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六味安神胶囊联合氨氯地平贝那普利治疗老年原发性高血压伴焦虑抑郁障碍患者的临床疗效及对NR2B蛋白表达的干预作用

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广州中医药大学学报 2024年第8期41卷 2001-2008页

作者：李慧琼马圣军马训平刘丽柳丹湖北省国药葛洲坝中心医院湖北宜昌443000

【目的】分析六味安神胶囊联合氨氯地平贝那普利治疗老年原发性高血压(essential hypertension,EH)伴焦虑抑郁障碍患者的临床疗效及对N-甲基-D-天冬氨酸受体2B亚基(NR2B)蛋白表达的干预作用。【方法】选取该院老年科2020年12月至2022年1... 详细信息

【目的】分析六味安神胶囊联合氨氯地平贝那普利治疗老年原发性高血压(essential hypertension,EH)伴焦虑抑郁障碍患者的临床疗效及对N-甲基-D-天冬氨酸受体2B亚基(NR2B)蛋白表达的干预作用。【方法】选取该院老年科2020年12月至2022年12月就诊的138例老年原发性高血压伴焦虑抑郁障碍痰热壅盛证患者进行回顾性研究,根据治疗方案的不同将患者分为观察组和对照组,每组各69例。对照组给予氨氯地平贝那普利及常规心理治疗,观察组在对照组的基础上给予六味安神胶囊治疗,疗程为1个月。观察2组患者治疗前后血压指标[收缩压(SBP)、舒张压(DBP)]、汉密尔顿焦虑量表(HAma)评分、汉密尔顿抑郁量表(HAMD)-17项评分、NR2B蛋白表达量、单胺类神经递质[多巴胺(DA)、肾上腺素(NE)、5-羟色胺(5-HT)]的变化情况,并比较2组患者的临床疗效和不良反应总发生率。【结果】(1)治疗1个月后,观察组的总有效率为95.65%(66/69),对照组为75.36%(52/69),组间比较(χ^(2)检验),观察组的疗效明显优于对照组(Pma评分和HAMD-17项评分均较治疗前明显降低(Pma评分和HAMD-17项评分的降低作用均明显优于对照组(P0.05)。【结论】六味安神胶囊联合氨氯地平贝那普利可有效减轻老年原发性高血压伴焦虑抑郁障碍痰热壅盛证患者的不良情绪,降低血压,抑制NR2B蛋白过度表达,纠正单胺类神经递质紊乱,且联合治疗未引发严重不良反应,安全有效。

关键词：六味安神胶囊氨氯地平贝那普利老年原发性高血压焦虑抑郁障碍痰热壅盛 N-甲基-D-天冬氨酸受体2B亚基(NR2B)蛋白

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中成药均一化投料研究策略

中国中药杂志 2024年第16期49卷 4537-4544页

作者：刘佳萌刘岩彭佳慧孙博杨晶凡付钰马生军朱广伟中国中医科学院中药研究所北京100700 河南中医药大学河南郑州450046 北京中医药大学北京102488 中国医学科学院医药生物技术研究所北京100050 新疆农业大学食品科学与药学学院新疆乌鲁木齐830052 中国中医科学院博士后科研流动站北京100700

中成药是中医药产业的重要组成部分,也是中医药现代化的重要标志。目前,中成药制剂批间质量稳定性问题成为制约中药产业高质量发展的关键因素之一,投料饮片质量不均一是影响该问题的直接因素。该文就提高中成药投料饮片质量的均一性问题... 详细信息

中成药是中医药产业的重要组成部分,也是中医药现代化的重要标志。目前,中成药制剂批间质量稳定性问题成为制约中药产业高质量发展的关键因素之一,投料饮片质量不均一是影响该问题的直接因素。该文就提高中成药投料饮片质量的均一性问题,提出了均一化投料研究方案。分别从均一化对象及前处理、均一化投料操作规程、均一化评价指标的选择、均一化投料算法、均一化投料工艺等方面进行系统阐述,依据关键质控指标作为均一化目标,探讨均一化投料工艺及其质量分析,形成中成药均一化投料示范性工艺策略,以期为推进中成药制剂批间质量一致性研究提供科学依据。

关键词：中成药中药制剂质量标准均一性均一化投料

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基于蒙特卡洛模拟的虚拟测试场景生成方法

计算机仿真 2024年第2期41卷 473-476,481页

作者：姚明菊李志远羊雪玲马军生吉利学院智能科技学院四川成都610000 国防科技大学信息通信学院湖北武汉430000

为了提高用户在虚拟测试场景中的体验感,提高虚拟测试场景的真实度,提出基于蒙特卡洛模拟的虚拟测试场景生成方法。采用Meanshift分割方法分割输入图像,并对分割后的图像块实施融合,标记图像区域,获取对应的深度图,融合上述深度图获得... 详细信息

