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BIOCELL 2022年第1期46卷 37-49页

作者： MAURA BENEDETTI MARIA ELISA GIULIANI marica mezzelani ALESSANDRO NARDI LUCIA PITTURA STEFANIA GORBI FRANCESCO REGOLI Dipartimento di Scienze della Vitaedell’Ambiente UniversitàPolitecnica delle MarcheAncona60131Italy

Oxidative stress is a critial condition derived from the imbalance between the genention of reactive oxygen species and the sophisticated network of antioidant *** pollut ants and envronmental factors can afet this system through connected mechanisms,indirect relationships,and cascade effects from pre-transcriptional to catalytic level,by either enhancing intracellular ROS formation or impairing antioxidant *** review summariaces the current kmnowledge on the pro oxidant challenges from emerging environmental stressors threatening marine organisms,such as pharmaceutials microplastics and dimate related ocean *** will be placed on oxidative pathways,including signaling proteins and transcription factors involved in regulation of antioxidant *** insights and lack of knowdedge will be pointed out by presenting single and combined efects of multiple stessors,unraveling questions to be adresed by future resarch in marine ectoicology.

关键词： Antioxidant Pharmaceuticals Microplastics/Nanoplastics Ocean acidification Thermal stress

Inhibition of host immune response in colorectal cancer:Human leukocyte antigen-G and beyond

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World Journal of Gastroenterology 2014年第14期20卷 3778-3794页

作者： marica Garziera Giuseppe Toffoli Experimental and Clinical Pharmacology Unit CRO Aviano National Cancer Institute 33081 Aviano Italy

Colorectal cancer (CRC) is one of the most diffuse cancers worldwide and is still a clinical burden. Increasing evidences associate CRC clinical outcome to immune contexture represented by adaptive immune cells. Their type, density and location are summarized in the Immune Score that has been shown to improve prognostic prediction of CRC patients. The non-classical MHC class I human leukocyte antigen-G (HLA-G), is a crucial tumor-driven immune escape molecule involved in immune tolerance. HLA-G and soluble counterparts are able to exert inhibitory functions by direct interactions with inhibitory receptors present on both innate cells such as natural killer cells, and adaptive immune cells as cytotoxic T and B lymphocytes. HLA-G may play a prominent role in CRC strategies to avoid host immunosurveillance. This review highlights the current knowledge on HLA-G contribution in CRC, in related inflammatory diseases and in other type of cancers and disorders. HLA-G genetic setting (specific haplotypes, genotypes and alleles frequencies) and association with circulating/soluble profiles was highlighted. HLA G prognostic and predictive value in CRC was investigated in order to define a novel prognostic immune biomarker in CRC.

关键词： Colorectal cancer Human leukocyte antigen-G Immune score T lymphocytes Untranslated regions

Significance of bilayer-forming phospholipids for skeletal muscle insulin sensitivity and mitochondrial function

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The Journal of Biomedical Research 2020年第1期34卷 1-13页

作者： Sophie Grapentine marica Bakovic Department of Human Health and Nutritional Sciences University of GuelphGuelphOntario N1G2W1Canada

Phosphatidylcholine(PC) and phosphatidylethanolamine(PE), which make up the bulk of mammalian cell membrane phospholipids, are recognized for their importance in metabolic health. Perturbations in the ratio of PC:PE can affect membrane integrity and function, which thus have serious health consequences. Imbalance in the hepatic PC and PE membrane content can be linked to metabolic disturbances such as ER stress, fatty liver and insulin resistance. Given that impaired insulin sensitivity underlies the pathology of many metabolic disorders and skeletal muscle is a significant regulator of energy metabolism, it is likely that aberrant phospholipid metabolism in skeletal muscle affects whole-body insulin sensitivity. Sarco/endoplasmic reticulum Ca^(2+) ATPase(SERCA) activity and mitochondrial function respond to alterations in PC:PE ratio and are associated with glucose homeostasis. Moreover, PC and PE content within the mitochondrial membrane influence mitochondrial respiration and biogenesis and thus, metabolic function. As skeletal muscle phospholipids respond to stimuli such as diet and exercise, understanding the implications of imbalances in PC:PE ratio is of great importance in the face of the rising epidemic of obesity related diseases. This review will summarize the current state of knowledge signifying the links between skeletal muscle PC:PE ratio and insulin sensitivity with respects to PC and PE metabolism, SERCA activity, mitochondrial function and exercise.

