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Chemical Research in Chinese Universities 2001年第4期17卷 407-414页

作者： WU Wei-dong ma ling-tai ZHANG Li-he National Laboratory of Natural and Biomimetic Drugs School ofPharmaceutical SciencesPeking UniversityBeijing 100083P.R.China

The syntheses of 5-substituted-3-[( 2’ R, 4’ R)-4 ’ -hydroxy-2 ’ -hydroxymethyltetra-hydrofuran-4’ -yl]D-1 ,2, 4-oxadiazoles and their epimers were accomplished with the aid of th construction of 1,2, 4-oxadiazoles by condensation of O-acylated cyanohydrins with hydroxylamine via intramolecular transacylation and subsequent cyclization.

关键词： Nucleoside analogue 1,2,4-Oxadiazole Transacylation

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碳核苷类似物的合成与生物活性

高等学校化学学报 1999年第6期20卷 895-899页

作者：孙德群朱京马灵台张礼和中国科学院成都有机化学研究所成都610041)(北京医科大学药学院

利用杂环金属盐法，通过呋喃碳核苷中间体，合成了哒嗪、哒嗪酮等碳核苷，讨论了反应机理；

关键词：呋喃碳核苷哒嗪哒嗪酮碳核苷碳核苷类似物合成生物活性抗肿瘤药物

Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun Zhao De-En Xu Ming-Lei Wu Ji-Chuan Liu Zi-ling Shi Quan-Hong ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

The Citron homology domain of maP4Ks improves outcomes of traumatic brain injury

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Neural Regeneration Research 2025年第11期20卷 3233-3244页

作者： Xiaoling Zhong Wenjiao tai Meng-Lu Liu Shuaipeng ma Tianjin Shen Yuhua Zou Chun-Li Zhang Department of Molecular Biology University of Texas Southwestern Medical CenterDallasTXUSA Hamon Center for Regenerative Science and Medicine University of Texas Southwestern Medical CenterDallasTXUSA Peter O’Donnell Jr.Brain Institute University of Texas Southwestern Medical CenterDallasTXUSA

The mitogen-activated protein kinase kinase kinase kinases(maP4Ks)signaling pathway plays a pivotal role in axonal regrowth and neuronal degeneration following *** targeting this pathway is beneficial to brain injury remains *** this study,we showed that adeno-associated virus-delivery of the Citron homology domain of maP4Ks effectively reduces traumatic brain injury-induced reactive gliosis,tauopathy,lesion size,and behavioral *** inhibition of maP4Ks replicated the ameliorative effects observed with expression of the Citron homology ***,the Citron homology domain acted as a dominant-negative mutant,impeding maP4K-mediated phosphorylation of the dishevelled proteins and thereby controlling the Wnt/β-catenin *** findings implicate a therapeutic potential of targeting maP4Ks to alleviate the detrimental effects of traumatic brain injury.

关键词： adeno-associated virus Citron homology Citron homology domain gene therapy mitogen-activated protein kinase kinase kinase kinases traumatic brain injury

2-(4-氨酰基-2-噻唑基)-1,4-脱水-L-木糖醇及其氟代衍生物的构象研究

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高等学校化学学报 1998年第11期19卷 1767-1770页

作者：张虎翼张亮仁马灵台张礼和崔育新刘雪辉北京医科大学药学院抗肿瘤药物研究室

计算机分子模拟方法研究了２－（４－氨酰基－２－噻唑基）－１，４－脱水－Ｌ－木糖醇及其氟代衍生物的糖基构象．计算结果显示，６个碳核苷类似物的糖基构象均为Ｓ型．核磁共振谱和晶体Ｘ射线衍射结果与计算结果相吻合．

关键词：构象 NMR 晶体 X射线分析异碳核苷核苷

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基于人工神经网络的串联水库水质模拟预测

内蒙古农业大学学报（自然科学版） 2010年第2期31卷 260-264页

作者：马太玲朝伦巴根高瑞忠内蒙古农业大学水利与土木建筑工程学院呼和浩特010018

将人工神经网络(A-BP)模型用于串联水库水质的空间模拟预测,建立了基于A-BP的一维和二维水质模型。根据串联水库的水质在一维空间上的连续性,构建模拟水质一维空间分布的A-BP模型;二维A-BP水质模型是在将二维水质扩散问题视为平流扩散... 详细信息

将人工神经网络(A-BP)模型用于串联水库水质的空间模拟预测,建立了基于A-BP的一维和二维水质模型。根据串联水库的水质在一维空间上的连续性,构建模拟水质一维空间分布的A-BP模型;二维A-BP水质模型是在将二维水质扩散问题视为平流扩散、横向扩散和纵向扩散3个方面问题的基础上建立的。模拟预测结果表明,本文建立的A-BP水质模型模拟预测效果较好,模型构建合适,可以作为进行水库水质模拟预测的有效工具。

关键词：串联水库水质模拟预测人工神经网络

Hydration, Microstructure, and Properties of Sulphoaluminate Cement in Pure Water and Simulated Seawater

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Journal of Wuhan University of Technology(materials Science) 2025年第1期40卷 187-193页

作者： ma Jie China Railway Design Corporation Tianjin 300250China

Paste and mortar specimens were prepared with sulfoaluminate cement(SAC),P⋅O 42.5 ordinary Portland cement(OPC),and standard sand,and mixed and cured with pure water and artificial seawater,*** mechanical properties of mortar specimens were *** and microstructure of paste specimens were also investigated using X-ray diffraction(XRD),scanning electron microscope(SEM),and 27Al nuclear magnetic resonance(NMR),*** results indicate that SAC mortar samples mixed and cured by seawater have faster strength growth before 28 d and higher compressive strength than OPC mortar *** to curing in deionized water,the hydration products of SAC are somewhat coarser when cured in simulated *** evolution of aluminum phase hydration products during the hydration process of SAC mixed and cured in simulated seawater is quite different from that of *** 3 to 28 d,the content of each aluminum phase hydration product in SAC paste cured in simulated seawater changed little,while that in OPC paste changed significantly;for example,from 7 to 28 d,the content of ettringite(AFt)in OPC paste increased *** type of AFt formed loosely,harming the mortar's microstructure.

关键词： sulfoaluminate cement seawater mixing and curing 27Al NMR AFt

Reversing anther thermotolerance by manipulating the cis-elements in the promoter of a high-temperature upregulated gene Casein Kinase I in upland cotton

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Science China Life Sciences 2025年

作者： Yanlong Li Yinuo Fu Yaoyao Li Rui Zhang Jing Yang Huanhuan ma ling Min Xianlong Zhang National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural University

High temperature (HT) stress causes male sterility,leading to reduced upland cotton ***,we identified a key gene,Casein Kinase I (GhCKI),that negatively regulates male fertility in upland cotton under ***,conventional genetic manipulations of GhCKI would result in male sterility,hindering its utilization in breeding ***,we engineered quantitative variation for anther thermotolerance-related traits in upland cotton by creating weak promoter alleles of GhCKI genes,using CRISPR/Cas9 and CRISPR/Cpf1genome ***,we screened and identified two new upland cotton plant lines exhibiting a HT-tolerant phenotype with edited GhCKI promoters,and characterized their corresponding heat-tolerant allelic *** research revealed that the primary reason for the HT tolerance of the GhCKI promoter editing mutants is that the trans-acting factors GhMYB73 and GhMYB4,which positively regulate GhCKI expression under HT,failed to bind and activate the expression of ***,our study not only provides a rapid strategy to generate new beneficial alleles but also offers novel germplasm resources and molecular insights for crop HT tolerance breeding.

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大河口水库表层沉积物有机质特征及来源解析

农业环境科学学报 2019年第12期38卷 2835-2843页

作者：张晓晶卢俊平张圣微马太玲张自豪内蒙古农业大学水利与土木建筑工程学院

为深入分析水库生态系统的污染来源和水环境的营养状况,本文对大河口水库表层沉积物中总有机碳(TOC)、总氮(TN)含量的分布特征,碳同位素(δ13C)、氮同位素(δ15N)和C/N值的组成进行分析,探讨了沉积物中有机质的来源。结果表明:大河口水... 详细信息

为深入分析水库生态系统的污染来源和水环境的营养状况,本文对大河口水库表层沉积物中总有机碳(TOC)、总氮(TN)含量的分布特征,碳同位素(δ13C)、氮同位素(δ15N)和C/N值的组成进行分析,探讨了沉积物中有机质的来源。结果表明:大河口水库表层沉积物以远源搬运的风成沉积物为主,TOC含量在1.38%~3.52%,平均值为2.34%;TN分布范围在0.06%~0.21%,平均值为0.11%;δ13C分布范围在-2.69%^-2.41%,平均值为-2.54%,δ15N范围在0.19%~0.54%,平均值为0.39%。通过端元混合模型对沉积物有机质来源进行定性和半定量分析表明,陆生C3植物、土壤有机质和淡水水生植物是大河口水库沉积物有机质的3种主要来源,其中陆生C3植物贡献最大,其次是土壤有机质,个别断面有淡水水生植物来源。研究表明,大河口水库整体的初级生产力不高,有机质来源组成差异较小,有机质来源大都为外源。

关键词：大河口水库有机质碳同位素(δ13C) 氮同位素(δ15N) 来源

Recent advances in exploring new blood-based biomarkers for the early diagnosis of gastric cancer

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Science China Chemistry 2025年第1期68卷 35-45页

作者： Xinyu Peng Qian ma Da Han School of Life Science Shanghai University Institute of Molecular Medicine Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine State Key Laboratory of Oncogenes and Related Genes Renji Hospital School of Medicine Shanghai Jiao Tong University Department of Research and Development Intellinosis Biotechnologies Co.Ltd.

Gastric cancer(GC) is a prevalent and lethal malignancy worldwide, and the 5-year survival rate is less than 30%. The absence of distinctive symptoms often leads to late-stage diagnosis, contributing to a grim prognosis. Early detection is pivotal for improving the survival rates and outcomes of GC patients. Traditional diagnostic methods, including gastroscopy and histopathological examination, are restricted in the early diagnosis of GC. Conventional protein biomarkers, such as carcinoembryonic antigen(CEA), carbohydrate antigen 19-9(CA19-9), and carbohydrate antigen 72-4(CA72-4), exhibit insufficient sensitivity and specificity for GC screening, which diminishes their clinical value. Recently, novel circulating biomarkers, such as circulating tumor cells(CTCs), circulating tumor cell DNA(ct DNA), and circulating free RNA(cf RNA), have emerged as promising candidates in the burgeoning field of liquid biopsy due to their superior sensitivity and specificity. This review focuses on the latest research on blood-based biomarkers for GC diagnosis and examines the clinical potentials and challenges associated with these emerging biomarkers.

关键词： gastric cancer early diagnosis blood