为了提高用户在虚拟测试场景中的体验感,提高虚拟测试场景的真实度,提出基于蒙特卡洛模拟的虚拟测试场景生成方法。采用Meanshift分割方法分割输入图像,并对分割后的图像块实施融合,标记图像区域,获取对应的深度图,融合上述深度图获得虚拟测试场景的深度图。采用透射率估计方法融合虚拟测试场景的深度图,通过梯度融合方法融合归一化处理低照度图像,将支持向量机学习方法引入场景生成过程中,控制场景生成过程。采用蒙特卡洛模拟方法消除场景中存在的噪声斑点,优化生成的虚拟测试场景。实验结果表明,研究方法的场景生成误差较小,生成的虚拟测试场景具有较高的逼真度和真实感。

关键词：蒙特卡洛模拟透射率估计方法梯度融合方法虚拟测试场景生成

In silico optimization of actuation performance in dielectric elastomercomposites via integrated finite element modeling and deep learning

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Theoretical & Applied Mechanics Letters 2024年第1期14卷 48-56页

作者： Jiaxuan ma sheng Sun materials Genome Institute Shanghai UniversityShanghai 200444China Zhejiang Laboratory Hangzhou 311100China Shanghai Frontier Science Center of Mechanoinformatics Shanghai UniversityShanghai 200444China

Dielectric elastomers(DEs)require balanced electric actuation performance and mechanical integrity under applied *** high dielectric particles as fillers provides extensive design space to optimize concentration,morphology,and distribution for improved actuation performance and material *** study presents an integrated framework combining finite element modeling(FEM)and deep learning to optimize the microstructure of DE *** first calculates actuation performance and the effective modulus across varied filler combinations,with these data used to train a convolutional neural network(CNN).Integrating the CNN into a multi-objective genetic algorithm generates designs with enhanced actuation performance and material modulus compared to the conventional optimization approach based on FEM approach within the same *** framework harnesses artificial intelligence to navigate vast design possibilities,enabling optimized microstructures for high-performance DE composites.

关键词： Dielectric elastomer composites Multi-objective optimization Finite element modeling Convolutional neural network

Diagnostic performance of dynamic contrast-enhanced magnetic resonance imaging parameters and serum tumor markers in rectal carcinoma prognosis

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1796-1807页

作者： Ren-Qi Mu jun-Wei Lv Cai-Yun ma Xiao-Hui ma Dong Xing Hou-sheng ma Department of Radiology Yantai Mountain HospitalYantai 264001Shandong ProvinceChina Department of Radiology Yantai Yuhuangding HospitalYantai 264000Shandong ProvinceChina Department of Gynaecology Yantai Yuhuangding HospitalYantai 264000Shandong ProvinceChina The First Clinical Medical College Xinjiang Medical UniversityUrumqi 830011Xinjiang Uygur Autonomous RegionChina

BACKGROUND Rectal carcinoma(RC),one of the most common malignancies globally,presents an increasing incidence and mortality year by year,especially among young people,which seriously affects the prognosis and quality of life of *** present,dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)parameters and serum carbohydrate antigen 19-9(CA19-9)and CA125 Levels have been used in clinical practice to evaluate the T stage and differentiation of ***,the accuracy of these evaluation modalities still needs further *** study explores the application and value of these methods in evaluating the T stage and differentiation degree of *** To analyze the diagnostic performance of DCE-MRI parameters combined with serum tumor markers(TMs)in assessing pathological processes and prognosis of RC *** A retrospective analysis was performed on 104 RC patients treated at Yantai Yuhuangding Hospital from may 2018 to January *** were categorized into stages T1,T2,T3,and T4,depending on their T stage and differentiation *** addition,they were assigned to low(L group)and moderate-high differentiation(M+H group)groups based on their differentiation *** levels of DCE-MRI parameters and serum CA19-9 and CA125 in different groups of patients were *** addition,the value of DCE-MRI parameters[volume transfer constant(Ktrans),rate constant(Kep),and extravascular extracellular volume fraction(Ve)in assessing the differentiation and T staging of RC patients was ***,the usefulness of DCE-MRI parameters combined with serum CA19-9 and CA125 Levels in the evaluation of RC differentiation and T staging was *** Ktrans,Ve,CA19-9 and CA125 were higher in the high-stage group and L group than in the low-stage group and M+H Group,respectively(P<0.05).The areas under the curve(AUCs)of the Ktran and Ve parameters were 0.638 and 0.694 in the diagnosis of high and low stages,respectively,and 0.672 and 0

关键词： Rectal carcinoma Volume transfer constant Rate constant Extravascular extracellular volume fraction Serum carbohydrate antigen 19-9 Serum carbohydrate antigen 125

Active components of Dengzhan shengmai ameliorate cognitive impairment by facilitating hippocampal long-term potentiation via the NMDA receptor-mediated Ca^(2+)/CaMKII pathway

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Journal of Pharmaceutical Analysis 2024年第3期14卷 435-438页

作者： Congyu ma Ning sheng jun Wu Lulu Wang Jiandong Jiang Haibo Yu Jinlan Zhang State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100050China Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100050China

Abnormal synaptic plasticity causes cognitive *** long-term potentiation(LTP)is a critical synaptic plasticity process[1].Rescuing impaired LTP is challenging;hence,novel agents are required for LTP *** medicine Dengzhan shengmai(DzSM)has shown notable clinical efficacy against cognitive deficits[2].However,it remains unclear how DzSM modulates *** previous study[3]revealed the influence of DZSM on glutamatergic and GABAergic synapses following chronic cerebral hypoperfusion(CCH),which motivated us to assess how DzSM affects synaptic functions.

关键词： impaired impairment hence

Cloning of XET gene from Anthocephalus chinensis and its plant expression vector construction

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Forestry Studies in China 2010年第2期12卷 79-84页

作者： ma sheng-jun ZHU Song-lin LI Wei OUYANG Kun-xi LI Na CHEN Xiao-yang Key Laboratory for Genetics and Breeding in Forest Trees and Ornamental Plants of Ministry of Education National Engineering Laboratory for Forest Tree Breeding Beijing Forestry University Beijing 100083 P. R. China State-owned Forest Administration of Lvliangshan Mountain Linfen 041000 P. R. China Forestry Research Institute of Hebei Province Shijiazhuang 050061 P. R. China College of Forestry South China Agricultural University Guangzhou 200064 P. R. China

A full-length cDNA sequence of xyloglucan endotransglycosylase gene （XET）, abundantly expressed in the cambium of Anthocephalus chinensis was cloned by conserved PCR, rapid-amplification of cDNA ends and by chromosome walking. Analytical results of the DNA sequence show that a 912 bp complete open reading frame （ORF） encoded a 303-amino acid protein was in the 1205 bp full cDNA sequence. The deduced amino acid sequence of AcXET, which contained the conserved specific EIDFE catalytic site sequence to XETs was homologous to the other known XET proteins. In order to study the gene function of AcXET and obtain transgenic plants, a plant expression vector pBIAcXET was constructed by recombinating the AcXET fragment from the cloning vector pMD19AcXET and the binary vector pBI121 between the XbaI and SmaI sites. The fragment ofAcXET gene was inserted between the CaMV 35S promotor and the coding region of the GUS gene in pBI121. The identification results show that the plant expression binary vector pBIAcXET was constructed successfully. These results lay the foundation for studying the molecular mechanism ofAcXET gene during wood formation.

关键词： cDNA cloning sequence analysis AcXET gene plant expression vector

Cohomology groups of a new class of Kadison-Singer algebras

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Science China mathematics 2024年第3期67卷 593-606页

作者： Guangyu An Xing Cheng jun sheng School of mathematics and Data Science Shaanxi University of Science and TechnologyXi’an 710021China

Let N be a maximal discrete nest on an infinite-dimensional separable Hilbert space H,ξ=∑^(∞)_(n=1)en/2n be a separating vector for the commutant N',E_(ξ)be the projection from H onto the subspace[Cξ]spanned by the vectorξ,and Q be the projection from K=H⊕H⊕H onto the closed subspace{(η,η,η)^(T):η∈H}.Suppose that L is the projection lattice generated by the projections(E_(ξ) 0 0 0 0 0 0 0 0),{(E 0 0 0 0 0 0 0 0):E∈N},(I 0 0 0 I 0 0 0 0) and *** show that L is a Kadison-Singer lattice with the trivial ***,we prove that every n-th bounded cohomology group H~n(AlgL,B(K))with coefficients in B(K)is trivial for n≥1.

关键词： Kadison-Singer algebra Kadison-Singer lattice derivation cohomology group

Volume of fluid simulation of single argon bubble dynamics in liquid steel under RH vacuum conditions

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Journal of Iron and Steel Research International 2024年第4期31卷 828-837页

作者： Gu-jun Chen sheng-ping He College of materials Science and Engineering Yangtze Normal UniversityChongqing 400044China College of materials Science and Engineering Chongqing UniversityChongqing 400044China

Single argon bubble dynamics in liquid steel under Ruhrstahl-Heraeus(RH)vacuum conditions were simulated using the volume of fluid method,and the ideal gas law was used to consider bubble growth due to heat transfer and pressure *** simulation with a constant bubble density was also performed to validate the numerical method,and the predicted terminal bubble shape and velocity were found to agree with those presented in the Grace diagram and calculated by drag correlation,*** simulation results under RH conditions indicate that the terminal bubble shape and velocity cannot be *** primary bubble growth occurs within a rising distance of 0.3 m owing to heating by the high-temperature liquid steel;subsequently,the bubble continues to grow under equilibrium with the hydrostatic *** the initial diameter is 8-32 mm,the bubble diameter and rising velocity near the liquid surface are 80-200 mm and 0.5-0.8 m/s,*** bubble rises rectilinearly with an axisymmetric shape,and the shape evolution history includes an initial sphere,(dimpled)ellipsoid,and spherical cap with satellite bubbles.

关键词： Bubble dynamics Liquid steel Volume of fluid Bubble growth Bubble shape Rising velocity