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mitochondria as a therapeutic:a potential new frontier in driving the shift from tissue repair to regeneration

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Regenerative Biomaterials 2023年第1期10卷 1332-1355页

作者： Evan N.main Thaiz m.cruz Gary L.Bowlin Department of Biomedical Engineering University of Memphis330 Engineering Technology BuildingMemphisTN 38152USA

Fibrosis,or scar tissue development,is associated with numerous pathologies and is often considered a worst-case scenario in terms of wound healing or the implantation of a *** that remains is a disorganized,densely packed and poorly vascularized bundle of connective tissue,which was once functional *** creates a significant obstacle to the restoration of tissue function or integration with any ***,it is of paramount importance in tissue engineering and regenerative medicine to emphasize regeneration,the successful recovery of native tissue function,as opposed to repair,the replacement of the native tissue(often with scar tissue).A technique dubbed‘mitochondrial transplantation’is a burgeoning field of research that shows promise in in vitro,in vivo and various clinical applications in preventing cell death,reducing inflammation,restoring cell metabolism and proper oxidative balance,among other reported ***,there is currently a lack of research regarding the potential for mitochondrial therapies within tissue engineering and regenerative ***,this review explores these promising findings and outlines the potential for mitochondrial transplantation-based therapies as a new frontier of scientific research with respect to driving regeneration in wound healing and host-biomaterial interactions,the current successes of mitochondrial transplantation that warrant this potential and the critical questions and remaining obstacles that remain in the field.

关键词： mitochondrial transplantation host-biomaterial integration biomaterials wound healing fibrosis

Kinetic and morphology study of alginate-vineyard pruning waste biocomposite vs. non modified vineyard pruning waste for dye removal

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Journal of Environmental Sciences 2015年第12期27卷 158-167页

作者： Xanel Vecino Rosa Devesa-Rey Salvador Villagrasa Jose m.cruz Ana B.moldes Chemical Engineering Department School of Industrial Engineering (EEI)University of VigoCampus As Lagoas-Marcosende Defense University Center Naval AcademyUniversity of Vigo materials Engineering Department School of Industrial Engineering (EEI)University of VigoCampus As Lagoas-Marcosende

In this work a comparative bioadsorption study between a biocomposite consisting of hydrolysed vineyard pruning waste entrapped in calcium alginate spheres and non entrapped vineyard residue was carried *** have demonstrated that the biocomposite based on lignocellulose-calcium alginate spheres removed 77.3% of dyes,while non entrapped lignocellulose eliminated only removed 27.8% of colour *** experimental data were fitted to several kinetic models（pseudo-first order,pseudo-second order,Chien-Clayton model,intraparticle diffusion model and Bangham model）; being pseudo-second order the kinetic model that better described the adsorption of dyes onto both *** addition,a morphological study（roughness and shape） of alginate-vineyard biocomposite was established under extreme conditions,observing significant differences between hydrated and dehydrated alginate-vineyard *** techniques used to carry out this morphological study consisted of scanning electron microscopy（SEm）,perfilometry and 3D surface analysis.

关键词： Immobilized alginate-vineyard Dyes Kinetic studies Roughness Spherical shape

Higher incidence of steroid-induced ocular hypertension in keratoconus

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Eye and Vision 2016年第1期3卷 29-36页

作者： Anastasios John Kanellopoulos Emerson m.cruz Robert Edward T.Ang George Asimellis Laservision.gr Clinical and Research Eye Institute 17 Tsocha StreetAthens Postal Code:11521Greece NYU medical School New YorkNYUSA Asian Eye Institute MakatiPhilippines

Background:To compare intraocular pressure(IOP)changes following topical dexamethasone administration for 1 month in keratoconic versus normal ***:This is a retrospective,single-center,non-randomized case series evaluation of 350 *** groups were formed:normal/control Group A(n_(A)=73),eyes that underwent excimer laser photorefractive keratectomy;and keratoconic(KCN)Group B(n_(B)=277),eyes that were subjected to partial laser photorefractive keratectomy combined with collagen cross-linking(The Athens Protocol).All eyes received the same post-operative regimen of topical dexamethasone 0.1%for at least 1 *** applanation tonometry IOP readings and central corneal thickness(CCT)measurements were *** with induced ocular hypertension(OHT,defined as post-operative IOP higher than 21 mmHg),were identified and correlated to refractive procedure,gender,and corneal ***:At 4 weeks postoperatively,OHT was noted on 27.4%(20/73 eyes)in Group A,and 43.7%(121/277 eyes)in KCN Group B,(pmonths post-operatively(following 5-months of discontinuing topical dexamethasone treatment and commencing treatment of IOP-lowering medications),OHT rate was 1.8%in Group A and 3.9%in the KCN Group ***:This study demonstrates a potentially significant pre-disposition of keratoconic eyes to the development of steroid-induced OHT.

