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Neural Regeneration Research 2019年第6期14卷 971-972页

作者： magdalena Kondeva-Burdina Maya Georgieva Alexandra Kasabova-Angelova Virginia Tzankova Alexander Zlatkov Laboratory of Drug Metabolism and Drug Toxicity Department of PharmacologyPharmacotherapy and ToxicologyFaculty of PharmacyMedical University of Sofia Department of Pharmaceutical Chemistry Faculty of PharmacyMedical University of Sofia

The expected growth of the elderly population at highest risk for Parkinson’s disease(PD)in the next decades makes the identification of factors that promote or prevent the disease an important *** addition,new therapies-aiming to delay the progression of PD are also needed(Prediger,2010).However,there have been few clinical trials designed to investigate *** the application of an appropriate in vitro model such as the neuroblastoma SH-SY5Y cell line is extremely *** cells were selected due to its human origin,catecholaminergic neuronal properties,and ease of maintenance(Xicoy et al.,2017).

关键词： Preliminary neuroprotective monoamine oxidase

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Insights on the crosstalk between dendritic cells and helper T cells in novel genetic etiology for mendelian susceptible mycobacterial disease

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Cellular & Molecular Immunology 2018年第12期15卷 1091-1094页

作者： Emma Rey-Jurado magdalena S.Pizarro-Ortega Alexis M.Kalergis Millennium Institute on Immunology and Immunotherapy Departamento de Genética Molecular y MicrobiologíaFacultad de Ciencias BiológicasPontificia Universidad Católica de ChileSantiago 8330644Chile Departamento de Endocrinología Facultad de MedicinaPontificia Universidad Católica de ChileSantiago 8330644Chile

Mendelian susceptibility to mycobacterial disease(MSMD)is an inherited predisposition to infections by Bacille-Calmette Guérin(BCG)vaccine or by environmental *** etiology of MSMD has been associated with up to nineteen different genetic mutations in interferon(IFN)-γ-related genes.1 Although mycobacteria susceptibility-associated genetic mutations are rare in the population,their diagnosis is crucial for an efficient and timely *** et al.2 have recently described an autosomal recessive deficiency in the signal peptidase-like 2 A(SPPL2-a)as a new genetic etiology for MSMD in three patients that had suffered BCG dissemination disease.

关键词： mendelian susceptibility to mycobacterial disease SPPL2a deficiency cDC2 mycobacterial-specific priming IFN-γ

Wave Interaction with an Emerged Porous Media

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Advances in Applied Mathematics and Mechanics 2014年第5期6卷 680-692页

作者： I.magdalena S.R.Pudjaprasetya L.H.Wiryanto Industrial&Financial Mathematics Research Group Faculty of Mathematics and Natural SciencesInstitut Teknologi BandungIndonesiaJalan Ganesha 10BandungWest JavaIndonesia

In this paper,we study wave interaction with an emerged porous *** governing equation is shallow water equations with a friction term of the linearized Dupuit-Forcheimer’s *** the continuity of surface and horizontal flux,we derived the wave reflection and transmission coefficient *** are similar with the corresponding formulas of the submerged solid bar *** solve the equations numerically using finite volume method on a staggered *** numerical wave reduction in the porous media confirms the analytical wave transmission curve.

关键词： Emerged porous media shallow water equation wave transmission coefficient wave reflection coefficient

Disordered carbon anodes for Na-ion batteries—quo vadis?

