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A new hydrophobic deep eutectic solvent composed of menthol and tris(2-ethylhexyl) phosphate for solvent bar microextraction of parabens from biological fluids

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Emerging Contaminants 2024年第2期10卷 135-145页

作者： Nabil N.AL-Hashimi Husam Abed Alfattah Khaleel I.Assaf Asma A.Fakhoury Saja H.Hamed Amjad H.El-Sheikh Khairi m.Fahelelbom The Hashemite University Faculty of Pharmaceutical SciencesDepartment of Pharmaceutical ChemistryP.O.Box 330127Zarqa13133Jordan The Hashemite University Faculty of ScienceDepartment of ChemistryP.O.Box 150459Zarqa13115Jordan Al-Balqa Applied University Faculty of ScienceDepartment of Chemistry19117 Al-SaltJordan The Hashemite University Faculty of Pharmaceutical SciencesDepartment of Pharmaceutics and Pharmaceutical TechnologyP.O.Box 330127Zarqa13133Jordan Al Ain University College of PharmacyDepartment of Pharmaceutical SciencesP.O.Box 64141Al AinAl AinUnited Arab Emirates

Parabens are antimicrobial preservatives with extensive applications in cosmetics,toiletries,pharmaceuticals,and *** the legitimate concerns relating to their potential to disrupt multiple endocrine functions,it becomes imperative to prioritize the development of innovative bioanalytical techniques for effectively monitoring their presence in biological *** this study,an efficient solvent bar microextraction(SBmE)was established,utilizing new hydrophobic deep eutectic solvents(DEs)to determine methylparaben and propylparaben in urine and plasma *** DEs comprising menthol and tris(2-ethylhexyl)phosphate(m-TEHP)at various molar ratios were synthesized for the first time to enhance the extraction capacity and promote the eco-friendliness of the DE used as an extraction ***-transform infrared(FT-IR)and proton nuclear magnetic resonance(1H NmR)spectroscopies were employed to confirm and investigate the properties of the successful synthesis(m-TEHP)DE at a molar ratio of 1:*** synthesized DE exhibits low microbial toxicity and can be considered an eco-friendly solvent for ***,quantum-chemical calculations were utilized to predict synthesized DE's structure and interaction energy with selected *** influential operational factors of DE-SBmE on the extraction efficiency(EE%)of both parabens were evaluated using response surface methodology based on central composite design,and a total of 30 extraction tests were conducted to determine the optimal *** optimized DE-SBmE,in combination with HPLC-DAD,exhibited low detection limits(0.54–0.91μg L^(−1)),excellent linearity(R^(2)≥0.9993),precise results(RSDs≤7.6%),satisfactory recoveries(92–97%)and negligible matrix ***,it had remarkable effectiveness and applicability in determining selected parabens in real urine and plasma samples.

关键词： Hydrophobic deep eutectic solvent Solvent bar microextraction Parabens Response surface methodology and central composite design HPLC-DAD Urine and plasma

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精确农业田间土壤空间变异与采样方式研究

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农业工程学报 2001年第2期17卷 33-36页

作者：王珂沈掌泉 John S.Bailey Craw ford jordan 浙江大学环境与资源学院资源科学系杭州310029 Department of Agriculture for Northern Ireland

以英国 Hillsborough农业研究所附近的一块 7.9hm2的牧草地为研究区 ,采用地统计的半方差分析和克立格方法研究其空间变异性和空间插值。同时对研究田块的样点根据不同间距、不同形状进行删选 ,对不同布局状况下的结果进行统计比较 ,以... 详细信息

以英国 Hillsborough农业研究所附近的一块 7.9hm2的牧草地为研究区 ,采用地统计的半方差分析和克立格方法研究其空间变异性和空间插值。同时对研究田块的样点根据不同间距、不同形状进行删选 ,对不同布局状况下的结果进行统计比较 ,以获取满足一定精度下的最少采样个数和采样形状。研究结果表明 ,单纯利用样方统计 ,土壤有效钾需要 6 5个采样点 ,大致为原始采样点的一半。而在考虑空间采样形状和空间插值效果 ,再采用最小显著性差异 (L SD)进行比较 ,该田块土壤有效钾采样最好使用规则三角网布点 (样点数为 6 2个 )。