关键词： Keratoconus Intraocular pressure Corticosteroid induced ocular hypertension IOP spike Corneal collagen cross-linking CXL The Athens protocol Topography-guided Photorefractive keratectomy Dexamethasone topical ophthalmic solution

Quantum teleportation and information splitting via four-qubit cluster state and a Bell state

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Frontiers of physics 2017年第5期12卷 171-179页

作者： marlon David González Ramirez Babatunde James Falaye Guo-Hua Sun m. cruz-irisson Shi-Hai Dong ESImE-Culhuaean Instituto Politécnico Nacional Av. Santa Ana 1000 Mexico CDMX 04430 Mexico Departamento de Fisica Escuela Superior de Fisica y Matemdticas Instituto Politécnico Nacional Edificio 9 UPALM CDMX 07738 Mexico Applied Theoretical Physics Division Department of Physics Federal University Lafia P. M. B. 146 LafiaNigeria Catedrdtica CONACyT CIC Instituto Politéenico Nacional UPALM CDMX 07700 Mexico Laboratorio de Información Cudntica CIDETEC Instituto Politécnico Nacional UPALM CDMX 07700Mexico

Quantum teleportation provides a ＂bodiless＂ way of transmitting the quantum state from one object to another, at a distant location, using a classical communication channel and a previously shared entangled state. In this paper, we present a tripartite scheme for probabilistic teleportation of an arbitrary single qubit state, without losing the information of the state being teleported, via a fourqubit cluster state of the form ｜Ф） 1234 = α｜10000）＋β｜1010）＋ γ｜0101） - η｜1111）, as the quantum channel, where the nonzero real numbers α, β, γ, and η satisfy the relation ｜α｜^2 ＋｜β｜^2 ＋｜γ｜^2 ＋｜η｜^2 = 1. With the introduction of an auxiliary qubit with state ｜0}, using a suitable unitary transformation and a positive-operator valued measure （POVm）, the receiver can recreate the state of the original qubit. An important advantage of the teleportation scheme demonstrated here is that, if the teleportation fails, it can be repeated without teleporting copies of the unknown quantum state, if the concerned parties share another pair of entangled qubit. We also present a protocol for quantum information splitting of an arbitrary two-particle system via the aforementioned cluster state and a Bell-state as the quantum channel. Problems related to security attacks were examined for both the cases and it was found that this protocol is secure. This protocol is highly efficient and easy to implement.

关键词： teleportation positive-operator valued measure tripartite scheme security attacks

Comparison of white‑to‑white measurements using four devices and their determination of ICL sizing

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Eye and Vision 2024年第5期10卷 28-40页

作者： Robert Edward T.Ang Edward Kenneth F.Reyes Fernando Amado J.Ayuyao Jr maria Isabel N.Umali Emerson m.cruz Asian Eye Institute Phinma PlazaRockwell Center8Th Floor1200 MakatiPhilippines Cardinal Santos medical Center 10 Wilson St.Greenhills1502 San JuanPhilippines

Background:To compare the measurements obtained from the Orbscan II,IOLmaster 700,Pentacam AXL,and Castroviejo caliper and their effects on calculating the recommended implantable collamer lens(ICL)size and postoperative vault ***:This is a retrospective cross-sectional study of patients who underwent ICL surgery by a single surgeon from march 1,2018 to July 31,*** were reviewed for the anterior chamber depth(ACD)and white-to-white(WTW)measurements obtained from the Orbscan II,IOLmaster 700,Pentacam AXL,and Castroviejo caliper(WTW only).These were used to calculate the recommended ICL *** actual ICL size implanted,and vault measurements obtained one month postoperatively were also ***:One hundred seven eyes with a mean age of 27.9±7.7 years were included in the *** WTW measurements were significantly different between devices(Pmaster 700 having the highest value(12.14±0.04 mm)and the caliper having the lowest value(11.45±0.04 mm).mean ACD measurements were the lowest in Orbscan II(3.12±0.25 mm)and the highest in Pentacam AXL(3.16±0.24 mm).The Pentacam AXL produced an ICL size similar to the Orbscan in 69.2%of *** IOLmaster yielded an ICL measurement one size larger than Orbscan-based calculations in 64.5%of *** the Orbscan WTW and ACD,the desired vault of 0.25 to 0.75 mm and 0.25 to 1.00 mm was achieved in 70%and 91%of eyes,*** caliper WTW to IOLmaster 700 or Pentacam AXL WTW increases the percentage of achieving the desired vault to 80%,similar to the ***:The Orbscan II,IOLmaster 700,and Pentacam AXL cannot be used interchangeably for calculating ICL *** the WTW from caliper measurement with the ACD of the IOLmaster 700 or Pentacam AXL could improve ICL sizing and achieve a higher percentage of eyes with the desired vault.

