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Outcome of COVID-19 infection in patients on antihypertensives:A cross-sectional study

World Journal of Critical Care Medicine 2024年第3期13卷 42-52页

作者： Sakthivadivel Varatharajan Gopal K Bohra Pradeep K Bhatia Satyendra Khichar mahadev Meena Naveenraj Palanisamy Archana Gaur Mahendra K Garg Department of General Medicine All India Institute of Medical Sciences-BibinagarHyderabad 508126TelanganaIndia Department of General Medicine All India Institute of Medical SciencesJodhpur 342005RajasthanIndia Department of Anaesthesiology and Critical Care All India Institute of Medical SciencesJodhpur 342005RajasthanIndia Department of General Medicine All India Institute of Medical SciencesBhopal 462020Madhya PradeshIndia Department of General Medicine ESIC Medical College&HospitalChennai 600021TamilnaduIndia Department of Physiology All India Institute of Medical Sciences-BibinagarHyderabad 508126TelanganaIndia Department of Endocrinology&Metabolism All India Institute of Medical SciencesJodhpur 342005RajasthanIndia

BACKGROUND Patients with coronavirus disease 2019(COVID-19)infection frequently have hypertension as a co-morbidity,which is linked to adverse *** may affect the outcome of COVID-19 *** To assess the effects of antihypertensive agents on the outcomes of COVID-19 *** A total of 260 patients were included,and their demographic data and clinical profile were *** patients were categorized into nonhypertensive,angiotensin-converting enzyme inhibitor/angiotensin receptor blocker(ACEI/ARB),calcium channel blocker(CCB),a combination of ACEI/ARB and CCB,and beta-blocker ***,hematological,and inflammatory markers were *** severity of infection,intensive care unit(ICU)intervention,and outcome were *** The mean age of patients was approximately 60-years-old in all groups,except the nonhypertensive *** were predominant in all *** was the most common presenting *** respiratory distress syndrome was the most common complication,and was mostly found in the CCB *** cases,ICU intervention,and mortality were also higher in the CCB *** logistic regression analysis revealed that age,duration of antihypertensive therapy,erythrocyte sedimentation rate,high-sensitivity C-reactive protein,and interleukin 6 were significantly associated with *** duration of antihypertensive therapy exhibited a sensitivity of 70.8%and specificity of 55.7%,with a cut-off value of 4.5 years and an area under the curve of 0.670(0.574-0.767;95%confidence interval)for COVID-19 *** The type of antihypertensive medication has no impact on the clinical sequence or mortality of patients with COVID-19 ***,the duration of antihypertensive therapy is associated with poor outcomes.

关键词： Antihypertensive COVID-19 Hypertension Mortality Outcome

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Current innovations and future prospects of metal oxide electrospun materials for supercapacitor technology:A review

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Journal of Materials Science & Technology 2023年第35期166卷 208-233页

作者： Sonali Ajay Beknalkar Aviraj mahadev Teli Jae Cheol Shin Division of Electronics and Electrical Engineering Dongguk University-Seoul30Pildong-roJung-guSeoul 04620South Korea

Metal oxides with one-dimensional(1-D)nanostructures have shown promise as electrode materials for supercapacitors due to their unique properties,such as high aspect ratio,increased interaction between electrode and electrolyte,favourable mechanical strength,and short ion transportation pathways that im-prove the charge-discharge rates of electrons and *** is an effective technique for cre-ating 1-D metal oxide nanostructures that produce highly porous nanofibrous structures with exceptional specific surface areas,predictable pore size distributions,and tunable interconnected *** paper provides a comprehensive review of the literature on electrospun metal oxide nanostructures for superca-pacitors,including the principles and key parameters of electrospinning,an overview of supercapacitors,the charge storage mechanism of electrospun metal oxides,and recent developments in 1-D electrospun nanostructures,from binary to ternary metal *** review also discusses unresolved issues and future directions in this research ***,this paper offers valuable insights into the latest devel-opments,unresolved issues,and prospects of 1-D nanostructured metal oxides fabricated through elec-trospinning for supercapacitor applications,providing a critical analysis of their potential in this rapidly evolving field.

