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测定功能表现作为ALS临床试验的终点

世界核心医学期刊文摘（神经病学分册） 2005年第4期1卷 45-45页

作者： Traynor B.J. Shefner J.m. 姚庆和 massachusetts General Hospital- East Day Lab. for Neuromuscular Research Building 114 16th Street Charlestown MA 02129 United States Dr

The topiramate study was a 12- month randomized placebocontrolled trial in patients with ALS. Follow- up evaluation of the placebo group (n = 97) constituted a well- described cohort of patients with ALS, in whom multiple outcome measures were assessed at 3- month intervals. During the 12- month study period, the decline of forced vital capacity (FVC% ) and ALS functional rating scale (ALSFRS) was linear, whereas the decline of maximum voluntary isometric contraction- arm (mVIC- arm) and mVIC- grip z scores was curvilinear. Rates of FVC% and ALFRS decline, but not of mVIC- arm or mVIC- grip, were independent predictors of survival.

关键词：临床试验 ALS 托吡酯最大肺活量安慰剂随机对照试验等长收缩等级评分随访评估

通过mRI对踝部数据的测量来评估足跟畸形:对4种测量技术的评价

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国际医学放射学杂志 2013年第6期 600-600页

作者： F.m.Buck A.Hoffmann N.mamisch-Saupe m.Farshad D.Resnick N.Espinosa 张恩龙张琪 Radiology University Hospital Balgrist University of zurich Forchstrasse 3408008 ZürichSwitzerland

摘要目的通过研究冠状位非承重状态下的mR影像来鉴别正常和异常的足跟部基本结构。方法对49例病人使用3种不同的测量技术(足跟的轴,内侧/外侧跟骨等高线)

关键词：足跟基线足跟基线平片 mRI 内翻畸形角度失准

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沙枣中芳香化合物的分离与结构鉴定

中国药物化学杂志 2022年第12期32卷 931-937页

作者：付洋杨丁山鲁梦琪阮静雅王涛张祎天津中医药大学天津市中药化学与分析重点实验室天津301617

目的研究沙枣(Elaeagnus angustifolia L.)乙醇提取物的化学成分。方法采用多种色谱和波谱技术对沙枣乙醇提取物的化学成分进行分离纯化和结构鉴定。结果与结论从沙枣体积分数为70%的乙醇提取物中分离得到15个化合物,分别鉴定为对羟基... 详细信息

目的研究沙枣(Elaeagnus angustifolia L.)乙醇提取物的化学成分。方法采用多种色谱和波谱技术对沙枣乙醇提取物的化学成分进行分离纯化和结构鉴定。结果与结论从沙枣体积分数为70%的乙醇提取物中分离得到15个化合物,分别鉴定为对羟基苯甲酸(1)、原儿茶醛(2)、3,4-二羟基苯甲酸(3)、3,4-二羟基苯甲酸乙酯(4)、香草酸(5)、没食子酸(6)、淫羊藿次苷F2(7)、苯乙基-β-D-葡萄糖苷(8)、淫羊藿次苷(9)、4-O-β-D-吡喃葡萄糖基反式肉桂酸(10)、顺式对羟基肉桂酸(11)、4-O-β-D-吡喃葡萄糖基顺式苯丙烯酸(12)、顺式-阿魏酸4-O-β-D-葡萄糖苷(13)、(E)-芥子酸4-O-β-D-葡萄糖苷(14)和(z)-芥子酸4-O-β-D-葡萄糖苷(15)。其中,化合物2、4、7~15为首次从胡颓子属植物中分离得到,并首次报道了化合物15的核磁共振波谱数据。

关键词：沙枣芳香化合物提取分离结构鉴定

4-4 Double-slit Interferences Observed in Dielectronic Transitions in Collisions of H2+ on Helium

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ImP & HIRFL Annual Report 2014年第1期 181-182页

作者： zhang Shaofeng D. Fischer m. Schulz A. B. Voitkiv A. Senftleben A. Dorn J. Ullrich X. ma R. moshammer 不详

Young's double-slit interference is a clear manifestation of the wave character of light. The feasibility of an atomicversion of Young's double slit experiment for matter waves in ion-atom collisions was first discussed theoreticallyby Tuan and Gerjuoy in 1960[1]. They studied capture processes in collisions of protons with H2 and suggestedthat diffraction of the protons from the two atomic centers of the molecule could lead to interference effects. Suchinterference effects are more difficult to observe in ionization processes, since there the final state of the collisioninvolves at least three unbound particles. The experimental observation of this process is particularly challengingbecause the determination of the phase angle in such processes is not straightforward.