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Science China Chemistry 2021年第10期64卷 1679-1692页

作者： Fei Xie Zhen Xu Zhenyu Guo Yaxiang Lu Liquan Chen Maria-magdalena Titirici Yong-Sheng Hu Key Laboratory for Renewable Energy Beijing Key Laboratory for New Energy Materials and DevicesBeijing National Laboratory for Condensed Matter PhysicsInstitute of PhysicsChinese Academy of SciencesBeijing 100190China Department of Chemical Engineering Imperial College LondonLondon SW72AZUK

Na-ion batteries(NIBs)are gradually attracting much attention as an alternative to lead-acid batteries and supplement to Li-ion batteries(LIBs)owing to the abundant Na resources and excellent *** the most commonly used graphite as an anode material in LIBs cannot be inherently used in NIBs,tremendous efforts have been made to advance the fundamental understanding and design of suitable anode materials for NIBs,including the improvement of Na storage capacity and the study on Na storage *** to all these studies,disordered carbons are now the most promising anode candidates for *** this review,we discuss the current challenges and remaining problems to be solved in the area of disordered carbon anode materials for NIBs and provide future insights and research directions.

关键词： disordered carbon anode Na-ion batteries

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Effect of scots pine forest management on soil properties and carabid beetle occurrence under post-fire environmental conditions——a case study from Central Europe

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Forest Ecosystems 2020年第3期7卷 366-377页

作者： Ewa Błońska Bartłomiej Bednarz magdalena Kacprzyk Wojciech Piaszczyk Jarosław Lasota Department of Ecology and Forest Silviculture Faculty of ForestryUniversity of Agriculture in KrakowAl.29-go Listopada 4631-425KrakówPoland Department of Forest Ecosystems Protection Faculty of ForestryUniversity of Agriculture in KrakowAl.29-go Listopada 4631-425KrakówPoland

Background: Fires have a fundamental impact on phytocoenoses and, depending on the size of the fire, can have a positive or negative effect. The role of fires in the formation of the species composition of plants, restoration of stands and changes in soil properties is well studied. However, the long-term relationship between forest management methods, soil properties and epigeic entomofauna assemblages in post-fire areas is still not clear. The effects of Scots pine stand management methods on biochemical soil properties and ground beetle assemblages in the largest post-fire area in Central Europe after the second World were investigated. The study was conducted in the Rudy Raciborskie Forest district in southern Poland. The soil properties and epigeic beetle community structure were analysed. The research covered areas with natural and artificial pine regeneration, which were subjected to various care ***: The tendency for higher accumulations of organic matter in the soil of stands that underwent natural regeneration was proven. The stimulating role of soil organic carbon on the activity of dehydrogenases in the soil of naturally renewed areas with silvicultural treatment(NRAT) was noted. Regardless of the manner of stand regeneration, the activity of β-glucosidase was higher in the areas in which breeding treatments were ***, managed forest stands presented a higher abundance of carabid beetles than stands without treatment practices. Thirteen epigeic beetle species from the families Geotrupidae, Carabidae, Curculionidae,Cerambycidae and Silphidae were captured, with beetles from the first two families being the most numerous. Rare epigeal carabid species in the fauna of Poland and Europe, such as Carabus glabratus(Paykull) and Carabus auronitens Fabr., found appropriate habitat conditions for survival in the post-fire areas. Compared with the other areas, in the NRAT area, there were better stand and soil properties and more fea

关键词： Stand treatment strategy Forest regeneration Enzyme activity Soil organic carbon Epigeic beetle assemblage structure

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Increased expression of PELP1 in human sperm is correlated with decreased semen quality

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Asian Journal of Andrology 2018年第5期20卷 425-431页

作者： Izabela Skibinska Miroslaw Andrusiewicz Michal Soin magdalena Jendraszak Paulina Urbaniak Piotr Jedrzejczak Malgorzata Kotwicka Department of Cell Biology Faculty of Health Sciences Poznan University of Medical Sciences Rokietnicka 5D Poznan 60-806 Poland Division of Infertility and Reproductive Endocrinology Faculty of Medicine I Poznan University of Medical Sciences Polna 33 Poznan 60-535 Poland.

