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SARS-CoV-2 induced myocarditis:Current knowledge about its molecular and pathophysiological mechanisms

BIOCELL 2022年第8期46卷 1779-1788页

作者： domenico MARIA CARRETTA marina di domenico ROBERTO LOVERO ROBERTO ARRIGONI ANGELIKA ELZBIETA WEGIERSKA MARIAROSARIA BOCCELLINO ANDREA BALLINI IOANNIS ALEXANDROS CHARITOS LUIGI SANTACROCE AOU Policlinico Consorziale di Bari-Ospedale Giovanni XXIII Cardiology UnitPoliclinico University Hospital of BariBari70124Italy Department of Precision Medicine University of Campania Luigi VanvitelliNaples80138Italy AOU Policlinico Consorziale di Bari-Ospedale Giovanni XXIII Clinical Pathology UnitPoliclinico University Hospital of BariBari70124Italy CNR Institute of Biomembranes Bioenergetics and Molecular Biotechnologies(IBIOM)Bari70125Italy Department Interdisciplinary of Medicine University of Bari Aldo MoroBari70124Italy School of Medicine University of Bari Aldo MoroBari70124Italy Department of Emergency and Urgency National Poisoning CentreRiuniti University Hospital of FoggiaFoggia71122Italy

The existence of an inflammatory process in the heart muscle,related to a progressive worsening of myocardial function,different etiopathogenetic mechanisms concur and often overlap,thus making the diagnosis and the therapeutic approach *** the COVID-19 pandemic progresses,the effects of the disease on the organ systems and in particular on the cardiovascular system are becoming more and more *** involvement is a well-known event with a high percentage of findings in the heart’s magnetic field,even in asymptomatic *** are numerous uncertainties regarding their evolution,in the long and short term,due not only to a difficult to determine the varied clinical expression and the rarely performed intramyocardial biopsy which additionally presents diagnostic problems but also in part to different clinical ***,the new SARS-CoV-2 virus that uses the angiotensin converting enzyme 2(ACE2)which is present at high levels in myocardial cells as its entrance it can create even severe heart *** pathophysiology in all of these cases can involve multiple immune and non-immune mechanisms within organs and vessels and can be occur in the clinical *** mechanisms of direct and indirect myocardial infarction in patients with COVID-19 include additional lesion and oxygen-rich and generalized inflammation response with myocardial immune hyperactivity(myocarditis).Therefore,these can occur through the excessive release of cytokines,the presence of thrombocytopenia,endocrine damage,heart failure,arrhythmias and *** can show average signs of myocardial damage,and some develop spontaneous cardiac complications,such as heart failure,arrhythmias and,rarely,rare cardiogenic *** in all of these may involve multiple mechanisms within the cytokine cephalic membrane,endocrine damage and *** diagnosis of this myocardial injuri is mainly based on the myocardial enzyme *** viewpoint paper

关键词： Viruses Infections SARS-CoV-2 Pandemics Myocarditis Molecular diagnosis

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Nutrient restriction-activated Fra-2 promotes tumor progression via IGF1R in miR-15a downmodulated pancreatic ductal adenocarcinoma

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1132-1146页

作者： Gian Luca Rampioni Vinciguerra marina Capece Luca Reggiani Bonetti Giovanni Nigita Federica Calore Sydney Rentsch Paolo Magistri Roberto Ballarin Fabrizio di Benedetto Rosario distefano Roberto Cirombella Andrea Vecchione Barbara Belletti Gustavo Baldassarre Francesca Lovat Carlo M.Croce Department of Cancer Biology and Genetics and Comprehensive Cancer Center The Ohio State UniversityColumbus 43210 OHUSA Department of Clinical and Molecular Medicine Faculty of Medicine and PsychologySant’Andrea HospitalUniversity of Rome“Sapienza”Rome 00189Italy Department of diagnostic Clinic and Public Health MedicineUniversity of Modena and Reggio EmiliaModena 41100Italy Hepato-pancreato-biliary Surgery and Liver Transplantation Unit University of Modena and Reggio EmiliaModena 41100Italy division of Molecular Oncology Centro di Riferimento Oncologico di Aviano(CRO)Istituto di Ricovero e Cura a Carattere Scientifico(IRCCS)National Cancer InstituteAviano 33081Italy

Pancreatic ductal adenocarcinoma(PDAC)is a lethal disease,characterized by an intense desmoplastic reaction that compresses blood vessels and limits nutrient *** aggressiveness largely relies on its extraordinary capability to thrive and progress in a challenging tumor *** of the onco-suppressor miR-15a has been extensively documented in ***,we identified the transcription factor Fos-related antigen-2(Fra-2)as a miR-15a target mediating the adaptive mechanism of PDAC to nutrient *** report that the IGF1 signaling pathway was enhanced in nutrient deprived PDAC cells and that Fra-2 and IGF1R were significantly overexpressed in miR-15a downmodulated PDAC ***,we discovered that miR-15a repressed IGF1R expression via Fra-2 *** miR-15a-low context,IGF1R hyperactivated mTOR,modulated the autophagic flux and sustained PDAC growth in nutrient *** a genetic mouse model,Mir15aKO PDAC showed Fra-2 and Igf1r upregulation and mTOR activation in response to diet ***,nutrient restriction improved the efficacy of IGF1R inhibition in a Fra-2 dependent ***,our results point to a crucial role of Fra-2 in the cellular stress response due to nutrient restriction typical of pancreatic cancer and support IGF1R as a promising and vulnerable target in miR-15a downmodulated PDAC.

关键词： IGF1R Fra miR

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Use of infrared thermography to detect reactions to stressful events:does animal personality matter?

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Integrative Zoology 2024年第2期19卷 224-239页

作者： Maria Vittoria MAZZAMUTO marina MORANdiNI William LAMPMAN Lucas Armand WAUTERS Damiano PREATONI John Lad KOPROWSKI Adriano MARTINOLI School of Natural Resources and Environment College of Agriculture and Life ScienceUniversity of ArizonaArizonaUSA Unitàdi Analisi e Gestione delle Risorse Ambientali Dipartimento di Scienze Teoriche e ApplicateGuido Tosi Research GroupUniversitàdegli Studi dell’InsubriaVareseItaly Haub School of Environment and Natural Resources University of WyomingWyomingUSA

The study of the relationship between animal stress and personality for free-ranging animals is limited and provides contrasting *** perception of stressors by an individual may vary due to its personality,and certain personality traits may help individuals to better cope with *** non-invasive infrared thermography(IRT),we investigated the link between physiological and behavioral components expressed during an acute stress event by free-ranging Fremont’s squirrels(Tamiasciurus fremonti).We expected that,during the acute stress event of being approached by the researcher,individuals that showed a fast pace-of-life syndrome(bolder,more active,and less social/more aggressive)based on an arena test would exhibit stronger sympathetic-adrenal-medullary system reactivity showing a more intense stress-induced hyperthermia(high core body temperature and low peripheral temperature)than individuals with a slow pace of life(shy,less active,and more social).We successfully employed IRT technology to images of Fremont’s squirrels with identification of the individuals’body parts(eye,nose,ear,hind foot).However,we found no support for our ***’body surface temperatures told us more about a squirrel’s external environment and less about the thermal state of the body in that environment following a stressful *** studies need to assess how to make IRT effective and efficient in the field and improve its performance in studying the relationships between physiology and personality in wildlife.

关键词： non-invasive method open field test physiology stress-induced hyperthermia Tamiasciurus fremonti

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Biliverdin Reductase-A correlates with inducible nitric oxide synthasein in atorvastatin treated aged canine brain

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Neural Regeneration Research 2013年第21期8卷 1925-1937页

作者： Fabio di domenico Marzia Perluigi Eugenio Barone Department of Chemistry Center of Membrane Sciences and Sanders-Brown Center on Aging University of Kentucky Department of Biochemical Sciences Sapienza University of Rome Brain Mind Institute School of Life Sciences Swiss Federal Institute of Technology (EPFL)

Alzheimer’s disease is a neurodegenerative disorder characterized by progressive cognitive impairment and neuropathology. Recent preclinical and epidemiological studies proposed statins as a possible therapeutic drug for Alzheimer’s disease, but the exact mechanisms of action are still unknown. Biliverdin reductase-A is a pleiotropic enzyme involved in cellular stress responses. It not only transforms biliverdin-IX alpha into the antioxidant bilirubin-IX alpha but its serine/threonine/ tyrosine kinase activity is able to modulate cell signaling networks. We previously reported the beneficial effects of atorvastatin treatment on biliverdin reductase-A and heme oxygenase-1 in the brains of a well characterized pre-clinical model of Alzheimer’s disease, aged beagles, together with observed improvement in cognition. Here we extend our knowledge of the effects of atorvastatin on inducible nitric oxide synthase in parietal cortex, cerebellum and liver of the same animals. We demonstrated that atorvastatin treatment （80 mg/day for 14.5 months） to aged beagles selectively increased inducible nitric oxide synthase in the parietal cortex but not in the cerebellum. In contrast, inducible nitric oxide synthase protein levels were significantly decreased in the liver. Significant positive correlations were found between biliverdin reductase-A and inducible nitric oxide synthase as well as heme oxygenase-1 protein levels in the parietal cortex. The opposite was observed in the liver. Inducible nitric oxide synthase up-regulation in the parietal cortex was positively associated with improved biliverdin reductase-A functions, whereas the oxidative-induced impairment of biliverdin reductase-A in the liver negatively affected inducible nitric oxide synthase expression, thus suggesting a role for biliverdin reductase-A in atorvastatin-dependent inducible nitric oxide synthase changes. Interestingly, increased inducible nitric oxide synthase levels in the parietal cortex were not assoc

关键词： neural regeneration age Alzheimer’s disease atorvastatin biliverdin reductase-A cell stress-response cognitive function 4-hydroxy-2-nonenal heme oxygenase-1 inducible nitric oxide synthase oxidative stress neuroregeneration.

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Ultrasonographic study of postcibal gastro-esophageal reflux and gastric emptying in infants with recurrent respiratory disease

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World Journal of Gastroenterology 2005年第46期11卷 7296-7301页

作者： Agostino di Ciaula Piero Portincasa Leonardo di Terlizzi domenico Paternostro Giuseppe Palasciano division of Internal MedicineHospital of Bisceglie Italy Section of Internal MedicineDepartment of Internal Medicine and Public Medicine(diMIMP) University Medical SchoolBariItaly division of PediatricsHospital of Bisceglie Italy

AIM: To check the utility of postcibal ultrasonography for the evaluation of reflux in relation to gastric emptying in infants with recurrent respiratory symptoms and to link imaging with clinical ***: Esophageal reflux (hyperechoic retrograde filling) and gastric emptying (antral areas) were quantified before and after ingestion of a standard formula in 35 untreated infants (13 with chronic cough,22 with recurrent bronchitis) and in 31 ***: The prevalence of abnormal (≥8 episodes)postcibal refluxes was 74% in patients and 3% in controls. Number, duration of the longest episode and extent of refluxes were significantly higher in patients compared to controls. Number of refluxes was higher in patients with symptomatic refluxes than in those *** with recurrent bronchitis had more refluxes than those with chronic cough and controls. Extent and timing of gastric emptying were similar in patients and ***: Esophageal ultrasonography is a useful and physiological test in infants with recurrent respiratory diseases, which have a high prevalence of abnormal postcibal esophageal reflux and a gastric emptying similar to that of normal controls. Esophageal reflux is more severe in subjects with recurrent bronchitis than in those with chronic cough.

关键词： Ultrasonography Gastm-esophageal reflux Gastric emptying Recurrent respiratory disease

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Intraepithelial lymphocytes: bystanders or causative factors in functional gastrointestinal disorders?

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Cellular & Molecular Immunology 2021年第7期18卷 1620-1621页

作者： Giuseppe Losurdo domenico Piscitelli Enzo Ierardi Alfredo di Leo Section of Gastroenterology Department of Emergency and Organ TransplantationUniversity of BariBariItaly Ph.D.Course in Organs and Tissues Transplantation and Cellular Therapies Department of Emergency and Organ TransplantationUniversity of BariBariItaly Section of Pathology Department of Emergency and Organ TransplantationUniversity of BariBariItaly

Intraepithelial lymphocytes(IELs)are immune cells located in the epithelium of the mucosal layer of the gastrointestinal tract that typically show a CD3-positive *** are T lymphocytes that are involved in the primary immune response to several luminal antigens,such as food proteins and infectious *** this reason,their increase may be pathogenetic in several diseases,the most important being celiac ***,an increase above 25 IELs/100 enterocytes in the duodenum,which is considered the cutoff value for celiac disease,may occur in several conditions,such as nonceliac gluten sensitivity,food allergy,Helicobacter pylori(***)infection,gastroenteritis,and even irritable bowel syndrome(IBS).Therefore,the generic term“microscopic enteritis”or“duodenal lymphocytosis”has been proposed for this condition.

关键词： lymphocytes gastrointestinal epithelium

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Drug-induced liver injury:Is it somehow foreseeable?

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World Journal of Gastroenterology 2009年第23期15卷 2817-2833页

作者： Giovanni Tarantino Matteo Nicola Dario di Minno domenico Capone Depart-ment of Clinical and Experimental Medicine Section of Hepa-tology in Internal Medicine Federico Ⅱ University Medical School of Naples 5 80131 Napoli Italy Department of Neurosciences Unit of Clinical Pharmacology Federico Ⅱ University Medical School of Naples 5 80131 Napoli Italy

The classic view on the pathogenesis of drug-induced liver injury is that the so-called parent compounds are made hepatotoxic by metabolism (formation of neosubstances that react abnormally), mainly by cytochromes P-450 (CYP), with further pathways, such as mitochondrial dysfunction and apoptosis, also playing a role. Risk factors for drug-induced liver injury include concomitant hepatic diseases, age and genetic polymorphisms of CYP. However, some susceptibility can today be predicted before drug administration, working on the common substrate, by phenotyping and genotyping studies and by taking in consideration patients' health status. Physicians should always think of this adverse effect in the absence of other clear hepatic disease. Ethical and legal problems towards operators in the health care system are always matters to consider.