关键词： Interferences Observed Dielectronic

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临床试验中复合终点的有效性

英国医学杂志中文版 2005年第5期8卷 315-318页

作者： Victor m montori Gaietà Permanyer-miralda Ignacio Ferreira-González Jason W Busse Valeria Pacheco-Huergo Dianne Bryant Jordi Alonso Elie A Akl Antònia Domingo-Salvany Edward mills Holger J Schünemann Roman Jaeschke Gordon H Guyatt 杜昕 epartment ofmedicine MayoClinic Collegeof MedicineRochesterMN 55905 USAassistant professor Cardiology Service Epidemiology UnitHospital GeneralVall d'HebronBarcelona 08035 Spainsenior consultant Department de medicina UniversitatAutònoma de BarcelonaHospital GeneralVall d'Hebronresearch fellow Department ofClinical Epidemiologyand Biostatistics McMaster UniversityHamiltonON L8N 3Z5 Canadaresearch associate Primary Care Centre Turó EAP VilapicinaInstitut Catalàde la SalutBarcelona Spaingeneral practitioner Department ofClinical Epidemiologyand Biostatistics McMaster UniversityHamiltonON L8N 3Z5instructor Health Services Research Unit Institut Municipald'InvestigacióMèdica BarcelonaSpainhead Department ofmedicine andof Social andPreventive medicine University atBuffalo BuffaloNY 14214 USAresearchassistant professor Health Services Research Unit Institut Municipald'InvestigacióMèdica BarcelonaSpain senior scientist Department ofResearch Canadian Collegeof Naturopathic Medicine TorontoCanada M2K 1E2director ofresearch Department ofmedicine andof Social andPreventive medicine University atBuffalo BuffaloNY 14214 USAassociate professor Department of medicine McMaster Universityclinical professor Department ofClinical Epidemiologyand Biostatistics McMaster UniversityHamiltonON L8N 3Z5professor

采用复合终点作为随机临床试验的主要结局指标有时会掩盖各个终点事件间的巨大差别，在临床实践中如何参照这些临床试验的结果呢？

关键词：随机临床试验终点复合临床实践

DISPLACEmENT HISTORY OF THE GANGDESE THRUST, zEDONG WINDOW, SOUTHEASTERN TIBET

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地学前缘 2000年第S1期7卷 109-109页

作者： T. mark Harrison 1,Yin An 1, marty Grove 1, Oscar m. Lovera 1,F.J. Ryerson 2,zhou Xinhua 3[WT5,5”BX](1 Department of Earth and Space Sciences & IGPP, UCLA, Los Angeles, CA, 90095\|1567, USA. 2 Institute of Geophysics & Planetary Physics

Determining the timing, magnitude, and location of deformation due to the Indo\|Asian collision is widely acknowledged as an important step in understanding how the lithosphere responds during continental collision. Thus a puzzling result of geological investigations of the Lhasa Block over the past two decades has been the apparent lack of significant Tertiary deformation there. Perhaps the most important structural feature of the Lhasa Block is the south\|directed Gangdese Thrust System, which developed along its southern edge. The thrust system, which separates the Andean\|type batholith of southern Asia from rocks of Indian affinity, is obscured at most locations across southeastern Tibet by backthrusts of the younger, north\|directed Renbu zedong Thrust System. The best documented site where both thrusts are exposed is a structural window near zedong.

关键词： displacement geochronologic analyses the Gangdese Thrust the z edong Window Southeastern Tibet

原发性胃间质瘤肿瘤体积估计的准确性及可行性:127例病人使用半自动技术验证

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国际医学放射学杂志 2016年第2期 209-209页

作者： S.H.Tirumani A.B.Shinagare A.C.O 'Neill m.Nishino m.H..Rosenthal N.H.Ramaiya 牟文莹 Department of Imaging Dana Farber Cancer Institute Harvard Medical School

摘要目的采用半自动容量法验证原发性胃间质瘤肿瘤体积估计方法的可靠性。方法经伦理委员会批准,选择2000—2013年间在本学院的127例原发性胃间质瘤病人(女52例,男75例,平均年龄61岁)的CT影像行回顾性研究。在CT影像上,测量了肿瘤X轴、... 详细信息

摘要目的采用半自动容量法验证原发性胃间质瘤肿瘤体积估计方法的可靠性。方法经伦理委员会批准,选择2000—2013年间在本学院的127例原发性胃间质瘤病人(女52例,男75例,平均年龄61岁)的CT影像行回顾性研究。在CT影像上,测量了肿瘤X轴、Y轴及z轴3个方向的

关键词：胃间质瘤肿瘤体积原发性病人

The Characterization of Poly(lactic-co-glycolic acid) /Silk Fibroin Blend Nanofibrous mats with the methanol Vapor Treatment

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The Characterization of Poly(lactic-co-glycolic acid) /Silk ...

生物材料与再生医学的现状与未来——2010年第十届上海地区医用生物材料研讨会

作者： LIU Jun-yi~1,Wu Jing-lei~1,Fan lin-peng~1,HE Chuang-long~1,WANG Hong-sheng~1,,m0 Xiu-mei~(1,2) Biomaterials and Tissue Engineering Lab,College of Chemistry and Chemical Engineering and Biological Engineering,Donghua University,Shanghai,201620,P.R.China State Key Laboratory for modification of Chemical Fibers and Polymer materials,College of materials Science and Engineering,Donghua University,Shanghai,201620,P.R.China

In this study,the PLGA/SF blended nanofibrous mats with different weight ratios were fabricated using 1,1,1,3,3,3-hexa uoro-2-propanol(HFIP) as a solvent via *** unique aspect of the postprocessing protocol in this study involves the use of methanol as the post -processing agent,because the electrospun mats immediately dissolve when placed in an aqueous *** the pure PLGA mats is not necessary treatment,because it is insoluble in an aqueous *** SF/PLGA nanofibers were studied by SEm,XRD and mechanical *** characters have significant changed between the treated and untreated *** nanofibrous morphologies were observed by SEm,the results showed that the nanofibers still maintained an excellent morphology after treated by methanol *** analyses demonstrated that the crystallinity occured significant *** tensile strength and elongation at break of post -processed nanofibrous membrances decreased compared with untreated mats except the pure SF *** tensile strength of the treated SF sample was increased,but the elongation at break was *** blended nanofibers are potential for their application in tissue engineering scaffolds and to develop functional biomaterials.

关键词： silk fibroin PLGA nanofibrous methanol,treatment

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《血吸虫病健康教育盒》的研制与预试验

中国血吸虫病防治杂志 2004年第6期16卷 443-445页

作者：张矩胡广汉杨新跃葛军陈年高黄美娇李东康增华江西省寄生虫病防治研究所南昌330046 江西省职业病防治所江西省恒湖农场血防组

目的　研制科学、直观、方便、具有针对性的新型血防健康教育材料 ,并检验其对目标人群的适用性。方法　将实物标本和图片有机结合 ,制作成《血吸虫病健康教育盒》。采用专题小组讨论和把关人咨询两种方法对材料进行预试验。结果　根据... 详细信息

目的　研制科学、直观、方便、具有针对性的新型血防健康教育材料 ,并检验其对目标人群的适用性。方法　将实物标本和图片有机结合 ,制作成《血吸虫病健康教育盒》。采用专题小组讨论和把关人咨询两种方法对材料进行预试验。结果　根据目标受众信息的需求 ,采用了主要信息 5条 :血吸虫病的传播 ;血吸虫病的危害 ;儿童血吸虫病的预防 ;成年妇女血吸虫病的预防 ;血吸虫病要早检查早治疗。另采用血吸虫病防治的二级信息 4条。结论　研制的《血吸虫病健康教育盒》可批量制作 ,供疫区使用。

关键词：血吸虫病健康教育预试验