检索结果-南通市图书馆

luteolin alleviates sorafenib-induced ferroptosis of BRL-3A cells through modulation of the Nrf2/GPX4 signaling pathway

在线全文

学校读者我要写书评

暂无评论

Traditional Medicine Research 2024年第10期9卷 1-9页

作者： Bo-Wen Zhang Di Yang Jin-Tao Li mei-Hao Peng Jia-Qing Liao Qi Zhao Yi-Xi Yang Qiu-Xia lu Engineering Research Center of Sichuan-Tibet Traditional Medicinal Plant Chengdu UniversityChengdu 610106China School of Food and Biological Engineering Chengdu UniversityChengdu 610106China School of Pharmacy Chengdu UniversityChengdu 610106China

Background:luteolin is a flavonoid chemical that exists in a variety of medicinal and edible plants and holds many biologically active properties in liver protection,anti-cancer,antioxidants,anti-inflammatory,neuroprotective,*** to its hepatoprotective properties,luteolin was selected to co-treat with sorafenib,one of the approved protein kinase inhibitors,to reduce sorafenib-induced normal liver cell ***:The BRL-3A cell line was treated with sorafenib to establish a liver injury model,followed by luteolin *** cell viability was detected,and the mechanism of action was detected by immunofluorescence,western blotting,and real-time quantitative ***:The research findings demonstrated that luteolin could increase cystine/glutamate transporter xCT(SLC7A11)and glutathione peroxidase 4(GPX4)expression and display a chelating effect on iron,which led to increased glutathione and decreased malondialdehyde,Fe^(2+) and lipid reactive oxygen species contents in BRL-3A cells,and the sorafenib-induced mitochondrial membrane potential decrease was also *** addition,when sorafenib caused the accumulation of lipid reactive oxygen species,luteolin could help release this oxidative stress by activating nuclear factor E2-related factor 2(Nrf2)and up-regulating the expression of the associated genes heme oxygenase 1(HO-1)and quinone oxidoreductase 1(NQO1).Conclusion:Therefore,luteolin may ameliorate sorafenib-induced ferroptosis by activating the Nrf2-associated pathway without any impact on sorafenib anti-cancer *** can be used as an adjuvant to sorafenib to reduce liver injury in patients with hepatocellular carcinoma.

关键词： luteolin sorafenib liver injury ferroptosis Nrf2/GPX4

Outcomes research:science and action

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第8期14卷 659-663页

作者： Henry H.ting mei-xiang XIANG jian-an WANG Division of Cardiovascular Diseases Knowledge and Evaluation Research UnitMayo ClinicRochesterMinnesota 55905USA Cardiovascular Key Lab of Zhejiang Province Department of Cardiologythe Second Affiliated HospitalSchool of MedicineZhejiang University

Outcomes research, which investigates the outcomes of health care practices, is intended to provide scientific evidence for clinical decision making and health care. This paper elucidates the goal and domains of outcomes research. Also it shows the potential and promise of outcomes research to provide a methodology to uncover what to do and how to do it, and enable the health care profession to achieve the right care, for the right patient, at the right time, the first time, every time, nothing more, and nothing less.

关键词：心脏疾病临床冠状动脉调查结果

正畸修复联合疗法对改善深覆[牙合]伴下前牙严重磨耗患者咀嚼功能的效果评价

在线全文

学校读者我要写书评

暂无评论

上海口腔医学 2024年第2期33卷 190-194页

作者：路茜王静庞淑婷周建营冯艳芬卢文娟张倩沧州市人民医院口腔内科河北沧州061000 沧州市人民医院口腔正畸科河北沧州061000 沧州市人民医院口腔修复科河北沧州061000

目的:观察正畸修复联合治疗对深覆[牙合]伴下前牙严重磨耗患者咀嚼功能的改善效果。方法:选择2018年1月—2022年1月接诊的164例深覆[牙合]伴下前牙严重磨耗患者,根据治疗方案不同分为2组,即对照组72例(单纯口腔修复治疗)和试验组92例(... 详细信息

目的:观察正畸修复联合治疗对深覆[牙合]伴下前牙严重磨耗患者咀嚼功能的改善效果。方法:选择2018年1月—2022年1月接诊的164例深覆[牙合]伴下前牙严重磨耗患者,根据治疗方案不同分为2组,即对照组72例(单纯口腔修复治疗)和试验组92例(正畸修复联合治疗)。评价2组咀嚼效能,计算颞下颌关节功能障碍指数(dysfunction index,DI)、肌肉压痛指数(palpation index,PI)与颞下颌关节紊乱指数(cranio-mandibular index,CMI)。评价面容美观满意度、中文版口腔健康影响程度量表(OHIP-14)评分和修复满意度评分,并比较2组不良事件发生情况。采用SPSS 23.0软件包对数据进行统计学分析。结果:治疗后,试验组咀嚼效能较对照组显著提高,DI、PI和CMI较对照组显著降低(P<0.05)。治疗后,试验组面容美观满意度和修复满意度显著高于对照组,OHIP-14评分显著低于对照组(P<0.05)。与对照组的不良事件(25.00%)相比,试验组(6.52%)降低显著(P<0.05)。结论:正畸修复联合治疗可提高深覆[牙合]伴下前牙严重磨耗患者的治疗效果,改善患者咀嚼功能及颞下颌关节平衡,提高患者满意度及生活质量,减少不良事件发生风险。

