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Assessing risks for gastric cancer: New tools for pathologists

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World Journal of Gastroenterology 2006年第35期12卷 5622-5627页

作者： Robert m Genta massimo Rugge Department of Pathology University of Texas Southwestern Medical Center at Dallas Texas United states Department of Oncological and Surgical Sciences University of Padova Italy

Although the Sydney Systems (original and updated) for the classification of gastritis have contributed substantially to the uniformity of the reporting of gastric conditions, they lack immediacy in conveying to the user information about gastric cancer risk. In this review, we summarize the current understanding of the gastric lesions associated with an increased risk for cancer, and present the rationale for a proposal for new ways of reporting gastritis. In addition to the traditional histopathological data gathered and evaluated according to the Sydney System rules, pathologists could add an assessment expressed as grading and staging of the gastric inflammatory and atrophic lesions and integrate these findings with pertinent laboratory information on pepsinogens and gastrin levels. Such an integrated report could facilitate clinicians’ approach to the management of patients with gastric conditions.

关键词： Gastritis Staging and grading Gastritis Histology

miRNAs in precancerous lesions of the gastrointestinal tract

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World Journal of Gastroenterology 2011年第48期17卷 5231-5239页

作者： matteo Fassan Carlo m Croce massimo Rugge Department of medical Diagnostic Sciences and Special Therapies Surgical Pathology and Cytopathology Unit University of Padova Department of Oncological and Surgical Sciences General Oncology Unit University of Padova Comprehensive Cancer Center Ohio State University Istituto Oncologico del Veneto-IOV-IRCCS

In spite of the well-established understanding of the phenotypic lesions occurring in the shift from native epithelia to invasive （adeno） carcinoma, the molecular b/ping of the precancerous changes in the gastrointes- tinal tract remains unreliable. In recent years, no biomarkers have aroused as much interest as the miRNAs, a class of non-coding RNA molecules that function as endogenous silencers of numerous target genes. Aberrant miRNA expression is a hallmark of human disease, including cancer. Unlike most mRNAs, miRNAs are both long-living in vivo and very stable in vitro. Such charac- teristics allow their testing in paraffin-embedded tissue samples, which is essential in the biological profiling of small （phenotypically characterized） preneoplastic lesions of the gastrointestinal tract （as well as in other fields of human pathology）. The upcoming challenge lies in the reliable identification of disease-specific targets of dysregulated miRNAs, to enable miRNA testing in the clinical management of the secondary prevention of gastrointestinal cancer.

关键词： miRNA Dysplasia Barrett's esophagus Atro-phic gastritis Inflammatory bowel disease

Global-in-time Uniform Convergence for Linear Hyperbolic-Parabolic Singular Perturbations

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Acta mathematica Sinica,English Series 2006年第4期22卷 1161-1170页

作者： marina GHISI massimo GOBBINO Universitàdegli Studi di Pisa Dipartimento di Matematicavia M.Buonarroti 256127 PISAItaly Universitàdegli Studi di Pisa Dipartimento di Matematica Applicata "Ulisse Dini"via Bonanno 25/B56126 PISAItaly

We consider the Cauchy problem εu^″ε ＋ δu′ε ＋ Auε = 0, uε（0） = uo, u′ε（0） = ul, where ε 〉 0, δ 〉 0, H is a Hilbert space, and A is a self-adjoint linear non-negative operator on H with dense domain D（A）. We study the convergence of （uε） to the solution of the limit problem ,δu＇＋ Au = 0, u（0） = u0. For initial data （u0, u1） ∈ D（A1/2）× H, we prove global-in-time convergence with respect to strong topologies. moreover, we estimate the convergence rate in the case where （u0, u1）∈ D（A3/2） ∈ D（A1/2）, and we show that this regularity requirement is sharp for our estimates. We give also an upper bound for ｜u′ε（t）｜ which does not depend on ε.

