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neurocircuit regeneration by extracellular matrix reprogramming

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neural Regeneration Research 2025年第8期20卷 2300-2301页

作者： Shengzhang Su Ian n.Levasseur Kimberly m.Alonge Department of medicinal Chemistry University of WashingtonSeattleWAUSA Department of Chemistry University of WashingtonSeattleWAUSA Department of medicine University of Washington Medicine Diabetes InstituteSeattleWAUSA

The brain's extracellular matrix(ECm),which is comprised of protein and glycosaminoglycan(GAG)scaffolds,constitutes 20%-40% of the human brain and is considered one of the largest influencers on brain cell functioning(Soles et al.,2023).Synthesized by neural and glial cells,the brain's ECm regulates a myriad of homeostatic cellular processes,including neuronal plasticity and firing(miyata et al.,2012),cation buffering(moraws ki et al.,2015),and glia-neuron interactions(Anderson et al.,2016).Considering the diversity of functions,dynamic remodeling of the brain's ECm indicates that this understudied medium is an active participant in both normal physiology and neurological diseases.

关键词： matrix programming

Influence of surface treatments on fatigue life of a two-stroke free piston linear engine component using random loading

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第11期7卷 1819-1830页

作者： RAHmAn m.m. ARIFFIn A.K. jamaludin n. HAROn C.H.C. Department of mechanical and materials Engineering Faculty of Engineering Universiti Kebangsaan Malaysia 43600 UKM Bangi Selangor DE Malaysia

This paper describes the finite element (FE) analysis technique to predict fatigue life using the narrow band frequency response approach. The life prediction results are useful for improving the component design methodology at the very early development stage. The approach is found to be suitable for a periodic loading but requires very large time records to accurately describe random loading processes. This paper is aimed at investigating the effects of surface treatments on the fatigue life of the free piston linear engine’s components. Finite element modelling and frequency response analysis were conducted using computer aided design and finite element analysis commercial codes, respectively. In addition, the fatigue life prediction was carried out using finite element based fatigue analysis commercial code. narrow band approach was specially applied to predict the fatigue life of the free piston linear engine cylinder block. Significant variation was observed between the surface treatments and untreated cylinder block of free piston engine. The obtained results indicated that nitrided treatment yielded the longest life. This approach can determine premature products failure phenomena, and therefore can reduce time to market, improve product reliability and customer confidence.

关键词： Vibration fatigue Finite element (FE) Power spectral density function Frequency response Surface treatment

Survey of Robotics in Education, Taxonomy, Applications, and Platforms during COVID-19

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Computers, materials & Continua 2021年第4期67卷 687-707页

作者： Hussain A.Younis A.S.A.mohamed R.jamaludin m.n.ab Wahab College of Education for Women University of Basrah BasrahIraq School of Computer Sciences Universiti Sains MalaysiaMinden11800PenangMalaysia Centre For Instructional Technology&multimedia Universiti Sains MalaysiaMinden11800PenangMalaysia

The coronavirus disease 2019(COVID-19)is characterized as a disease caused by a novel coronavirus known as severe acute respiratory coronavirus syndrome 2(SARS-CoV-2;formerly known as 2019-nCoV).In December 2019,COVID-19 began to appear in a few *** the beginning of 2020,it had spread to most countries across the *** is when education challenges began to *** COVID-19 crisis led to the closure of thousands of schools and universities all over the *** a situation requires reliance on e-learning and robotics education for students to continue their studies to avoid the mingling between people and *** relation to this alternative learning solution,the present study was conducted.A systematic literature review on educational robotics(ER)keywords between 2015–2020 was carried out for the purpose to review a total of 2253 articles from the selected sources;Scopus(452),Taylor&Francis(311),Science Direct(427),IEEE Xplore(221),and Web of Science(842).This review procedure was labelled as Taxonomy *** ltering Taxonomy 1,it was found that 98 scientic articles formed the so-called Taxonomy II that was categorized into six categories:(i)Robotics concepts,(ii)Device,(iii)Robotic applications,(iv)manufacturing robots,(v)Robotics analysis,and(vi)Education/*** this study,only 35 articles in this specic eld were selected,of which were then assigned into three categories:(i)Application,(ii)Platform,and(iii)*** results show that the application category carries 17.4%,platform 20%,and education 22.85%.This study serves as the application platform to help students,academics,and researchers.

关键词： COVID-19 educational educational robotics taxonomy application platform

Structural & magnetic Characterizations of niLiZn nanoferrites Synthesized by Co-precipitation method

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Journal of materials Science & Technology 2011年第11期27卷 991-995页

作者： D.n. Rohadiana Z.A.Z. Jamal S.B. jamaludin m.F. Bari J. Adnan Sustainable Engineering Research Cluster Universiti Malaysia Perlis School of microelectronic Engineering Universiti Malaysia Perlis

Synthesis of ***（0.5-x）Fe204 nanoparticles with x=0, 0.1, 0.2, 0.3, 0.4 and 0.5 were realized via coprecipitation method. X-ray diffraction （XRD） and vibrating sample magnetometer （VSm） measurements were performed on the samples to determine the characteristics of the crystal structures and the magnetic properties of the samples, respectively. The spinel phase structures of the samples were confirmed by XRD analysis. Patterns of decreased lattice parameter and increased crystallite size values were observed by increasing the Li concentration at longer synthesis reaction periods. Similarly, for the magnetic properties, both the saturation magnetization （ms） and coercivity （Hc） were found to vary with increasing patterns at higher Li doping levels and longer synthesis reaction periods. The results and mechanisms concerned were discussed.

关键词： Lithium nickel zinc ferrite Co-precipitation Crystal structure magnetic properties

Regulator of G protein signaling 6 mediates exercise-induced recovery of hippocampal neurogenesis,learning,and memory in a mouse model of Alzheimer’s disease

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neural Regeneration Research 2025年第10期20卷 2969-2981页

作者： mackenzie m.Spicer Jianqi Yang Daniel Fu Alison n.DeVore marisol Lauffer nilufer S.Atasoy Deniz Atasoy Rory A.Fisher Department of neuroscience and Pharmacology University of Iowa Carver College of MedicineIowa CityIAUSA Iowa neuroscience Institute University of Iowa Carver College of MedicineIowa CityIAUSA Interdisciplinary Graduate Program in molecular medicine University of Iowa Carver College of MedicineIowa CityIAUSA neural Circuits and Behavior Core University of Iowa Carver College of MedicineIowa CityIAUSA

Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s *** hippocampal neurogenesis is reduced in patients with Alzheimer’s *** stimulates adult hippocampal neurogenesis in rodents and improves memory and slows cognitive decline in patients with Alzheimer’s ***,the molecular pathways for exercise-induced adult hippocampal neurogenesis and improved cognition in Alzheimer’s disease are poorly ***,regulator of G protein signaling 6(RGS6)was identified as the mediator of voluntary running-induced adult hippocampal neurogenesis in ***,we generated novel RGS6fl/fl;APP_(SWE) mice and used retroviral approaches to examine the impact of RGS6 deletion from dentate gyrus neuronal progenitor cells on voluntary running-induced adult hippocampal neurogenesis and cognition in an amyloid-based Alzheimer’s disease mouse *** found that voluntary running in APP_(SWE) mice restored their hippocampal cognitive impairments to that of control *** cognitive rescue was abolished by RGS6 deletion in dentate gyrus neuronal progenitor cells,which also abolished running-mediated increases in adult hippocampal *** hippocampal neurogenesis was reduced in sedentary APP_(SWE) mice versus control mice,with basal adult hippocampal neurogenesis reduced by RGS6 deletion in dentate gyrus neural precursor ***6 was expressed in neurons within the dentate gyrus of patients with Alzheimer’s disease with significant loss of these RGS6-expressing ***,RGS6 mediated voluntary running-induced rescue of impaired cognition and adult hippocampal neurogenesis in APP_(SWE) mice,identifying RGS6 in dentate gyrus neural precursor cells as a possible therapeutic target in Alzheimer’s disease.

关键词： adult hippocampal neurogenesis Alzheimer’s disease dentate gyrus exercise learning/memory neural precursor cells regulator of G protein signaling 6(RGS6)

Aristolochia gehrtii inhibits liver toxicity and apoptosis in Schistosoma malayensis infection

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Asian Pacific Journal of Tropical medicine 2014年第9期7卷 685-692页

作者： Khaled m.m.Koriem Razmy E.Shahabudin Rafiq Z.jamaludin Advanced medical and Dental Institute(AmDI) Universiti Sains Malaysia(USM)13200 Kepala BatasPulau PinangMalaysia Department of medical Physiology National Research Centre12622 DokkiGizaEgypt

Objective:To evaluate a protective effect of Aristolochia gehrtii(***)leaves to inhibit liver toxicity and apoptosis in Schistosoma malayensis(***)***:Forty male albino mice were divided into four equal groups:group 1 control including noninfected healthy mice and groups 2,3&4 subcutaneously infected with *** cercariae where groups 3&4 pretreated with *** leaves(200 mg/kg,bwt)&cinnamoylamide(250mg/kg,bwt),***:*** caused a significant increase in serum AST,ALT,ALP,mDA,nO,bilirubin,urea,creatinine,total cholesterol,LDL,triglycerides,and HDL *** pretreatment of A,gehrtii leaves and cinnamoylamide significantly inhibited that *** the other hand,*** induced a significant decrease in serum total protein,albumin,globulin,albumin/globulin ratio,blood SOD and GPx,while *** leaves and cinnamoylamide pretreatment increased the above *** with *** leaves and cinnamoylamide to *** infected mice increased p53 expression but decreased *** results were supported by hislopalholqgical ***:*** inhibits liver toxicity and apoptosis in *** infection and this effect is associated with the major cinnamoylamide ingredient of *** leaves.

关键词： Schistosoma malayensis Aristolochia gehrtii Aristolochiaceae Liver Apoptosis mice

Amyloid-beta pathology-induced nanoscale synaptic disruption:the case of the GABA_B-GIRK assembly

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neural Regeneration Research 2025年第5期20卷 1409-1410页

作者： Rafael Lujan Alejandro martín-Belmonte Sergi Ferré Francisco Ciruela Synaptic Structure Laboratory Instituto de Biomedicina de la UCLM(IB-UCLM)Departamento de Ciencias MédicasInstituto de Investigación en Salud de Castilla-La Mancha(IDISCAM)Facultad de MedicinaUniversidad Castilla-La ManchaCampus BiosanitarioC/AlmansaAlbaceteSpain Integrative neurobiology Section National Institute on Drug AbuseIntramural Research ProgramNational Institutes of HealthBaltimoreMDUSA Pharmacology Unit Department of Pathology and Experimental TherapeuticsSchool of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaNeuropharmacology&Pain GroupNeuroscience ProgramBellvitge Institute for Biomedical ResearchL’Hospitalet de LlobregatSpain

Alzheimer's disease (AD) is characterized by an imbalance between excitatory and inhibitory brain networks,leading to aberrant homeostatic synaptic *** has progressively been recognized as syna ptopathy and syna ptic dysfunction has been identified as a key component of its pathogenesis (Schirinzi et al.,2020).Syna ptic dysfunction is believed to precede synapse loss,a primary biological correlate of cognitive decline in AD,inevita bly associated with neuronal death.

关键词： Alzheimer pathology

The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

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neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer m.Colón-mercado Aranza I.Torrado-Tapias Iris K.Salgado Jose m.Santiago Samuel E.Ocasio Rivera Dina P.Bracho-Rincon Luis H.Pagan Rivera Jorge D.miranda Department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA national Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain EAAT-1/GLAST EAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

Brain-derived neurotrophic factor signaling in the neuromuscular junction during developm.n.al axonal competition and synapse elimination

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neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs Víctor Cilleros-mañé Laia Just-Borràs marta Balanyà-Segura Aleksandra Polishchuk Laura nadal marta Tomàs Carolina Silvera-Simón manel m.Santafé maria A.Lanuza Unitat d’Histologia i neurobiologia(UHneurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developm.n.al synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developm.n.al *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75nTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the n-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB