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Glyphosate as a direct or indirect activator of pro-inflammatory signaling and cognitive impairment

Neural regeneration research 2024年第10期19卷 2212-2218页

作者： Yukitoshi Izumi Kazuko A.O'dell Charles F.Zorumski Department of Psychiatry Washington University School of MedicineSt.LouisMOUSA Taylor Family Institute for Innovative Psychiatric research Washington University School of MedicineSt.LouisMOUSA

Glyphosate-based herbicides are widely used around the world, making it likely that most humans have significant exposure. Because of habitual exposure, there are concerns about toxicity including neurotoxicity that could result in neurological, psychiatric, or cognitive impairment. We recently found that a single injection of glyphosate inhibits long-term potentiation, a cellular model of learning and memory, in rat hippocampal slices dissected 1 day after injection, indicating that glyphosate-based herbicides can alter cognitive function. Glyphosate-based herbicides could adversely affect cognitive function either indirectly and/or directly. Indirectly, glyphosate could affect gut microbiota, and if dysbiosis results in endotoxemia(leaky gut), infiltrated bacterial by-products such as lipopolysaccharides could activate pro-inflammatory cascades. Glyphosate can also directly trigger pro-inflammatory cascades. Indeed, we observed that acute glyphosate exposure inhibits long-term potentiation in rat hippocampal slices. Interestingly, direct inhibition of long-term potentiation by glyphosate appears to be similar to that of lipopolysaccharides. There are several possible measures to control dysbiosis and neuroinflammation caused by glyphosate. Dietary intake of polyphenols, such as quercetin, which overcome the inhibitory effect of glyphosate on long-term potentiation, could be one effective strategy. The aim of this narrative review is to discuss possible mechanisms underlying neurotoxicity following glyphosate exposure as a means to identify potential treatments.

关键词： cognitive impairment glyphosate microglia neuroinflammation roundup toll-like receptor 4 zinc chelation

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Tri-axial accelerometry allows to determine parental food provisioning behaviour in a marine bird

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Avian research 2024年第3期15卷 345-351页

作者： Monserrat Del Caño Flavio Quintana Giacomo dell’Omo Agustina Gómez-Laich Instituto de Biología de Organismos Marinos(IBIOMAr) CONICETBoulevard Brown 2915U9120ACDPuerto MadrynChubutArgentina Ornis Italica Piazza Crati 1500199RomeItaly Departamento de Ecología Genética y Evolución(EGE)and Instituto de EcologíaGenética y Evolución de Buenos Aires(IEGEBA)CONICETFacultad de CienciasExactas y NaturalesUniversidad de Buenos AiresPabellón II Ciudad UniversitariaC1428EGACiudad Autónoma de Buenos AiresArgentina

The study of parental food provisioning is essential for understanding the breeding ecology of *** conducted the first study using accelerometry to detect food provisioning in birds,using Support Vector Machine(SVM)models to identify when adults feed chicks of three different age *** were attached to the head of adult female Imperial Shags(Leucocarbo atriceps),and various attributes derived from the acceleration signals were used to train SVM models for each chick age *** performance improved with chick age class,with SVM models achieving high overall accuracy(>88%)and highest sensitivity in older chick categories(>91%).However,precision values,especially for younger chicks,remained relatively low(between 26%and 45%).The application of a time filter based on the minimum duration of the observed food provisioning behaviours for each chick age category,improved model performance by reducing false provisioning behaviours,particularly in the model for older chicks,which showed the highest precision(72.4%).This study highlights the effectiveness of accelerometry and machine learning in studying parental food provisioning in birds,providing a rapid and accurate data collection method to complement traditional *** described methodology can be applied to any bird species that exhibits distinctive movements while feeding its offspring and has suitable characteristics for attaching an accelerometer to the body part that best captures this ***,it is hoped that the results of this study will contribute to future research on key questions in parental investment theory and reproductive strategies in birds.

