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The association analysis polymorphism of CDKAL1 and diabetic retinopathy in Chinese Han population

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International Journal of Ophthalmology(English edition) 2016年第5期9卷 707-712页

作者： Nai-Jia Liu Qian Xiong hui-hui Wu Yan-Liang Li Zhen Yang Xiao-ming Tao Yan-Ping Du Bin Lu ren-ming hu Xuan-Chun Wang jie Wen Department of Endocrinology and Metabolism Huashan Hospital Affiliated to Fudan University Department of Endocrinology and Metabolism Jing'an District Center Hospital of Shanghai Department of Endocrinology and Metabolism Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Department of Endocrinology and Metabolism Hua Dong Hospital Affiliated to Fudan University

AIM： To identify the contribution of CDKAL1 to the development of diabetic retinopathy（DR） in Chinese population.·METHODS： A case-control study was performed to investigate the genetic association between DR and polymorphic variants of CDKAL1 in Chinese Han population with type 2 diabetes mellitus（T2DM）. A welldefined population with T2 DM, consisting of 475 controls and 105 DR patients, was recruited. All subjects were genotyped for the genetic variant（rs10946398） of CDKAL1. Genotyping was performed by i PLEX technology. The association between rs10946398 and T2 DM was assessed by univariate and multivariate logistic regression（MLR） analysis.· RESULTS： There were significant differences in C allele frequencies of rs10946398（CDKAL1） between control and DR groups（45.06% versus 55.00%, P 〈0.05）.The rs10946398 of CDKAL1 was found to be associated with the increased risk of DR among patients with diabetes.·CONCLUSION： Our findings suggest that rs10946398 of CDKAL1 is independently associated with DR in a Chinese Han population.

关键词： CDKAL1 polymorphism association analysis diabetic retinopathy Chinese Han population

Liposuction of the zygomatic arch area facilitates correction of temporal depression

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Chinese Medical Journal 2020年第14期133卷 1757-1758页

作者： Chun-hu Wang Zi-Rong Li xin Li jie Li meng Wang Xue-Bing Liang Xiao-Ning Yang Ke-ming Wang Ji-guang Ma Fa-Cheng Li 17th Department of Plastic Surgery Plastic Surgery HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100041China Department of Plastic Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China 18th Department of Plastic Surgery Plastic Surgery HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100041China

To the Editor:Temporal depression is characterized by height difference between temporal concavity and lateral projection of the zygomatic *** aim of correction of temporal depression is to decrease the height difference between the concavity and lateral *** this study,we investigated whether decreasing the projection of the zygomatic arch by liposuction would benefit for correction of temporal depression.

关键词： correction cavity projection

Epidemiological features and temporal trends of the co-infection between HIV and tuberculosis, 1990-2021: findings from the Global Burden of Disease Study 2021

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Infectious Diseases of Poverty 2024年第4期13卷 79-94页

作者： Shun-Xian Zhang Ji-Chun Wang Jian Yang Shan Lv Lei Duan Yan Lu Li-guang Tian Mu-xin Chen Qin Liu Fan-Na Wei xin-Yu Feng Guo-Bing Yang Yong-Jun Li Yu Wang Xiao-jie hu ming Yang Zhen-hui Lu Shao-Yan Zhang Shi-Zhu Li Jin-xin Zheng Longhua Hospital Shanghai University of Traditional Chinese MedicineShanghai 200032China National Institute of Parasitic Diseases at Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research) NHC Key Laboratory of Parasite and Vector BiologyWHO Collaborating Centre for Tropical DiseasesNational Center for International Research on Tropical DiseasesNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious DiseasesShanghai 200025China Department of Science and Technology Chinese Center for Disease Control and PreventionNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious DiseasesBeIjing 102206China School of Global health Chinese Center for Tropical Diseases Research-Shanghai Jiao Tong University School of MedicineShanghai 200025China Gansu Provincial Center for Disease Control and Prevention Lanzhou 730000China

Background The co-infection of human immunodeficiency virus(HIV)/acquired immune deficiency syndrome(AIDS)and tuberculosis(TB)poses a significant clinical challenge and is a major global public health *** study aims to elucidate the disease burden of HIV-TB co-infection in global,regions and countries,providing critical informa-tion for policy decisions to curb the HIV-TB *** The ecological time-series study used data from the Global Burden of Disease(GBD)Study *** data encompass the numbers of incidence,prevalence,mortality,and disability-adjusted life year(DALY),as well as age-standardized incidence rate(ASIR),prevalence rate(ASPR),mortality rate(ASMR),and DALY rate for HIV-infected drug-susceptible tuberculosis(HIV-DS-TB),HIV-infected multidrug-resistant tuberculosis(HIV-MDR-TB),and HIV-infected extensively drug-resistant tuberculosis(HIV-XDR-TB)from 1990 to *** 1990 to *** estimated annual percentage change(EAPC)of rates,with 95%confidence intervals(C/s),was *** In 2021,the global ASIR for HIV-DS-TB was 11.59 per 100,000 population(95%UI:0.37-13.05 per 100,000 population),0.55 per 100,000 population(95%UI:0.38-0.81 per 100,000 population),for HIV-MDR-TB,and 0.02 per 100,000 population(95%UI:0.01-0.03 per 100,000 population)for *** EAPC for the ASIR of HIV-MDR-TB and HIV-XDR-TB from 1990 to 2021 were 4.71(95%CI:1.92-7.59)and 13.63(95%CI:9.44-18.01),*** global ASMR for HIV-DS-TB was 2.22 per 100,000 population(95%UI:1.73-2.74 per 100,000 population),0.21 per 100,000 population(95%UI:0.09-0.39 per 100,000 population)for HIV-MDR-TB,and 0.01 per 100,000 population(95%UI:0.00-0.03 per 100,000 population)for HIV-XDR-TB in *** EAPC for the ASMR of HIV-MDR-TB and HIV-XDR-TB from 1990 to 2021 were 4.78(95%CI:1.32-8.32)and 10.00(95%Cl:6.09-14.05),*** The findings indicate that enhancing diagnostic and treatment strategies,strengthening healthcare infrastructure,increasing a

关键词： Co-infection Tuberculosis HIV/AIDS Epidemiology Global burden of disease 2021

The wide-field photometric system of the Nanshan One-meter Telescope

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Research in Astronomy and Astrophysics 2020年第12期20卷 373-382页

作者： Chun-Hai Bai Guo-jie Feng Xuan Zhang hu-Biao Niu Abdusamatjan Eskandar guang-xin Pu Shu-Guo Ma Jin-Zhong Liu Xiao-Jun Jiang Lu Ma Ali Esamdin Na Wang xinjiang Astronomical Observatories Chinese Academy of SciencesUrumqi 830011China Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China

The Nanshan One-meter Wide-field Telescope is a prime focus system that is located at Nanshan Station of xinjiang Astronomical *** field of view was designed to 1.5°× 1.5°,and the Johnson-Cousins UBVRI system was chosen as the main filter *** telescope has been providing observation services for astronomers since September *** source searching and time-domain surveys are the main scientific *** system’s test results are reported including linearity,dark current,bias,readout noise and gain of the CCD *** accurate instrumental calibration coefficients in UBVRI bands were driven with Landolt standard stars during photometric ***,the limiting magnitudes are given with signal-to-noise ratios and various exposure times for observers.

关键词： telescope filter CCD photometry

New experimental measurement of^(nat)Se(n,γ)cross section between 1 eV to 1 keV at the CSNS Back-n facility

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Chinese Physics B 2022年第8期31卷 117-124页

作者： xin-Rong hu Long-Xiang Liu Wei Jiang jie ren Gong-Tao Fan Hong-Wei Wang Xi-guang Cao Long-Long Song Ying-Du Liu Yue Zhang xin-Xiang Li Zi-Rui Hao Pan Kuang Xiao-he Wang Ji-Feng hu Bing Jiang De-xin Wang Suyalatu Zhang Zhen-Dong An Yu-Ting Wang Chun-Wang Ma Jian-Jun he Jun Su Li-Yong Zhang Yu-Xuan Yang Sheng Jin Kai-jie Chen Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Spallation Neutron Source Science Center Dongguan 523803China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China Xiangtan University Xiangtan 411105China Institute of Nuclear Physics Inner Mongolia University for the NationalitiesTongliao 028000China Sun Yat-sen University Zhuhai 510275China henan Normal University Xinxiang 453007China Beijing Normal University Beijing 100875China School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450052China ShanghaiTech University Shanghai 200120China

The^(74)Se is one of 35 p-nuclei,and^(82)Se is a r-process only nucleus,and their(n,γ)cross sections are vital input parameters for nuclear astrophysics reaction network *** neutron capture cross section in the resonance range of isotopes and even natural selenium samples has not been ***γ-rays originating from neutron-induced capture events were detected by four C_(6)D_(6) liquid scintillator detectors at the Back-n facility of China Spallation Neutron Source(CSNS).The pulse height weighting technique(PHWT)was used to analyze the data in the 1 e V to 100 ke V *** deduced neutron capture cross section was compared with ENDF/B-VIII.0,JEFF-3.2,and JENDL-4.0,and some differences were *** parameters were extracted by the R-matrix code SAMMY in the 1 e V-1 ke V *** the cross sections ofnatSe and resonance parameters are given in the *** datasets are openly available at http://***/10.11922/sciencedb.j00113.00019.

关键词： ^(nat)Se(n γ)cross section CSNS Back-n facility C_6D_6 detectors resolved resonance region Rmatrix

Simulation and test of the SLEGS TOF spectrometer at SSRF

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Nuclear Science and Techniques 2023年第3期34卷 171-184页

作者： Kai-jie Chen Long-Xiang Liu Zi-Rui Hao Yu-Gang Ma Hong-Wei Wang Gong-Tao Fan Xi-guang Cao Hang-hua Xu Yi-Fei Niu xin-Xiang Li xin-Rong hu Yu-Xuan Yang Sheng Jin Pan Kuang School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China University of Chinese Academy of Science Beijing 100080China Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China School of Nuclear Science and Technology University of South ChinaHengyang 421001China School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450052China

The Shanghai laser electron gamma source(SLEGS)is a powerful tool for exploring photonuclear physics,such as giant dipole resonance(GDR)and pygmy dipole resonance,which are the main mechanisms of collective nuclear *** goal of the SLEGS neutron time-of-flight(TOF)spectrometer is to measure GDR and specific nuclear structures in the energy region above the neutron *** SLEGS TOF spectrometer was designed to hold 20 sets of EJ301 and LaBr3 ***4 was used to simulate the efficiency of each detector and the entire spectrometer,which provides a reference for the selection of detectors and layout of the SLEGS TOF *** the events of 208Pb,implementations of coincidence and time-of-flight technology for complex experiments are available;thus,and neutron decay events can be *** performance of SLEGS TOF spectrometer was systematically evaluated using offline experiments,in which the time resolution reached approximately 0.9 ns.

关键词： SLEGS Time-of-flight Photoneutron nuclear reaction

A novel pillar[5]arene-cucurbit[10]uril based host-guest complex: Synthesis, characterization and detection of paraquat

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Chinese Chemical Letters 2023年第3期34卷 134-137页

作者： Yang Luo Wei Zhang jie Zhao Mao-Xia Yang Qian ren Carl Redshaw Zhu Tao xin Xiao Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province Institute of Applied ChemistryGuizhou UniversityGuiyang 550025China Department of Chemistry University of HullHull HU67RXUnited Kingdom

The macrocyclic family comprising pillar[n]arenes and cucurbit[n]urils have received much attention recently. However, studies on the construction of supramolecular complexes formed directly with derivatized pillar[n]arenes and cucurbit[n]urils are scant. Given the interest in such systems, herein we have synthesized a new type of naphthalene-derivatized pillar[n]arene NTP5 and selected Q[10] as the host molecule. The 4-[2-(1-naphthalenyl)ethenyl]pyridine of NTP5 is encapsulated by Q[10] and formed a hostguest complex in water-acetic acid(1:1) solution accompanied by enhanced fluorescence, which changed the morphology of NTP5 from a sphere to a porous form. In addition, the fluorescence of Q[10]-NTP5 can be quenched by the addition of the highly toxic pesticide paraquat(PQ), and the mechanism was shown to be the formation of a new charge transfer ternary system of Q[10]-NTP5-PQ. This work provides new ideas for the contribution of supramolecular assemblies based on derivatized pillar[n]arenes and their combination with cucurbit[n]urils and reveals their potential applications.

关键词： Pillar[n]arene Cucurbit[n]uril Paraquat Supramolecular assembly Detection

Comparison of acute pneumonia caused by SARS-CoV-2 and other respiratory viruses in children:a retrospective multi-center cohort study during COVID-19 outbreak

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Military Medical Research 2021年第4期8卷 468-480页

作者： guang-Li ren Xian-Feng Wang Jun Xu Jun Li Qiong meng Guo-Qiang Xie Bo huang Wei-Chun Zhu Jing Lin Cheng-he Tang Sheng Ye Zhuo Li jie Zhu Zhen Tang ming-xin Ma Cong Xie Ying-Wen Wu Chen-Xi Liu Fang Yang Yu-Zong Zhou Ying Zheng Shu-Ling Lan Jian-Feng Chen Feng Ye Yu he BenQing Wu Long Chen Si-Mao Fu Cheng-Zhong Zheng Yuan Shi Department of Pediatrics General Hospital of Southern Theater Command of PLA111 Liuhua RoadYuexiu DistrictGuangzhou 510010GuangdongChina. Department of Pediatrics the Third People’s Hospital of ShenzhenShenzhen 518100GuangdongChina. Pediatric Intensive Care Unit Wuhan Children’s HospitalTongji Medical CollegeHuazhong University of Science&TechnologyWuhan 430010China. Pediatric Intensive Care Unit Maternal and Child Health Hospital of HuangshiHuangshi 435000HubeiChina. Department of Pediatrics the Second People’s Hospital of Guangdong ProvinceGuangzhou 510317China. Department of Pediatrics the Third Affiliated Hospital of Zunyi Medical University(the First People’s Hospital of Zunyi)Guizhou 563000China. Department of Pediatrics the Eighth People’s Hospital of GuangzhouGuangzhou 510440China. Department of Pediatrics the First Affiliated Hospital of Xinxiang Medical UniversityXinxiang 453100HenanChina. Pediatric Intensive Care Unit the Children’s Hospital Zhejiang University School of MedicineHangzhou 310000China. Department of Emergency/Critical Medicine Children’s Hospital of Nanjing Medical UniversityNanjing 210008China. Department of Pediatrics the Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510260China. Department of Medical information date room General Hospital of Southern Theater Command of PLAGuangzhou 510010China. Department of Pediatrics the First Affiliated Hospital of Jinan UniversityGuangzhou 510632China. Department of Pediatrics Maternal and Child Health Hospital of YangjiangYangjiang 529500GuangdongChina. Department of Pediatrics Shenzhen Hospital Affiliated to the University of Chinese Academy of SciencesShenzhen 518107GuangdongChina. Department of Pediatrics Nanfang Hospital of Southern Medical UniversityGuangzhou 510515China. Department of Pediatrics Zhujiang Hospital of Southern Medical UniversityGuangzhou 510280China. Department of Pediatrics Military Hospital of 74 Group of PLAGuangzhou 510318China. Department of Neonatology

Background:Until January 18,2021,coronavirus disease-2019(COVID-19)has infected more than 93 million individuals and has caused a certain degree of *** pneumonia caused by common viruses such as respiratory syncytial virus,rhinovirus,human metapneumovirus,human bocavirus,and parainfluenza viruses have been more common in ***,the incidence of COVID-19 in children was significantly lower than that in *** purpose of this study was to describe the clinical manifestations,treatment and outcomes of COVID-19 in children compared with those of other sources of viral pneumonia diagnosed during the COVID-19 ***:Children with COVID-19 and viral pneumonia admitted to 20 hospitals were enrolled in this retrospective multi-center cohort study.A total of 64 children with COVID-19 were defined as the COVID-19 cohort,of which 40 children who developed pneumonia were defined as the COVID-19 pneumonia *** 284 children with pneumonia caused by other viruses were defined as the viral pneumonia *** epidemiologic,clinical,and laboratory findings were compared by Kolmogorov-Smirnov test,t-test,Mann-Whitney U test and Contingency table *** usage,immunotherapy,blood transfusion,and need for oxygen support were collected as the treatment ***,intensive care needs and symptomatic duration were collected as the outcome ***:Compared with the viral pneumonia cohort,children in the COVID-19 cohort were mostly exposed to family members confirmed to have COVID-19(53/64 vs.23/284),were of older median age(6.3 years vs.3.2 years),and had a higher proportion of ground-glass opacity(GGO)on computed tomography(18/40 vs.0/38,Pren in the COVID-19 pneumonia cohort had a lower proportion of severe cases(1/40 vs.38/284,P=0.048),and lower cases with high fever(3/40 vs.167/284,Phe propor

关键词： Children Severe acute respiratory syndrome Coronavirus disease-2019 Viral pneumonia

Single-nucleus transcriptomic landscape of primate hippocampal aging

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Protein & Cell 2021年第9期12卷 695-716页

作者： hui Zhang Jiaming Li jie ren Shuhui Sun Shuai Ma Weiqi Zhang Yang Yu Yusheng Cai Kaowen Yan Wei Li Baoyang hu Piu Chan Guo-guang Zhao Juan Carlos Izpisua Belmonte Qi Zhou Jing Qu Si Wang guang-hui Liu State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Advanced Innovation Center for human Brain Protection National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China China National Center for Bioinformation Beijing 100101China Aging Translational Medicine Center Xuanwu HospitalCapital Medical UniversityBeijing 100053China Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijing 100053China Sino Danish CollegeUniversity of Chinese Academy of SciencesBeijing 101408China Sino Danish Center for Education and ResearchBeijing 101408China Department of Obstetrics and Gynecology Center for Reproductive MedicinePeking University Third HospitalBeijing 100191China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China Stem Cell Research Center Peking University Third HospitalBeijing 100191China Gene Expression Laboratory Salk Institute for Biological StudiesLa JollaCAUSA

The hippocampus plays a crucial role in learning and memory,and its progressive deterioration with age is functionally linked to a variety of human neurodegenerative *** a systematic profiling of the aging effects on various hippocampal cell types in primates is still ***,we reported a variety of new aging-associated phenotypic changes of the primate *** include,in particular,increased DNA damage and heterochromatin erosion with time,alongside loss of proteostasis and elevated *** understand their cellular and molecular causes,we established the first single-nucleus transcriptomic atlas of primate hippocampal *** the 12 identified cell types,neural transiently amplifying progenitor cell(TAPC)and microglia were most affected by ***-depth dissection of gene-expression dynamics revealed impaired TAPC division and compromised neuronal function along the neurogenesis trajectory;additionally elevated pro-inflammatory responses in the aged microglia and oligodendrocyte,as well as dysregulated coagulation pathways in the aged endothelial cells may contribute to a hostile microenvironment for *** rich resource for understanding primate hippocampal aging may provide potential diagnostic biomarkers and therapeutic interventions against age-related neurodegenerative diseases.

关键词： aging hippocampus primate single-cell RNA sequencing