Proline-, glutamic acid-, and leucine-rich protein 1 （PELP1） is a scaffolding protein involved in both genomic and nongenomic estrogen signal transduction pathways. To date, the role of PELP1 protein has yet to be characterized in human sperm and has not been associated with sperm parameters. To confirm the presence of PELP1 in human sperm, fresh semen samples were obtained from 178 donors. The study was designed to establish both mRNA and protein presence, and protein cellular localization. Additionally, the number of PELP1-positive spermatozoa was analyzed in men with normal and abnormal semen parameters. Sperm parameters were assessed according to the World Health Organization （WHO） 2010 standards. The presence of PELP1 in spermatozoa was investigated using four precise, independent techniques. The qualitative presence of transcripts and protein was assessed using reverse transcription-polymerase chain reaction （RT-PCR） and western blot protocols, respectively. The cellular localization of PELP1 was investigated by immunocytochemistry. Quantitative analysis of PELP1-positive cells was done by flow cytometry. PELP1 mRNA and protein was confirmed in spermatozoa. Immunocytochemical analysis identified the presence of PELP1 in the midpieces of human sperm irrespective of sperm parameters. Becton Dickinson fluorescence-activated cell sorting （FACSCalibur^Tm） analysis revealed a significantly lower number of PELP1-positive cells in males with normal semen parameters versus abnormal samples （42.78% ± 11.77% vs 61.05% ± 21.70%, respectively; P = 0.014）. The assessment of PELP1 may be a time-saving method used to obtain information about sperm quality. The results of our study suggest that PEPL1 may be utilized as an indicator of sperm quality; thereby, PELP1 may be an additional biomarker useful in the evaluation of male infertility.

关键词： male infertility proline glutamic acid- and leucine-rich protein 1 semen parameters sperm quality spermatozoa

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The Bauhaus

The Bauhaus

Mitogen-Activated Protein Kinase 4 Is a Salicylic Acid-Independent Regulator of Growth But Not of Photosynthesis in Arabidopsis

作者： (author.)Droste magdalena

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Molecular Plant 2014年第7期7卷 1151-1166页

作者： Piotr Gawronski Damian Witon Kateryna Vashutin magdalena Bederska Blaiej Betlihski Anna Rusaczonek Stanislaw Karpinski Department of Plant Genetics Breeding and Biotechnology Faculty of Horticulture and Landscape Architecture Warsaw University ofLife Sciences--SGGW Nowoursynowska 159 Warsaw 02-776 Poland Department of Botany Faculty of Agriculture and Biology Warsaw University of Life Sciences--SGGW Nowoursynowska 159 Warsaw02-776 Poland

Mitogen-activated protein kinase （MAPK） pathways regulate signal transduction from different cellular com- partments and from the extracellular environment to the nucleus in all eukaryotes. One of the best-characterized MAPKs in Arabidopsis thaliana is MPK4, which was shown to be a negative regulator of systemic-acquired resistance. The mpk4 mutant accumulates salicylic acid （SA）, possesses constitutive expression of pathogenesis-related （PR） genes, and has an extremely dwarf phenotype. We show that suppression of SA and phylloquinone synthesis in chloroplasts by knocking down the IC51 gene （by crossing it with the icsl mutant） in the mpk4 mutant background did not revert mpk4-impaired growth. However, it did cause changes in the photosynthetic apparatus and severely impaired the quantum yield of pho- tosystem Ih Transmission microscopy analysis revealed that the chloroplasts＇ structure was strongly altered in the mpk4 and mpk4/icsl double mutant. Analysis of reactive oxygen species （ROS）-scavenging enzymes expression showed that suppression of SA and phylloquinone synthesis in the chloroplasts of the mpk4 mutant caused imbalances in ROS homeo- stasis which were more pronounced in mpk4/icsl than in mpk4. Taken together, the presented results strongly suggest that MPK4 is an ROS/hormonal rheostat hub that negatively, in an SA-dependent manner, regulates immune defenses, but at the same time positively regulates photosynthesis, ROS metabolism, and growth. Therefore, we concluded that MPK4 is a complex regulator of chloroplastic retrograde signaling for photosynthesis, growth, and immune defenses in Arabidopsis.

