检索结果-南通市图书馆

基于Green-Ampt模型的变水头积水入渗模型建立及其参数求解

在线全文

学校读者我要写书评

暂无评论

水利学报 2010年第1期40卷 61-67页

作者：马娟娟孙西欢郭向红太原理工大学永利科学与工程学院山西太原030024

通过对变水头积水入渗物理机制的分析,将入渗水头对入渗的影响归结为对表面饱和导水率的影响,基于Green-Ampt入渗模型,引用了湿润区的平均含水率的概念,并考虑了湿润区平均含水率随入渗时间的变化,建立了具有物理意义的3种变水头积水入... 详细信息

通过对变水头积水入渗物理机制的分析,将入渗水头对入渗的影响归结为对表面饱和导水率的影响,基于Green-Ampt入渗模型,引用了湿润区的平均含水率的概念,并考虑了湿润区平均含水率随入渗时间的变化,建立了具有物理意义的3种变水头积水入渗模型,分析了利用入渗率-累积入渗量及入渗率-真实湿润锋图形获得模型参数的求解方法。通过室内试验,得到了湿润区的平均含水率与入渗时间之间呈乘幂函数变化的规律。利用实测资料对模型及其参数求解的方法进行检验,结果表明所建立的3种模型是正确的,求解参数的方法合理。

关键词：变水头入渗模型 Green—Ampt公式表层饱和导水率湿润区的平均含水率

在线全文

学校读者我要写书评

暂无评论

元代高昌偰氏家族再探

北方民族大学学报（哲学社会科学版） 2009年第4期 27-32页

作者：马娟兰州大学历史文化学院甘肃兰州730020

高昌偰氏,畏兀儿人,其家族支系繁茂,于政治、文学诸领域均有杰出代表,历经唐、元、明、清、民国,绵延至今,在中国家族史、民族史上均占有十分突出的地位。正因如此,偰氏家族引起了中外学者广泛兴趣与关注。在前辈学者研究的基础上,对高... 详细信息

高昌偰氏,畏兀儿人,其家族支系繁茂,于政治、文学诸领域均有杰出代表,历经唐、元、明、清、民国,绵延至今,在中国家族史、民族史上均占有十分突出的地位。正因如此,偰氏家族引起了中外学者广泛兴趣与关注。在前辈学者研究的基础上,对高昌偰氏家族入华后在汉地的支系繁衍、生息、分布及其族属演变再做探讨,并指出其家族文化背景、宗教信仰从唐到元乃至现代的发展变化。

关键词：元代高昌偰氏家族

在线全文

学校读者我要写书评

暂无评论

公民政策参与的功能分析

北京行政学院学报 2007年第2期 21-24页

作者：马小娟武汉大学政治与公共管理学院湖北武汉430072

公民政策参与是指公民参与和影响公共政策过程的行为和活动。公民政策参与对于实现民主价值、保障公民权利,维护和增强政府合法性,保证政策的科学制定和顺利执行,保证政策的公共价值和提高公共服务的品质和效能等方面都有重要的积极意... 详细信息

公民政策参与是指公民参与和影响公共政策过程的行为和活动。公民政策参与对于实现民主价值、保障公民权利,维护和增强政府合法性,保证政策的科学制定和顺利执行,保证政策的公共价值和提高公共服务的品质和效能等方面都有重要的积极意义。但公民政策参与并不必然对所有方面的政策问题解决都带来积极的效果,它也可能会使政策的质量、成本、利益取向以及政府效率和权威方面产生问题。重要的是要把握好“度”,尽可能地因势利导,使其扬长避短。

关键词：公民政策参与功能

Roles of LmCDA1 and LmCDA2 in cuticle formation in the foregut and hindgut of Locusta migratoria

在线全文

学校读者我要写书评

暂无评论

Insect Science 2021年第5期28卷 1314-1325页

作者： Min Zhang Peng-juan ma Ting-Ting Zhang Zhi-Mei Gao Pan Zhao Xiao-Jjian Liu Xue-Yao Zhang Wei-Min Liu Rong-Rong Yu Bernard Moussian Jian-Zhen Zhang Research Institute of Applied Biology Shanxi UniversityTaiyuanChina School of Life Science Shanxi UniversityTaiyuanChina Department of Biology Taiyuan Normal UniversityTaiyuanChina iBV Universite Cote d'AzurParc ValroseFrance

Chitin deacetylases(CDAs,including CDAI and CDA2)are considered key enzymes for body cuticle formation and tracheal morphogenesis in various insect ***,their functions in the formation of the cuticular intima of the foregut and hindgut are ***,we investigated the roles of their respective genes LmCDAI and Lm-CD42 in this process,in the hemimetabolous insect Locusta *** of LmCDAI and LmCDA2 were highly expressed both before and after molting in the *** the hindgut,their expression was high only before *** both the foregut and hindgut,LmCDA1 protein was localized in the basal half of the chitin matrix(procuti-cle),whereas LmCDA2 was detected in the upper half of the procuticle.K nockdown of LmCDAI by RNA interference(RNAi)in 5th-instar nymphs caused no visible defcts of the hindgut *** contrast,the chitinous lamellae of the cuticular intima in the foregut of knockdown animals were less compact than in control *** against LmCDA2 led to thickening of both the foregut and hindgut cuticles,with a greater number of thinner laminae than in the respective control *** together,our results show that LmCDAI and LmCDA2 have distinct,but overlapping,functions in chitin organization in the foregut ***,in the hindgut,this process seems independent of LmCDA1 activity but requires LmCDA2 ***,the CDAs reflect tissue-specific differences in cuticular organization and function,which need further detailed molecular and histological analyses for full comprehension.

关键词： CDA:cuticle digestion foregut hindgut laminae

Discovery of human pancreatic lipase inhibitors from root of Rhodiola crenulata via integrating bioactivity-guided fractionation,chemical profiling and biochemical assay

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2022年第4期12卷 683-691页

作者： Li-juan ma Xu-Dong Hou Xiao-Ya Qin Rong-Jing He Hao-Nan Yu Qing Hu Xiao-Qing Guan Shou-Ning Jia Jie Hou Tao Lei Guang-Bo Ge Shanghai Frontiers Science Center of TCM Chemical Biology Institute of Interdisciplinary Integrative Medicine ResearchShanghai University of Traditional Chinese MedicineShanghai201203China Department of Endocrinology Putuo HospitalShanghai University of Traditional Chinese MedicineShanghai200062China College of Basic Medical Sciences Dalian Medical UniversityDalian116044China Qinghai Hospital of Traditional Chinese Medicine Xining810099China

Although herbal medicines(HMs)are widely used in the prevention and treatment of obesity and obesity-associated disorders,the key constituents exhibiting anti-obesity activity and their molecular mechanisms are poorly ***,we assessed the inhibitory potentials of several HMs against human pancreatic lipase(hPL,a key therapeutic target for human obesity),among which the root-extract of Rhodiola crenulata(ERC)showed the most potent anti-hPL *** this study,we adopted an integrated strategy,involving bioactivity-guided fractionation techniques,chemical profiling,and biochemical assays,to identify the key anti-hPL constituents in *** ERC fractions(retention time=12.5e35 min),obtained using reverse-phase liquid chromatography,showed strong anti-hPL activity,while the major constituents in these bioactive fractions were subsequently identified using liquid chromatography-quadrupole time-of-flight mass spectrometry(LC-Q-TOF-MS/MS).Among the identified ERC constituents,1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose(PGG)and catechin gallate(CG)showed the most potent anti-hPL activity,with pIC50 values of 7.59±0.03 and 7.68±0.23,*** investigations revealed that PGG and CG potently inhibited hPL in a non-competitive manner,with inhibition constant(Ki)values of 0.012 and 0.082 mM,***,our integrative analyses enabled us to efficiently identify and characterize the key anti-obesity constituents in ERC,as well as to elucidate their anti-hPL *** findings provide convincing evidence in support of the anti-obesity and lipid-lowering properties of ERC.

关键词： Human pancreatic lipase Rhodiola crenulata 1,2,3,4,6-Penta-O-Galloyl-β-D-glucopyranose Catechin gallate Inhibitory mechanism

Effects of advanced glycosylation end products and rosiglitazone on the expression and secretion of galectin-3 in human renal mesangial cells

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2009年第9期122卷 1067-1071页

作者： SUN Zi-lin ma Chan-juan JIN Hui YUAN Yang LIU Nai-feng Department of Endocrinology Zhongda Hospital Southeast University Nanjing Jiangsu 210009China Department of Cardiology Zhongda Hospital SoutheastUniversity Nanjing Jiangsu 210009 China

Background Galectin-3 is the most recently identified advanced glycosylation end products （AGEs） binding protein. This study aimed to investigate the effects of AGEs and rosiglitazone on the expression and secretion of galectin-3 in cultured human renal mesangial cells （HRMCs）. Methods HRMCs were incubated with different concentrations of AGE-bovine serum albumin （BSA）（0, 50, 100, 200, and 400 mg/L） for different time （0, 24, 36, 48, and 72 hours）, and exposed to AGE-BSA in the presence of different concentrations of rosiglitazone （1, 10, and 100 μmol/L）. The mRNA and protein expression of galectin-3 in HRMCs were analyzed by reverse transcription polymerase chain reaction （RT-PCR） and Western blotting. The culture medium of HRMCs was collected and concentrated, and the content of galectin-3 in the medium was detected by Western blotting. Results Both RT-PCR and Western blotting revealed that AGE-BSA up-regulated the expression of galectin-3 in HRMCs in a concentration- （P 〈0.05） and time-dependent （P 〈0.05） manner compared with the control. Compared with the control, AGE-BSA elevated the content of galectin-3 in the culture medium of HRMCs time- and concentrationdependently （P 〈0.05, respectively）. Both protein and mRNA expression of galectin-3, and its content in the medium of HRMCs exposed to different concentrations of rosiglitazone in the presence of AGE-BSA were increased compared with those of cells exposed to AGE-BSA alone （P 〈0.05）. Rosiglitazone increased the expression and secretion of galectin-3 in a dose-dependent manner （P 〈0.05）. Conclusions AGEs up-regulates the expression and secretion of galectin-3 in HRMCs. Rosiglitazone further enhances the upregulation of galectin-3 in HRMCs induced by AGEs, which suggests that rosiglitazone may play a role of reno-protection via up-regulation of galectin-3.

关键词： glycosylation end products, advanced galectin 3 diabetic nephropathies rosiglitazone mesangial cells

Genetic dissection of top three leaf traits in rice using progenies from a japonica × indica cross

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2017年第12期59卷 866-880页

作者： Changbin Yin Huihui Li Zhigang Zhao Zhiquan Wang Shijia Liu Liangming Chen Xi Liu Yunlu Tian juan ma Lidong Xu Dashuang Zhang Susong Zhu Danting Li Jianmin Wan Jiankang Wang The National Key Facility for Crop Gene Resources and Genetic Improvement and Institute of Crop ScienceChinese Academy of AgriculturalSciencesBeijing 100081China National Key Laboratory for Crop Genetics and Germplasm Enhancement Research Center of Jiangsu Plant Gene EngineeringNanjingAgricultural UniversityNanjing 210095China Rice Research Institute Jiangxi Academy of Agricultural SciencesNanchang 330200China Rice Research Institute Guizhou Academy of Agricultural SciencesGuiyang 550006China Rice Research Institute Guangxi Academy of Agricultural SciencesNanning 530007China

The size of the top three leaves of rice plants is strongly associated with yield; thus, it is important to consider quantitative traits representing leaf size （e.g., length and width） when breeding novel rice varieties. It is challenging to measure such traits on a large scale in the field, and little is known about the genetic factors that determine the size of the top three leaves. In the present study, a population of recombinant inbred lines （RILs） and reciprocal single chromosomal segment substitution lines （SSSLs） derived from the progeny of a japonica Asominori x indica IR24 cross were grown under four diverse environmental conditions. Six morphological traits associated with leaf size were measured,namely length and width of the flag, second and third leaves. In the RIL population, 49 QTLs were identified that clustered in 30 genomic region. Twenty-three of these QTLs were confirmed in the SSSL population. A comparison with previously reported genes/QTLs revealed eight novel genomic regions that contained uncharacterized ORFs associated with leaf size. The QTLs identified in this study can be used for marker- assisted breeding and for fine mapping of novel genetic elements controlling leaf size in rice.

关键词： indica cross Genetic dissection of top three leaf traits in rice using progenies from a japonica RIL

在线全文

学校读者我要写书评

暂无评论

论事业化价值导向下的辅导员发展路径

高校教育管理 2015年第4期9卷 97-101页

作者：马娟广东农工商职业技术学院学生工作处广东广州510507

辅导员职业化、专业化、专家化("三化")是一个承前启后、先行后续的发展过程,而事业化价值导向与"三化"有着密切的联系。"三化"在发展的同时面临多重困境。引入事业化价值导向,以"三要素"测试定辅导员选拔机制,以"二元分割"定辅导员管... 详细信息

辅导员职业化、专业化、专家化("三化")是一个承前启后、先行后续的发展过程,而事业化价值导向与"三化"有着密切的联系。"三化"在发展的同时面临多重困境。引入事业化价值导向,以"三要素"测试定辅导员选拔机制,以"二元分割"定辅导员管理机制,以"差异化"定辅导员发展机制,将有利于"三化"从外在的制度约束转变为辅导员内在的价值追求,从而实现"三化"与事业化的统一发展。

关键词：高校辅导员事业化发展路径

在线全文

学校读者我要写书评

暂无评论

几个特殊时期的员工沟通管理

中国人力资源开发 2010年第6期27卷 42-44页

作者：马娟建研科技股份有限公司

本文基于实践中的经验和教训,提出了企业管理中五个特殊时期的员工沟通管理技巧。

关键词：特殊时期沟通管理