Ma yue Gao Zhijun Ouyang yu Fan Hongwei yu mengsi Zhan Han Wang Xiangyang Shi Mingwu Shen State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative MedicineCollege of ChemistryChemical Engineering and BiotechnologyDonghua UniversityShanghai 201620China Department of Radiology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China

The development of promising strategies to improve the treatment efficacy of pancreatic carcinoma still remains to be a challenging *** report here the development of a new dendrimer-based nanomedicine formulation to tackle pancreatic carcinoma through apoptosis-enhanced ferroptosis *** this article,G5 dendrimers were partially modified with a Fe(Ⅲ)chelator hydroxyquinoline-2-carboxylic acid(8-HQC)on their periphery,entrapped with gold nanoparticles(Au NPs)within their internal cavities,and chelated with Fe(Ⅲ).The thus created dendrimer-entrapped Au NPs(Fe-Au DENP-HQC)with an Au core size of 1.9 nm and 20.0 Fe(Ⅲ)ions complexed per dendrimer are stable,have a pH-dependent Fe(Ⅲ)release profile,and can generate reactive oxygen species under the tumor microenvironment(TME)and effectively compact plasmid DNA encoding p53 protein to form polyplexes with a hydrodynamic size of 143.9 nm and a surface potential of 33.6 *** show that cancer cells treated with the created Fe-Au DENP-HQC/p53 polyplexes can be more significantly inhibited through vector-mediated chemodynamic therapy(CDT)effect via Fe(Ⅲ)-induced Fenton reaction and the p53 gene delivery-boosted cell apoptosis and oxidative stress in the TME than single-mode CDT and gene *** investigations using a xenografted tumor model validated the effectiveness of apoptosis-enhanced ferropotosis therapy through the downregulation of GPX-4 and SLC7A11proteins,upregulation of p53 and PTEN proteins,as well as histological ***,the dendrimer nanoplatform enabled tumor fluorescence imaging through gene delivery-mediated enhanced green fluorescent protein *** Fe(Ⅲ)-complexed dendrimer vector system may be developed as a promising theranostic nanoplatform for ferroptosis or ferroptosis-based combination therapy of other cancer types.

关键词： dendrimers ferroptosis gene delivery pancreatic carcinoma fluorescence imaging

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Decomposition of factors influencing carbon emissions in the region of Beijing-Tianjin-Hebei,based on the perspective of terminal energy consumption

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Chinese Journal of Population,Resources and Environment 2014年第4期12卷 338-344页

作者： Xiaohong yu mengsi Zhang School of Management and Economics Beijing Institute of Technology

In order to analyze the factors influencing carbon emissions in the region of Beijing-Tianjin-Hebei and to explore the pathways to developing a low-carbon economy,this paper begins with the terminal energy consumption of three industries and residential consumption,and constructs an identical equation which is composed of population size,level of economic development,energy intensity,the proportion of energy consumption,energy structure,and the coefficient of carbon *** on the data of terminal energy consumption during 2000-2012,various factors are analyzed and their contribution is measured by Logarithmic Mean Divisia Index(LMDI).The results show that the levels of population and economy have a positive driving effect while energy intensity,energy structure,and carbon intensity have a negative driving effect;the proportion of energy consumption had a negative driving effect prior to 2006,then changed to *** suggestions for a low-carbon economy are controlling population size,improving the quality of economic development,supporting research into new energy technology,accelerating regional integration and optimizing industrial structure,and enhancing environmental protection and spreading the concept of a low-carbon economy.

关键词： carbon emission LMDI the region of Beijing-Tianjin-Hebei low-carbon economy

Brain delivery of fibronectin through bioactive phosphorous dendrimers for Parkinson’s disease treatment via cooperative modulation of microglia

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Bioactive Materials 2024年第8期38卷 45-54页

作者： Waicong Dai mengsi Zhan yue Gao Huxiao Sun yu Zou Regis Laurent Serge Mignani Jean-Pierre Majoral Mingwu Shen Xiangyang Shi State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative MedicineCollege of Biological Science and Medical EngineeringDonghua UniversityShanghai201620PR China Laboratoire de Chimie de Coordination du CNRS 205 Route de NarbonneCEDEX 431077ToulouseFrance Universit´e Toulouse 118 Route de NarbonneCEDEX 431077ToulouseFrance CQM-Centro de Química da Madeira Universidade da MadeiraCampus Universit´ario da Penteada9020-105FunchalPortugal

Effective treatment of Parkinson’s disease(PD),a prevalent central neurodegenerative disorder particularly affecting the elderly population,still remains a huge *** present here a novel nanomedicine formulation based on bioactive hydroxyl-terminated phosphorous dendrimers(termed as AK123)complexed with fibronectin(FN)with anti-inflammatory and antioxidative *** created optimized AK123/FN nanocomplexes(NCs)with a size of 223 nm display good colloidal stability in aqueous solution and can be specifically taken up by microglia through FN-mediated *** show that the AK123/FN NCs are able to consume excessive reactive oxygen species,promote microglia M2 polarization and inhibit the nuclear factor-kappa B signaling pathway to downregulate inflammatory *** the abundant dendrimer surface hydroxyl terminal groups,the developed NCs are able to cross blood-brain barrier(BBB)to exert targeted therapy of a PD mouse model through the AK123-mediated anti-inflammation for M2 polarization of microglia and FN-mediated antioxidant and anti-inflammatory effects,thus reducing the aggregation ofα-synuclein and restoring the contents of dopamine and tyrosine hydroxylase to normal levels in *** developed dendrimer/FN NCs combine the advantages of BBB-crossing hydroxyl-terminated bioactive per se phosphorus dendrimers and FN,which is expected to be extended for the treatment of different neurodegenerative diseases.

关键词： Phosphorous dendrimers Fibronectin Parkinson’s disease Blood brain barrier Combination therapy

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一体化反应堆扰动条件下自然循环特性研究

核动力工程 2018年第4期39卷 53-57页

作者：孔松于雷郝建立袁添鸿沈梦思海军工程大学核能科学与工程系武汉430033

基于多冷却支路组成的一体化反应堆,推导了多支路自然循环流量的理论解;采用拟合逼近方法得到扰动系数(m),分析了自然循环系统的扰动特性;并以某型一体化反应堆为对象进行验证。结果表明:对于多个冷却支路组成的对称环路系统,当某个支... 详细信息

基于多冷却支路组成的一体化反应堆,推导了多支路自然循环流量的理论解;采用拟合逼近方法得到扰动系数(m),分析了自然循环系统的扰动特性;并以某型一体化反应堆为对象进行验证。结果表明:对于多个冷却支路组成的对称环路系统,当某个支路因排热能力变化发生扰动时,环路流量变化(扰动后稳态值/初值)与系统雷诺数(Re)及上升段与下降段阻力特性比值(Rr)有关;m与Re及Rr有关,并随Rr的减小而增大,且在扰动发生时,m越大,自然循环流量受到的影响越小,即m可以表征自然循环系统的抗扰动能力。

关键词：自然循环一体化反应堆多冷却支路扰动分析

馥郁香型基酒陈酿过程中理化指标及挥发性成分变化分析

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食品与机械 2024年第5期40卷 29-36页

作者：陆梦思余佶余冰梁超宇姚茂君吉首大学化学化工学院湖南吉首416000 湘西自治州馥郁香型白酒酿造与品质控制重点实验室湖南吉首416000 酒鬼酒股份有限公司湖南吉首416000

目的:优化馥郁香型基酒陈酿技术,提升基酒品质。方法:通过检测分析新酒和陈酿1,3,5,8,10年的馥郁香型基酒的pH、电导率、黏度和总酸总酯等理化指标,利用GC和GC-MS对6个酒样的主要挥发性风味成分进行定性分析,并采用外标法对其中的26种... 详细信息

目的:优化馥郁香型基酒陈酿技术,提升基酒品质。方法:通过检测分析新酒和陈酿1,3,5,8,10年的馥郁香型基酒的pH、电导率、黏度和总酸总酯等理化指标,利用GC和GC-MS对6个酒样的主要挥发性风味成分进行定性分析,并采用外标法对其中的26种挥发性风味成分进行定量分析。结果:随着陈酿时间的增加,电导率升高、黏度升高、总酸含量升高、总酯含量降低;在6个馥郁香型基酒中定量26种挥发性风味成分,其中酯类8种,醇类8种,酸类5种,醛酮类5种,酯类物质含量先上升后下降,醇类物质含量呈缓慢下降趋势,酸类和醛类物质含量增加;主成分分析和偏最小二乘判别分析均能较好地区分不同陈酿时间馥郁香型基酒。结论:适当的陈酿时间可以提升基酒的品质。