关键词： Drug-induced liver injury CytochromeP-450 Drug metabolism Pharmacogenomics Herbalremedies

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Acute biliary pancreatitis and cholecystolithiasis in a child: one time treatment with laparoendoscopic "Rendez-vous" procedure

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World Journal of Gastroenterology 2006年第11期12卷 1782-1785页

作者： Gaetano La Greca Michele di Blasi Francesco Barbagallo Manuela di Stefano Saverio Latteri domenico Russello Department of Surgical Sciences Transplantation and Advanced Technologies University of Catania Cannizzaro HospitalVia Messina 829-95100CataniaItaly

Acute biliary pancreatitis （ABP） is rare in childhood and endoscopic sphincterotomy should be avoided in the child due to the risk of both early and late complications but, when necessary, the optimal timing between endoscopic procedure and cholecystectomy is still uncertain, A nine years old child with acute biliary pancreatitis underwent successfull laparo-endoscopic ＂Rendez-Vous＂ procedure in which endoscopic drainage of the common bile duct and laparoscopic cholecystectomy were performed simultaneously. This is the first case reported of laparo-endoscopic RendezoVous in a child. The excellent outcome of this patient and the review of the literature concerning other available options for the treatment of such cases suggest that this procedure offers great advantages, especially in children, of reducing the required number of treatments, the risk of ineffectiveness, the number of anaesthesia, the length of hospital stay and the risk of iatrogenic morbidity.

关键词： Acute biiiary pancreatitis Gallstones ERCP Laparoscopic cholecystectomy Endoscopic sphyncterotomy

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Legacy of neuropsychiatric symptoms associated with past COVID-19 infection:A cause of concern

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World Journal of Psychiatry 2022年第6期12卷 773-778页

作者： domenico De Berardis Francesco di Carlo Massimo di Giannantonio Mauro Pettorruso Mental Health NHSASL 4 TeramoTeramo 64100Italy Neurosciences and Imaging and Clinical Sciences University"G.D'Annunzio"Chieti 66100Italy

Although primarily affecting the respiratory system,growing attention is being paid to the neuropsychiatric consequences of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** and sub-acute neuropsychiatric manifestations of coronavirus disease 2019(COVID-19)disease and their mechanisms are better studied and understood currently than they had been when the pandemic began;however,many months or years will be necessary to fully comprehend how significant the consequences of such complications will *** this editorial,we discuss the possible long-term sequelae of the COVID-19 pandemic,deriving our considerations on experiences drawn from past coronaviruses’outbreaks,such as the SARS and the middle east respiratory syndrome,and from the knowledge of the mechanisms of neurotropism and invasiveness of *** the global spread of COVID-19 and the vast number of people affected,to date amounting to many millions,the matter of this pandemic’s neuropsychiatric legacy appears *** health monitoring strategies and early interventions seem to be necessary to manage the possible emergence of a severe wave of neuropsychiatric distress among the survivors.

关键词： COVID-19 Neuropsychiatric symptoms Neuropsychiatric sequelae Mental health Post-traumatic stress disorder Depression

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molecular pathology of intraductal papillary mucinous neoplasms of the pancreas

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World Journal of Gastroenterology 2014年第29期20卷 10008-10023页

作者： marina Paini Stefano Crippa Stefano Partelli Filippo Scopelliti domenico Tamburrino Andrea Baldoni Massimo Falconi Department of Surgery University of Verona division of Pancreatic Surgery Ospedali RiunitiUniversità Politecnica delle Marche division of Pancreatic Surgery Casa di Cura Dott.Pederzoli37019 Peschiera del Garda (VR)Italy

Since the first description of intraductal papillary mucinous neoplasms(IPMNs)of the pancreas in the eighties,their identification has dramatically increased in the last decades,hand to hand with the improvements in diagnostic imaging and sampling techniques for the study of pancreatic ***,the heterogeneity of IPMNs and their malignant potential make difficult the management of these *** objective of this review is to identify the molecular characteristics of IPMNs in order to recognize potential markers for the discrimination of more aggressive IPMNs requiring surgical resection from benign IPMNs that could be *** briefly summarize recent research findings on the genetics and epigenetics of intraductal papillary mucinous neoplasms,identifying some genes,molecular mechanisms and cellular signaling pathways correlated to the pathogenesis of IPMNs and their progression to *** knowledge of molecular biology of IPMNs has impressively developed over the last few years.A great amount of genes functioning as oncogenes or tumor suppressor genes have been identified,in pancreatic juice or in blood or in the samples from the pancreatic resections,but further researches are required to use these informations for clinical intent,in order to better define the natural history of these diseases and to improve their management.

关键词： Intraductal papillary mucinous neoplasm Pancreas Pancreatic cancer Molecular pathology Oncogene Tumor suppressor gene Dysplasia Malignant transformation

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