关键词： ICL vault Orbscan II IOLmaster 700 Pentacam AXL Caliper

Safety and effectiveness of the SUPRACOR presbyopic LASIK algorithm on hyperopic patients

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Eye and Vision 2016年第1期3卷 253-262页

作者： Robert Edward T.Ang Emerson m.cruz Alex U.Pisig maria Luisa Patricia C.Solis Rosalie mae m.Reyes Gerhard Youssefi Asian Eye Institute 8th Floor PHINMA PlazaRockwell CenterMakati City 1200Philippines Department of Ophthalmology Cardinal Santos Medical Center10 Wilson St.Greenhills WestSan Juan CityPhilippines TECHNOLAS PerfectVision GmbH A Bausch&Lomb CompanyMesserschmittstrasse 1-3Munich 80992Germany

Background:To evaluate the safety and effectiveness of the Supracor excimer laser algorithm to treat hyperopic presbyopic patients using laser in-situ keratomileusis(LASIK).methods:This is a retrospective case review of patients diagnosed with hyperopia(Sphere≥+0.0 D and presbyopia reading add≥1.0 D)who underwent Supracor excimer laser treatment on at least one eye for presbyopia correction from year may 2011 to may *** vision was further analyzed after patients were subdivided into three groups:Group A(n=22 eyes,11 patients)had Supracor on both eyes;Group B(n=18 eyes,18 patients)had Supracor in one eye and hyperopic LASIK on fellow eye;and Group C(n=29 eyes,29 patients)had Supracor in one eye and no treatment on the fellow ***:This study evaluated 58 patients wherein 69 eyes underwent Supracor presbyopic ***,mean manifest refraction spherical equivalent(mRSE)of all eyes that underwent Supracor was+1.37±0.72 D with mean uncorrected distance visual acuity(UDVA),uncorrected intermediate visual acuity(UIVA),and uncorrected near visual acuity(UNVA)of 20/50(0.35 logmAR),20/50(0.35 logmAR),and J9(0.61 logmAR),*** 6 months postoperatively,mean mRSE was−0.43±0.59 D with mean UDVA,UIVA and UNVA of 20/25(0.13 logmAR),20/20(0.01 logmAR),and J1(0.05 logmAR),*** of two lines of best-corrected distance visual acuity(BCDVA)was seen in 6%of *** corneal steepening of 1.0 D at the 3 mm zone and 0.7 D in the 5 mm zone was *** vertical coma increased from−0.02 to+0.10 while mean 4th order spherical aberration became more negative from 0.20 to−*** binocular UDVA,UIVA,and UNVA are 20/20,20/20 and J1,respectively,in all treatment groups at the 6 month postoperative *** significant differences in binocular UDVA(p≥0.36),UIVA(p≥0.19)and UNVA(p≥0.56)among groups were ***:Supracor excimer laser algorithm is safe and effective for the treatment of presbyopia in *** and bil

关键词： Presbyopia LASIK Supracor Hyperopia

Nonlinear forced vibration in a subcritical regime of a porous functionally graded pipe conveying fluid with a retaining clip

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Applied mathematics and mechanics(English Edition) 2025年第1期46卷 101-122页

作者： m.GHOLAmI m.EFTEKHARI Department of mechanical Engineering Shahid Bahonar University of Kerman

This study examines the nonlinear behaviors of a clamped-clamped porous pipe made of a functionally graded material(FGm) that conveys fluids and is equipped with a retaining clip, focusing on primary resonance and subcritical dynamics. The nonlinear governing equations for the FGm pipe are derived by the extended Hamilton's principle, and subsequently discretized through the application of the Galerkin *** direct method of multi-scales is then used to solve the derived equations. A thorough analysis of various parameters, including the clip stiffness, the power-law index, the porosity, and the clip location, is conducted to gain a comprehensive understanding of the system's nonlinear dynamics. Through the analysis of the first natural frequency, the study highlights the influence of the flow velocity and the clip stiffness, while the comparisons with metallic pipes emphasize the role of FGm composition. The examination of the forced response curves reveals saddle-node bifurcations and their dependence on parameters such as the detuning parameter and the power-law index, offering valuable insights into the system's nonlinear resonant behavior. Furthermore, the frequency-response curves illustrate the hardening nonlinearities influenced by factors such as the porosity and the clip stiffness, revealing nuanced effects on the system response and resonance characteristics. This comprehensive analysis enhances the understanding of nonlinear behaviors in FGm porous pipes with a retaining clip, providing key insights for practical engineering applications in system design and optimization.

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Neurogenesis dynamics in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

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Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： moawiah m.Naffaa Department of Psychology and Neuroscience Duke UniversityDurhamNCUSA Department of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and glomerular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit remodeling triggered by memory and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. moreover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory information processing. This adaptive process responds to changes in epithelial composition and contributes to the formation of olfactory memories by modulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions remains a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around mitral and tufted cells. This organizational pattern significantly impacts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and memory. Additionally, this organization is further shaped by axon terminals originating from cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these complex and highly interconnected processes have not been comprehensively studied as a whole. Therefore, this manuscript aims to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These mechanisms are thought to support olfactory learning and memory, potentially through increased

关键词： network adaptability neurogenesis neuronal communication olfactory bulb olfactory learning olfactory memory synaptic plasticity

mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología molecular Severo Ochoa(CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting