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Robustness and breakup of the spiral wave in a two-dimensional lattice network of neurons

Science china(physics,Mechanics & Astronomy) 2010年第4期53卷 672-679页

作者： ma jun 1,2, tang jun 2 , zhang aihua 3.& jia ya 2 1 department of physics, lanzhou university of technology, lanzhou 73.050, china 2 department of physics, Central china Normal university, Wuhan 430079, china 3 College of Electrical and Information Engineering, lanzhou university of technology, lanzhou 73.050, china department of physics Lanzhou University of Technology Lanzhou China department of physics Central China Normal University Wuhan China College of Electrical and Information Engineering Lanzhou University of Technology Lanzhou China

The robustness and breakup of spiral wave in a two-dimensional lattice networks of neurons are investigated. The effect of small- world type connection is often simplified with local regular connection and the long-range connection with certain probability. The network effect on the development of spiral wave can be better described by local regular connection and changeable long-range connection probability than fixed long-range connection probability because the long-range probability could be changeable in realistic biological system. The effect from the changeable probability for long-range connection is simplified by multiplicative noise. At first, a stable rotating spiral wave is developed by using appropriate initial values, parameters and no-flux boundary conditions, and then the effect of networks is investigated. Extensive numerical studies show that spiral wave keeps its alive and robust when the intensity of multiplicative noise is below a certain threshold, otherwise, the breakup of spiral wave occurs. A statistical factor of synchronization in two-dimensional array is defined to study the phase transition of spiral wave by checking the membrane potentials of all neurons corresponding to the critical parameters(the intensity of noise or forcing current)in the curve for factor of synchronization. The Hindmarsh-Rose model is investigated, the Hodgkin-Huxley neuron model in the presence of the channel noise is also studied to check the model independence of our conclusions. And it is found that breakup of spiral wave is easier to be induced by the multiplicative noise in presence of channel noise.

关键词： spiral wave factor of synchronization breakup multiplicative noise robustness

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Analyzing the potential mechanism of Buyang Huanwu decoction for the treatment of salt-sensitive hypertension based on network pharmacology and in vivo experiments

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Traditional Medicine Research 2024年第7期9卷 49-61页

作者： jian-Bo Wang Yi Qu Ren-jun Yu Guo-Rui Xu ya-Nan Xue jia-Hao zhang Yong-Gang ma Li-De zhang Traditional Chinese Medicine Innovation Engineering technology Center Liaoning University of Traditional Chinese MedicineShenyang 110847China. Key Laboratory of Visceral Image Theory and Application of Traditional Chinese Medicine Ministry of EducationShenyang 110847China. Center for Research and Evaluation of Higher Traditional Chinese Medicine Education Liaoning University of Traditional Chinese MedicineShenyang 110847China. Emergency department Nanjing Lishui District Hospital of Traditional Chinese MedicineJiangsu 211200China. College of Acupuncture and Moxibustion Liaoning University of Traditional Chinese MedicineShenyang 110847China. department of Rehabilitation the Second Affiliated Hospital of Liaoning University of Chinese MedicineShenyang 110034China. College of Integrated Chinese and Western Medicine Liaoning University of Traditional Chinese MedicineShenyang 110847China.

Background:Buyang Huanwu decoction(BHD)is a traditional Chinese medicine herbal formula used for treating hypertension,particularly in the later stages of hypertension when it is associated with intracerebral *** study aims to investigate the treatment mechanism of BHD to provide a basis for its clinical application in hypertension ***:Network pharmacology analysis and cell culture experiments were performed to explore the potential proteins and mechanisms of action of BHD against *** compounds related to BHD were screened,and relevant targets associated with hypertension and BHD were *** docking technology was used to identify the effective signaling pathway based on the Kyoto Encyclopedia of Genes and Genomes and protein-protein interaction network ***,the effects and mechanisms of BHD on salt-sensitive hypertensive endothelial cells were ***:Ninety-three potential therapeutic targets for BHD and salt-sensitive hypertension were found to be closely associated with the PI3K/Akt/eNOS signaling pathway and oxidative *** experiments further indicated the pivotal role of endothelial cells in hypertension,and validation analysis showed that BHD significantly preserved cell morphology,suppressed oxidative stress reactions,activated the PI3K/Akt/eNOS signaling pathways,preserved normal endothelial cell function,and reduced cell ***:BHD effectively activates the PI3K/Akt/VEGF signaling pathway,attenuates oxidative stress-induced injury in endothelial cells exposed to high salt levels,and mitigates apoptosis,supporting the use of traditional Chinese medicine BHD in the treatment of salt-sensitive hypertension.

关键词： BHD salt-sensitive hypertension network pharmacology oxidative stress

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Development of a High-throughput Sequencing Platform for Detection of Viral Encephalitis Pathogens Based on Amplicon Sequencing

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Biomedical and Environmental Sciences 2024年第3期37卷 294-302页

作者： zhang ya Li SU Wen Zhe WANG Rui Chen LI yan zhang jun Feng LIU Sheng Hui HU Dan He XU Chong Xiao YIN jia Yu YIN Qi Kai HE Ying LI Fan FU Shi Hong NIE Kai LIANG Guo Dong TAO Yong XU Song Tao ma Chao Feng WANG Huan Yu Shaanxi university of Chinese Medicine Xianyang 712000ShaanxiChina National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Guangzhou Center for Disease Control and Prevention Guangzhou 510000GuangdongChina Shandong Center for Disease Control and Prevention Jinan 250000ShandongChina department of Ophthalmology Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Xi'an Center for Disease Control and Prevention Xi’an 710054ShaanxiChina

Objective Viral encephalitis is an infectious disease severely affecting human *** is caused by a wide variety of viral pathogens,including herpes viruses,flaviviruses,enteroviruses,and other *** laboratory diagnosis of viral encephalitis is a worldwide ***,high-throughput sequencing technology has provided new tools for diagnosing central nervous system ***,In this study,we established a multipathogen detection platform for viral encephalitis based on amplicon *** We designed nine pairs of specific polymerase chain reaction(PCR)primers for the 12 viruses by reviewing the relevant *** detection ability of the primers was verified by software simulation and the detection of known positive *** sequencing was used to validate the samples,and consistency was compared with Sanger *** The results showed that the target sequences of various pathogens were obtained at a coverage depth level greater than 20×,and the sequence lengths were consistent with the sizes of the predicted *** sequences were verified using the National Center for Biotechnology Information BLAST,and all results were consistent with the results of Sanger *** Amplicon-based high-throughput sequencing technology is feasible as a supplementary method for the pathogenic detection of viral *** is also a useful tool for the high-volume screening of clinical samples.

关键词： Viral encephalitis Amplicon sequencing High-throughput sequencing Multipathogen detection

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Senktide blocks aberrant RTN3 interactome to retard memory decline and tau pathology in social isolated Alzheimer’s disease mice

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Protein & Cell 2024年第4期15卷 261-284页

作者： He-Zhou Huang Wen-Qing Ai Na Wei Ling-Shuang Zhu Zhi-Qiang Liu Chao-Wen Zhou man-Fei Deng Wen-Tao zhang jia-Chen zhang Chun-Qing yang ya-Zhuo Hu Zhi-Tao Han Hong-Hong zhang jian-jun jia Jing Wang Fang-Fang Liu Ke Li Qi Xu Mei Yuan Hengye man Ziyuan Guo Youming Lu Kai Shu Ling-Qiang Zhu Dan Liu department of Pathophysiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China department of Medical Genetics School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China department of Pathology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450002China department of Pathology School of Basic MedicineZhengzhou UniversityZhengzhou 450002China The Second Affiliated Hospital Department of NeurologyHengyang Medical SchoolUniversity of South ChinaHengyang 421001China Beijing Key Laboratory of Aging and Geriatrics National Clinical Research Center for Geriatric DiseaseInstitute of GeriatricsChinese PLA General Hospital and Chinese PLA Medical AcademyBeijing 100853China department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China department of Neurology Union HospitalHuazhong University of Science and TechnologyWuhan 430022China department of Biology Boston UniversityBostonMA 02215USA Center for Stem Cell and Organoid Medicine(CuSTOM) Division of Developmental BiologyCincinnati Children’s Hospital Medical CenterCincinnatiOH 45229USA

Sporadic or late-onset Alzheimer’s disease(LOAD)accounts for more than 95%of Alzheimer’s disease(AD)cases without any family *** genome-wide association studies have identified associated risk genes and loci for LOAD,numerous studies suggest that many adverse environmental factors,such as social isolation,are associated with an increased risk of ***,the underlying mechanisms of social isolation in AD progression remain *** the current study,we found that 7 days of social isolation could trigger pattern separation impairments and presynaptic abnormalities of the mossy fibre-CA3 circuit in AD *** also revealed that social isolation disrupted histone acetylation and resulted in the downregulation of 2 dentate gyrus(DG)-enriched miRNAs,which simultaneously target reticulon 3(RTN3),an endoplasmic reticulum protein that aggregates in presynaptic regions to disturb the formation of functional mossy fibre boutons(MFBs)by recruiting multiple mitochondrial and vesicle-related ***,the aggregation of RTN3 also recruits the PP2A B subunits to suppress PP2A activity and induce tau hyperphosphorylation,which,in turn,further elevates RTN3 and forms a vicious ***,using an artificial intelligence-assisted molecular docking approach,we determined that senktide,a selective agonist of neurokinin3 receptors(NK3R),could reduce the binding of RTN3 with its ***,application of senktide in vivo effectively restored DG circuit disorders in socially isolated AD *** together,our findings not only demonstrate the epigenetic regulatory mechanism underlying mossy fibre synaptic disorders orchestrated by social isolation and tau pathology but also reveal a novel potential therapeutic strategy for AD.

关键词： Alzheimer’s disease memory impairment synaptic disorder tau pathology

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Frontiers in high entropy alloys and high entropy functional materials

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Rare Metals 2024年第10期43卷 4639-4776页

作者： Wen-Tao zhang Wen Huang Fu-Jie Yu Qi Zhao Xin-Dong Zhu Tao Feng yao jiang Xiao-Ming Li Xue-Fei Miao He Zhu Si Lan Xue-Qian Wang Bao-Long Shen Zhe jia Feng-Qi zhang Wei Wang Qi Liu yang Ren Xun-Li Wang Xiao-ya Cui Xiao-yang Wang ya-Nan Chen Bing-Bing Fan Meng-Ru Li Qi-Long Gao jia-Ming Guo Zeng-Bao jiao Zhi-Min Guo Yu-Ping Zhao Qian Yu Rui Huang Ling-Kun zhang Yi-Ping Lu Xu-Bo Li Huai-jun Lin yan ma Wei-Ming yang Zhi-Hua Shen Hai-yan He Yong-Gang Sun Yong-jiang Huang De-Zhuang Wang Qing-Feng Liu Fei-yang Wang Hui Liu Hong-Hui Wu Li-Qiang Wang yang Lu Nan Wang Tian-Li Wang Wei-Bing Liao Yi-Han Wang Yuan Wu Yu-Zhen Yin Jie Pan Yi zhang Qing Wang jian-yang zhang Tao yang yasir Sohail Jin-Yu zhang Hua Ji Qiang Li Wei-Di Liu Zhi-Gang Chen Xiong-jun Liu Wen ma Liang mao Zhen-Duo Wu School of materials Science and Engineering Nanjing University of Science and Technology jiangsu Key Laboratory for Advanced Metallic materials School of Materials Science and Engineering Southeast University department of physics City University of Hong Kong School of materials Science and Engineering Tianjin University School of physics and Microelectronics Zhengzhou University department of Mechanical Engineering Research Institute for Advanced Manufacturing The Hong Kong Polytechnic University Center of Electron Microscopy and State Key Laboratory of Silicon materials School of Materials Science and Engineering Zhejiang University Key Laboratory of Solidification Control and Digital Preparation technology (Liaoning Province) School of Materials Science and Engineering Dalian University of Technology Institute of Advanced Wear & Corrosion Resistance and Functional materials Jinan University School of Mechanics and Civil Engineering China University of Mining and Technology School of Physical Sciences Great Bay University School of materials Science andEngineering Harbin Institute of Technology State Key Laboratory of materials-Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University Beijing Advanced Innovation Center for materials Genome Engineering Research Institute for Carbon Neutrality University of Science and Technology Beijing department of Mechanical Engineering The University of Hong Kong School of Computing Macquarie University Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic Engineering Shenzhen University State Key Laboratory for Advanced Metals and materials University of Science and Technology Beijing State Key Laboratory of materials Processing and Die & Mould technology School of Materials Science and Engineering Huazhong University of Science and Technology Institute of materials Shanghai University department of materials Science and Engineering C