关键词：正畸修复深覆[牙合] 磨耗咀嚼功能

Incidence and prognosis of olfactory and gustatory dysfunctions related to SARS-CoV-2 Omicron strain infection in China:A national multicenter survey of 35,566 individuals

在线全文

学校读者我要写书评

暂无评论

World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 113-120页

作者： Meng-Fan Liu Rui-Xia Ma Xian-Bao Cao Hua Zhang Shui-Hong Zhou wei-Hong jiang Yan jiang Jing-Wu Sun Qin-Tai Yang Xue-Zhong Li Ya-Nan Sun Li shi Min Wang Xi-Cheng Song Fu-Quan Chen Xiao-Shu Zhang Hong-Quan wei Shao-Qing Yu Dong-Dong Zhu luo Ba Zhi-wei Cao Xu-Ping Xiao Xin wei Zhi-Hong Lin Feng-Hong Chen Chun-Guang Shan Guang-Ke Wang Jing Ye Shen-Hong Qu Chang-Qing Zhao Zhen-Lin Wang Hua-Bin Li Feng Liu Xiao-Bo Cui Sheng-Nan Ye Zheng Liu Yu Xu Xiao Cai wei Huang Ru-Xin Zhang Yu-Lin Zhao Guo-Dong Yu Guang-Gang shi mei-Ping lu Yang Shen Yu-Tong Zhao Jia-Hong Pei Shao-Bing Xie Long-Gang Yu Ye-Hai Liu Shao-wei Gu Yu-Cheng Yang Lei Cheng jian-Feng liu Graduate School of Beijing University of Chinese Medicine BeijingChina Department of Otorhinolaryngology Head and Neck Surgery China-Japan Friendship HospitalBeijingChina Department of Otorhinolaryngology Head and Neck Surgery The First People's Hospital of YinchuanYinchuanChina Department of Otorhinolaryngology The First People's Hospital of Yunnan ProvinceKunmingChina Department of Otorhinolaryngology The First Affiliated Hospital of Xinjiang Medical UniversityUrumqiChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Zhejiang University School of MedicineHangzhouChina Department of Otorhinolaryngology Head and Neck Surgery Xiangya Hospital Central South UniversityChangshaChina Department of Otorhinolaryngology Head and Neck Surgery The Affiliated Hospital of Qingdao UniversityQingdaoChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of USTCHefeiChina Department of Otorhinolaryngology Head and Neck Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Department of Otorhinolaryngology Head and Neck Surgery Qilu Hospital of Shandong UniversityJinanChina Department of Otorhinolaryngology Head and Neck Surgery The Second Affiliated Hospital of Harbin Medical UniversityHarbinChina Department of Otolaryngology The Second Hospital of Shandong UniversityShandong UniversityJinanChina Department of Otorhinolaryngology Head and Neck Surgery Peking University People's HospitalBeijingChina Department of Otorhinolaryngology Head and Neck Surgery Yantai Yuhuangding HospitalQingdao UniversityYantaiChina Department of Otorhinolaryngology Head and Neck Surgery Xijing HospitalThe Fourth Military Medical UniversityXi'anChina Gansu Provincial Center for Disease Control and Prevention LanzhouChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of China Medical UniversityShenyangChina Department of Otorhinolaryngology Head and Neck Surgery Tongji Hospit

Objective:This cross-sectional study aimed to determine the epidemiology of olfactory and gustatory dysfunctions related to COVID-19 in ***:This study was conducted by 45 tertiary Grade-A hospitals in *** and offline questionnaire data were obtained from patients infected with COVID-19 between December 28,2022,and February 21,*** collected information included basic demographics,medical history,smoking and drinking history,vaccination history,changes in olfactory and gustatory functions before and after infection,and other postinfection symptoms,as well as the duration and improvement status of olfactory and gustatory ***:Complete questionnaires were obtained from 35,566 *** overall incidence of olfactory and taste dysfunction was 67.75%.Being female or being a cigarette smoker increased the likelihood of developing olfactory and taste *** received four doses of the vaccine or having good oral health or being a alcohol drinker decreased the risk of such *** infection,the average olfactory and taste VAS scores were 8.41 and 8.51,respectively;after infection,they decreased to 3.69 and 4.29 and recovered to 5.83 and 6.55 by the time of the *** median duration of dysosmia and dysgeusia was 15 and 12 days,respectively,with 0.5%of patients having symptoms lasting for more than 28 *** overall self-reported improvement rate was 59.16%.Recovery was higher in males,never smokers,those who received two or three vaccine doses,and those that had never experienced dental health issues,or chronic accompanying ***:The incidence of dysosmia and dysgeusia following infection with the SARS-CoV-2 virus is high in *** and prognosis are influenced by several factors,including sex,SARS-CoV-2 vaccination,history of head-facial trauma,nasal and oral health status,smoking and drinking history,and the persistence of accompanying symptoms.

