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Development of Angle Resolved HXPS Instrument for Laboratory Use

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Development of Angle Resolved HXPS Instrument for Laboratory...

第18届国际真空大会

作者： H. Iwai m. Kobata I. Pí H. yoshikawa S. Tanuma H. Yamazui H. Takahashi m. Kodama A. Tanaka m. Suzuki E. Ikenaga H. matsuda H. Daimon K. Kobayashi materials Analysis Station National Institute for Materials ScienceTsukuba 305-0047Japan NImS Beamline Station at Spring-8 National Institute for Materials ScienceSayo 679-5148Japan Department of Surface and Plasma Science Charles University in Prague 18000Czech Republic

We have developed high throughput angle resolved hard X-ray photoelectron spectroscopy （HXPS） instrument for laboratory use [1], which are composed by combining a monochromatic Cr Kα focused X-ray source and a wide acceptance objective for a spectrometer. The Cr Kα X-rays （5.4 keV） excited by micro focused electron beam are monochromatized and focused on to a sample surface by an ellipsoidal bent crystal monochromater with 300 mm Roland circle. The X-ray spot size is variable from 10 μm （1.25 W） to 200 μm （50 W） in diameter. In front of a VG Scienta R4000 10 kV spectrometer, a wide acceptance objective lens is integrated as a hybrid lens to collect photoelectrons emitted from a sample in the range of ±35 degrees for high sensitivity and angle resolved XPS spectra without tilting the sample. The total energy resolution of 0.53 eV was verified by Au Fermi edge measurement. A typical acquisition time for angle resolved Si 1s spectra of a SiO2（4 nm）/Si（001） overlayered thin film sample is around 1 hour in the emission angle of 10 to 80 degrees with 0.5 degrees angler resolution without tilting the sample. The Si 1s peak from the substrate at kinetic energy of 3569 eV is observed through the 25 nm thickness overlayered SiO2 on Si（001）.

关键词： HAXPES ARXPS nondestructive depth profiling

Astrometric VLBI Observation of Spacecraft with Phase Delay

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Astrometric VLBI Observation of Spacecraft with Phase Delay

2004无线电科学国际会议

作者： mamoru Sekido Ryuichi Ichikawa Hiro Osaki Tetsuro Kondo Yasuhiro Koyama makoto yoshikawa Takafumi Ohnishi Wayne Cannon Alexander Novikov mario Berube National Institute of Information and Communications Technology Kashima Space Research Center 893-1 Hirai Kashima Ibaraki 314-8501 Japan National Institute of Information and Communications Technology Kashima Space Research Center 893-1 Hirai Kashima Ibaraki 314-8501 Japan National Institute of Information and Communications Technology Kashima Space Research Center 893-1 Hirai Kashima Ibaraki 314-8501 Japan National Institute of Information and Communications Technology Kashima Space Research Center 893-1 Hirai Kashima Ibaraki 314-8501 Japan National Institute of Information and Communications Technology Kashima Space Research Center 893-1 Hirai Kashima Ibaraki 314-8501 Japan Institute of Space and Astronautical Sciences/JAXA 3-1-1 Yoshinodai Sagamihara Kanagawa 229-8510 Japan Advanced Science Solutions Group/Fujitsu Limited. 4-1-1 Kamikodanaka Nakahara-ku Kawasaki Kanagawa 211-8588 Japan Space Geodynamics Laboratory Department of Physics and Astronomy York University 4700 Keele Street Toronto Ontario M3J 1P3 Canada Space Geodynamics Laboratory Department of Physics and Astronomy York University 4700 Keele Street Toronto Ontario M3J 1P3 Canada Geodetic Survey Division/Natural Resources Canada 615 Booth Street Room 440 Ottawa OntarioK1A 0E9 Canada.

A series of VLBI observations for spacecraft NOZOmI was performed in the period between the end of 2002 and July 2003 with aim of supporting the orbit determi- nation. We have made astrometric anal

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Impairment of autophagic signaling in murine forebrain disrupts GABAA receptor trafficking leading to excitatoryinhibitory imbalance and ASD-like behaviours

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Impairment of autophagic signaling in murine forebrain disru...

中国神经科学学会第十二届全国学术会议

作者： Kelvin Hui Noriko Takashima Hiroshi matsukawa Akiko Watanabe Per Nilsson Ryo Endo Takaomi Saido Shigeyoshi Itohara Takeo yoshikawa motomasa Tanaka Laboratory for Protein Conformation Diseases RIKEN Brain Science Institute Laboratory for Behavioral Genetics RIKEN Brain Science Institute Laboratory for molecular Psychiatry RIKEN Brain Science Institute Laboroatory for Proteolytic Neuroscience RIKEN Brain Science Institute Department of Neurobiology Care Sciences and Society Karolinska Institutet