关键词： Accelerometry Food provisioning Imperial shag Leucocarbo atriceps Seabird Support vector machine

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Tetrachloroethane(TeCA)removal through sequential graphite-mixed metal oxide electrodes in a bioelectrochemical reactor

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Environmental Science and Ecotechnology 2024年第1期17卷 59-67页

作者： Marco Zeppilli Hafsa Yaqoubi Edoardo dell’Armi Agnese Lai Mustapha Belfaquir Laura Lorini Marco Petrangeli Papini Department of Chemistry University of Rome SapienzaPiazzale Aldo Moro 5Rome00185Italy Department of Chemistry Ibn Tofail UniversityLaboratory of Advanced Material and Process EngineeringCampus UniversitaireBP.242KenitraMorocco

Electro-bioremediation offers a promising approach for eliminating persistent pollutants from groundwater since allows the stimulation of biological dechlorinating activity,utilizing renewable electricity for process operation and avoiding the injection of chemicals into *** this study,a two-chamber microbial electrolysis cell has been utilized to achieve both reductive and oxidative degradation of tetrachloroethane(TeCA).By polarizing the graphite granules cathodic chamber at650 mV vs the standard hydrogen electrode and employing a mixed metal oxide(MMO)counter electrode for oxygen production,the reductive and oxidative environment necessary for TeCA removal has been *** experiments were conducted using two feeding solutions:an optimized mineral medium for dechlorinating microorganisms,and synthetic groundwater containing sulphate and nitrate anions to investigate potential side *** bioelectrochemical process efficiently reduced TeCA to a mixture of trans-dichloroethylene,vinyl chloride,and ethylene,which were subsequently oxidized in the anodic chamber with removal efficiencies of 37±2%,100±4%,and 100±5%,*** introduction of synthetic groundwater with nitrate and sulphate stimulated reductions in these ions in the cathodic chamber,leading to a 17%decrease in the reductive dechlorination rate and the appearance of other chlorinated by-products,including cis-dichloroethylene and 1,2-dichloroethane(1,2-DCA),in the cathode ***,despite the lower reductive dechlorination rate during synthetic groundwater operation,aerobic dechlorinating microorganisms within the anodic chamber completely removed VC and 1,*** study represents the first demonstration of a sequential reductive and oxidative bioelectrochemical process for TeCA mineralization in a synthetic solution simulating contaminated groundwater.

关键词： Chlorinated aliphatic hydrocarbons Microbial electrolysis cells Oxidative dechlorination reductive dechlorination Sulphate reduction Nitrate reduction

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数字支付垄断中的银行竞争与家庭隐私

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新金融 2024年第3期 36-43页

作者： Itai Agur Anil Ari Giovanni dell'Ariccia 李丽丽(翻译) 周正铭(翻译) 国际货币基金组织不详

贷款人可以利用家庭的支付数据来推断他们的信誉。当家庭重视隐私时,他们就会在保护隐私和信贷条件之间做出权衡。本文研究了引入更具信息入侵性的数字支付工具是如何对家庭的现金使用、信贷获取和福利产生影响,以及私人和社会最优是如... 详细信息

贷款人可以利用家庭的支付数据来推断他们的信誉。当家庭重视隐私时,他们就会在保护隐私和信贷条件之间做出权衡。本文研究了引入更具信息入侵性的数字支付工具是如何对家庭的现金使用、信贷获取和福利产生影响,以及私人和社会最优是如何分化的。新技术正在从根本上改变支付和信贷提供的方式,并为数据垄断创造了前所未有的空间。技术垄断者控制着新支付方式的入侵性,操纵家庭和寡头垄断银行之间的信息不对称,以获取比自己放贷更有利可图的数据合同。自由放任的均衡需要一种比最优状态更具入侵性的数字支付工具,为监管提供窗口。本刊编译此篇国际货币基金组织的工作论文,以期为读者带来启示。

关键词：数字支付家庭隐私金融中介大数据数据监管

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Effects of urea and(NH_4)_2 SO_4 on nitrification and acidification of Ultisols from Southern China

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Journal of Environmental Sciences 2012年第4期24卷 682-689页

作者： dell Tong renkou Xu State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China Graduate University of Chinese Academy of Sciences Beijing 100049China

The mechanisms for the effects of ammonium-based fertilizers on soil acidification in subtropical regions are not well understood. Two Ultisols collected from cropland and a tea garden in Anhui and Jiangxi Provinces in subtropical southern China, respectively, were used to study the effects of urea and （NH4）aSO4 on the nitrification and acidification of soils with incubation experiments. Nitrification occurred at very low pH with no N fertilizer added and led to lowering of the soil pH by 0.53 and 0.30 units for the soils from Jiangxi and Anhui, respectively. Addition of urea accelerated nitrification and soil acidification in both Ultisols; while nitrification was inhibited by the addition of （NH4）2SO4, and greater input of （NH4）2SO4 led to greater inhibition of nitrification. Ammonia-oxidizing bacteria （AOB） played an important role in nitrification in cropland soil under acidic conditions. Addition of urea increased the soil pH at the early stages of incubation due to hydrolysis and stimulated the increase in the AOB population, and thus accelerated nitrification and soil acidification. At the end of incubation, the pH of Ultisol from Jiangxi had decreased by 1.25, 1.54 and 1.84 units compared to maximum values for the treatments with 150, 300 and 400 mg/kg of urea-N added, respectively; the corresponding figures were 0.95, 1.25 and 1.69 for the Ultisol from Anhui. However, addition of （NH4）：SO4 inhibited the increase in the AOB population and thus inhibited nitrification and soil acidification. Soil pH for the treatments with 300 and 400 mg/kg of （NHn）2SOa-N remained almost constant during the incubation. AOB played an important role in nitrification of the cropland soil under acidic conditions. Addition of urea stimulated the increase in the AOB population and thus accelerated nitrification and soil acidification; while addition of （NH4）2SO4 inhibited the increase in the AOB population and thus inhibited nitrification.

关键词： ammonium-based fertilizer nitrification soil acidification ammonia-oxidizing prokaryotes

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Proficiency score as a predictor of early trifecta achievement during the learning curve of robot-assisted radical prostatectomy for high-risk prostate cancer:results of a multicentric series

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Current Urology 2024年第2期18卷 110-114页

作者： Umberto Anceschi rocco Simone Flammia Antonio Tufano Michele Morelli Antonio Galfano Lorenzo Giuseppe Luciani Leonardo Misuraca Paolo dell’Oglio Gabriele Tuderti Aldo Brassetti Maria Consiglia Ferriero Alfredo Maria Bove riccardo Mastroianni Francesco Prata Isabella Sperduti Giovanni Petralia SilviaSecco Ettore Di Trapani DanieleMattevi Tommaso Cai Aldo Massimo Bocciardi Giuseppe Simone Department of Urology IRCCS“Regina Elena”National Cancer InstituteRomeItaly Urologic Clinic Department of Maternal-Child and Urologic SciencesSapienza University of RomeItaly Ospedale Niguarda Ca’Granda Department of UrologyMilanItaly Department of Urology APSS Santa Chiara Regional HospitalTrentoItaly Department of Biostatistical Unit IRCCS Regina Elena National Cancer InstituteRomeItaly

Background:recently,an innovative tool called“proficiency score”was introduced to assess the learning curve for robot-assisted radical prostatectomy(rArP).However,the initial study only focused on patients with low-risk prostate cancer forwhompelvic lymph node dissection(PLND)was not *** address this issue,we aimed to validate proficiency scores of a contemporarymulticenter cohort of patients with high-risk prostate cancer treated with rArP plus extended PLND by trainee *** andmethods:Between 2010 and 2020,4 Italian institutional prostate-cancer datasets weremerged and queried for“rArP”and“high-risk prostate cancer.”High-risk prostate cancer was defined according to the most recent European Association of Urology guidelines as follows:prostate-specific antigen>20 ng/mL,International Society ofUrological Pathology≥4,and/or clinical stage(cT)≥2c on preoperative *** selected cohort(n=144)included clinical cases performed by trainee surgeons(n=4)after completing their rArP learning curve(50 procedures for low-risk prostate cancer).The outcome of interest,the proficiency score,was defined as the coexistence of all the following criteria:a comparable operation time to the interquartile range of the mentor surgeon at each center,absence of any significant perioperative complications Clavien-Dindo Grade 3–5,no perioperative blood transfusions,and negative surgical margins.A logistic binary regression model was built to identify the predictors of 1-year trifecta achievement in the trainee *** all statistical analyses,a 2-sided pred ***:A proficiency score was achieved in 42.3%*** univariable level,proficiency score was associated with 1-year trifecta achievement(odds ratio,8.77;95%confidence interval,2.42–31.7;p=0.001).After multivariable adjustments for age,nerve-sparing,and surgical technique,the proficiency score independently predicted 1-year trifecta achievement(odds ratio,9.58;95%confidence i

关键词： Trifecta Learning curve robot-assisted radical prostatectomy High-risk prostate cancer

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Phosphorus requirements for containerized Pterocarpus indicus seedlings

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Journal of Forestry research 2015年第3期26卷 657-662页

作者： Eng Hai Lok Bernard dell Forest Plantation Programme Forest Research Institute Malaysia 52109 Kepong Selangor Darul Ehsan Malaysia School of Veterinary and Life Sciences Murdoch UniversityPerth 6150 Australia

Pterocarpus indicus Willd is a tropical woody legume that holds promise for plantation forestry. Two glasshouse experiments were undertaken on two soil types to determine the phosphorus （P） concentration ranges in the foliage of P-stressed and healthy plants, and to define cri- tical P concentrations for the diagnosis of deficiency and toxicity. There was a narrow range in rates of P fertilizer, supplied as Ca（H2PO4）2.H2O, between deficiency and toxicity compared to other tree species. The relationship between shoot yield and P concentration in the youngest fully expanded leaf enabled critical P concentrations for the diagnosis of deficiency （0.17 %） and toxicity （0.41%） to be determined at 90 % maximum yield from linear re- gressions fitted to the data. The foliar P concentration ranges for deficiency and toxicity were similar to other nitrogen-fixing trees. The defined P concentration ranges and the critical P concentrations for the diagnosis of P deficiency and P toxicity should be useful for monitoring the P status of nursery stock and the health of young seedlings after out-planting.

关键词： Deficiency Diagnosis Nutrition Symptoms Toxicity

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Successful management of an asymptomatic bilateral synchronous testicular carcinoid tumor with a testicular-sparing surgery

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Asian Journal of Andrology 2017年第4期19卷 507-508页

作者： Lucio dell'Atti Department of Urology University Hospital 'St. Anna' Ferrara Italy.

Dear Editor, Carcinoid tumors have been described in a large range of organs, but they most commonly involve the gastrointestinal and bronchopulmonary systems.1 These tumors of the testis are rare entity comprising 〈1% of all testis tumors and can arise as a metastasis from an extratesticular primary as a part of a teratoma or as primary tumor.2 Patients affected by carcinoid tumors present symptoms of carcinoid syndrome, such as diarrhea, flushings, and bronchospasm.3 We report a first case described in scientific literature of primary bilateral synchronous testicular carcinoid tumor that does not associated with carcinoid syndrome. From this publication, at the time of writing,

关键词： Successful synchronous surgery

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Mechanical response of fabric sheets to three-dimensional bending, twisting, and stretching

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Acta Mechanica Sinica 2015年第3期31卷 373-382页

作者： David J.Steigmann Francesco dell'Isola Department of Mechanical Engineering University of California International research Center for Mathematics and Mechanics of Complex Systems Università dell’Aquila Dipartimento di Ingegneria Strutturale e Geotecnica Università di Roma ‘La Sapienza’

A model for the mechanics of woven fabrics is developed in the framework of two-dimensional elastic surface theory. Thickness effects are modeled indirectly in terms of appropriate constitutive equations. The model accounts for the strain of the fabric and additional effects associated with the normal bending, geodesic bending, and twisting of the constituent fibers.

关键词： Woven fabrics Elastic surface theory Strain gradients

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INFLUENCE OF TIBETAN PLATEAU ON LOW LEVEL JET IN EAST ASIA

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Science China Chemistry 1985年第1期28卷 68-81页

作者：孙淑清,LOrENZO dell'OSSO Institute of Atmospheric Physics Academia Sinica Beijing European Centre for Medium range Weather Forecasts reading England

In this paper, the essential role played by tie Tibetan Plateau in the formation of large scale low level jet over China is shown. Using the ECMWF limited area model we have performed some numerical experiments with various modified orography for a real case. The comparison of no-mountain run with the control one shows that the Plateau acts as a west boundary to the flows from the south, thus helping concentrate the momentum in a narrow belt. The close connection between the jet and the monsoon current is also investigated. The confluence of the currents from the subtropical high and mid-latitude trough mainly results in the strong wind centre at mid-troposphere rather than at lower level.

关键词： EAST JET high than

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