Owing to their exceptional properties, high-entropy alloys(HEAs) and high-entropy materials have emerged as promising research areas and shown diverse applications. Here,the recent advances in the field are comprehensively reviewed,organized into five sections. The first section introduces the background of HEAs, covering their definition, significance,application prospects, basic properties, design principles, and microstructure. The subsequent section focuses on cutting-edge high-entropy structural materials, highlighting developments such as nanostructured alloys, grain boundary engineering,eutectic systems, cryogenic alloys, thin films, micro-nano-lattice structures, additive manufacturing, high entropy metallic glasses, nano-precipitate strengthened alloys, composition modulation, alloy fibers, and refractory systems. In the following section, the emphasis shifts to functional materials, exploring HEAs as catalysts, magneto-caloric materials, corrosion-resistant alloys, radiation-resistant alloys, hydrogen storage systems, and materials for biomedicine. Additionally, the review encompasses functional high-entropy materials outside the realm of alloys, including thermoelectric, quantum dots, nanooxide catalysts, energy storage materials, negative thermal expansion ceramics,and high-entropy wave absorption materials. The paper concludes with an outlook, discussing future directions and potential growth areas in the field. Through this comprehensive review,researchers, engineers, and scientists may gain valuable insights into the recent progress and opportunities for further exploration in the exciting domains of high-entropy alloys and functional materials.

关键词： Cutting-edge structural materials Cutting-edgefunctional materials High entropy alloys

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The In-Flight Realtime Trigger and Localization Software of GECAM

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Research in Astronomy and Astrophysics 2024年第10期24卷 11-24页

作者： Xiao-Yun Zhao Shao-Lin Xiong Xiang-yang Wen Xin-Qiao Li Ce Cai Shuo Xiao Qi Luo Wen-Xi Peng Dong-ya Guo Zheng-Hua An Ke Gong Jin-Yuan Liao yan-Qiu zhang Yue Huang Lu Li Xing Wen Fei zhang Jing Duan Chen-Wei Wang Dong-Li Shi Peng zhang Qi-Bin Yi Chao-yang Li yan-Bing Xu Xiao-Hua Liang ya-Qing Liu Da-Li zhang Xi-Lei Sun Fan zhang Gang Chen Huan-Yu Wang Sheng yang Xiao-Jing Liu Min Gao mao-Shun Li Jin-Zhou Wang Xing Zhou Yi Zhao Wang-Chen Xue Chao Zheng jia-Cong Liu Xing-Bo Han Jin-Ling Qi jia Huang Ke-Ke zhang Can Chen Xiong-Tao yang Dong-Jie Hou Yu-Sa Wang Rui Qiao Xiang ma Xiao-Bo Li Ping Wang Xin-Ying Song Li-Ming Song Shi-Jie Zheng Bing Li Hong-Mei zhang Yue Zhu Wei Chen jian-jian He Zhen zhang Jin Hou Hong-jun Wang yan-Chao Hao Xiang-Yu Wang Zong-Yuan yang Zhi-Long Wen Zhi Chang Yuan-Yuan Du Rui Gao Xiao-Fei Lan yan-Guo Li Gang Li Xu-Fang Li Fang-jun Lu Hong Lu Bin Meng Feng Shi Hui Wang Hui-Zhen Wang Yu-Peng Xu jia-Wei yang Xue-Juan yang Shuang-Nan zhang Chao-Yue zhang Cheng-Mo zhang Zhi-Cheng tang Cheng Cheng Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China university of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China School of Information Science and technology Southwest Jiaotong UniversityChengdu 611756China Key Laboratory of Stellar and Interstellar physics and department of physics Xiangtan UniversityXiangtan 411105China physics and Space Science College China West Normal UniversityNanchong 637002China department of Astronomy Beijing Normal UniversityBeijing 100875China Innovation Academy for Microsatellites of CAS Shanghai 201203China Changchun university of Science and technology Changchun 130022China Chinese Academy of Sciences South America Center for Astronomy National Astronomical ObservatoriesCASBeijing 100101China

Realtime trigger and localization of bursts are the key functions of GECAM,an all-sky gamma-ray monitor launched on 2020 December *** developed a multifunctional trigger and localization software operating in the CPU of the GECAM Electronic *** onboard software has the following features:high trigger efficiency for real celestial bursts with a suppression of false triggers caused by charged particle bursts and background fluctuation,dedicated localization algorithm optimized for both short and long bursts,and low time latency of the trigger information which is downlinked through the Global Short Message Communication service of the global BeiDou navigation *** paper provides a detailed description of the design and development of the trigger and localization software system for *** covers the general design,workflow,the main functions,and the algorithms used in the *** paper also includes on-ground trigger tests using simulated gamma-ray bursts generated by a dedicated X-ray tube,as well as an overview of the performance for real celestial bursts during its in-orbit operation.

关键词： telescopes instrumentation:detectors methods:observational

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Measurements of absolute electron capture cross sections in He^(2+)–He and Ne^(8+)–O_(2'), N_(2'), CH_4 collisions

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Nuclear Science and Techniques 2023年第10期34卷 126-135页

作者： Pu-Fang ma jia-Rong Wang Zi-Xiao zhang Tian-Ming Meng Zi-Han Xia Bai-Hui Ren Long Wei Ke yao jun Xiao ya-Ming Zou Bing-Sheng Tu Bao-Ren Wei Institute of Modern physics Department of Nuclear Science and TechnologyFudan UniversityShanghai 200433China Key Laboratory of Nuclear physics and Ion‑Beam Application(MOE) Fudan UniversityShanghai 200433China

The total absolute cross sections of single-and double-electron capture (SEC and DEC) in the collisions of He^(2+)with He and Ne^(8+)with O_(2),N_(2),and CH_(4) were studied in the energy ranges 3.5–50 keV/u and 2.8–40 keV/u,*** a deep analysis of the experimental systematic uncertainties in the measurement procedure and data evaluation,the error in the experimental results of the SEC cross sections is less than 9%.Within the uncertainties,the present results of the He^(2+)–He collision show good consistency with previous measurements,validating the experimental system and paving the way for precise measurements of EC cross sections for a variety of ions and neutral *** present measurements allow for a test of EC theory and provide crucial EC cross section data for the establishment of plasma models in fusion research and astrophysical X-ray studies.

关键词： Highly charged ions Cross section Electron capture Charge exchange

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Offspring of rats with cerebral hypoxia-ischemia manifest cognitive dysfunction in learning and memory abilities

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Neural Regeneration Research 2020年第9期15卷 1662-1670页

作者： Lu-Lu Xue Fang Wang Rui-Ze Niu ya-Xin Tan jia Liu Yuan Jin Zheng ma Zi-Bin zhang ya jiang Li Chen Qing-Jie Xia jun-Jie Chen Ting-Hua Wang Liu-Lin Xiong department of Anesthesiology Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou ProvinceChina School of Pharmacy and Medical Sciences Division of Health SciencesUniversity of South AustraliaAdelaideAustralia Institute of Neuroscience Kunming Medical UniversityKunmingYunnan ProvinceChina department of Science and technology Kunming Medical UniversityKunmingYunnan ProvinceChina department of Laboratory Zoology Kunming Medical UniversityKunmingYunnan ProvinceChina Institute of Neurological Disease Department of AnesthesiologyTranslational Neuroscience CenterWest China HospitalSichuan UniversityChengduSichuan ProvinceChina Southwest Medical university LuzhouSichuan ProvinceChina

Neonatal hypoxic-ischemic encephalopathy is a serious neurological disease,often resulting in long-term neurodevelopmental disorders among surviving ***,whether these neurodevelopmental issues can be passed to offspring remains *** right common carotid artery of 7-day-old parental-generation rats was subjected to permanent ligation using a vessel *** hypoxic-ischemic rat models were established by subjecting the rats to 8%O2–92%N2 for 2 *** results showed that 24 hours after hypoxia and ischemia,pathological damage,cerebral atrophy,liquefaction,and impairment were found,and Zea-Longa scores were significantly *** parental-generation rats were propagated at 3 months old,and offspring were *** changes in the overall brain structures of these offspring rats were identified by magnetic resonance ***,the escape latency was longer and the number of platform crossings was reduced among these offspring compared with normal *** results indicated that the offspring of hypoxic-ischemic encephalopathy model rats displayed cognitive impairments in learning and *** study was approved by the Animal Care&Welfare Committee of Kunming Medical university,china in 2018(approval ***2019072).

关键词： cerebral atrophy cerebral infarct cerebral liquefaction cognitive impairment magnetic resonance imaging neonatal brain hypoxia and ischemia neuronal apoptosis offspring

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High-density lipoprotein regulates angiogenesis by long non-coding RNA HDRACA

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Signal Transduction and Targeted Therapy 2023年第9期8卷 4320-4337页

作者： Zhi-Wei Mo Yue-Ming Peng Yi-Xin zhang yan Li Bi-Ang Kang ya-Ting Chen Le Li mary GSorci-Thomas Yi-jun Lin yang Cao Si Chen Ze-Long Liu jian-jun Gao Zhan-Peng Huang jia-Guo Zhou Mian Wang Guang-Qi Chang Meng-Jie Deng Yu-jia Liu Zhen-Sheng ma Zuo-jun Hu Yu-Gang Dong Zhi-jun Ou Jing-Song Ou Division of Cardiac Surgery Cardiovascular Diseases InstituteThe First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases NHC Key Laboratory of Assisted Circulation(Sun Yat-sen University)Guangdong Provincial Engineering and Technology Center for Diagnosis and Treatment of Vascular DiseasesGuangzhouChina Division of Vascular Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Division of Hypertension and Vascular Diseases Department of CardiologyHeart CenterThe First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Medical College of Wisconsin MilwaukeeWIUSA Center for Translational Medicine Institute of Precision MedicineThe First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina department of Cardiology Heart CenterThe First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina department of Pharmacology Cardiac and Cerebral Vascular Research CenterZhongshan School of Medicine of Sun Yat-sen UniversityGuangzhouChina Guangdong Provincial Key Laboratory of Brain Function and Disease Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080P.R.China

Normal high-density lipoprotein(nHDL)can induce angiogenesis in healthy ***,HDL from patients with coronary artery disease undergoes various modifications,becomes dysfunctional(dHDL),and loses its ability to promote ***,we identified a long non-coding RNA,HDRACA,that is involved in the regulation of angiogenesis by *** this study,we showed that nHDL downregulates the expression of HDRACA in endothelial cells by activating WW domain-containing E3 ubiquitin protein ligase 2,which catalyzes the ubiquitination and subsequent degradation of its transcription factor,Kruppel-like factor 5,via sphingosine 1-phosphate(S1P)receptor *** contrast,dHDL with lower levels of S1P than nHDL were much less effective in decreasing the expression of *** was able to bind to Ras-interacting protein 1(RAIN)to hinder the interaction between RAIN and vigilin,which led to an increase in the binding between the vigilin protein and proliferating cell nuclear antigen(PCNA)mRNA,resulting in a decrease in the expression of PCNA and inhibition of *** expression of human HDRACA in a hindlimb ischemia mouse model inhibited the recovery of *** together,these findings suggest that HDRACA is involved in the HDL regulation of angiogenesis,which nHDL inhibits the expression of HDRACA to induce angiogenesis,and that dHDL is much less effective in inhibiting HDRACA expression,which provides an explanation for the decreased ability of dHDL to stimulate angiogenesis.

关键词： angiogenesis lipoprotein inhibited

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Predicted 10-year Cardiovascular Disease Risk and Its Association with Sleep Duration among Adults in Beijing-Tianjin-Hebei Region,china

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Biomedical and Environmental Sciences 2021年第10期34卷 803-813页

作者： WANG Yu Xue zhang Li LI Chun jun QI Xin FAN ya Qi HE jiang Shan GUO Pei HU jia Lin CHEN Shuo NIU Yu Jie LIU Feng zhang Rong LI Qiang ma Shi Tao zhang Mian Zhi HONG Cheng Lin zhang Min Ying School of Medicine Nankai UniversityTianjin 300071China Tianjin First Central Hospital Tianjin 300071China Tianjin Union Medical Center Tianjin 300071China Beijing Physical Examination Center Beijing 100021China Hebei Key Laboratory of Environment and Human Health Shijiazhuang 050000HebeiChina department of Occupational Health and Environmental Health Hebei Medical UniversityShijiazhuang 050000HebeiChina Dongfang Hospital Beijing University of Chinese MedicineBeijing 100071China Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital Tianjin 300120China department of Social Welfare School of Public AffairsUniversity of CaliforniaLos Angeles 90095CAAmerica

Objective The study aims to predict 10-year cardiovascular disease(CVD)risk and explore its association with sleep duration among Chinese urban *** We analyzed part of the baseline data of a cohort that recruited adults for health screening by cluster *** simplified Pittsburgh Sleep Quality Index(PSQI)and Framingham 10-year risk score(FRS)were used to measure sleep duration and CVD *** characteristics,personal history of chronic diseases,lifestyle factors were collected using a ***,weight,total cholesterol(TC),and high-density lipoprotein cholesterol(HDL-C)were also *** logistic regression models were performed to explore the association of sleep duration with the predicted CVD *** We included 31,135 participants(median age 44 years,53.02%males)free of CVD,cerebral stroke,and not taking lipid-lowering ***,14.05%,and 25.55%of participants were at medium and high predicted CVD risk,*** sleep was independently associated with increased odds of medium to high risk of predicted 10-year CVD among males(OR=1.10;95%CI:1.01–1.19)and increased odds of medium to high and high risk of predicted 10-year CVD among females(OR=1.23;95%CI:1.08–1.40;OR=1.27;95%CI:1.11–1.44).In contrast,long sleep had no association with cardiovascular *** A substantial number of adults free of CVD were at high 10-year CVD *** sleep was associated with increased odds of predicted CVD risk.

关键词： Predicted 10-year CVD risk Framingham risk score Sleep duration

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