关键词：采样方法精确农业牧草田空间变异土壤特性

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Transcranial magnetic stimulation: potential treatment for co-occurring alcohol, traumatic brain injury and posttraumatic stress disorders

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Neural Regeneration Research 2014年第19期9卷 1712-1730页

作者： Amy A.Herrold Sandra L.Kletzel Brett C.Harton R.Andrew Chambers Neil jordan Theresa Louise-Bender Pape Edward Hines Jr.VA Hospital Research Service PO Box 5000 (M/C 151H)HinesILUSA The Department of Veterans Affairs (VA) Center for Innovation for Complex Chronic HealthcareEdward Hines Jr.VA HospitalPO Box 5000 (M/C 151H)HinesILUSA Department of Psychiatry & Behavioral Sciences Northwestern University Feinberg School of Medicine446 East Ontario#7-200ChicagoILUSA Chicago Association for Research and Education in Science HinesILUSA Department of Psychiatry Laboratory for Translational Neuroscience of Dual Diagnosis & DevelopmentNeuroscience Research CenterIndiana University School of Medicine320 West 15~(th)StreetIndianapolisINUSA Northwestern University Feinberg School of medicine Department of Physical Medicine and RehabilitationOffice of Medical Educ.(1574)345 E.Superior St.ChicagoILUSA

Alcohol use disorder （AUD）, mild traumatic brain injury （mTBI）, and posttraumatic stress disorder （PTSD） commonly co-occur （AUD ＋ mTBI ＋ PTSD）. These conditions have overlapping symptoms which are, in part, reflective of overlapping neuropathology. These conditions become problematic because their co-occurrence can exacerbate symptoms. Therefore, treatments must be developed that are inclusive to all three conditions. Repetitive transcranial magnetic stimulation （rTmS） is non-invasive and may be an ideal treatment for co-occurring AUD ＋ mTBI ＋ PTSD. There is accumulating evidence on rTmS as a treatment for people with AUD, mTBI, and PTSD each alone. However, there are no published studies to date on rTmS as a treatment for co-occurring AUD ＋ mTBI ＋ PTSD. This review article advances the knowledge base for rTmS as a treatment for AUD ＋ mTBI ＋ PTSD. This review provides background information about these co-occurring conditions as well as rTmS. The existing literature on rTmS as a treatment for people with AUD, TBI, and PTSD each alone is reviewed. Finally, neurobiological findings in support of a theoretical model are discussed to inform TmS as a treatment for co-occurring AUD ＋ mTBI ＋ PTSD. The peer-reviewed literature was identified by targeted literature searches using Pubmed and supplemented by cross-referencing the bibliographies of relevant review articles. The existing evidence on rTmS as a treatment for these conditions in isolation, coupled with the overlapping neuropathology and symptomology of these conditions, suggests that rTmS may be well suited for the treatment of these conditions together.

关键词： transcranial magnetic stimulation traumatic brain injury posttraumatic stress disorder treatment neuroimaging substance use disorders addiction co-morbidity mental health disorders behavioral health neuroimaging non-invasive brain stimulation

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Chronic disease care integration into primary care services in sub-Saharan Africa:a‘best fit’framework synthesis and new conceptual model

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Family medicine and Community Health 2022年第3期10卷 43-59页

作者： Simon R Harrison Aileen m.jordan Biomedical Sciences The University of Edinburgh College of Medicine and Veterinary MedicineEdinburghUK

Objective To examine the relevance of existing chronic care models to the integration of chronic disease care into primary care services in sub-Saharan Africa and determine whether additional context-specific model elements should be ***‘Best fit’framework synthesis comprising two systematic *** systematic review of existing chronic care conceptual models with construction of a priori *** systematic review of literature on integrated HIV and diabetes care at a primary care level in sub-Saharan Africa,with thematic analysis carried out against the a priori *** conceptual model constructed from a priori themes and new *** of bias of included studies was assessed using CASP and *** criteria Conceptual models eligible for inclusion in construction of a priori framework if developed for a primary care context and described a framework for long-term management of chronic disease *** eligible for inclusion in second systematic review described implementation and evaluation of an intervention or programme to integrate HIV and diabetes care into primary care services in *** sources Pubmed,Embase,CINAHL Plus,Global Health and Global Index medicus databases searched in April 2020 and September *** Two conceptual models of chronic disease care,comprising six themes,were used to develop the a priori *** systematic review of primary research identified 16 articles,within which all 6 of the a priori framework themes,along with 5 new themes:Improving patient access,stigma and confidentiality,patient-provider partnerships,task-shifting,and clinical mentoring.A new conceptual model was constructed from the a priori and new *** The a priori framework themes confirm a need for co-ordinated,longitudinal chronic disease care integration into primary care services in sub-Saharan *** of the primary research suggests integrated care for HIV and diabetes at a