关键词： Parabolic equations Damped hyperbolic equations Singular perturbations

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A giant crocodile in the Dubois Collection from the Pleistocene of Kali Gedeh(Java)

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Integrative Zoology 2014年第2期9卷 141-147页

作者： massimo DELFINO John DE VOS Earth Sciences Department University of TorinoTorinoItaly Catalan Institute of Palaeontology miquel Crusafont Autonomous University of BarcelonaCerdanyola del VallèsSpain Naturalis Biodiversity Center LeidenNetherlands

The fauna of the Pleistocene Homo-bearing sites of Java has been well known for more than a century.A recent revision of the crocodylian remains confirmed both the validity of Gavialis bengawanicus and the synonymiza-tion of Crocodylus ossifragus with *** we report on a still unpublished crocodylian specimen collected by Eugene Dubois in the latest Early Pleistocene of Kali Gedeh that can be tentatively referred to the genus *** size of the specimen,the approximately 1 m long lower jaw in particular,indicat-ed that this crocodile attained a total length of approximately 6 or 7 *** with specimens from the Plio-Pleistocene of Africa,this material provides evidence for gigantism in *** is not clear whether or not the‘temperature-size rule’applies to fossil crocodylians,but due to the growing interest in predicting future temperature-related size changes of the extant organisms,it would be interesting to study in detail the past reac-tion to temperature changes of crocodylians and other terrestrial ectothermic animals.

关键词： Crocodylus fossil Homo erectus fauna Pleistocene gigantism temperature-size rule

A Novel Gaussian Extrapolation Approach for 2D Gel Electrophoresis Saturated Protein Spots

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Genomics, Proteomics & Bioinformatics 2012年第6期10卷 336-344页

作者： massimo Natale Alfonso Caiazzo Enrico m. Bucci Elisa Ficarra Department of Control and Computer Engineering Politecnico di Torino BioDigitalValley S.r.l. WIAS Berlin Istituto di Biostrutture e Bioimmagini

Analysis of images obtained from two-dimensional gel electrophoresis （2D-GE） is a topic of utmost importance in bioinformatics research, since commercial and academic software available currently has proven to be neither completely effective nor fully automatic, often requiring manual revision and refinement of computer generated matches. In this work, we present an effective technique for the detection and the reconstruction of over-saturated protein spots. Firstly, the algorithm reveals overexposed areas, where spots may be truncated, and plateau regions caused by smeared and overlapping spots. Next, it reconstructs the correct distribution of pixel values in these overexposed areas and plateau regions, using a two-dimensional least-squares fitting based on a generalized Gaussian distribution. Pixel correction in saturated and smeared spots allows more accurate quantification, providing more reliable image analysis results. The method is validated for *** exposed 2D-GE images, comparing reconstructed spots with the corresponding non-saturated image, demonstrating that the algorithm enables correct spot quantification.

关键词： Image analysis Two-dimensional gel electrophoresis Proteomics Software tools

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Sequencing of systemic treatment for hepatocellular carcinoma: Second line competitors

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World Journal of Gastroenterology 2020年第16期26卷 1888-1900页

作者： Federico Pinero marcelo Silva massimo Iavarone Hospital Universitario Austral Facultad de Ciencias BiomédicasUniversidad AustralBuenos Aires B1629HJArgentina Latin American Liver Research Educational and Awareness Network Buenos Aires B1629HJArgentina Division of Gastroenterology and Hepatology CRC“A.M.e A.Migliavacca”Center for the Study of Liver DiseaseUniversity of MilanFondazione IRCCS Ca’Granda Maggiore HospitalMilan 20121Italy

During the last decades,further knowledge of hepatocellular carcinoma(HCC)molecular mechanisms has led to development of effective systemic treatments including tyrosine kinase inhibitors(TKIs)and *** this review,we describe first and second line systemic treatment options for advanced *** trials have evaluated new drugs for the treatment of HCC patients:In first line,lenvatinib resulted non-inferior to sorafenib and it can be used as alternative,even in the lack of evidence for sequential treatment options in second line after ***,atezolizumab plus bevacizumab have shown superiority over sorafenib in ***-regorafenib sequential administration in selected patients has opened a new paradigm of treatment in advanced HCC with a life expectancy exceeding two *** TKIs for second line treatment include cabozantinib and ramucirumab(specifically for patients with Alpha-fetoprotein values≥400 ng/mL).The combination of TKIs with immunotherapy may represent a big step forward for these patients in the near future.

关键词： Hepatocellular carcinoma Systemic Options Sequencing Advanced Future

Autoimmune gastritis:Pathologist's viewpoint

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World Journal of Gastroenterology 2015年第42期21卷 12179-12189页

作者： Irene Coati matteo Fassan Fabio Farinati David Y Graham Robert m Genta massimo Rugge Department of medicine (DImED) Surgical Pathology Unit University of Padua Department of Surgery Oncology and Gastroenterology Gastroenterology Unit University of Padua Department of medicine Veterans Administration Hospital Baylor College of Medicine Houston miraca Life Sciences Research Institute Departments of Pathology and medicine VA North Texas Health Care System and University of Texas Southwestern Medical Center Dallas

Western countries are seeing a constant decline in the incidence of Helicobacter pylori-associated gastritis, coupled with a rising epidemiological and clinical impact of autoimmune gastritis. This latter gastropathy is due to autoimmune aggression targeting parietal cells through a complex interaction of auto-antibodies against the parietal cell proton pump and intrinsic factor, and sensitized T cells. Given the specific target of this aggression, autoimmune gastritis is typically restricted to the gastric corpus-fundus mucosa. In advanced cases, the oxyntic epithelia are replaced by atrophic(and metaplastic) mucosa, creating the phenotypic background in which both gastric neuroendocrine tumors and(intestinal-type) adenocarcinomas may develop. Despite improvements in our understanding of the phenotypic changes or cascades occurring in this autoimmune setting, no reliable biomarkers are available for identifying patients at higher risk of developing a gastric neoplasm. The standardization of autoimmune gastritis histology reports and classifications in diagnostic practice is a prerequisite for implementing definitive secondary prevention strategies based on multidisciplinary diagnostic approaches integratingendoscopy, serology, histology and molecular profiling.

关键词： Autoimmune gastritis metaplasia Carcinoids Operati

The elegance of a macrophage

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Cellular & molecular Immunology 2018年第3期15卷 196-198页

作者： maria De Santis massimo Locati Carlo Selmi Rheumatology and Clinical Immunology Humanitas Research HospitalRozzanoItaly Laboratory of Leukocyte Biology Humanitas Research HospitalRozzanoItaly BIOmETRA Department University of MilanMilanItaly

In the latest issue of Nature Immunology,Piccolo et al.1 elegantly explored the effect of coexisting interferon-γ(IFN-γ)and interleukin 4(IL-4)antagonistic signals on macrophage transcriptional and epigenetic profiles and,interestingly,identified a plastic cross-talk as opposed to mutually exclusive programs between m1 and m2 polarized *** results support the fascinating hypothesis that transcriptional and epigenetic reprogramming overcame genetics to drive the evolution of eukaryotic organisms.A rapid reshaping of chromatin acetylation redirected the expression of hundreds of genes under the control of a few transcription factors in response to two coexisting but opposing signals that indicated inflammation and its resolution simultaneously.

关键词： macrophage interferon inflammation

Vibro-acoustic characteristics of multifunctional carbon fiber reinforced panel

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Defence Technology（防务技术） 2023年第6期24卷 129-139页

作者： Liberata Guadagno marialuigia Raimondo Luigi Vertuccio Giuseppina Barra maurizio Arena massimo Viscardi Department of Industrial Engineering University of SalernoVia Giovanni Paolo II13284084FiscianoSAItaly Department of Engineering University of Campania“Luigi Vanvitelli”Via Roma 29I-81031AversaItaly Department of Industrial Engineering Aerospace SectionUniversity of Naples“Federico Ⅱ”Via Claudio 2180125NaplesItaly

This paper deals with the assessment of vibro-acoustic properties of a multifunctional carbon fiber reinfo rced panel manu factured by bulk infu sion,a modified resin film infusion *** components of the epoxy resin were chosen to contrast the electrical insulating property and poor flame resistance of the epoxy resins impregnating carbon woven *** confer electrical conductivity to the resin a percentage of 0.5 wt%of multi-Wall Carbon Nanotubes(mWCNTs)was dispersed in the resin,whereas to increase flame resistance a percentage of 5 wt%of Glycidil Polyhedral Oligomeric Silsesquioxanes(GPOSS)was solubilized in the epoxy ***,as hardener agents,a mixture of 4,4’-DiaminoDiphenyl Sulfone(DDS)(53.4 wt%)and Bis(3-Aminophenyl)methyl Phosphine Oxide(BAmPO)(46.7 wt%)was *** values of the electrical conductivity were found satisfactory enough,being4.02×10^(-2)S/m for the multifunctional resin and 1.39×10^(4)S/m for the in-plane conductivity of the panel,whereas the Limiting Oxygen Index(LOI)value of the multifunctional resin was found to increase from 27%to 36%.Considering these promising results,an experimental assessment of the vibro-acoustic properties of the manufactured multifunctional panel was also *** panel was tested mainly to evaluate its low-frequency vibration damping and sound insulation *** manufactured panel demonstrated an improved efficiency if compared to a baseline configuration,presenting almost the double modal damping and a gain of 10 dB on the global noise reduction.

关键词： Composite materials Electrical properties Damping Tunneling atomic force microscopy(TUNA) Vibro-acoustic properties

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