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Author Correction to:T-lymphoid progenitor-based immunotherapies:clinical perspectives for one and all

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Cellular & molecular Immunology 2022年第12期19卷 1442-1442页

作者： P.Gaudeaux R.D.moirangthem J.Paillet m.martin-corredera H.Sadek P.Rault A.Joshi J.Zuber T.S.Soheili O.Negre I.Andre Laboratory of Human Lymphohematopoieisis Imagine Institute INSERM UMR 1163 Université Paris Cité Paris France Smart Immune Paris France

Correction to:Cellular&molecular Immunology https://***/10.1038/s41423-022-00927-5,published online 30 September 2022 In this article the affliation 2 Smart Immune,Paris,France for *** was *** original article has bee... 详细信息

关键词： missing corrected clinical

Wear dependent virtual flow rate sensor for progressing cavity pumps with deformable stator

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Petroleum Science 2024年第2期21卷 1346-1353页

作者： Jens müller Sebastian Leonow Johannes Schulz Christian Hansen martin monnigmann Ruhr-Universitat Bochum Universit atsstraûe 150Bochum44801Germany SEEPEX GmbH Scharnh olzstraûe 344Bottrop46240Germany

This contribution presents a novel wear dependent virtual flow rate sensor for single stage single lobe progressing cavity pumps. We study the wear-induced material loss of the pump components and the impact of this material loss on the volumetric efficiency. The results are combined with an established backflow model to implement a backflow calculation procedure that is adaptive to wear. We use a laboratory test setup with a highly abrasive fluid and operate a pump from new to worn condition to validate our approach. The obtained measurement data show that the presented virtual sensor is capable of calculating the flow rate of a pump being subject to wear during its regular operation.

关键词： Backflow Progressing cavity pump Virtual sensor Wear

A reduced model for particle calcination for use in DEm/CFD simulations

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Particuology 2024年第10期93卷 316-327页

作者： Lucas mieg Torben Bergold Enric Illana mahiques Viktor Scherer martin mönnigmann Automatic Control and System Theory Ruhr University BochumGermany Energy Plant Technology Ruhr University BochumGermany

We treat the accurate simulation of the calcination reaction in particles,where the particles are large and,thus,the inner-particle processes must be *** these processes need to be described with coupled partial differential equations(PDEs)that must be solved numerically,the computation times for a single particle are too high for use in simulations that involve many *** of this type arise when the Discrete Element method(DEm)is combined with Computational Fluid Dynamics(CFD)to investigate industrial systems such as quicklime production in lime shaft *** show that,based on proper orthogonal decomposition and Galerkin projection,reduced models can be derived for single particles that provide the same spatial and temporal resolution as the original PDE models at a considerably reduced computational *** the finite volume particle models with the reduced models results in an overall reduction of the reactor simulation time by about 40%for the sample system treated here.

关键词： Calcination Reactive bulk model reduction Discrete element method Galerkin projection

CO_(2)capture costs of chemical looping combustion of biomass:A comparison of natural and synthetic oxygen carrier

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Journal of Energy Chemistry 2024年第5期92卷 296-310页

作者： Benjamin Fleiß Juraj Priscak martin Hammerschmid Josef Fuchs Stefan müller Hermann Hofbauer Institute of Chemical Environmental and Bioscience EngineeringTU WienVienna1060 ViennaAustria BEST–Bioenergy and Sustainable Technologies GmbH Graz8010 StyriaAustria

Chemical looping combustion has the potential to be an efficient and low-cost technology capable of contributing to the reduction of the atmospheric concentration of CO_(2) in order to reach the 1.5/2°C goal and mitigate climate *** this process,a metal oxide is used as oxygen carrier in a dual fluidized bed to generate clean CO_(2) via combustion of *** commonly,natural ores or synthetic materials are used as oxygen carrier whereas both must meet special requirements for the conversion of solid *** oxygen carriers are characterized by higher reactivity at the expense of higher costs versus the lower-cost natural *** determine the viability of both possibilities,a techno-economic comparison of a synthetic material based on manganese,iron,and copper to the natural ore ilmenite was *** synthetic oxygen carrier was characterized and tested in a pilot plant,where high combustion efficiencies up to 98.4%and carbon capture rates up to 98.5%were *** techno-economic assessment resulted in CO_(2) capture costs of 75 and 40€/tCO_(2) for the synthetic and natural ore route respectively,whereas a sensitivity analysis showed the high impact of production costs and attrition rates of the synthetic *** synthetic oxygen carrier could break even with the natural ore in case of lower production costs and attrition rates,which could be reached by adapting the production process and recycling *** comparison to state-of-the-art technologies,it is demonstrated that both routes are viable and the capture cost of CO_(2) could be reduced by implementing the chemical looping combustion technology.

关键词： Chemical looping combustion BECCS Techno-economic assessment CO_(2)capture costs Oxygen carrier development Synthetic materials Ilmenite

Identifying the validity domain of machine learning models in building energy systems

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Energy and AI 2024年第1期15卷 328-341页

作者： martin Rätz Patrick Henkel Phillip Stoffel Rita Streblow Dirk müller RWTH Aachen University E.ON Energy Research CenterInstitute for Energy Efficient Buildings and Indoor ClimateMathieustraβe 10Aachen52074Germany

The building sector significantly contributes to climate *** improve its carbon footprint,applications like model predictive control and predictive maintenance rely on system ***,the high modeling effort hinders practical *** learning models can significantly reduce this modeling *** ensure a machine learning model’s reliability in all operating states,it is essential to know its validity *** states outside the validity domain might lead to extrapolation,resulting in unpredictable *** paper addresses the challenge of identifying extrapolation in data-driven building energy system models and aims to raise knowledge about *** that,a novel approach is proposed that calibrates novelty detection algorithms towards the machine learning *** novelty detection algorithms are identified through a literature review and a benchmark test with 15 candidates.A subset of five algorithms is then evaluated on building energy ***,on two-dimensional data,displaying the results with a novel visualization *** on more complex multi-dimensional use *** methodology performs well,and the validity domain could be *** visualization allows for a profound analysis and an improved understanding of the fundamental effects behind a machine learning model’s validity domain and the extrapolation regimes.

关键词： Extrapolation detection Validity domain Novelty detection machine learning Artificial neural network Data-driven model predictive control Building energy systems

Genomic mosaicism of the Brain:Origin,Impact,and Utility

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Neuroscience Bulletin 2024年第6期40卷 759-776页

作者： Jared H.Graham Johannes C.m.Schlachetzki Xiaoxu Yang martin W.Breuss Department of Pediatrics Section of Clinical Genetics and MetabolismUniversity of Colorado School of MedicineAurora80045-2581COUSA Department of Cellular and molecular medicine University of California San DiegoLa Jolla92093-0021San DiegoCAUSA Department of Neurosciences University of California San DiegoLa Jolla92093-0021San DiegoCAUSA Rady Children’s Institute for Genomic medicine San Diego92123CAUSA

Genomic mosaicism describes the phenomenon where some but not all cells within a tissue harbor unique genetic ***,research focused on the impact of genomic mosaicism on clinical phenotype—motivated by its involvement in cancers and overgrowth *** recently,we increasingly shifted towards the plethora of neutral mosaic variants that can act as recorders of cellular lineage and environmental ***,we summarize the current state of the field of genomic mosaicism research with a special emphasis on our current understanding of this phenomenon in brain development and *** the field of genomic mosaicism has a rich history,technological advances in the last decade have changed our approaches and greatly improved our *** will provide current definitions and an overview of contemporary detection approaches for genomic ***,we will discuss the impact and utility of genomic mosaicism.

关键词： Genomics Brain development Brain homeostasis Genomic mosaicism

Convective drying of wood chips:Accelerating coupled DEm-CFD simulations with parametrized reduced single particle models

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Particuology 2024年第1期84卷 158-167页

作者： Lucas Reineking Jonas Fischer Ali mjalled Enric Illana Siegmar Wirtz Viktor Scherer martin monnigmann Automatic Control and System Theory Ruhr-Universität-BochumUniversitätstraße 150Bochum44801Germany Energy Plant Technology Ruhr-Universität-BochumUniversitätstraße 150Bochum44801Germany

The simulation of industry-scale reactive bulks is challenging due to the complex interaction between fluid and *** particles in the bulk and their interaction with the fluid flow can be described by combined Discrete Element method-Computational Fluid Dynamics(DEm-CFD)***,the computational cost of the Finite Volume(FV)methods deployed in these models can become prohibi-tively expensive,especially for high inner-particle *** particle Reduced models(Rms)can be used to achieve both fast and accurate descriptions of the processes in each *** an example of bulk systems comprising heat and mass transfer,we compared FV and Rm simulations for the drying of wood chips in a bulk reactor.A manifold-based nonlinear interpolation was applied to resolve changing boundary conditions for the *** simulations showed that Rms provide accurate values for the thermodynamic state variables of the ***,the time required for the bulk simulation was reduced by 67%with the *** is evident that simulations with high inner-particle resolution can be accelerated by Rms if manifold-based nonlinear interpolation is used to address changing boundary conditions.

关键词： Reduced model Reactive bulk Discrete element method manifold-based interpolation Drying of porous mediaDEm-CFD

NeuroPNm:model reduction of pore network models using neural networks

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Particuology 2024年第3期86卷 239-251页

作者： Robert Jendersie Ali mjalled Xiang Lu Lucas Reineking Abdolreza Kharaghani martin monnigmann Christian Lessig Otto-von-Guericke-Universitat magdeburg Universitatsplatz 2Magdeburg39106Germany Ruhr-Universitat-Bochum Universitatstraβe 150Bochum44801Germany

Reacting particle systems play an important role in many industrial applications,for example biomass drying or the manufacturing of *** numerical modeling and simulation of such systems is therefore of great importance for an efficient,reliable,and environmentally sustainable operation of the *** complex thermodynamical,chemical,and flow processes that take place in the particles are a particular challenge in a ***,typically a large number of particles is involved,rendering an explicit treatment of individual ones impossible in a reactor-level *** approach for overcoming this challenge is to compute effective,physical parameters from single-particle,high-resolution *** can be combined with model reduction methods if the dynamical behaviour of particles must be *** network models with their unrivaled resolution have thereby been used successfully as high-resolution models,for instance to obtain the macroscopic diffusion coeffcient of *** parameter identification and model reduction have recently gained new impetus by the dramatic progress made in machine learning in the last *** report results on the use of neural networks for parameter identification and model reduction based on three-dimensional pore network models(PNm).We believe that our results provide a powerful complement to existing methodologies for reactor-level simulations with many thermally-thick particles.

关键词： Porenetwork models Neural networks Parameter estimation Reduced order model

Particle Size Optimization of Thermochemical Salt Hydrates for High Energy Density Thermal Storage

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Energy & Environmental materials 2024年第2期7卷 326-333页

作者： Andrew martin Drew Lilley Raνi Prasher Sumanjeet Kaur Energy Technologies Area Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA Department of mechanical Engineering UC BerkeleyBerkeleyCA 94720USA

Thermal energy storage(TES)solutions offer opportunities to reduce energy consumption,greenhouse gas emissions,and ***,they can help reduce the peak load and address the intermittency of renewable energy sources by time shifting the load,which are critical toward zero energy *** materials(TCms)as a class of TES undergo a solid-gas reversible chemical reaction with water vapor to store and release energy with high storage capacities(600 kWh m^(-3))and negligible self-discharge that makes them uniquely suited as compact,stand-alone units for daily or seasonal ***,TCms suffer from instabilities at the material(salt particles)and reactor level(packed beds of salt),resulting in poor multi-cycle efficiency and high-levelized cost of *** this study,a model is developed to predict the pulverization limit or Rcrit of various salt hydrates during thermal *** is critical as it provides design rules to make mechanically stable TCm composites as well as enables the use of more energy-efficient manufacturing process(solid-state mixing)to make the *** model is experimentally validated on multiple TCm salt hydrates with different water content,and effect of Rcrit on hydration and dehydration kinetics is also investigated.

关键词： high energy density hydration kinetics long-term cycling thermal energy storage thermochemical materials