关键词： services integration synthesis

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国际铸件缺陷图谱

国际铸件缺陷图谱

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作者： (美)m.T.·罗利(m.T. rowley)

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Radiation-induced oral mucositis hamster model using a linear accelerator enhances clinical relevance of preclinical studies for treatment strategy investigation

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Animal models and Experimental medicine 2021年第1期4卷 47-53页

作者： Carolyn T.jordan Emily m.Bradford Dennis C.Cheek mahesh Kudrimoti Craig S.miller molly H.Smith J.Zach Hilt Thomas D.Dziubla Department of Chemical and materials Engineering University of KentuckyLexingtonKYUSA Department of Internal medicine University of KentuckyLexingtonKYUSA Department of Radiation medicine University of KentuckyLexingtonKYUSA Department of Oral Health Practice University of KentuckyLexingtonKYUSA Department of Oral and maxillofacial Pathology University of KentuckyLexingtonKYUSA

Translational animal models for oral mucositis(Om)are necessary to simulate and assess the bioclinical effects and response in *** models should simulate high levels of radiation exposure that leads to oxidative stress and inflammatoryinitiated tissue *** models have been extensively studied to observe pathological effects of radiation exposure and help in the development of effective *** successfully evaluate the potential for treatment regimens with consistency and relevance,a radiation-induced Om hamster model was developed using a clinical linear accelerator utilized by cancer patients *** dose exposure to the isolated,everted cheek pouch of a hamster,as well as the progression of injury,proinflammatory marker,histological,and elasticity analyses of the buccal pouch were conducted to verify replicability and reproducibility of the injury *** findings from this model demonstrated its ability to consistently induce injury and resolution over 28 days using an acute dose of 60 *** model was developed to enhance clinical relevance when evaluating potential efficacious treatments and can now be utilized in efficacy studies to better evaluate developed therapeutics in a preclinical model that is easy to translate to clinical studies..

关键词： animal models radiotherapy stomatitis

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The LaTeX Companion (Addison-Wesley Series on Tools and Techniques for Computer Typesetting) 2nd ed. /

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丛书名： Tools and Techniques for Computer Typesetting

2004年

作者： Frank mittelbach Chris rowley David Carlisle Johannes Braams

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Protective effect of unilateral vasospasm in the setting of HHH-associated posterior reversible encephalopathy syndrome:case report, review of the literature, and treatment considerations

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Chinese Neurosurgical Journal 2019年第1期5卷 47-55页

作者： Alankrita Raghavan jordan Xu James m.Wright Christina Huang Wright Benjamin miller Yin Hu School of medicine Case Western Reserve University2109 Adelbert RoadClevelandOH 44106USA Department of Neurological Surgery University of California Irvine SOM1001 Health Sciences RdIrvineCA 92617USA Department of Neurological Surgery University Hospitals Cleveland Medical Center11100 Euclid AvenueClevelandOH 44106USA Department of Neurology University of Minnesota420 Delaware St SEMinneapolisMN 55455USA

Background:Hyperdynamic therapy,also called triple-H therapy,is the standard treatment and prophylaxis for aneurysmal-associated *** patients who are able to tolerate cardiopulmonary stressors induced by this therapy,it is of benefit as a modality for prevention and treatment of delayed ischemic neurologic ***,it can be a cause of significant cardiopulmonary or neurologic *** rare cases,it can be associated with posterior reversible encephalopathy syndrome(PRES),secondary to prolonged vasopressor and hypertensive *** presentation:We present the case of a patient with right-sided aneurysmal-associated vasospasm who,after 10 days of triple-H therapy,experienced a seizure and was found to have left-sided ***-sided vasospasm served as a protective mechanism from triple-H therapy-associated *** presented a treatment conundrum due to contradictory perfusion *** therapy was curtailed and in efforts to preserve local cerebral perfusion and vasodilation,local therapy with intrathecal nicardipine was *** present our case,a review of the literature,and management ***:Therapies that have conventionally functioned as second line treatments for aneurysmal subarachnoid hemorrhage(intra-arterial vasodilators and intrathecal vasodilators)may be beneficial as earlier treatments in the setting of vasospasm given the systemic difficulties and complications associated with HHH therapy in patients with PRES.

关键词： Subarachnoid hemorrhage Hyperdynamic therapy Posterior reversible encephalopathy syndrome

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Power Output and Electromyography Activity of the Back Squat Exercise with Cluster Sets

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Journal of Sports Science 2013年第1期1卷 37-45页

作者： jordan m. Joy Jonathan m. Oliver Sean A. mcCleary Ryan P. Lowery Jacob m. Wilson Department of Health Sciences and Human Performance The University of Tampa Tampa 33606 FL USA musclePharm Sports Science Institute MusclePharm Corp. Denver 80239 CO USA Department of Kinesiology Texas Christian University Fort Worth 76129 TX USA

Recently, it has been demonstrated that hypertrophic training with CLU （cluster） sets produces greater strength and power following a 12-week periodized program. The results suggest possible differences in neuromuscular adaptations. Therefore, we sought to compare the acute effect of TRD （traditional） and CLU set configurations during the parallel back squat on mean power output and integrated EmG （electromyography） activity of the VL （vastus lateralis） and BF （biceps femoris）. Ten males （23 ~ 2.4 years; height 182.9 ~ 6.1 cm; weight 86.2 ~ 4.2 kg; 5 ~ 2 years training） performed the parallel back squat using TRD and CLU with 75% 1Rm （one-repetition maximum） in a randomized crossover design. Data was analyzed by a repeated measures--ANOVA （analysis of variance）. A significant effect of set （P = 0.006） was observed in mean power output. mean power output decreased over each successive set when collapsed for condition. Clusters resulted in greater mean power output during latter repetitions of each set （repetition 4, 6-10; P 〈 0.05）. A significant effect of set （P = 0.049） was observed in VL EmG. VL EmG increased over each successive set when collapsed for condition. TRD training produced significantly greater VL EmG during latter repetitions of each set （repetition 6-8; P 〈 0.05）. An interaction was observed in BF EmG. No significant differences were observed in post-hoc. Thus, cluster sets can be used to achieve greater power output, but greater neuromuscular activity should not be expected relative to traditional training.

关键词： Cluster interset rest electromyography power squat intraset rest.

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metastatic disease to the liver:Locoregional therapy strategies and outcomes

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World Journal of Clinical Oncology 2021年第9期12卷 725-745页

作者： Kylie E Zane jordan m Cloyd Khalid S mumtaz Vibhor Wadhwa mina S makary Department of Radiology The Ohio State University Wexner Medical CenterColumbusOH 43210United States Department of Surgery The Ohio State University Wexner Medical CenterColumbusOH 43210United States Department of Internal medicine The Ohio State University Wexner Medical CenterColumbusOH 43210United States Department of Radiology Weill Cornell Medical CenterNew York CityNY 10065United States

Secondary cancers of the liver are more than twenty times more common than primary tumors and are incurable in most *** surgical resection and systemic chemotherapy are often the first-line therapy for metastatic liver disease,a majority of patients present with bilobar disease not amenable to curative local ***,by the time metastasis to the liver has developed,many tumors demonstrate a degree of resistance to systemic ***,catheter-directed and percutaneous locoregional approaches have evolved as major treatment modalities for unresectable metastatic *** novel techniques can be used for diverse applications ranging from curative intent for small localized tumors,downstaging of large tumors for resection,or locoregional control and palliation of advanced *** use has been associated with increased tumor response,increased disease-free and overall survival,and decreased morbidity and mortality in a broad range of metastatic *** review explores recent advances in liver-directed therapies for metastatic liver disease from primary colorectal,neuroendocrine,breast,and lung cancer,as well as uveal melanoma,cholangiocarcinoma,and *** discussed include bland transarterial embolization,chemoembolization,radioembolization,and ablative therapies,with a focus on current treatment approaches,outcomes of locoregional therapy,and future directions in each type of metastatic disease.

关键词： metastatic liver cancer Transarterial embolization Chemoembolization Radioembolization Ablation Transarterial chemoembolization Transarterial radioembolization

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