关键词：馥郁香型白酒基酒陈酿理化指标风味成分

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社区骨关节炎管理现状和策略的系统综述

中国全科医学 2022年第25期25卷 3157-3164页

作者：刘茜张含之邱梦思于德华同济大学附属杨浦医院全科医学科上海市200090 同济大学医学院全科医学系上海市200092 上海市全科医学与社区卫生发展研究中心 200090 上海市全科医学临床质量控制中心 200090

背景骨关节炎是中老年人常见的慢性病,严重影响中老年人的生活质量。在社区开展骨关节炎的疾病管理有利于资源配置的优化和提高疾病的整体防治水平,但目前骨关节炎的管理存在诸多问题,效果不佳。目的分析目前国内外社区骨关节炎的管理... 详细信息

背景骨关节炎是中老年人常见的慢性病,严重影响中老年人的生活质量。在社区开展骨关节炎的疾病管理有利于资源配置的优化和提高疾病的整体防治水平,但目前骨关节炎的管理存在诸多问题,效果不佳。目的分析目前国内外社区骨关节炎的管理情况和策略进展,比较其优缺点,为我国社区骨关节炎管理提供更为优化的策略,以改善骨关节炎患者的诊疗效果和预后。方法于2020年10月至2021年1月,在中国知网、万方数据知识服务平台、维普网数据库主题检索“骨关节炎”与“管理”、“骨关节炎”与“模式”、“骨关节炎”与“策略”,在Pubmed、Web of Science、Cochrane Library数据库主题检索("Osteoarthritis")AND("Management"OR"Mode"OR"Strategy")获得发表时间为2010-01-01至2020-01-01的文献。剔除重复及涉及骨关节炎自我管理的文献,对入选涉及社区骨关节炎管理的文献进行系统分析。结果检索到文献2695篇,删除2642篇,入选53篇涉及社区骨关节炎管理的文献。其中5篇文献涉及社区骨关节炎管理现况调查,均提及目前国内外对骨关节炎的管理缺乏协调性和目的性,同时治疗的重点是缓解症状、延缓软骨退化、减少畸形的发生,但疗效不能令人满意,且症状常反复发作;而且我国骨关节炎管理多停留在健康教育层面,管理模式单一。6篇文献内容涉及社区骨关节炎管理影响因素,结果提示目前患者及其家属对骨关节炎的认知不足,基层医院部分医生对骨关节炎认识不足、重视程度不够,医疗资源配置不协调,多种因素导致社区骨关节炎管理缺乏协调性和目的性。3篇文献内容涉及社区骨关节炎管理的意义,主要强调通过社区骨关节炎管理减轻患者疼痛、延缓疾病进展,从而改善患者生活质量、提高患者和医疗保健专业人员的满意度、优化医疗保健资源的使用。39篇文献内容涉及社区骨关节炎管理策略,其中22篇涉及系统性管理策略,包括社区骨关节炎多学科或综合管理模式(18篇)、社区骨关节炎分级管理(4篇),整体来说社区骨关节炎管理策略借鉴了我国社区管理糖尿病及高血压的成功经验,但策略大多处于建设阶段,在实践中的应用尚需进一步研究;其余17篇涉及各种非系统性社区骨关节炎管理策略,其中8篇是以健康教育为主要方式的管理模式,3篇管理模式涉及网络模式,各有2篇涉及远程电话管理、非药物管理、书面信息指南。结论社区骨关节炎的管理策略中存在诸多问题,包括管治不协调、方法不健全、制度不完善。未来对骨关节炎患者进行管理可借鉴的策略包括:社区多学科或综合管理、分级管理等系统性的管理策略;充分利用医疗服务技术和工具,如电子医疗、网络远程管理、健康手册等;优化资源配置,如将骨关节炎健康管理纳入国家基本公共卫生服务项目,加大政府对骨关节炎管理的政策扶持。

关键词：骨关节炎社区卫生服务疾病管理信息技术系统综述