关键词： phospholipids membranes skeletal muscle insulin resistance mitochondria

Aspergillus niger prolyl endopeptidase in celiac disease

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World Journal of Gastroenterology 2024年第24期30卷 3044-3047页

作者： marica Colella Concetta Cafiero Raffaele Palmirotta Interdisciplinary Department of Medicine Section of Microbiology and VirologyUniversity of Bari“Aldo Moro”Bari 70124Italy Area of Molecular Pathology Anatomic Pathology UnitFabrizio Spaziani HospitalFrosinone 03100Italy

We comment here on the article by Stefanolo et al entitled“Effect of Aspergillus niger prolyl endopeptidase in patients with celiac disease on a long-term gluten-free diet”,published in the World Journal of *** disease is a well-recognized systemic autoimmune *** genetically susceptible people,the most evident damage is located in the small intestine,and is caused and worsened by the ingestion of *** that reason,celiac patients adopt a gluten-free diet(GFD),but it has some limitations,and it does not prevent re-exposure to *** aims to develop adjuvant therapies,and one of the most studied alternatives is supplementation with Aspergillus niger prolyl endopeptidase protease(AN-PEP),which is able to degrade gluten in the stomach,reducing its concentration in the small *** study found a high adherence to the GFD,but did not address AN-PEP as a gluten immunogenic peptide reducer,as it was only tested in patients following a GFD and not in gluten-exposing *** study opens up new research perspectives in this area and shows that further study is needed to clarify the points that are still in doubt.

关键词： Celiac disease Aspergillus niger prolyl endoprotease Gluten immunogenic peptides Trial Symptoms Real-life trial

Frequent Applications of Organic Matter to Agricultural Soil Increase Fungistasis

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Pedosphere 2017年第1期27卷 86-95页

作者： Giuliano BONANOMI Salvatore A. GAGLIONE Gaspare CESARANO Tushar C. SARKER marica PASCALE Felice SCALA Astolfo ZOINA Dipartimento di Agraria Universita di Napoli Federico II via Universit& 100 80055 Portici (Italy) CNR-Istituto per la Protezione Sostenibile delle Piante via Universiffz 133 80055 Portici (Italy)

Soil-borne plant pathogens are among the most important limiting factors for the productivity of agro-ecosystems. Fungistasis is the natural capability of soils to inhibit the germination and growth of soil-borne fungi in the presence of optimal abiotic conditions. The objective of this study was to assess the effects of different soil managements, in terms of soil amendment types and frequency of application, on fungistasis. For this purpose, a microcosm experiment was performed by conditioning a soil with frequent applications of organic matter with contrasting biochemical quality （i. e., glucose, alfalfa straw and wheat straw）. Thereafter, the fungistasis response was assessed on four fungi （Aspergillus niger, Botrytis cinerea, Pyrenoehaeta lycopersici and Trichoderma harzianum）. Conditioned soils were characterized by measuring microbial activity （soil respiration） and functional diversity using the BIOLOG EcoPlatesTM method. Results showed that irrespective of the fungal species and amendment types, frequent applications of organic matter reduced fungistasis relief and shortened the time required for fungistasis restoration. The frequent addition of easily decomposable organic compounds enhanced soil respiration and its specific catabolic capabilities. This study demonstrated that frequent applications of organic matter affected soil fungistasis likely as a result of higher microbial activity and functional diversity.

关键词： biological control disease suppression microbial activity microbial functional diversity organic C soil-borne pathogens

Microbiota revolution:How gut microbes regulate our lives

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World Journal of Gastroenterology 2023年第28期29卷 4368-4383页

作者： marica Colella Ioannis Alexandros Charitos Andrea Ballini Concetta Cafiero Skender Topi Raffaele Palmirotta Luigi Santacroce Interdisciplinary Department of Medicine Section of Microbiology and VirologyUniversity of Bari“Aldo Moro”Bari 70124Italy Maugeri Clinical Scientific Research Institutes(IRCCS)of Pavia-Division of Pneumology and Respiratory Rehabilitation Scientific Institute of BariBari 70124Italy Department of Clinical and Experimental Medicine University of FoggiaFoggia 71122Italy Department of Precision Medicine University of Campania“Luigi Vanvitelli”Naples 80138Italy Area of Molecular Pathology Anatomic Pathology UnitFabrizio Spaziani HospitalFrosinone 03100Italy Department of Clinical Disciplines School of Technical Medical SciencesUniversity of Elbasan“A.Xhuvani”Elbasan 3001Albania

The human intestine is a natural environment ecosystem of a complex of diversified and dynamic microorganisms,determined through a process of competition and natural selection during *** intestinal microorganisms called microbiota and are involved in a variety of mechanisms of the organism,they interact with the host and therefore are in contact with the organs of the various ***,they play a crucial role in maintaining host homeostasis,also influencing its ***,microorganisms perform a series of biological functions important for human *** host provides the microorganisms with the environment and nutrients,simultaneously drawing many benefits such as their contribution to metabolic,trophic,immunological,and other *** these reasons it has been reported that its quantitative and qualitative composition can play a protective or harmful role on the host ***,a dysbiosis can lead to an association of unfavourable factors which lead to a dysregulation of the physiological processes of ***,it has previously noted that the gut microbiota can participate in the pathogenesis of autoimmune diseases,chronic intestinal inflammation,diabetes mellitus,obesity and atherosclerosis,neurological disorders(e.g.,neurological diseases,autism,etc.)colorectal cancer,and more.

关键词： Microbiology Human microbiota Intestinal microbiota Immune system Metabolites Dysbiosis Probiotics Diseases Cancer

Presentation, patterns and predictive value of baseline liver tests on outcomes in COVID-19 patients without chronic liver disease

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World Journal of Gastroenterology 2021年第42期27卷 7350-7361页

作者： David Bernstein Nitzan Roth Angela Kim marica Epstein David Hirschwerk Charlotte L Kvasnovsky Sanjaya K Satapathy Department of Medicine/Hepatology Northwell HealthZucker School of Medicine at Hofstra/NorthwellManhassetNY 11030United States Division of Infectious Diseases Department of Medicine Northwell HealthZucker School of Medicine at Hofstra/NorthwellManhassetNY 11030United States Cohen Children's Medical Center Zucker School of Medicine at Hofstra/NorthwellNew Hyde ParkNY 11042United States

BACKGROUND Coronavirus disease 2019(COVID-19)infection is known to cause abnormal hepatic *** long term consequences of such elevations are *** To assessed the prevalence and prognostic value of initial liver enzymes in a large cohort of COVID-19 *** We reviewed electronic medical records of 10614 COVID-19 patients without known chronic liver disease who were admitted to our health system from March 1,2020,to April 30,*** analyzed baseline demographics and liver *** primary outcome was in-hospital mortality,and the secondary outcome was a composite of in-hospital mortality or need for mechanical *** Subjects with abnormal liver tests had increased risks of mortality and composite outcome when compared to patients with normal measurements on unadjusted analysis and after adjustment for demographic *** In our diverse patient population,liver enzyme abnormalities are associated with increased mortality and the need for mechanical ventilation in subjects without chronic liver *** patients are at the greatest risk for poor outcomes.

关键词： COVID-19 Liver enzymes Outcomes Predictors

Salivary biomarkers: novel noninvasive tools to diagnose chronic inflammation

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International Journal of Oral Science 2023年第2期15卷 229-240页

作者： Paola Dongiovanni marica Meroni Sara Casati Riccardo Goldoni Douglas Vieira Thomaz Nermin Seda Kehr Daniela Galimberti Massimo Del Fabbro Gianluca MTartaglia Medicine and Metabolic Diseases Fondazione IRCCS CàGranda Ospedale Maggiore Policlinico Department of Biomedical Surgical and Dental SciencesUniversity of Milan Department of Electronics Information and Bioengineering(DEIB) Istituto di Elettronica e di Ingegneria dell'Informazione e delle Telecomunicazioni CNR Laboratory of Medicinal Pharmaceutical Chemistry Faculty of PharmacyFederal University of Goiás Department of Chemistry ?zmir Institute of TechnologyGülbah?e Kampüsü Neurology-Neurodegenerative Diseases Fondazione IRCCS CàGrandaOspedale Maggiore Policlinico UOC Maxillo-Facial Surgery and Dentistry Fondazione IRCCS CàGranda Ospedale Maggiore Policlinico

Several chronic disorders including type 2 diabetes(T2D),obesity,heart disease and cancer are preceded by a state of chronic lowgrade *** for the early assessment of chronic disorders encompass acute phase proteins(APP),cytokines and chemokines,pro-inflammatory enzymes,lipids and oxidative stress *** substances enter saliva through the blood flow and,in some cases。

关键词： inflammation acute chronic

Old-fashioned and newly discovered biomarkers:the future of NAFLD-related HCC screening and monitoring

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Hepatoma Research 2022年第1期8卷 415-434页

作者： Roberto Piciotti Miriam Longo Adele Agresta Erika Paolini Annalisa Cespiati marica Meroni Paola Dongiovanni General Medicine and Metabolic Diseases Fondazione IRCCS Ca’Granda Ospedale Maggiore PoliclinicoMilan 20122Italy Department of Pathophysiology and Transplantation Universitàdegli Studi di MilanoMilano 20122Italy Department of Clinical Sciences and Community Health Universitàdegli Studi di MilanoMilano 20122Italy Department of Pharmacological and Biomolecular Sciences Universitàdegli Studi di MilanoMilano 20133Italy

Nonalcoholic fatty liver disease(NAFLD)is the major contributor to the global burden of chronic liver diseases and ranges from simple and reversible steatosis to nonalcoholic steatohepatitis(NASH),which may progress into cirrhosis and hepatocellular carcinoma(HCC).HCC represents the most common liver cancer,and it is a leading cause of death worldwide with an increasing trend for the *** to late diagnosis,non-responsiveness to systemic therapy,and high cancer heterogeneity,the treatment of this malignancy is *** date,liver biopsy and ultrasound(US)are the gold standard procedures for HCC diagnosis and surveillance,although they are not suitable for mass ***,it is impelling to find new,less invasive diagnostic strategies able to detect HCC at an early stage as well as monitor tumor progression and *** and rare inherited variations that boost the switching from NASH to liver cancer may help to predict tumor ***,epigenetic changes which reflect intertumoral heterogeneity occur early in tumorigenesis and are highly stable under pathologic *** severity of hepatic injuries can be detected through the analysis of cell circulating tumor DNAs(ctDNAs),microRNAs(miRNAs),and noncoding RNAs(ncRNAs),which are involved in several pathological processes that feature cancer,including cell growth,survival,and differentiation,thus representing appealing biomarkers for ***,this review discusses the current options for HCC surveillance,focusing on the role of genetic and epigenetic biomarkers as new strategies to refine HCC management.

关键词： NAFLD-HCC screening genetic biomarkers ncRNAs epigenetics early HCC detection

Role of high-dose amoxicillin dual therapy for Helicobacter pylori eradication in an Irish cohort:A prospective study

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World Journal of Clinical Cases 2024年第35期12卷 6859-6863页

作者： Raffaele Palmirotta Concetta Cafiero marica Colella Interdisciplinary Department of Medicine University of Bari“Aldo Moro”Bari 70124Italy Area of Molecular Pathology Anatomic Pathology UnitFabrizio Spaziani HospitalFrosinone 03100Italy

Helicobacter pylori(***)infections may cause chronic gastritis,peptic ulcer disease,gastric cancers,and other conditions outside of the gastrointestinal ***,it is important to diagnose and treat it *** is resistant to certain drugs in traditional eradication therapy,so alternative therapy protocols are needed,such as high-dose amoxicillin dual therapy(HDADT).This article aims to comment on a recent paper by Costigan et al in the World Journal of Clinical *** this study,the authors recruited 139 patients diagnosed with ***,all treated with *** these,93 were treatment-naïve and 46 had received at least one alternative treatment in the *** weeks after the end of the treatment,the urea breath test was administered to estimate the eradication *** total eradication rate was 56%(78/139),62%for the treatment-naïve arm and 43%for the previous treatment arm,thus indicating a lower success rate for the arm that had previously received a different treatment *** conclusion,a therapeutic approach with first-line HDADT may potentially be a better treat-ment,but the results are not sufficient to recommend the use of this regimen in a country with high levels of dual resistance.

关键词： Helicobacter pylori Helicobacter pylori eradication High dose amoxicillin High dose amoxicillin dual therapy Triple therapy