QUANTITATIVE EVALUATION OF RETINAL TUMOR VOLUME IN MOUSE MODEL OF RETINOBLASTOMA BY USING ULTRA HIGH-RESOLUTION OPTICAL COHERENCE TOMOGRAPHY
作者机构:Bascom Palmer Eye Institute University of Miami Miller School of Medicine 1638 NW 10th Ave.MiamiFL 33136USA Electrical and Computer Engineering Department University of Miami1251 Memorial Dr Coral GablesFL 33124USA
出 版 物:《Journal of Innovative Optical Health Sciences》 (创新光学健康科学杂志(英文))
年 卷 期:2008年第1卷第1期
页 面:17-28页
核心收录:
学科分类:1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金:supported in part by the NIH(NEI grant R01 EY01629) the NEI P30 Core Grant Ey014801 and U.S.Army Medical Research and Materiel Command(USAMRMC)grant W81XWH-07-1-0188
主 题:3D imaging retina mouse models optical coherence tomography image segmentation
摘 要:An ultra high resolution spectral-domain optical coherence tomography(SD-OCT)together with an advanced animal restraint and positioning system was built for noninvasive non-contact in vivo three-dimensional imaging of rodent models of ocular *** animal positioning system allowed the operator to rapidly locate and switch the areas of interest on the *** function together with the capability of precise spatial registration provided by the generated OCT fundus image allows the system to locate and compare the same lesion(retinal tumor in the current study)at different time point throughout the entire course of the disease *** algorithm for fully automatic segmentation of the tumor boundaries and calculation of tumor volume was *** system and algorithm were successfully applied to monitoring retinal tumor growth quantitatively over time in the LHBETATAG mouse model of retinoblastoma.