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HOP co-chaperones contribute to GA signaling by promoting the accumulation of the F-box protein SNE in Arabidopsis

Plant Communications 2023年第3期4卷 244-257页

作者： Silvina mangano Alfonso muñoz Lourdes Fernández-Calvino m.mar castellano Centro de Biotecnología y Genómica de Plantas Universidad Politécnica de Madrid(UPM)-Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria(INIA/CSIC)Campus Montegancedo UPM28223 Pozuelo de Alarcón(Madrid)Spain Fundación Instituto Leloir and Instituto de Investigaciones Bioquímicas de Buenos Aires(IIBA CONICET)Av.Patricias Argentinas 435Buenos Aires C1405BWEArgentina Departamento de Botánica Ecologíay Fisiología VegetalCampus de RabanalesEdificio Severo OchoaUniversidad de Córdoba14071 CórdobaSpain

Gibberellins(GAs)play important roles in multiple developmental processes and in plant response to the *** the GA pathway,a central regulatory step relies on GA-dependent degradation of the DELLA transcriptional ***,the relevance of the stability of other key proteins in this pathway,such as SLY1 and SNE(the F-box proteins involved in DELLA degradation),remains ***,we take advantage of mutants in the HSP70-HSP90 organizing protein(HOP)co-chaperones and reveal that these proteins contribute to the accumulation of SNE in ***,HOP proteins,along with HSP90 and HSP70,interact in vivo with SNE,and SNE accumulation is significantly reduced in the hop ***,greater accumulation of the DELLA protein RGA is observed in these *** agreement with these molecular phenotypes,hop mutants show a hypersensitive response to the GA inhibitor paclobutrazol and display a partial response to the ectopic addition of GA when GA-regulated processes are *** mutants also display different phenotypes associated with alterations in the GA pathway,such as reduced germination rate,delayed bolting,and reduced hypocotyl elongation in response to warm ***,ectopic overexpression of SNE reverts the delay in germination and the thermally dependent hypocotyl elongation defect of the hop1 hop2 hop3 mutant,revealing that SNE accumulation is the key aspect of the hop mutant ***,these data reveal a pivotal role for HOP in SNE accumulation and GA signaling.

关键词： HSP70-HSP90 organizing protein seed germination thermomorphogenesis RGA protein folding protein stability

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Differential response of injured and healthy retinas to syngeneic and allogeneic transplantation of a clonal cell line of immortalized olfactory ensheathing glia:a double-edged sword

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Neural Regeneration Research 2025年第8期20卷 2395-2407页

作者： maría Norte-muñoz maría Portela-Lomba Paloma Sobrado-Calvo Diana Simón Johnny Di Pierdomenico Alejandro Gallego-Ortega mar Pérez JosémCabrera-maqueda Javier Sierra manuel Vidal-Sanz maría Teresa moreno-Flores marta Agudo-Barriuso Grupo de Investigación Oftalmología Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaSpain Experimental Sciences Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain Anatomy Histology and Neuroscience DepartmentMedicine FacultyUniversidad Autónoma de MadridMadridSpain Center of Neuroimmunology Service of NeurologyLaboratory of Advanced Imaging in Neuroimmunological DiseasesHospital Clínic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)and Universitat de BarcelonaBarcelonaSpain medicine Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain

Olfactory ensheathing glia promote axonal regeneration in the mammalian central nervous system,including retinal ganglion cell axonal growth through the injured optic ***,it is unknown whether olfactory ensheathing glia also have neuroprotective *** ensheathing glia express brain-derived neurotrophic factor,one of the best neuroprotectants for axotomized retinal ganglion ***,we aimed to investigate the neuroprotective capacity of olfactory ensheating glia after optic nerve *** ensheathing glia cells from an established rat immortalized clonal cell line,TEG3,were intravitreally injected in intact and axotomized retinas in syngeneic and allogeneic mode with or without microglial inhibition or immunosuppressive *** and gene expression analyses were *** bulb-derived primary olfactory ensheathing glia and TEG3 express major histocompatibility complex classⅡ*** and syngenically transplanted TEG3 cells survived in the vitreous for up to 21 days,forming an *** axotomized retinas,only the allogeneic TEG3 transplant rescued retinal ganglion cells at 7 days but not at 21 *** these retinas,microglial anatomical activation was higher than after optic nerve crush *** intact retinas,both transplants activated microglial cells and caused retinal ganglion cell death at 21 days,a loss that was higher after allotransplantation,triggered by pyroptosis and partially rescued by microglial inhibition or ***,neuroprotection of axotomized retinal ganglion cells did not improve with these *** different neuroprotective properties,different toxic effects,and different responses to microglial inhibitory treatments of olfactory ensheathing glia in the retina depending on the type of transplant highlight the importance of thorough preclinical studies to explore these variables.

关键词： cell therapy immune recognition major histocompatibility complex class II(mHCII) neuroprotection olfactory ensheathing glia retinal ganglion cells

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Agglutination of Helicobacter pylori coccoids by lectins

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World Journal of Gastroenterology 2000年第2期6卷 202-209页

作者： mar mar Khin Jie Song Hua Han Cong Ng Torkel Wadstrm Bow Ho Departments of microbiology Faculty of MedicineNational University of Singapore5Science Drive 2Singapore 117597Republic of Singapore Department of medical microbiology Lund UniversitySolvegatan 23S 223 62 LundSweden

AIm To study the agglutination pattern ofHelicobacter pylori coccoid and spiral *** Assays of agglutination andagglutination inhibition were applied usingfifteen commercial *** Strong agglutination was observedwith mannose-specific Concanavalin A(Con A),fucose-specific Tetragonolobus purpureas(Lotus A)and N-acetyl glucosamine-specificTriticum vulgaris(WGA)*** andfucose specific lectins were reactive with allstrains of *** coccoids as compared to *** carbohydrates,glycoproteinsand mucin were shown to inhibit ***-agglutination ***-treatment ofthe bacterial cells with formalin and sulphuricacid did not alter the agglutination patterns ***,sodium periodate treatment ofbacterial cells were shown to inhibitagglutination reaction with Con A,Lotus A andWGA *** the contrary,enzymatictreatment of coccoids and spirals did not showmarked inhibition of ***,heating of *** cells at 60℃ for 1 hour was shown toaugment the agglutination with all of the *** The considerable differences inlectin agglutination patterns seen among the twodifferentiated forms of *** might beattributable to the structural changes during theevents of morphological transformation,resulting in exposing or masking some of the sugar residues on the cell *** ofvarious sugar residues on the cell wall of thecoccoids may allow them to bind to differentcarbohydrate receptors on gastric mucus andepithelial *** coccoids with adherencecharacteristics like the spirals could aid in thepathogenic process of Helicobacter *** may probably lead to different clinicaloutcome of *** associated gastroduodenaldisease.

关键词： Helicobacter pylori coccoids lectin gastric mucosa

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Contemporary climate infuence on variability patterns of Anadenanthera colubrina ***,a key species in seasonally dry tropical forests

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Journal of Forestry Research 2022年第1期33卷 89-101页

作者： maría Victoria García maría Eugenia Barrandeguy Kathleen Prinz Genética de Poblaciones y Cuantitativa-Departamento de Genética-Facultad de Ciencias Exactas Químicas y Naturales-Universidad Nacional deMisionesInstituto de Biología Subtropical(UNaM-CONICET)Nodo PosadasFélix de Azara 15523300 PosadasArgentina Consejo Nacional de Investigaciones Científicas Y Técnicas(CONICET) PosadasMisionesArgentina Institute of Systematic Botany With Herbarium Haussknecht and Botanical Gardens Friedrich-Schiller-University Jena07743 JenaGermany

The distribution of many plant species has been shaped by climate changes,and their current phenotypic and genetic variability refect microclimatically suitable *** study relates contemporary climate to variability patterns of phenotypic traits and molecular markers in the Argentinean distribution of Anadenanthera colubrina ***,as well as to identify the most relevant phenotypic trait or molecular marker associated with those *** from four populations in both biogeographic provinces,Paranaense and Yungas,were *** analyses and multiple linear regressions were carried out to determine relationships among phenotypic traits and nuclear microsatellites,respectively,to climatic variables,and to identify the phenotypic traits as well as nuclear microsatellite loci most sensitive to *** and three clusters of individuals were detected based on genetic and phenotypic data,*** clusters based on genetic data refected the biogeographic origin of *** traits were the most relevant indicators of climatic *** microsatellite locus Ac41.1 appeared to be non-neutral presenting a strong correlation with climate variable temperature *** findings show complex patterns of genetic and phenotypic variability in the Argentinean distribution of *** *** related to the present or contemporary climate,and provides an example for an integrative approach to better understand climate impact on contemporary genetic and phenotypic variability in light of global climate change.

关键词： Contemporary climate Curupay Genetic variability Phenotypic variability Seasonally dry tropical forests

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Challenges and improvement strategies in the hospitalization of chronic multimorbid patients

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World Journal of Clinical Cases 2025年第3期13卷 35-41页

作者： Andres Fontalba-Navas Francisco Pozo muñoz Rogelio Garcia Cisneros maria Jose Garcia Larrosa maria del mar Callejon Gil Ignacio Garcia Delgado maria Belen Jimenez martinez Antequera Hospital Northern Málaga Integrated Healthcare AreaAntequera 29200AndalusiaSpain Department of Public Health and Psychiatry University of MálagaMálaga 29010Spain Antequera Hospital Northern Málaga Antequera Integrated Healthcare AreaAntequera 29200MálagaSpain

BACKGROUND Addressing the growing challenge of hospitalizing chronic multimorbid patients,this study examines the strain these conditions impose on healthcare systems at a local level,focusing on a pilot *** diseases and complex patients require comprehensive management strategies to reduce healthcare burdens and improve patient *** proven effective,this pilot model has the potential to be replicated in other healthcare settings to enhance the management of chronic multimorbid *** To evaluate the effectiveness of the high complexity unit(HCU)in managing chronic multimorbid patients through a multidisciplinary care model and to compare it with standard hospital *** The study employed a descriptive longitudinal approach,analyzing data from the Basic minimum Data Set(BmDS)to compare hospitalization variables among the HCU,the Internal medicine Service,and other services at Antequera Hospital throughout *** HCU,designed for patients with complex chronic conditions,integrates a patient-centered model emphasizing multidisciplinary care and continuity *** The study employed a descriptive longitudinal approach,analyzing data from the BmDS to compare hospitalization variables among the HCU,the Internal medicine Service,and other services at Antequera Hospital throughout *** HCU,designed for patients with complex chronic conditions,integrates a patient-centered model emphasizing multidisciplinary care and continuity *** This study demonstrates the effectiveness of the HCU in managing patients with complex chronic diseases through a multidisciplinary *** coordinated care provided by the HCU results in improved patient outcomes,reduced unnecessary hospitalizations,and better management of patient *** superiority of the HCU compared to standard care is evident in key outcomes such as fewer readmissions and higher patient satisfaction,reinforcing its value as a model of ca

关键词： High complexity unit Chronic multimorbidity Patient-centered care Integrated care Healthcare management

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Prevalence of and risk factors for erectile dysfunction in young nondiabetic obese men:results from a regional study

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Asian Journal of Andrology 2020年第4期22卷 372-378页

作者： maría molina-Vega maite Asenjo-Plaza maría JoséBanderas-Donaire maría Dolores Hernández-Ollero Silvia Rodríguez-moreno Juan Jálvarez-millán Pablo Cabezas-Sanchez Fernando Cardona-Díaz Juan Alcaide-Torres Lourdes Garrido-Sánchez Daniel castellano-Castillo Francisco J Tinahones JoséC Fernández-García Department of Endocrinology and Nutrition Virgen de la Victoria University Hospital(IBIMA)Málaga UniversityMálaga 29010Spain Centro de Investigación Biomédica en Red de la Fisiopatología de la Obesidad y Nutrición(CIBEROBN) Instituto de Salud Carlos IIIMadrid 28029Spain Cruz de Humilladero Primary Care Center Málaga 29010Spain Teatinos Primary Care Center Málaga 29010Spain Chemical Sanitary Consulting(CQS Lab) Madrid 28003Spain

Erectile dysfunction(ED),a condition closely related to cardiovascular morbidity and mortality,is frequently associated with *** this study,we aimed to determine the prevalence of ED and evaluate the associated risk factors in a cohort of 254 young(18–49 years)nondiabetic obese(body mass index[BmI]≥30 kg m−2)men from primary *** function(International Index of Erectile Function[IIEF-5]questionnaire),quality of life(Aging males'Symptoms[AmS scale]),and body composition analysis(Tanita mC-180mA)were *** testosterone was determined using high-performance liquid chromatography–mass *** logistic regression analysis was used to study the factors associated with *** prevalence was 42.1%.Subjects with ED presented higher BmI,waist circumference,number of components of the metabolic syndrome,AmS score,insulin resistance,and a more unfavorable body composition than those without *** logistic regression analysis showed that a pathological AmS score(odds ratio[OR]:4.238,PmI≥40 kg m−2,OR:2.602,P=0.005,compared with BmI 30–34.9 kg m−2),high-density lipoprotein(HDL)-cholesterol levels(OR:0.956,P=0.004),and age(OR:1.047,P=0.016)were factors independently associated with *** conclusion,we demonstrate that,in a primary care-based cohort of nondiabetic young obese men,ED affected>40%of subjects.A pathological AmS score,the degree of obesity,and age were positively associated with ED,while elevated HDL-cholesterol levels were inversely associated with the odds of presenting *** prospective studies are needed to evaluate the long-term consequences of ED in this population.

关键词： Aging males'Symptoms score erectile dysfunction International Index of Erectile Function-5 questionnaire obesity testosterone

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Habitat and food preferences of European rabbits in core and edge populations along the invasion front Patagoniamonte,Argentina

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Current Zoology 2024年第3期70卷 310-319页

作者： Sabrina Yasmin Bobadilla maría A.Dacar Fabián m.Jaksic Ricardo A.Ojeda maría Fernanda Cuevas Ecología de mamíferos de Tierras Secas IADIZACCT-Mendoza CONICETAv.Ruiz Leal s/nParque General San MartínMendoza 5500MendozaArgentina Laboratorio de Filogeografía Taxonomía Integrativa y Ecología(LFTIE)IADIZACCT-Mendoza CONICETAv.Ruiz Leal s/nParque General San MartínMendoza 5500MendozaArgentina Center of Applied Ecology and Sustainability(CAPES) Pontifcia Universidad Católica de ChileAv.Libertador Bernardo O'Higgins 340Santiago 8320000Región MetropolitanaChile

The European rabbit Oryctolagus cuniculus is an exotic herbivorous mammal undergoing an active phase of geographical expansion in the arid ecosystems of *** Adaptive Flexibility Hypothesis states that populations at the range edge(new populations)will exhibit greater fexibility in the use of resources compared with populations located in the range core(older populations).The objective of this work was to compare the rabbit’s use of spatial and trophic resources in relation to the establishment time of their *** sampling was carried out for 2 years(2017 and 2018)in sites with different establishment times for rabbit *** sampling stratifed by type of habitat was applied using 115 fxed strip transects of 1,000 m^(2) laid out across the study *** rabbit signs were recorded in each transect,and environmental and anthropic variables were *** results show that the individuals from the range edge are more selective in the use of habitat than those from the range *** the microhabitat level,we observed a pattern in the particular components of habitat use by rabbits mainly linked to food availability and proximity to *** a trophic perspective,rabbits could show fexible adjustment to novel conditions and environments in the range *** variability in resource use by the European rabbit confrms its ecological fexibility,pivotal for their advance toward new environments in Argentina.

关键词： Arid ecosystems invasive species novel environments range invasion spatial use trophic use

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Onto the sense of smell in macaws, amazons and toucans: can they use volatile cues of fruits to make foraging decisions?

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Integrative Zoology 2023年第4期18卷 762-771页

作者： m.Carmen HERNÁNDEZ Ana maría VILLADA Isabel BARJA Unidad Zoología Departamento de BiologíaUniversidad Autónoma de MadridCampus Universitario de CantoblancoMadridSpain Toucan Rescue Ranch HerediaCosta Rica Centro de Investigación en Biodiversidad y Cambio Global(CIBC-UAm)Universidad Autónoma de madrid MadridSpain

Over the past decades,empirical evidence has been accumulated indicating that olfactory information plays a fundamental role in bird life ***,many aspects of avian olfaction remain poorly *** purpose was to broaden the knowledge about the importance of the sense of smell in some neglected bird groups:psittaciformes and ramphastids,and to compare how the response varied between the *** of the lack of information about the use of chemical cues for locating food in fruit-eating species,we also aimed to delve into this *** conducted a 3-choice(water/vinegar/papaya and banana juice)scent test in 5 Costa Rican native species:scarlet macaw(Ara macao),red-lored amazon(Amazona autumnalis),yellow-naped amazon(Amazona auropalliata),keel-billed toucan(Ramphastos sulfuratus),and yellow-throated toucan(Ramphastos ambiguus).Results revealed that macaws and toucans allocated signiﬁcantly more time to interacting with the fruit scent container,indicating that these species can perceive the volatile chemicals emitted by ripe fruits and that they can use this information to make foraging ***,amazons did not dedicate more time to interact with the fruit *** research provides theﬁrst evidence of the ability to exploit chemical volatile cues in macaws and toucans.

关键词： avian olfaction bird senses frugivorous birds psittaciformes ramphastids scent test

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Biochemical composition of the glomerular extracellular matrix in patients with diabetic kidney disease

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World Journal of Diabetes 2022年第7期13卷 498-520页

作者： maría m Adeva-Andany Natalia Carneiro-Freire Nephrology Hospital Juan CardonaFerrol 15406Spain

In the glomeruli,mesangial cells produce mesangial matrix while podocytes wrap glomerular capillaries with cellular extensions named foot processes and tether the glomerular basement membrane(GBm).The turnover of the mature GBm and the ability of adult podocytes to repair injured GBm are *** actin cytoskeleton is a major cytoplasmic component of podocyte foot processes and links the cell to the *** components of the normal glomerular extracellular matrix(ECm)include glycosaminoglycans,proteoglycans,laminins,fibronectin-1,and several types of *** patients with diabetes,multiorgan composition of extracellular tissues is anomalous,including the kidney,so that the constitution and arrangement of glomerular ECm is profoundly *** patients with diabetic kidney disease(DKD),the global quantity of glomerular ECm is *** level of sulfated proteoglycans is reduced while hyaluronic acid is augmented,compared to control *** concentration of mesangial fibronectin-1 varies depending on the stage of *** type III collagen is abundant in patients with DKD,unlike normal *** amount of type V and type VI collagens is higher in DKD and increases with the progression of the *** GBm contains lower amount of type IV collagen in DKD compared to normal ***,genetic variants in theα3 chain of type IV collagen may modulate susceptibility to DKD and end-stage kidney *** cellular models of glomerular cells,analyses of human glomerular proteome,and improved microscopy procedures have been developed to investigate the molecular composition and organization of the human glomerular ECm.

关键词： Diabetes Kidney disease Glycosaminoglycans Factor H Sialic acid Laminin Collagen Fibronectin-1 Extracellular matrix

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On a Variant of Giuga Numbers

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Acta mathematica Sinica,English Series 2012年第4期28卷 653-660页

作者： Jos maría GRAU Florian LUCA Antonio m. OLLER-marCN Departmento de matemáticas Universidad de Oviedo Avda. Calvo Sotelo s/n Instituto de matemáticas Universidad Nacional Autnoma de México The John Knopfmacher Centre for Applicable Analysis and Number Theory University of the Witwatersrand Centro Universitario de la Defensa Academia General Militar Ctra. Huesca s/n

In this paper, we characterize the odd positive integers n satisfying the congruence ∑j=1^n-1 j n-1/2 We show that the set of such positive integers has an asymptotic densitywhich turns out to be slightly larger than... 详细信息

关键词： Congruence Giuga numbers asymptotic density

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