many syndromic forms of autism spectrum disorder(ASD) are caused by mutations in proteins such as PTEN, TSC1, TSC2, and FmRP, which lie within the m TOR signaling pathway. While recent work has primarily focused on the dysregulation of protein translation via the deletion of these genes, few studies have examined how disruption of autophagy, another major downstream branch of m TOR signaling,contributes to neuronal dysfunction and ASD pathogenesis. To this end, we and others have previously examined mice deficient for autophagy in forebrain excitatory neurons via the deletion of Atg7 by Ca mKII-cre and observed ASD-like behavioural abnormalities in addition to neuronal dysfunctions from the molecular to the network level. As ASD is believed to be caused by an imbalance between excitatory and inhibitory signals in the brain, we have further extended our analysis to examine disruption of autophagy in forebrain GABAergic interneurons. Similar to disrupted autophagy in other neuronal and non-neuronal cell types, Atg7 deletion by Dlx5-cre results in time-dependent ubiquitin+ and p62+ aggregate formation in affected neurons. Notably, Dlx5-cre Atg7 c KO mice exhibit an overlapping set of ASD-like behavioural abnormalities previously observed in Ca mKII-cre Atg7 c KO animals. Furthermore, we have detected a disruption of the excitatory-inhibitory balance in both Ca mKII-cre and Dlx5-cre Atg7 c KO mice. Using primary cultured neurons, a specific reduction of surface GABAA receptors was observed in Atg7 c KO neurons. Unbiased mass spectrometric and subsequent antibody-based analyses demonstrated that members of the GABARAP(GABA receptor-associated protein) protein family accumulate and mislocalize to p62+ aggregates formed in affected neurons of both Ca mKII-cre and Dlx5-cre Atg7 c KO brains. Genetic manipulation of GABARAP family proteins and p62 in wild-type or Atg7 c KO neurons further revealed that GABAA receptor trafficking are influenced by p62 aggregates as they intera

关键词： autophagy autism protein aggregation GABAA receptors GABARAP

全身mRI检查、全身扩散mR成像与一体化FDG PET/CT诊断m期非小细胞肺癌的对照性研究

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国际医学放射学杂志 2008年第5期31卷 407-408页

作者： Y.Ohno H.Koyama Y.Onishi D.Takenaka m.Nogami T. yoshikawa 高莉 Department of Radiology Kobe University Graduate School of Medicine 7-5-2 Kusunoki-cho Chuo-ku Kobe 650-0017 Japan.

目的对单纯全身扩散加权成像（DWI）、全身磁共振成像（mRI）结合DWI、单纯全身mRI以及一体化^18F-氟脱氧葡萄糖（FDG）PET／CT对于非小细胞肺癌（NSCLC）病人m期的诊断价值进行前瞻陆直接对照研究。方法本研究经伦理委员会批准，所有... 详细信息

目的对单纯全身扩散加权成像（DWI）、全身磁共振成像（mRI）结合DWI、单纯全身mRI以及一体化^18F-氟脱氧葡萄糖（FDG）PET／CT对于非小细胞肺癌（NSCLC）病人m期的诊断价值进行前瞻陆直接对照研究。方法本研究经伦理委员会批准，所有受试者都签署了知情同意书。共计203例NSCLC病人（男109例，女94例，平均年龄72岁），进行了前瞻陛全身DWI、全身mRI和FDGPET／CT检。m期的最后诊断取决于所有影像检查和随访检查结果。

关键词： PET/CT 非小细胞肺癌 mRI检查全身扩散 CT诊断 FDG 一体化 mR成像

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mR化学交换饱和位移成像在胸部良恶性病变鉴别诊断中的初步研究

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国际医学放射学杂志 2016年第4期 433-434页

作者： Y.Ohno m.Yui H.Koyama T.yoshikawa S.Seki Y.Ueno 黄梦琪 Division of Functional and Diagnostic Imaging Research Department of Radiology Advanced Biomedical Imaging Research Center Kobe University Graduate School of Medicine

摘要目的探讨酰胺质子-mR化学交换饱和位移成像在胸部病变的定性诊断能力。材料与方法研究经伦理委员会同意并获得21例病人(男13例,女8例,平均年龄72岁)的知情同意书。每例病人均进行化学交换饱和位移mR成像,先行一系列磁化脉冲后做呼... 详细信息

摘要目的探讨酰胺质子-mR化学交换饱和位移成像在胸部病变的定性诊断能力。材料与方法研究经伦理委员会同意并获得21例病人(男13例,女8例,平均年龄72岁)的知情同意书。每例病人均进行化学交换饱和位移mR成像,先行一系列磁化脉冲后做呼吸校准的半傅里叶快速自旋

关键词：化学交换良恶性 mR 磁化传递率胸部躯干

应用等效纬度海拔模型进行地温及多年冻土制图(英)

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冰川冻土 2002年第5期24卷 526-531页

作者： Kenji yoshikawa\+1,\ Larry D. Hinzman\+1,\ Prasad Gogineni\+2 (1.Water and Environmental Research Center, University of Alaska Fairbanks, USA 2.The University of Kansas, Radar Systems and Remote Sensing Laboratory, USA) Water and Environmental Research Center University of Alaska Fairbanks 美国 The University of Kansas Radar Systems and Remote Sensing Laboratory 美国

This research presents a method for permafrost mapping in discontinuous permafrost regions based on equivalent latitude/elevation concept in interior Alaska. In winter months, study site has a strong temperature inversion in air up to 700 m elevation. Air temperature data and the effects of slope, aspect and elevation were used to create an equivalent latitude/elevation model. This model was well correlated with mean annual surface temperature (0\^79). In this watershed, the thawing index (\%I\%\-t≈\{1 400\} ℃\5days) at the ground surface and snow depth do not vary greatly from south facing to north facing slopes. The primary controlled factor that determines the mean annual surface temperature was the winter surface temperature. The permafrost stability is effectively controlled by the freezing index. We determined 37\^5% of Caribou-Poker Creeks Research Watershed has unstable or thawing permafrost. At least 2\^1% of the permafrost in this watershed may have disappeared in the last 90 years due to climate warming. This method makes it possible to evaluate the permafrost stability in the present, past and future.

关键词：等效纬度-海拔模型地温多年冻土制图

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Prognostic factors in stage IB gastric cancer

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World Journal of Gastroenterology 2014年第21期20卷 6580-6585页

作者： Toru Aoyama Takaki yoshikawa Hirohito Fujikawa Tsutomu Hayashi Takashi Ogata Haruhiko Cho Takanobu Yamada Shinichi Hasegawa Kazuhito Tsuchida Norio Yukawa Takashi Oshima mari S Oba Satoshi morita Yasushi Rino munetaka masuda Department of Gastrointestinal Surgery Kanagawa Cancer CenterYokohama 241-0815Japan Department of Surgery Yokohama City UniversityYokohama 236-0004Japan Department of Biostatistics and Epidemiology Yokohama City UniversityYokohama 236-0004Japan

AIm:To identify the subset of patients with stage IB gastric cancer with an unfavorable ***:Overall survival(OS)rates were examined in 103 patients with stage IB(T1N1m0 and T2N0m0)gastric cancer between January 2000 and *** and multivariate analyses were performed to identify risk factors using a Cox proportional hazards ***:The OS rates of patients with T1N1 and T2N0 cancer were 89.2%and 94.1%at 5-years,*** univariate and multivariate analyses demonstrated that tumor location was the only significant prognostic *** OS rate was 81.8%at5-years when the tumor was located in the upper third of the stomach and was 95.5%at 5-years when the tumor was located in the middle or lower third of the stomach(P=0.0093).CONCLUSION:These data may suggest that tumor location is associated with survival in patients with stage IB gastric cancer.

关键词： Gastric cancer Stage IB Prognostic factor

中药牡丹皮中5种新的抗氧化糖甙没食子酰氧化芍药甙及一种丹皮酚糖甙的分离

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国际中医中药杂志 1994年第1期16卷 43-43页

作者： yoshikawa-m 李宗友

已从中药牡丹皮(Paeonia suffruticosa)的根皮中分离出5种新的抗氧化糖甙(命名为没食子酰氧化芍药甙,suffruticoside A,B,C和D)和一种新的丹皮酚糖甙(命名为suffruticoside E),同时还分离到抗氧化物没食子酰芍药甙。根据化学和物理化学... 详细信息

已从中药牡丹皮(Paeonia suffruticosa)的根皮中分离出5种新的抗氧化糖甙(命名为没食子酰氧化芍药甙,suffruticoside A,B,C和D)和一种新的丹皮酚糖甙(命名为suffruticoside E),同时还分离到抗氧化物没食子酰芍药甙。根据化学和物理化学的数据,确定了它们的结构。在研

关键词：牡丹皮丹皮酚糖甙没食子酰氧化抗氧化中药

ENERGY-LOSS FUNCTIONS DERIVED FROm REELS SPECTRA FOR ALUmINUm

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Acta metallurgica Sinica(English Letters) 2005年第3期18卷 217-222页

作者： Z.m.Zhang Z.J.Ding H.m.Li K.Salma X.Sun R.Shimizu T.Koshikawa K.Goto StructureResearchLaboratoryandDepartmentofPhysics UniversityofScienceandTechnologyofChinaTheChineseAcademyofSciencesHefei230026China DepartmentofInformationScience OsakaInstituteofTechnologyOsaka573-0196Japan FundamentalElectronicsResearchInstitute OsakaElectro-CommunicationUniversityOsaka572-8530Japan DepartmentofSystemsEngineering NagoyaInstituteofTechnologyNagoya466-8555Japan

The effective energy loss functions for Al have been derived from differential i nverse inelastic mean free path based on the extended Landau approach. It has be en revealed that the effective energy loss function is very close in value to th e theoretical surface energy loss function in the lower energy loss region but g radually approaches the theoretical bulk energy loss function in the higher ener gy loss region. moreover, the intensity corresponding to surface excitation in e ffective energy loss functions decreases with the increase of primary electron e nergy. These facts show that the present effective energy loss function describe s not only surface excitation but also bulk excitation. At last, REELS spectra s imulated by monte Carlo method based on use of the effective energy loss functio ns has reproduced the experimental REELS spectra with considerable success.

关键词： effective energy loss function monte Carlo simulation extended Landau approach reflection electron energy loss spectro scopy Aluminum

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