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measurements of dihadron correlations relative to the event plane in Au+Au collisions at√^(S)NN=200 GeV

Chinese Physics C 2021年第4期45卷 198-241页

作者： H.Agakishiev m.m.Aggarwal Z.Ahammed A.V.Alakhverdyants I.Alekseev j.Alford B.D.Anderson C.D.Anson D.Arkhipkin G.S.Averichev j.Balewski D.R.Beavis N.K.Behera R.Bellwied m.j.Betancourt R.R.Betts A.Bhasin A.K.Bhat H.Bichsel j.Bieleik j.Bielcikova B.Biritz L.C.Bland W.Borowski j.Bouchet E.Braidot A.V.Brandin A.Bridgeman S.G.Brovko E.Bruna S.Bueltmann I.Bunzarov T.P.Burton X.Z.Cai H.Caines m.Calderon de la Barca Sanchez D.Cebra R.Cendejas m.C.Cervantes Z.Chajecki P.Chaloupka S.Chattopadhyay H.F.Chen j.H.Chen j.Y.Chen L.Chen j.Cheng m.Cherney A.Chikanian K.E.Choi W.Christie P.Chung m.j.m.Codrington R.Corliss j.G.Cramer H.j.Crawford S.Dash A.Davila Leyva L.C.De Silvat R.R.Debbe T.G.Dedovich A.A.Derevschikov R.Derradi de Souza L.Didenko P.Djawotho S.m.Dogra X.Dong j.L.Drachenberg j.E.Draper j.C.Dunlop L.G Efimov m.Elnim j.Engelage G Eppley m.Estienne L.Eun O.Evdokimov R.Fatemi j.Fedorisin A.Feng R.G.Fersch P.Filip E.Finch V.Fine Y.Fisyak C.A.Gagliardi D.R.Gangadharan A.Geromitsos F.Geurts P.Ghosh Y.N.Gorbunov A.Gordon O.Grebenyuk D.Grosnick S.m.Guertin A.Gupta W.Guryn B.Haag O.Hajkova A.Hamed L-X.Han j.W.Harris j.P.Hays-Wehle m.Heinz S.Heppelmann A.Hirsch E.Hjort G.W.Hoffmann D.j.Hofiman B.Huang H.Z.Huang T.j.Humanic L.Huo G.Igo P.jacobs W.W.jacobs C.jena F.jin j.joseph E.G.judd S.Kabana K.Kang j.Kapitan K.Kauder H.Ke D.Keane A.Kechechyan D.Kettler D.P.Kikola j.Kiryluk A.Kisiel V.Kizka A.G.Knospe D.D.Koetke T.Kollegger j.Konzer I.Koralt L.Koroleva W.Korsch L.Kotchenda V.Kouchpil P.Kravtsov K.Krueger m.Krus L.Kumar P.Kurnadi m.A.C.Lamont j.m.Landgraf S.LaPointe j.Lauret A.Lebedev R.Lednicky j.H.Lee W.Leight m.j.levine C.Lil L.Li N.Li W.Li X.Li X.Li Y.Li Z.m.Li m.A.Lisa F.Liu H.Liu j.Liu T.Ljubicic W.j.Llope R.S.Longacre W.A.Love Y.Lu E.V.Lukashov X.Luo G.L.ma Y.G.mai D.P.mahapatra R.majka O.I.mall L.K.mangotra R.manweiler S.margetis C.markert H.masui H.S.matis Yu.A.matulenko D.meDonald T.S.mcShane A.meschanin R.milner N.G.minaev S.mioduszewski A.mischke m.K.mitrovski B.mohanty m.m.mondal B.morozov D.A.morozov m.G.munhoz m Argonne National Laboratory Argonnellinois 60439USA Brookhaven National Laboratory UptonNew York 11973USA University of Califomia BerkeleyCaliformnia 94720USA University of California DavisCalifornia 95616USA University of Califormnia Los AngelesCalifomia 90095USA Universidade Estadual de Campinas Sao PauloBrazil University of Illinois at Chicago ChicagoIlinois 60607USA Creighton University OmahaNebraska 68178USA Czech Technical University in Prague FNSPEPrague11519Czech Republic Nuclear Physics Institute AS CR 25068 Rez/PragueCzech Republic University of Frankfurt FrankfurtGermany Institute of Physics Bhubaneswar 751005India Indian Institute of Technology MumbaiIndia Indiana University BloomingtonIndiana 47408USA Alikhanov Instiute for Theoretical and Experimental Physics MoscowRussia University of jammu Jammu 180001India joint Institute for Nuclear Research Dubna141980Russia Kent State University KentOhio 44242USA University of Kentucky LexingtonKentucky40506-0055USA Institute of modern Physics LanzhouChina Lawrence Berkeley National Laboratory BerkeleyCalifornia 94720USA massachusetts Institute of Technology CambridgeMA 02139-4307USA mx-Planck-Institut fir Physik MunichGermany michigan State University East LansingMichigan 48824USA moscow Engineering Physics Institute Moscow Russia NIKHEF and Utrecht University AmsterdamThe Netherlands Ohio State University ColumbusOhio 43210USA Old Dominion University NorfolkVA23529USA Panjab University Chandigarh 160014India PennsyIvania State University University ParkPennsylvania 16802USA Institute of High Energy Physics ProtvinoRussia Purdue University West LafayetteIndiana 47907USA Pusan National University PusanRepublic of Korea University of Rajasthan Jaipur 302004India Rice University HoustonTexas 77251USA Universidade de Sao Paulo Sao PauloBrazil University of Science&Technology of China Hefei 230026.China Shandong University JinanShandong 250100China Shanghai Institute of Applied Physics Shanghai 201800Chi

Dihadron azimuthal correlations containing a high transverse momentum(pr)trigger particle are sensit-ive to the properties of the nuclear medium created at RHIC through the strong interactions occurring between the traversing parton and the medium,*** measurements revealed a strong modification to di-hadron azimuthal correlations in Au+Au collisions with respect to ptp and d+Au *** modification in-creases with the collision centrality,suggesting a path-length or energy density dependence to the je-quenching *** paper reports STAR measurements of dihadron azimuthal correlations in mid-central(20%-60%)Au+Au collisions at√^(S)NN=200 GeV as a function of the trigger particle's azimuthal angle relative to the event plane,Ф_(s)=|Ф_(t)-ψ_(Ep)|.The azimuthal correlation is studied as a function of both the trigger and associated particle *** subtractions of the combinatorial background and anisotropic flow,assuming Zero Yield At minimum(ZYAm),are *** correlation results are first discussed with subtraction of the even harmonic(elliptic and quadrangu-lar)flow *** away-side correlation is strongly modifed,and the modification varies withФ_(s),with a double-peak structure for out-of-plane trigger *** near-side ridge(long range pseudo-rapidity△_(η)correla-tion)appears to drop with increasingФ_(s)while the jet-like component remains approximately *** correla-tion functions are further studied with the subtraction of odd harmonic triangular flow background arising from *** is found that the triangular flow,while responsible for the majority of the amplitudes,is not sufficient to explain theφs-dependence of the ridge or the away-side double-peak *** dropping ridge withФ_(s)could be attributed to aФ_(s)-dependent lliptie anisotropy;however,the physics mechanism of the ridge remains an open *** with aФ_(s)-dependent elliptic flow,the away-side correlation structure

关键词： relativistic heavy ion collisions dihadron correlations jet-medium interactions anisotropic flow background event plane

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Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri j.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

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Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert j.Thomas m.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

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Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage mark L.Dell’Acqua Brian m.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

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modern treatment strategies for penile prosthetics in Peyronie’s disease:a contemporary clinical review

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Asian journal of Andrology 2020年第1期22卷 51-59页

作者： matthew j Ziegelmann m Ryan Farrell Laurence A levine Division of Urology Rush University Medical CenterChicagoIL 60612USA

Peyronie's disease is a common condition resulting in penile deformity,psychological bother,and sexual *** dysfunction is one common comorbid condition seen in men with Peyronie’s disease,and its presence significantly impacts treatment *** a man with Peyronie's disease and significant erectile dysfunction who desires the most reliable treatment,penile prosthesis placement should be strongly *** some instances,such as those patients with relatively mild curvature,prosthesis placement alone may result in adequate ***,many patients will require additional straightening maneuvers such as manual modeling,penile plication,and tunica albuginea incision with or without *** patients with severe penile shortening,penile length restoration techniques may also be ***,we provide a comprehensive clinical review of penile prosthesis placement in men with Peyronie's ***,we discuss preoperative indications,intraoperative considerations,adjunctive straightening maneuvers,and postoperative outcomes.

关键词： collagenase grafting penile length penile prosthesis Peyronie's

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The many faces of p53:something for everyone

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journal of molecular Cell Biology 2019年第7期11卷 524-530页

作者： Arnold j.levine Institute for Advanced Study PrincetonNJ 08540USA

The p53 gene,from discovery to classification:the first 10 years Forty years ago four research laboratories in London,Paris,NewYork/Bethesda,and Princeton uncovered the existence of the p53 protein (Deleo et al.,1979;Lane and Crawford,1979;Linzer and levine,1979;Kress et al.,1979).Each laboratory came upon this protein for a different reason and with a different experimental approach that uncovered this unanticipated ***,the four papers permitted one to con elude the following:(i) in SV40-infected and transformed cells the SV40-e ncoded on cogene protein,the large T-antigen,formed a protein complex with a cellular-encoded protein of -53000 daltons in size,(ii) This p53 protein was detected at high levels in a variety of transformed cells derived from viral,chemical,or inherited (teratocarcinomas) transformation events,(iii) Nontransformed cells expressed lower levels of the p53 protein,(iv) Animals bearing tumors produced antibodies directed against the p53 protein.

关键词： discovery years protein

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Surgery for Peyronie＇s disease

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Asian journal of Andrology 2013年第1期15卷 27-34页

作者： Laurence A levine Stephen m Larsen Department of Urology Rush University Medical Center Chicago IL 60612 USA

Peymnie＇s disease （PD） is most simply referred to as a fibrotic wound-healing disorder of the tunica albuginea. It is both a physically and psychologically devastating disorder that causes penile deformity, curvature, hinging, narrowing and shortening, which may compromise sexual function. Although a variety of non-surgical treatments have been suggested, none to date offer a reliable and effective correction of the penile deformity. As a result, surgery remains the gold standard treatment option, offering the most rapid and reliable treatment which will be the focus of this article. We review the preoperative evaluation, surgical algorithm, graft materials and postoperative management of PD. Outcomes for tunical shortening, tunical lengthening and penile prosthesis placement for penile straightening are reviewed. Tunica albuginea plication is the preferred method of straightening for men with adequate rigidity and less severe disease defined as curvature less than 70° without narrowing/hinging. men who have more severe, complex deformity, but maintain strong preoperative erectile function should be considered candidates for straightening with plaque incision or partial excision and grafting. Finally, for those men who have inadequate rigidity and PD, penile prosthesis placement with straightening is the best approach to address both problems.

关键词： penile prosthesis Peyronie's disease, penile reconstruction plaque excision and grafting plaque incision tunica albuginea plication

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Endoscopic ultrasound fine needle aspiration vs fine needle biopsy for pancreatic masses,subepithelial lesions,and lymph nodes

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World journal of Gastroenterology 2021年第26期27卷 4194-4207页

作者： Irving levine Arvind j Trindade Division of Gastroenterology Long Island Jewish Medical CenterZucker School of Medicine at Hofstra/NorthwellNorthwell Health SystemNew Hyde ParkNY 11040United States

Endoscopic ultrasound tissue acquisition,in the form of both fine needle aspiration(EUS-FNA)and fine needle biopsy(EUS-FNB),is utilized for pancreatic mass lesions,subepithelial lesions,and lymph node *** procedures are safe and yield high diagnostic *** its high diagnostic yield,EUS-FNA has potential limitations associated with cytological aspirations,including inability to determine histologic architecture,and a small quantitative sample for further immunohistochemical ***-FNB,with its larger core biopsy needle,was designed to overcome these potential ***,it remains unclear which technique should be used and for which *** trials are plagued by heterogeneity at every stage of comparison;including variable needles used,and different definitions of endpoints,which therefore limit ***,we present a review of prospective trials,systematic reviews,and meta-analyses on studies examining EUS-FNA vs *** comparative trials of EUS-FNA vs EUS-FNB primarily focus on pancreatic mass lesions,and yield conflicting results in terms of demonstrating the superiority of one ***,consistent among trials is the potential for diagnosis with fewer passes,and a larger quantity of sample achieved for next generation *** regard to subepithelial lesions and lymph node biopsy,fewer prospective trials exist,and larger prospective studies are *** on the available literature,we would recommend EUS-FNB for peri-hepatic lymph nodes.

关键词： Endoscopic ultrasound fine needle aspiration Endoscopic ultrasound fine needle biopsy Pancreatic lesions Subepithelial lesions Lymph node biopsy

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Real-world analysis of two ischaemic stroke and TIA systolic blood pressure goals on 12-month mortality and recurrent vascular events

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Stroke & Vascular Neurology 2024年第5期9卷 519-529页

作者： jason j Sico Xin Hu Laura j myers Deborah levine Dawn m Bravata Greg W Arling Internal medicine and Neurology Yale University School of MedicineNew HavenConnecticutUSA Department of Neurology Veterans Affairs Connecticut Healthcare SystemWest HavenConnecticutUSA Yale School of Public Health New HavenConnecticutUSA VA Health Services Research and Development(HSR&D)Center for Healthcare Informatics and Communication and the HSR&D Stroke Quality Enhancement Research Initiative(QUERI) IndianapolisIndianaUSA Richard L.Roudebush VA medical Center IndianapolisIndianaUSA Departments of medicine and Neurology University of Michigan School of MedicineAnn ArborMichiganUSA Health Services Research and Development(HSR&D)Center for Healthcare Informatics and Communication and the HSR&D Stroke Quality Enhancement Research Initiative(QUERI) Department of Veterans Affairs(VA) Health Services Research and Development(HSR&D)Precision Monitoring to Transform Care(PRISM)Quality Enhancement Research Initiative(QUERI)IndianapolisIndianaUSA Department of Nursing Purdue UniversityWest LafayetteIndianaUSA

Introduction Whether obtaining the more intensive goal systolic blood pressure(SBP)of140mm Hg).Separate multivariable Cox proportional hazard regressions were used to examine the relationship between average SBP group... 详细信息

Introduction Whether obtaining the more intensive goal systolic blood pressure(SBP)ofmm Hg,rather than a less intensive SBP goal ofmm Hg poststroke/transient ischaemic attack(TIA)is associated with incremental mortality and recurrent vascular event benefit is largely unexplored using real-world *** SBP excessively may result in poorer *** This is a retrospective cohort study of 26368 Veterans presenting to a Veterans Administration medical Center(VAmC)with a stroke/TIA between October 2015 and july *** were excluded from the study if they had missing or extreme BP values,receiving dialysis or palliative care,left against medical advice had a cancer diagnosis,were cared for in a VAmC enrolled in a stroke/TIA quality improvement initiative,died or had a cerebrovascular or cardiovascular event within 90 days after their index stroke/*** analytical sample included 12337 *** SBP during 90 days after discharge was assessed in categories(≤105mm Hg,106–115mm Hg,116–130mm Hg,131–140mm Hg and>140mm Hg).Separate multivariable Cox proportional hazard regressions were used to examine the relationship between average SBP groups and time to:(1)mortality and(2)any recurrent vascular event,from 90 days to up to 365 days after discharge from the index emergency department visit or inpatient *** Compared with those with SBP>140mm Hg,patients with SBP between 116 and 130mm Hg had a significantly lower risk of recurrent stroke/TIA(HR 0.77,95%CI 0.60 to 0.99)but not cardiovascular *** with SBP lower than 105mm Hg,compared with those with>140mm Hg demonstrated a statistically significant higher risk of death(HR 2.07,95%CI 1.43 to 3.00),but no statistical differences were found in other SBP *** Data support a more intensive SBP goal to prevent recurrent cerebrovascular events among stroke/TIA patients by 90 days poststroke/TIA compared with less intensive *** low SBPs were associated wit

关键词： dialysis diagnosis TIA

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Development of a building information model-guided post-earthquake building inspection framework using 3D synthetic environments

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Earthquake Engineering and Engineering Vibration 2023年第2期22卷 279-307页

作者： Nathaniel m.levine Yasutaka Narazaki Billie F.Spencer Department of Civil and Environmental Engineering University of Illinois at Urbana-ChampaignUrbanaIllinois 61801USA Zhejiang University-University of Illinois at Urbana-Champaign Institute Zhejiang UniversityHaining 314400China

Computer vision-based inspection methods show promise for automating post-earthquake building *** methods survey a building with unmanned aerial vehicles and automatically detect damage in the collected ***,assessing the damage′s impact on structural safety requires localizing damage to specific building components with known design and *** paper proposes a BIm-based automated inspection framework to provide context for visual surveys.A deep learning-based semantic segmentation algorithm is trained to automatically identify damage in *** BIm automatically associates any identified damage with specific building ***,components are classified into damage states consistent with component fragility models for integration with a structural *** demonstrate the framework,methods are developed to photorealistically simulate severe structural damage in a synthetic computer graphics environment.A graphics model of a real building in Urbana,Illinois,is generated to test the framework;the model is integrated with a structural analysis to apply earthquake damage in a physically realistic manner.A simulated UAV survey is flown of the graphics model and the framework is *** method achieves high accuracy in assigning damage states to visible structural *** assignment enables integration with a performance-based earthquake assessment to classify building safety.

关键词： computer vision earthquake engineering building information model physics-based graphics model synthetic environment

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