关键词： chloroplast ultrastructure growth and photosynthesis regulation phylloquinone reactive oxygen species(ROS) retrograde signaling and salicylic acid (SA).

High-precision geochronological constraints on the duration of ‘Dinosaur Pompeii’ and the Yixian Formation

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National Science Review 2021年第6期8卷 117-119页

作者： Yuting Zhong magdalena H.Huyskens Qing-Zhu Yin Yaqiong Wang Qiang Ma Yi-Gang Xu State Key Laboratory of Isotope Geochemistry Guangzhou Institute of GeochemistryChinese Academy of Sciences CAS Center for Excellence in Deep Earth Science Department of Earth and Planetary Sciences University of California at Davis State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and Palaeontology and Center for Excellence in Life and PaleoenvironmentChinese Academy of Sciences State Key Laboratory of Geological Processes and Mineral Resources School of Earth SciencesChina University of Geosciences

The Early Cretaceous Jehol Biota,renowned for its exceptionally wellpreserved volcanic-influenced ecosystem, was buried in lacustrine and occasionally fluvial sediments. This includes, notably, the Huajiying, Yixian and Jiufotang Formations in northern Hebei and western Liaoning and equivalent ash-interbedding sediments in neighboring areas [1–3](Fig. 1). It harbors many evolutionarily significant taxonomies, e.g. feathered dinosaurs,early birds, mammals and flowering plants, representing one of the most diversified terrestrial biotas of the Mesozoic [1,2,4].

关键词： JEHOL BIOTA

Short- and medium-term reproducibility of gastric emptying of a solid meal determined by a low dose of ^(13)C-octanoic acid and nondispersive isotope-selective infrared spectrometry

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World Journal of Gastroenterology 2006年第8期12卷 1243-1248页

作者： Anna Kasicka-Jonderko magdalena Kami■ska Krzysztof Jonderko Olga Setera Barbara Blo■ska-Fajfrowska Department of Basic Biomedical Science.School of Pharmacy Medical University of SilesiaSosnowiecPoland Department of Basic Biomedical Science.School of Pharmacy Medical University of SilesiaSosnowiecPoland Department of PhysiologyInstitute of Occupational Medicine and Environmental HealthSosnowiecPoland

AIM： To evaluate the reproducibility of a modified 13^C breath test-based measurement of solid phase gastric emptying （GE） within the frames of a simple-repeated measure study protocol. METHODS： Twelve healthy subjects （6 females and 6 males, mean age 24.9＋0.7 years） were recruited to undergo three identical GE examinations. In six subjects the first two examinations were performed 2 d apart, and the third session was carried out at a median interval of 19.5 d （range 18 - 20 d） from the second one. In another six subjects the first two measurements were taken 20 d apart （median, range： 17-23 d）, whereas the third session took place 2 d after the second one. Probes of expiratory air collected before and during six hours after intake of a solid meal （378 kcal） labelled with 75 μL （68 mg） 13^C-octanoic acid, were measured for 13^CO2 enrichment with the nondispersive isotopeselective infrared spectrometry NDIRS apparatus. RESULTS： Taking coefficients of variation for paired examinations into account, the short-term reproducibility of the GE measurement was slightly but not significantly better than the medium-term one： 7.7% and 11.2% for the lag phase （T-Lag）, 7.3% and 10.9% for the gastric half emptying time （T1/2）. The least differences in GE parameters detectable at P= 0.05 level in the 12 paired examinations were 9.6 and 15.6 min for T-Lag, 11.6 and 19.7 min for T1/2 by a two-day or two to three-week time gap, respectively CONCLUSION： The low-cost modification of the breath test involving a lower dose of 13^C-octanoic acid and NDIRS, renders good short- and medium-term reproducibility, as well as sensitivity of the measurement of gastric emptying of solids.

关键词： 13^C breath test Gastric emptying Nondispersive isotope-selective infrared spectrometry 13^C-octanoic acid Reproducibility