关键词： Electrospinning Supercapacitor Metal oxides New strategies Nanofibers

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Life cycle environmental impact assessment of biochar-based bioenergy production and utilization in Northwestern Ontario,Canada

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Journal of Forestry Research 2015年第4期26卷 799-809页

作者： Krish Homagain Chander Shahi Nancy Luckai mahadev Sharma Faculty of Natural Resources Management Lakehead University Ontario Forest Research Institute

Biochar-based bioenergy production and sub- sequent land application of biochar can reduce greenhouse gas emissions by fixing atmospheric carbon into the soil for a long period of time. A thorough life cycle assessment of biochar-based bioenergy production and biochar land application in Northwestern Ontario is conducted using SimaPro Ver. 8.1. The results of energy consumption and potential environmental impact of biochar-based bioenergy production system are compared with those of conventional coal-based system. Results show that biocbar land application consumes 4847.61 MJ per tonne dry feedstock more energy than conventional system, but reduces the GHG emissions by 68.19 kg CO2e per tonne of dry feed- stock in its life cycle. Biochar land application improves ecosystem quality by 18 %, reduces climate change by 15 %, and resource use by 13 % but may adversely impact on human health by increasing disability adjusted life years by 1.7 % if biomass availability is low to medium. Replacing fossil fuel with woody biomass has a positiveimpact on the environment, as one tonne of dry biomass feedstock when converted to biochar reduces up to 38 kg CO2e with biochar land application despite using more energy. These results will help understand a comprehensive picture of the new interventions in forestry businesses, which are promoting biochar-based bioenergy production.

关键词： Woody biomass Carbon sequestration Environmental impact assessment Greenhouse gasemissions Life cycle analysis Soil amendment

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Life cycle cost and economic assessment of biochar-based bioenergy production and biochar land application in Northwestern Ontario, Canada

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Forest Ecosystems 2017年第1期4卷 12-21页

作者： Krish Homagain Chander Shahi Nancy Luckai mahadev Sharma Faculty of Natural Resources Management Lakehead University 955 Oliver Rd. Thunder Bay ON P7B 5E1 Canada Ontario Forest Research Institute 1235 Queen Street E Sault Ste. Marie ON P6A 2E5 Canada.

Background： Replacement of fossil fuel based energy with biochar-based bioenergy production can help reduce greenhouse gas emissions while mitigating the adverse impacts of climate change and global warming. However, the production of biochar-based bioenergy depends on a sustainable supply of biomass. Although, Northwestern Ontario has a rich and sustainable supply of woody biomass, a comprehensive life cycle cost and economic assessment of biochar-based bioenergy production technology has not been done so far in the region. Methods： In this paper, we conducted a thorough life cycle cost assessment （LCCA） of biochar-based bioenergy production and its land application under four different scenarios： 1） biochar production with low feedstock availability; 2） biochar production with high feedstock availability; 3） biochar production with low feedstock availability and its land application; and 4） biochar production with high feedstock availability and its land applicationusing SimaPro, EIOLCA software and spreadsheet modeling. Based on the LCCA results, we further conducted an economic assessment for the break-even and viability of this technology over the project period. Results： It was found that the economic viability of biochar-based bioenergy production system within the life cycle analysis system boundary based on study assumptions is directly dependent on costs of pyrolysis, feedstock processing （drying, grinding and pelletization） and collection on site and the value of total carbon offset provided by the system. Sensitivity analysis of transportation distance and different values of C offset showed that the system is profitable in case of high biomass availability within 200 km and when the cost of carbon sequestration exceeds CAD S60 per tonne of equivalent carbon （CO2e）. Conclusions： Biochar-based bioenergy system is economically viable when life cycle costs and environmental assumptions are accounted for. This study provides a medium scale slow-pyrolysis pla

关键词： LCA LCCA SimaPro Biochar Biomass Pyrolysis Bioenergy Wood Pellets

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Biochar-based bioenergy and its environmental impact in Northwestern Ontario Canada: A review

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Journal of Forestry Research 2014年第4期25卷 737-748页