关键词： epidemiologic studies incidence olfactory disorders prognosis SARS-CoV-2 taste disorders

EFFECT OF SWEEP AND EJECTION EVENTS ON PARTICLE DISPERSION IN WALL BOUNDED TURBULENT FLOWS

在线全文

学校读者我要写书评

暂无评论

Journal of Hydrodynamics 2012年第5期24卷 794-799页

作者： luO jian-ping lu Zhi-ming QIU Xiang LI Dong-mei LIU Yu-lu School of Mechanical Engineering Shanghai Institute of Technology Shanghai 200235 China Shanghai Key Laboratory of Mechanics in Energy Engineering and Shanghai Institute of Applied Mathematicsand Mechanics Shanghai University Shanghai 200072 China School of Science Shanghai Institute of Technology Shanghai 200235 China Shanghai Institute of Technology Shanghai 200235 China

This paper studies the sweep and ejection events in a channel flow with Reτ = 80 by using Direct Numerical Simulation （DNS）. The effects of ejection and sweep events on the transport of fluid particles are analyzed separately through a quadrant technique. By analyzing trajectories of the particles released at different wall-normal locations, it is found that the particles from the ejection events mainly move upward while the particles from the sweep events move downward of the flow during short and intermediate diffusion time durations. Numerical results show that the effects of the ejection and sweep events on the mean displacement and the mean square dispersion remain for a long time, one-order of magnitude larger than the streamwise Lagrangian integral ~cales.

关键词： sweep ejection dispersion quadrant analysis turbulent channel flow

在线全文

学校读者我要写书评

暂无评论

油莎豆茎叶代谢物与块茎形态的关联研究

中国油料作物学报 2024年第1期46卷 62-71页

作者：麻剑南单成彬冯旭马越王力伟张向前赵小庆路战远张德健马超美内蒙古大学生命科学学院牧草与特色作物生物学教育部重点实验室内蒙古呼和浩特010030 内蒙古医科大学药学院内蒙古呼和浩特010110 内蒙古自治区农牧业科学院内蒙古呼和浩特010031

为研究油莎豆表型差异与茎叶代谢物间的关联,比较分析了10份油莎豆样本的叶宽、块茎宽度、块茎厚度、块茎高度等表型参数,同时利用超高效液相色谱-串联质谱(UHPLC-MS/MS)技术定性定量分析其茎叶代谢物。10份油莎豆样本分为2个表型,即宽... 详细信息

为研究油莎豆表型差异与茎叶代谢物间的关联,比较分析了10份油莎豆样本的叶宽、块茎宽度、块茎厚度、块茎高度等表型参数,同时利用超高效液相色谱-串联质谱(UHPLC-MS/MS)技术定性定量分析其茎叶代谢物。10份油莎豆样本分为2个表型,即宽叶圆粒型和窄叶长粒型,其叶宽与块茎宽度和块茎厚度呈正相关。用UHPLC-MS/MS对油莎豆茎叶中28个主要代谢物,包括黄烷-3醇、咖啡酸衍生物和黄酮类成分的相对含量进行测定分析比较。结果表明,4个黄酮类化合物即木犀草素-7-二葡萄糖醛酸苷、荭草苷、木犀草素-7-葡萄糖醛酸苷和木犀草素在宽叶圆粒型油莎豆茎叶中的含量显著高于窄叶长粒型油莎豆茎叶。利用KEGG和PlantCyc推导绘制了4种差异黄酮代谢物在油莎豆茎叶中的生物合成途径,并预测宽叶圆粒型油莎豆相较于窄叶长粒型更具有耐旱性,可为油莎豆的品种鉴定、选育和茎叶资源利用提供依据。。

关键词：油莎豆表型二次代谢产物超高效液相色谱-串联质谱

维普期刊数据库博看期刊

Reporting and methodological quality of meta-analyses of acupuncture for patients with migraine:A methodological investigation with evidence map

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Medicine 2022年第3期20卷 213-220页

作者： ting-ting lu Cun-cun lu mei-xuan Li Li-xin Ke Hui Cai Ke-hu Yang Institution of Clinical Research and Evidence-Based Medicine Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Evidence-Based Medicine Center School of Basic Medical SciencesLanzhou UniversityLanzhou 730000Gansu ProvinceChina Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China Key Laboratory of Evidence-Based Medicine and Knowledge Translation of Gansu Province Lanzhou 730000Gansu ProvinceChina Hepatobiliary and Pancreatic Center the First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080Guangdong ProvinceChina General Surgery Clinical Medical Center Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

Background:Acupuncture has been widely used to relieve migraine-related ***,the findings of previous systematic reviews(SRs)and meta-analyses(MAs)are still not completely *** quality is also unknown,so a comprehensive study is ***:To evaluate the reporting and methodological quality of these MAs concerning acupuncture for migraine,and summarize evidence about the efficacy and safety of acupuncture for *** strategy:Pub Med,Embase,Cochrane Library,China National Knowledge Infrastructure,Chinese Biomedical Databases,Wanfang Data,and VIP databases were searched from inception to September 2020,with a comprehensive search *** criteria:The pairwise MAs of randomized controlled trials(RCTs)concerning migraine treated by acupuncture or acupuncture-based therapies,with a control group that received sham acupuncture,medication,no treatment,or acupuncture at different acupoints were *** extraction and analysis:Two independent investigators screened studies,extracted relevant data,and assessed reporting and methodological quality using Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)2009 and A Measurement Tool to Assess Systematic Reviews 2(AMSTAR 2),then all results were *** correlation test was used to evaluate the correlation between reporting and methodological quality ***:A total of 20 MAs were included in this *** included MAs indicated that acupuncture was efficacious and safe in preventing and treating migraine when compared with control *** was a high correlation between reporting and methodological quality scores(rs=0.87,Pluded SRs needs to be improved mainly with regard to protocol and prospective registration,using a comprehensive search strategy,summarizing the strength of evidence body for key outcomes,a full list of excluded studies with reasons for exclusion,reporting of RCTs’fundin

关键词： Migraine Acupuncture Systematic review Meta-analysis AMSTAR 2 PRISMA

Electronic States in Quasi-one-Dimensional Copolymeric Sandwich Structures

在线全文

学校读者我要写书评

暂无评论

Chinese Physics Letters 2001年第12期18卷 1644-1647页

作者： LIU De-Sheng WANG lu-Xia wei jian-Hua ZHENG Bin XIE shi-Jie HAN Sheng-Hao mei Liang-Mo School of Physics and Microelectronics Shandong UniversityJi'nan 250100 Department of Physics Jining Normal UniversityJining 272025 National Key Laboratory of Crystal Materials Shandong UniversityJi'nan 250100

The electronic properties of xPA/nPPP/yPA sandwiched copolymers with a well-barrier-well structure have been studied by using a tight-binding calculation. It was found that the electronic properties of the neutral states of these sandwiched copolymers are sensitive to the constitutions of PPP and PA monomers and the interface coupling between PA and PPP. It is verified that the quantum tunnelling effect will occur at the lowest conductive state of xPA/nPPP/xPA copolymers.

关键词： calculation sandwich Copolymer

Effects of B, Mo, Zn, and Their Interactions on Seed Yield of Rapeseed (Brassica napus L.)

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pedosphere 2009年第1期19卷 53-59页

作者： YANG mei shi Lei XU Fang-Sen lu jian-wei WANG Yun-Hua Microelement Research Center Huazhong Agricultural University Wuhan 430070 （China）. National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural University Wuhan 430070 （China）

A field experiment was conducted to study the effects of boron (B), molybdenum (Mo), zinc (Zn) and their interactions on seed yield and yield formation of rapeseed (Brassica napus L. var. Huashuang 4). Application of B fertilizer to a sandy soil increased the seed yield by 46.1% compared to the control and also created a considerably higher seed yield than the two treatments solely applying Mo and Zn fertilizers, which suggested that B was a main constraint for the seed yield of Huashuang 4 in this experiment. The effect of B fertilizer on the seed yield was attributed to an increase in the number of seeds per silique and siliques per plant. The combined application of B with Mo or Zn resulted in higher seed yield than the application of B, Mo or Zn alone, and the seed yield of the B+Mo+Zn treatment was the highest in all treatments, 68.1% above the control. Dry matter accumulation of seed followed a typical S-shaped curve and it was higher in plants supplied with B than in plants without B. A small but significant increase in the seed oil content and an improvement in the oil quality were also observed in all treatments compared with the control. These results suggested that optimal micronutrient application could provide both yield and quality advantages for rapeseed in poor soil.

关键词： boron Brassica napus molybdenum seed yield zinc