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PCSK9与脑胆固醇稳态及阿尔茨海默病的潜在关联

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医药导报 2021年第6期40卷 773-775页

作者：李媛赵震宇 md sayed ali sheikh 胡涛夏珂中南大学湘雅医院心血管内科长沙421008 中南大学湘雅医院临床药理研究所长沙421008 阿尔苏夫医科大学心血管内科沙特阿拉伯2014

前蛋白转化酶枯草杆菌蛋白酶kexin9型(PCSK9)抑制剂在血脂管理中备受关注,而PCSK9与脑胆固醇稳态及阿尔茨海默病(AD)的潜在关联鲜为人知。研究显示脑胆固醇依赖原位合成且AD患者脑脊液中PCSK9水平升高,但PCSK9不能穿过血-脑屏障。该文... 详细信息

前蛋白转化酶枯草杆菌蛋白酶kexin9型(PCSK9)抑制剂在血脂管理中备受关注,而PCSK9与脑胆固醇稳态及阿尔茨海默病(AD)的潜在关联鲜为人知。研究显示脑胆固醇依赖原位合成且AD患者脑脊液中PCSK9水平升高,但PCSK9不能穿过血-脑屏障。该文将阐述PCSK9参与脑胆固醇稳态及AD的可能机制及作用靶点,并进一步探讨PCSK9抑制剂在心血管领域的应用是否对患者神经认知功能产生影响。

关键词：前蛋白转化酶枯草杆菌蛋白酶kexin9型抑制剂脑胆固醇稳态阿尔茨海默病神经认知功能

冠心病合并代谢综合征患者血浆LOX-1和脂联素的水平变化及相关性研究

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冠心病合并代谢综合征患者血浆LOX-1和脂联素的水平变化及相关性...

作者：孟加拉阿里（DR md sayed ali sheikh）中南大学

学位级别：硕士

目的：评估血浆凝集素样氧化型低密度脂蛋白受体-1和脂联素在冠心病合并代谢综合征患者中的水平。方法：收集2009年8月-2010年6月间我院心内科住院的冠心病患者为研究对象,其中平均年龄为66岁的冠心病者30例（CAD组,男13,女7）;平... 详细信息

目的：评估血浆凝集素样氧化型低密度脂蛋白受体-1和脂联素在冠心病合并代谢综合征患者中的水平。方法：收集2009年8月-2010年6月间我院心内科住院的冠心病患者为研究对象,其中平均年龄为66岁的冠心病者30例（CAD组,男13,女7）;平均年龄为6 1岁的冠心病合并代谢综合征者30例（CAD+MS组,13男,17女）;平均年龄为53岁的代谢综合征者30例（MS组,23男,7女）;平均年龄为51岁的来我院体检中心的正常健康对照组30例（22男,8女）。对所有的研究对象进行问卷获取一般资料,并收集外周肘静脉血检测生化指标,采用ELISA法检测LOX-1和脂联素的浓度。结果：血压和BMI在CAD+MS组（142±9mmHg/82±7 mmHg、27.2±1Kg/m2）、MS组（136±6 mmHg/74±7mmHg、25.6±1 Kg/m2）合CAD组（129±10mmHg/77±7mmHg、23.7±1.3 Kg/m2）均高于正常对照组（124±8 mmHg/72±5mmHg、21.1±1.5 Kg/m2）,且差异有统计学意义（均P＜0.05）;血浆甘油三酯、空腹血糖、谷草转氨酶、谷丙转氨酶、肌酐、尿酸和高敏C反应蛋白在CAD+MS组（2.1±1.4mmol/L、6.2±0. mmol/L、23.5±4.8 U/L、21.2±4 U/L、89.3±16 mg/L、314.7±55.1 mmol/L、12.0±8.5 mg/L）均高于正常对照组（0.84±0.3mmol/L、4.5±0.3 mmol/L、11.2±3.6U/L、14.5±4.5U/L、71.0±9.8 mg/L、251.9±42mmol/L、0.7±0.8mg/L）,且差异有统计学意义（均P＜0.05）。尿素氮在CAD组（5.5±0.9mmol/L）均高于CAD+MS组（5.3±1mmol/L）、MS组（4.8±1.4mmol/L）和正常对照组（3.9±0.6mmol/L）、且差异有统计学意义（均P＜0.05）。血浆LOX-1在CAD+MS组（435.9±105.9pg/ml）水平最高,其次是CAD组（196.2±40.4pg/ml）、MS组（140.9±15pg/ml）、正常对照组（87.1±8.5 pg/ml）,且各组间差异有统计学意义（均P＜0.05）。相反,脂联素在CAD+MS组（263.6±26.6μg/L）水平最低,其次是CAD组（369.9±20.7μg/L）、MS组（450.8±25μg/L）、正常对照组（510.9±29.3μtg/L）,且四组间差异有统计学意义（均P＜0.05）。进一步分析发现,血浆LOX-1和脂联素水平不受年龄和性别的影响,且二者的变化呈显著负相关。结论：冠心病患者血浆LOX-1的水平增高,以CAD+MS组增高最为显著;相反,冠心病患者血浆脂联素的水平降低,以CAD+MS组降低最为显著。

关键词：冠心病凝集素样氧化型低密度脂蛋白受体-1 脂联素代谢综合征动脉粥样硬化

The role of circulating miRNAs in diagnosis of acute myocardial infarction and the pathological significance

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The role of circulating miRNAs in diagnosis of acute myocard...

Massive MIMO system lower bound spectral efficiency analysis with precoding and perfect CSI

第十一届全国免疫学学术大会

作者： Zhu Ping md sayed ali sheikh Li Chuanchang Xia Ke Li Fei Deng Xu Salma Umme Yang Tianlun Peng Jun Department of Cardiovascular Surgery Guangdong Cardiovascular InstituteGuangdong General HospitalGuangdong Academy of Medical Sciences Department of Cardiology Xiangya HospitalCentral South University Center for Vascular Biology and Inflammation Cardiovascular DivisionDepartment of MedicineBrigham and Women's HospitalHarvard Medical School Department of Gynecology and obstetrics Xiangya 3rd HospitalCentral South University Department of Pharmacology School of Pharmaceutical SciencesCentral South University

Objectives: We aimed to explore the diagnostic value of circulating miRNAs(miR-149, miR-208 b, miR-378, miR-424, miR-499 and miR-765) in AMI patients, and protective role of miR-208 b or miR-378 or metoprolol during H/R injury in H9c2 cell with their underlying mechanisms. Methods: 205 AMI patients and 85 healthy subjects, twelve week-old C57BL/6 mice AMI and H9c2 cells were included in this study. Total RNA was isolated from plasma and cardiac cell with TRIzol reagent. Circulating miRNAs levels were measured by quantitative real-time polymerase chain reaction. Results: We found that miR-208 b, miR-499 and miR-765 levels were significantly up-regulated by 9.6 fold, 5.2 fold, and 5.1 fold in AMI patients compared with healthy subjects(p<0.001). Plasma miR-149, miR-378 and miR-424 levels were markedly downregulated by 5.5 fold, 4.9 fold and 5 fold in AMI patients compared with controls(p<0.001). Plasma levels of these miRNAs were returned towards normal at 96 h after PCI(p<0.001). We also found that plasma miR-208 b, miR-499 and miR-765 levels were significantly elevated by 11.5 fold, 3.9 fold, and 4.7 fold, while miR-149, miR-378 and miR-424 levels were noticeably decreased by 3.7 fold, 4.1 fold and 3.8 fold in Mice AMI compared with controls(p<0.001). The ROC curves of plasma miR-208 b, miR-499, miR-765, miR-149, miR-378 and miR-424 represented a strong discrimination between AMI patients and healthy subjects, with an area under curve(AUC) of 0.974, 0.971, 0.965, 0.963 0.969 and 0.973, respectively. Conclusions: Our findings suggested that miR-208 b, miR-499, miR-765, miR-149, miR-378, miR-424 may be used as a novel and sensitive diagnostic biomarker for AMI patients. Inhibition of miR-208 b and overexpression of miR-378 were effectively protected cardiomyocyte damage during H/R injury through their potential targets NLK and TRAF6, represents a new therapeutic approach for ischemic heart disease. Furthermore, metoprolol protected cardiomyocytes damage against H/R in

关键词： cardiomyocytes damage circulating miRNAs AMI pathological new therapeutic approach

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Digital Communications and Networks 2021年第3期7卷 342-351页

作者： Tasher ali sheikh Joyatri Bora md Anwar Hussain Department of Electronics and Communication Engineering North Eastern Regional Institute of Science and TechnologyNirjuliArunachal Pradesh791109India

The analytical lower bound of Spectral Efficiency(SE)of downlink transmission of the Massive Multiple Input Multiple Output(Ma-MIMO)system is *** this paper,we derive some novel and approximate mathematical expressions for the lower bound of the SE of a Ma-MIMO with linear precoding schemes,i.e.,Minimum Mean Square Error(MMSE)and Zero-Forcing(ZF).For simulation analysis of the SE,we consider three joint users and antenna scheduling algorithms,namely,the semi-orthogonal,random,and distance-based user scheduling algorithms,whereas the antennas are selected based on Maximum Signal to Noise Ratio(MSNR)with scheduled *** channel between the user and the transmitter is assumed to have characteristics of Small Scale Fading(SSF)and Large Scale Fading(LSF)with the Rayleigh fading *** investigate the effect of the variation of transmitting SNR,the number of base station antennas(M),and the radius(R)of the cell area on the *** simulate the downlink transmission of Ma-MIMO and compare the simulation and analytical *** is observed that the trends of variation of both results are similar to the variation of identical factors,and the difference between the simulated and analytical lower bounds of the SE is approximately 1-1.5 *** analytical lower bound is smaller than the simulation result.

关键词： Fifth-generation Spectral efficiency Ma-MIMO LSF coefficient Precoding

Capacity maximizing in massive MIMO with linear precoding for SSF and LSF channel with perfect CSI

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Digital Communications and Networks 2021年第1期7卷 92-99页

作者： Tasher ali sheikh Joyatri Bora md.Anwar Hussain Department of Electronics and Communication Engineering Nordi Eastern Regional Institute of Science and TechnologyNirjuliArunachal Pradesh791109India

The capacity of a massive MIMO cellular network depends on user and antenna selection algorithms,and also on the acquisition of perfect Channel State Information(CSD).Low computational cost algorithms for user and an-tenna selection significantly may enhance the system capacity,as it would consume a smaller bandwidth out of the total bandwidth for downlink *** objective of this paper is to maximize the system sum-rate capacity with efficient user and antenna selection algorithms and linear *** consider in this paper,a slowly fading Rayleigh channel with perfect acquisition of CSI to explore the system sum-rate capacity of *** MIMO *** user selection,we apply three algorithms,namely Semi orthogonal user selection(SUS),Descending Order of SNR-based User Scheduling(DOSUS),and Random User Selection(RUS)*** all the user selection algorithms,the selection of Base Station(BS)antenna is based on the maximum Signal-to-Noise Ratio(SNR)to the selected *** users are characterized by having both Small Scale Fading(SSF)due to slowly fading Rayleigh channel and *** Fading(ISF)due to distances from the base ***,we use linear precoding techniques,such as Zero Forcing(ZF),Minimum Mean Square Error(MMSE),.and Maximum Ratio Transmission(MRT)to reduce interferences,thereby improving average system sum-rate *** using SUS,DOSUS,and RUS user selection algorithms with ZF,MMSE,and MRT precoding techniques are *** also analyzed and compared the computational complexity of all the three user selection *** computational complexities of the three algorithms that we achieved in this paper are 0(1)for RUS and DOSUS,and 0(M^2N)for suS which are less than the other conventional user selection methods.

关键词： Massive MIMO User selection Antenna selection Complexity DOSUS and antenna selection 5G

New approaches for diagnosis of dry eye disease

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International Journal of Ophthalmology(English edition) 2019年第10期12卷 1618-1628页

作者： Abdelrahman MElhusseiny ali AKhalil Reem HEl sheikh Mohammad ABakr MohamedGaber Eissa Yasmine MEl sayed Department of Ophthalmology Kasr Al Ainy School ofmedicineCairo UniversityDokki12611Egypt Department of Ophthalmology Bascom Palmer Eye InstituteUniversity of Miami Miller School of Medicine900NW17StreetMiamiFL33136USA Faculty of Medicine American University of BeirutBeirut2341Lebanon

We reviewed the literature for different diagnostic approaches for dry eye disease(DED) including the most recent advances, contradictions and promising diagnostic tools and technique. We performed a broad literature search for articles discussing different methods for diagnosis of DED including assessment of tear osmolarity, tear film stability, ocular biomarkers and others. Articles indexed in PubMed and google scholar were included. With the growing cosmetic industry, environmental pollution, and booming of digital screens, DED is becoming more prevalent. Its multifactorial etiology renders the diagnosis challenging and invites the emergence of new diagnostic tools and tests. Diagnostic tools can be classified, based on the parameter they measure, into tear film osmolarity, functional visual acuity, tear volume, tear turnover, tear film stability, tear film composition, ocular biomarkers and others. Although numerous methods exist, the most accurate diagnosis can be reached through combining the results of more than one test. Many reported tests have shown potential as diagnostic/screening tools, however, require more research to prove their diagnostic power, alone or in combination. Future research should focus on identifying and measuring parameters that are the most specific to DED diagnosis.

关键词： dry eye disease tear film stability tear osmolarity ocular biomarkers

Massive MIMO system lower bound spectral efficiency analysis with precoding and perfect CSI

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Digital Communications and Networks 2021年第3期 342-351页

作者： Tasher ali sheikh Joyatri Bora md Anwar Hussain Department of Electronics and Communication Engineering North Eastern Regional Institute of Science and Technology

The analytical lower bound of Spectral Efficiency(SE) of downlink transmission of the Massive Multiple Input Multiple Output(Ma-MIMO) system is *** this paper,we derive some novel and approximate mathematical expressions for the lower bound of the SE of a Ma-MIMO with linear precoding schemes,i.e.,Minimum Mean Square Error(MMSE) and Zero-Forcing(ZF).For simulation analysis of the SE,we consider three joint users and antenna scheduling algorithms,namely,the semi-orthogonal,random,and distance-based user scheduling algorithms,whereas the antennas are selected based on Maximum Signal to Noise Ratio(MSNR) with scheduled *** channel between the user and the transmitter is assumed to have characteristics of Small Scale Fading(SSF) and Large Scale Fading(LSF) with the Rayleigh fading *** investigate the effect of the variation of transmitting SNR,the number of base station antennas(M),and the radius(R) of the cell area on the *** simulate the downlink transmission of Ma-MIMO and compare the simulation and analytical *** is observed that the trends of variation of both results are similar to the variation of identical factors,and the difference between the simulated and analytical lower bounds of the SE is approximately 1-1.5 *** analytical lower bound is smaller than the simulation result.

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Tie-line Power Flow Control Method for Gridconnected Microgrids with SMES Based on Optimization and Fuzzy Logic

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Journal of Modern Power Systems and Clean Energy 2020年第5期8卷 941-950页

作者： sayed M.Said Abdelfatah ali Bálint Hartmann Department of Electrical Engineering Aswan University81542 AswanEgypt Department of Electric Power Engineering Budapest University of Technology and Economics1111 BudapestHungary Department of Electrical Engineering South Valley University83523 QenaEgypt

In an active distribution grid,renewable energy sources(RESs)such as photovoltaic(PV)and energy storage systems(e.g.,superconducting magnetic energy storage(SMES))can be combined with consumers to compose a microgrid(MG).The high penetration of PV causes high fluctuations of tie-line power flow and highly affects power system *** can lead to several technical problems such as voltage fluctuations and excessive power *** this paper,a fuzzy logic control based SMES method(FSM)and an optimized fuzzy logic control based SMES method(OFSM)are proposed for minimizing the tie-line power ***,the fluctuations and transmission power losses are *** FSM,SMES is used with a robust fuzzy logic controller(FLC)for controlling the tie-line power *** optimization model is employed in OFSM to simultaneously optimize the input parameters of the FLC and the reactive power of the voltage source converter(VSC)of *** objective function of minimizing the tieline power flow is incorporated into the optimization *** swarm optimization(PSO)algorithm is utilized to solve the optimization problem while the constraints of the utility power grid,VSC,and SMES are *** simulation results demonstrate the effectiveness and robustness of the proposed methods.

关键词： Utility power grid microgrid photovoltaic(PV) superconducting magnetic energy storage(SMES) tie-line power fuzzy logic control(FLC)

合并糖代谢异常的冠心病患者血浆脂联素水平变化及其临床意义

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中南大学学报（医学版） 2012年第2期37卷 179-184页

作者：夏珂郭兰燕赵震宇 ali sheikh md sayed 李非杨天伦中南大学湘雅医院心内科长沙410008 中南大学临床药理研究所长沙410008

目的:检测脂联素(adiponectin,ADPN)在合并糖代谢异常的冠心病患者血浆中浓度的变化,探讨其临床意义。方法:收集2009年8月至2010年4月在湘雅医院心内科经冠状动脉造影(coronary angiography,CAG)检查证实为冠心病的患者87名,根据糖代谢... 详细信息

目的:检测脂联素(adiponectin,ADPN)在合并糖代谢异常的冠心病患者血浆中浓度的变化,探讨其临床意义。方法:收集2009年8月至2010年4月在湘雅医院心内科经冠状动脉造影(coronary angiography,CAG)检查证实为冠心病的患者87名,根据糖代谢情况分为单纯冠心病组(coronary heart disease group,CHD组,n=31)、冠心病合并糖耐量异常组(CHD combine with impaired glucose tolerance group,CHD+IGT组,n=28)和冠心病合并糖尿病组(CHDcombine with diabetes mellitus group,CHD+DM组,n=28),另选健康体检者31例为正常对照组(normal control group,NC组)。采用酶联免疫吸附法检测血浆ADPN水平;为所有受试对象测身高、体质量、腰围、血压;测空腹血糖、胰岛素、血脂、高敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)、游离脂肪酸(free fatty acid,FFA)和肝、肾功能等,计算体质量指数(body mass index,BMI)和胰岛素抵抗指数(homeostasis model assessment for insulin resistance,HOMA-IR)。结果:1)CHD组、CHD+IGT组、CHD+DM组患者血浆ADPN水平均低于NC组(P<0.05);2)与CHD组相比,CHD+DM组ADPN水平最低,CHD+IGT组次之,各组间差异有统计学意义(P<0.05);3)ADPN与HDL-C呈正相关(r=0.483,P<0.01),与hs-CRP和冠脉Gensini积分呈负相关(r=–0.489,P<0.05;r=–0.252,P<0.05)。结论:冠心病患者血浆ADPN浓度降低;合并糖代谢异常的冠心病患者血浆ADPN浓度更低,且随着糖代谢异常程度加重降低更显著;冠心病与糖代谢异常是影响血浆ADPN浓度改变的两个重要因素,血浆ADPN水平显著降低反映了上述两种疾病状态的叠加作用。ADPN联合HDL-C,hs-CRP,Gensini积分等血清学指标可为判断合并糖代谢异常的冠心病患者的疾病严重程度提供一定参考。

关键词：脂联素冠心病糖代谢异常糖耐量异常糖尿病