作者： Krish Homagain Chander Shahi Nancy Luckai mahadev Sharma Faculty of Natural Resources Management Lakehead University 955 Oliver Road Thunder Bay ON Canada P7B 5E1 Ministry of Natural Resources Ontario Forest Research Institute (OFRI) 1235 Queen St E Sault Ste. Marie ON Canada P6A 2E5

Biochar is normally produced as a by-product of bioenergy. However, if biochar is produced as a co-product with bioenergy from sustainably managed forests and used for soil amendment, it could pro- vide a carbon neutral or even carbon negative solution for current envi- ronmental degradation problems. In this paper, we present a comprehen- sive review of biochar production as a co-product of bioenergy and its implications. We focus on biochar production with reference to biomass availability and sustainability and on bioehar utilization for its soil amendment and greenhouse gas emissions reduction properties. Past studies confirm that northwestern Ontario has a sustainable and sufficient supply of biomass feedstock that can be used to produce bioenergy, with biochar as a co-product that can replace fossil fuel consumption, increase soil productivity and sequester carbon in the long run. For the next step, we recommend that comprehensive life cycle assessment of bio- char-based bioenergy production, from raw material collection to bioehar application, with an extensive economic assessment is necessary for making this technology commercially viable in northwestern Ontario.

关键词： biomass life cycle assessment, LCA C02 carbon sequestra-tion greenhouse gas emissions soil amendment

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CRISPR-Mediated Engineering across the Central Dogma in Plant Biology for Basic Research and Crop Improvement

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Molecular Plant 2021年第1期14卷 127-150页

作者： Dibyajyoti Pramanik Rahul mahadev Shelake Mi Jung Kim Jae-Yean Kim Division of Applied Life Science(BK21 Four Program) Plant Molecular Biology and Biotechnology Research CenterGyeongsang National UniversityJinju 52828Korea These authors contributed equally to this article

The central dogma(CD)of molecular biology is the transfer of genetic information from DNA to RNA to *** CD processes governing genetic flow include the cell cycle,DNA replication,chromosome packaging,epigenetic changes,transcription,posttranscriptional alterations,translation,and posttranslational *** CD processes are tightly regulated in plants to maintain genetic integrity throughout the life cycle and to pass genetic materials to next *** of various CD processes involved in gene regulation will accelerate crop improvement to feed the growing world *** technology enables programmable editing of CD processes to alter DNA,RNA,or protein,which would have been impossible in the ***,an overview of recent advancements in CRISPR tool development and CRISPR-based CD modulations that expedite basic and applied plant research is ***,CRISPR applications in major thriving areas of research,such as gene discovery(allele mining and cryptic gene activation),introgression(de novo domestication and haploid induction),and application of desired traits beneficial to farmers or consumers(biotic/abiotic stress-resilient crops,plant cell factories,and delayed senescence),are ***,the global regulatory policies,challenges,and prospects for CRISPR-mediated crop improvement are discussed.

关键词： central dogma CRISPR crop improvement gene regulation genome editing

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Multiresidue pesticide analysis in tomato using GC-MS/MS using modified QuEChERS method with titanium-coated graphite with CNT-ABS nanocomposite as dispersive solid-phase extraction materials

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Food Quality and Safety 2022年第4期6卷 608-618页

作者： mahadev C.Khetagoudar G.T.Deepa P.T.Goroji mahadev B.Chetti Avvaru Praveen Kumar Dinesh C.Bilehal University of Agricultural Sciences DharwadKarnatakaIndia Department of Applied Chemistry School of Applied Natural ScienceAdama Science and Technology UniversityAdamaEthiopia Department of Chemistry Karnatak UniversityDharwadKarnatakaIndia

The presence of pesticide residues in food and vegetables is a growing concern for *** monitor these residues reliably,a selective and sensitive multiresidue system has been developed and validated in tomato by gas chromatography–tandem mass spectrometry(GC-MS/MS).Titanium-coated graphite with carbon nanotube(CNT)in acrylonitrile–butadiene–styrene(ABS)used as reversed-dispersive solid-phase extraction materials with modified QuEChERS(Quick,Easy,Cheap,Effective,Rugged,and Safe)***-coated graphite with CNT-ABS is synthesized,characterized by X-ray diffraction and scanning electron *** clean-up performance of titanium-coated graphite with CNT-ABS was demonstrated to be better to primary secondary amine and graphitized carbon black *** processing of two multiple reaction monitoring transformations for each analyte is done using GC-MS/MS in electron impact *** purification and recovery effects(74%–100%)of 35 pesticides were achieved in tomato matrices when using 5 mg of titanium-coated graphite ABS-CNT *** was observed that quinolphos and deltamethrin are present above the maximum residue *** technique proved to be reliable and sensitive in tomato samples for the routine testing of 35 pesticides.

关键词： Gas chromatography-tandem mass spectrometry pesticide residue analysis multiple reaction monitoring QuEChERS titanium-coated graphite with CNT-ABS nanocomposite

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Prediction modelling in the early detection of neonatal sepsis

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World Journal of Pediatrics 2022年第3期18卷 160-175页

作者： Puspita Sahu Elstin Anbu Raj Stanly Leslie Edward Simon Lewis Krishnananda Prabhu mahadev Rao Vijayanarayana Kunhikatta Department of Pharmacy Practice Manipal College of Pharmaceutical SciencesManipal Academy of Higher Education(MAHE)Manipal 576104KarnatakaIndia Department of Paediatrics Kasturba Medical CollegeManipal Academy of Higher Education(MAHE)ManipalKarnatakaIndia 576104 Department of Biochemistry Kasturba Medical CollegeManipal Academy of Higher Education(MAHE)ManipalKarnatakaIndia 576104

Background Prediction modelling can greatly assist the health-care professionals in the management of diseases,thus sparking interest in neonatal sepsis *** main objective of the study was to provide a complete picture of performance of prediction models for early detection of neonatal *** PubMed,Scopus,CINAHL databases were searched and articles which used various prediction modelling measures for the early detection of neonatal sepsis were *** extraction was carried out based on Critical Appraisal and Data Extraction for Systematic Reviews of Prediction Modelling Studies *** data consisted of objective,study design,patient characteristics,type of statistical model,predictors,outcome,sample size and *** model Risk of Bias Assessment Tool was applied to gauge the risk of bias of the *** An aggregate of ten studies were included in the review among which eight studies had applied logistic regression to build a prediction model,while the remaining two had applied artificial *** predictors like neonatal fever,birth weight,foetal morbidity and gender,cervicovaginitis and maternal age were identified for the early detection of neonatal ***,birth weight,endotracheal intubation,thyroid hypofunction and umbilical venous catheter were promising factors for predicting late-onset sepsis;while gestational age,intrapartum temperature and antibiotics treatment were utilised as budding prognosticators for early-onset sepsis *** Prediction modelling approaches were able to recognise promising maternal,neonatal and laboratory predictors in the rapid detection of early and late neonatal sepsis and thus,can be considered as a novel way for clinician decisionmaking towards the disease diagnosis if not used alone,in the years to come.

关键词： Neonatal sepsis Predictors Prediction modelling Systematic review Validation

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Synthesis and bioactivities of some new 1H-pyrazole derivatives containing an aryl sulfonate moiety

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Chinese Chemical Letters 2013年第4期24卷 325-328页

作者： Babasaheb V.Kendre mahadev G.Landge Wamanrao N.Jadhav Sudhakar R.Bhusare Department of Chemistry Dnyanopasak College

A new series of 1H-pyrazole derivatives 5a-j bearing an aryl sulfonate moiety have been synthesized by a one-pot cyclo-condensation reaction of 2-（3-（dimethylamino）acryloyl）phenyl-4-methyl benzene sulfonates 4a-e and hydrazine hydrate or phenyl hydrazine in ethanol under reflux conditions. Some of the newly synthesized compounds were screened for their anti-inflammatory activity. All synthesized compounds were screened against Gram positive and Gram negative bacterial and fungal strains. The compound 5b was found to be a potent anti-inflammatory agent while the majority of the compounds were found to be active against microbial strains.

关键词： PyrazoleEnaminonep-Toluene sulfonyl chlorideAnti-inflammatory activityCOX-2 inhibitors

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抗膀胱癌天然化合物木香烯内酯和高氯酸盐血竭素的确定和作用机制研究

抗膀胱癌天然化合物木香烯内酯和高氯酸盐血竭素的确定和作用机制...

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作者： mahadev（代夫）东北师范大学

学位级别：硕士

肿瘤是目前威胁人类健康的重大疾病,尚无有效治疗方法。很多临床药物经常产生耐药性和毒副作用,因此从中药天然产物中寻找新型抗肿瘤药物展示了良好的应用前景。本文以膀胱癌为靶点,系统研究了几种天然化合物的抗肿瘤效应,重点揭示了木... 详细信息

肿瘤是目前威胁人类健康的重大疾病,尚无有效治疗方法。很多临床药物经常产生耐药性和毒副作用,因此从中药天然产物中寻找新型抗肿瘤药物展示了良好的应用前景。本文以膀胱癌为靶点,系统研究了几种天然化合物的抗肿瘤效应,重点揭示了木香烯内酯和血竭素高氯酸盐促进膀胱癌凋亡的分子机制。在本论文中,我们首先研究了包括倍半萜内酯类(木香烯内酯,异土木香内酯和altholactone),生物碱类(吴茱萸碱)以及三萜式皂甙(土贝母皂甙-1),血竭素高氯酸盐六种天然化合物,对人膀胱癌T24细胞系的细胞活性及细胞凋亡的影响。通过MTT实验,检测六种天然化合物成分(木香烯内酯,异土木香内酯,altholactone,吴茱萸碱,血竭素高氯酸盐和土贝母皂甙-1)对T24细胞的抗增殖作用,发现六种天然化合物对T24细胞的增殖具有抑制作用,且呈现剂量性依赖。其中,吴茱萸碱(IC5。15 μM)对T24细胞的生长抑制效应最强,之后依次是土贝母皂甙-1(IC5022.5 μM),异土木香内酯(IC50 28.8 μM),altholactone(IC50 43.5μM)和木香烯内酯(IC50 46.5μM)血竭素高氯酸盐(IC5。80.7μM)。我们从六种天然化合物中筛选出木香烯内酯,血竭素高氯酸盐,对其抑制膀胱癌T24细胞系的细胞增殖的分子机制进行深入研究。通过细胞生存能力实验(钙黄绿素-AM(Calcein-AM),碘化丙啶(PI)染色),确定了木香烃内酯,血竭素高氯酸盐对T24细胞的增殖抑制效应。运用流式细胞术,证明木香烯内酯,血竭素高氯酸盐促进T24细胞凋亡,且呈剂量性依赖性。活性氧ROS重要的胞内信号级联的传递分子。体内过多的ROS能够引起细胞的氧化应激反应,诱导细胞功能丧失以及凋亡过程。利用荧光染料2,7-二氯荧光素二乙酸酯(DCF-DA)检测经药物处理的T24细胞内ROS的变化,结果表明,木香烯内酯,血竭素高氯酸盐诱导的膀胱癌T24细胞的凋亡与活性氧ROS上调以及线粒体膜电位改变有关,其作用可被ROS特异性抑制剂N-乙酰半胱氨酸(NAC)所阻断。促凋亡蛋白Bax和抗凋亡蛋白Bcl-2两者之间的相对比例参与调节细胞内线粒体凋亡途径的调节,表现为调节从线粒体膜通透性增加和细胞色素C释放后的Caspases级联反应激活和细胞凋亡的全过程。蛋白免疫印迹检测表明,木香烃内酯,血竭素高氯酸盐导致人膀胱癌T24细胞系Bax蛋白表达上调,Bcl-2蛋白和survivin蛋白表达下降,并显著促进了 caspase-3蛋白及其下游靶蛋白PARP的剪切活化。所以,本论文阐述了六种天然化合物对膀胱癌细胞增殖具有抑制作用,重点揭示了木香烃内酯,血竭素高氯酸盐抑制膀胱癌细胞增殖的深层分子机制,为这些天然化合物在膀胱癌治疗的潜在应用提供了的理论基础。

关键词：膀胱癌木香烯内酯高氯酸盐血竭素细胞凋亡

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