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QUANTITATIVE EVALUATION OF RETINAL TUMOR VOLUME IN MOUSE MODEL OF RETINOBLASTOMA BY USING ULTRA HIGH-RESOLUTION OPTICAL COHERENCE TOMOGRAPHY

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Journal of Innovative Optical Health Sciences 2008年第1期1卷 17-28页

作者： marco ruggeri HASSAN WEHBE GAVRIIL TSECHPENAKIS SHULIANG JIAO MARIA ELENA JOCKOVICH COLLEEN CEBULLA ELEUT HERNANDEZ TIMOTHY G.MURRA CARMEN A.PULIAFITO Bascom Palmer Eye Institute University of Miami Miller School of Medicine 1638 NW 10th Ave.Miami FL 33136USA Electrical and Computer Engineering Department University of Miami 1251 Memorial Dr Coral GablesFL 33124USA

An ultra high resolution spectral-domain optical coherence tomography(SD-OCT)together with an advanced animal restraint and positioning system was built for noninvasive non-contact in vivo three-dimensional imaging of rodent models of ocular *** animal positioning system allowed the operator to rapidly locate and switch the areas of interest on the *** function together with the capability of precise spatial registration provided by the generated OCT fundus image allows the system to locate and compare the same lesion(retinal tumor in the current study)at different time point throughout the entire course of the disease *** algorithm for fully automatic segmentation of the tumor boundaries and calculation of tumor volume was *** system and algorithm were successfully applied to monitoring retinal tumor growth quantitatively over time in the LHBETATAG mouse model of retinoblastoma.

关键词： 3D imaging retina mouse models optical coherence tomography image segmentation

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Liver magnetic resonance imaging for evaluation of response to treatment after stereotactic body radiation therapy of hepatocellular carcinoma

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World Journal of Hepatology 2022年第9期14卷 1790-1803页

作者： Alessandro Serafini Valeria ruggeri Riccardo Inchingolo marco Gatti Alessia Guarneri Cesare Maino Davide Ippolito Luigi Grazioli Umberto Ricardi Riccardo Faletti Department of Surgical Sciences University of TurinTurin 10126Italy Department of Radiology University of BresciaBrescia 25123Italy Interventional Radiology Unit Miulli HospitalAcquaviva Delle Fonti 70124Italy Department of Oncology-Radiation Oncology University of TurinTurin 10126Italy Department of Diagnostic Radiology University of Milano-BicoccaMonza 20900Italy Department of Radiology Spedali CiviliUniversity of BresciaBrescia 25023Italy

BACKGROUND Although stereotactic body radiation therapy(SBRT)is increasingly used,its application has not yet been regulated by the main international guidelines,leaving the decision to multidisciplinary *** To assess magnetic resonance imaging(MRI)features of hepatocellular carcinoma(HCC)treated with SBRT,highlighting the efficacy of the treatment and the main aspects of the lesion before and after the *** As part of a retrospective study,49 patients who underwent SBRT for HCC between January 2013 and November 2019 were *** patient under went a pre-treatment MRI examination with a hepatospecific contrast agent and a similar followup examination within 6 mo of *** addition,22 patients underwent a second follow-up examination after the first 6 *** following characteristics were analysed:Features analysed compared to pre-treatment MRI examination,presence or absence of infield and outfield progression,ring-like enhancement,signal hyperintensity in T2-weighted sequences in the perilesional parenchyma,capsular retraction,and"band"signal hypointensity in T1-weighted gradient echo fat saturated sequences obtained during hepatobiliary *** Signal hyperintensity in the T2-weighted sequences showed a statistically significant reduction in the number of lesions at the post-SBRT first control(P=0.0006).Signal hyperintensity in diffusionweighted imaging-weighted sequences was decreased at MRI first control(P<0.0001).A statistically significant increase of apparent diffusion coefficient values from a median of 1.01 to 1.38 at the first post-control was found(P<0.0001).Capsular retraction was increased at the late evaluation(P=0.006).Band-like signal hypointensity in the hepatobiliary phase was present in 94%at the late control(P=0.006).The study of the risk of outfield progression vs infield progression revealed a hazard ratio of *** The efficacy of SBRT should be evaluated not in the first 6 mo,but at least 9 mo pos

关键词： Hepatocellular carcinoma Stereotactic body radiation therapy Magnetic resonance imaging Histopatology Outcome Radiology

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