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Proof-of-Improved-Participation:A New Consensus Protocol for Blockchain Technology

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Computer Systems Science & Engineering 2023年第3期44卷 2007-2018页

作者： N.Anita m.vijayalakshmi S.mercy Shalinie Thiagarajar College of Engineering Madurai625015India

The Internet of Things(IoT)is converting today’s physical world into a complex and sophisticated network of connected devices on an enormous *** existing malicious node detection mechanism in traditional approaches lacks in transparency,availability,or traceability of the detection *** overcome these concerns,we provide a decentralized technique using blockchain *** the fact that blockchain technology is applicable to create that type of models,existing harmony set of instructions are susceptible to do violence to such as DoS and Sybil,making blockchain systems ***,a new Proof-of-Improved-Participation(PoIP)harmony instruction was suggested that benefits the participation rules to select honest peers for mining while limiting malicious *** an evaluation the PoIP outperforms the Proof-of-Work(PoW)instructions are demonstrated,Proof of Stake(PoS)instructions in terms of energy consumption,accuracy,and *** compare the three consensus protocols with respect to efficiency,we build a lightweight mining model andfind that PoIP consensus has greater efficiency than PoW and *** has 25%lower attack risk than existing *** a consequence,our suggested methodology can provide the needed security with minimal attack risk and high accuracy,according to the analysis *** a result,suggested consensus is more efficient than existing methods in terms of block generation *** we suggest that suggested consensus is very suitable for IoT-based applications especially in healthcare.

关键词： Blockchain confidentiality proof-of-improved-participation consensus security

Effect of processing routes on microstructure and mechanical properties of 2014 Al alloy processed by equal channel angular pressing

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Transactions of Nonferrous metals Society of China 2010年第10期20卷 1822-1828页

作者： P.VENKATACHALAm S.RAmESH KUmAR B.RAVISANKAR V.THOmAS PAUL m.vijayalakshmi Department of metallurgical and materials Engineering National Institute of Technology Physical metallurgy Division IGCAR

Al-Cu alloy was deformed through equal channel angular pressing(ECAP) by routes A,Ba,Bc and C up to 5 *** was done using a 90° die for three different conditions,namely 1) as received,2) solutionised at 768 K for 1 h and 3) solutionised at 768 K for 1 h + aged at 468 K for 5 *** microstructure,microhardness and tensile strength were studied for all the three conditions and four *** improvement in hardness(HV 184 after five passes) and strength(602 mPa after three passes) was observed in solutionised and aged 2014 Al alloy deformed through route *** evolution was reasonably equiaxed in route Bc with aspect ratio of *** and aged 2014 Al alloy deformed through route Bc was identified to have better microstructure and mechanical property than the other processing routes and conditions.

关键词： ECAP processing route 2014 aluminium alloy

Biological and mechanical investigation of novel flax/silk protein-based nanofibrous scaffold for bone regeneration

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Progress in Natural Science:materials International 2022年第4期32卷 443-455页

作者： m.Rama U.vijayalakshmi Department of Chemistry School of Advanced Sciences Vellore Institute of Technology

The process of bone tissue regeneration involves an intricate network of a biological macromolecules that includes proteins and peptides to support stimulation and healing response. Here, we have fabricated a novel flaxseed/silk fibroin based(dual protein) composite nanofibers using β-TCP to improve the biological properties and promote cartilage tissue regeneration along with a controllable rate of biodegradation. The physiochemical properties of PVA/β-TCP/FP:SF were characterized by FTIR, XRD, SEm, porosity, contact angle measurements and mechanical evaluation etc. This study demonstrates the biological performance of the developed nanofibers by using hemocompatibility, biodegradation ability, and apatite deposition in stimulated body fluid. moreover, the cell viability assay was performed on mG-63 osteoblast cells and long-term antibacterial rate against E. coli and S. aureus was analysed. Docking results of flax protein and silk fibroin protein further confirmed the stable modes of intramolecular bonding and the most stable electrostatic values using theoretical calculations. Taken together,the experimental results proved that the dual protein-based fibrous scaffold was found to be up-regulated in terms of biological activity with enhanced cell adhesion and proliferation.

关键词： Flax protein Silk fibroin β-TCP Electrospinning Docking Bone regeneration

Introgression of QTLs Controlling Spikelet Fertility maintains membrane Integrity and Grain Yield in Improved White Ponni Derived Progenies Exposed to Heat Stress

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Rice science 2017年第1期24卷 32-40页

作者： P.VIVITHA m.RAVEENDRAN D.vijayalakshmi Department of Crop Physiology Tamil Nadu Agricultural UniversityCoimbatore 641003India

To increase the thermotolerance of improved White Ponni（IWP）, two quantitative trait loci（QTLs）, q HTSF1.1 and q HTSF4.1, controlling spikelet fertility under high-temperature stress, were introgressed from Nagina 22 into IWP through marker-assisted breeding. The progenies were subjected to foreground selection of target QTLs using simple sequence repent markers Rm431 and Rm5757 linked to q HTSF1.1 and q HTSF4.1, respectively. At each generation, foreground selection with single target QTL or both QTLs was done together. The QTL-positive plants were forwarded to next generation by selfing. The F2：3 progenies were subjected to phenotypic analyses under high-temperature stress at the flowering stage. Chlorophyll stability index, malondialdehyde content, grain yield, and yield-related components of the F2：3 progenies were measured. The progenies IWP-295, IWP-277 and IWP-246 harboring both q HTSF1.1 and q HTSF4.1 showed higher fertility percentages under high-temperature stress at the flowering stage. These QTLs were responsible for maintaining membrane integrity and yield under elevated temperature conditions.

关键词： Grain fertility flowering phenotypic breeding alleles sterility foreground parent chambers

Nonlinear forced vibration in a subcritical regime of a porous functionally graded pipe conveying fluid with a retaining clip

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Applied mathematics and mechanics(English Edition) 2025年第1期46卷 101-122页

作者： m.GHOLAmI m.EFTEKHARI Department of mechanical Engineering Shahid Bahonar University of Kerman

This study examines the nonlinear behaviors of a clamped-clamped porous pipe made of a functionally graded material(FGm) that conveys fluids and is equipped with a retaining clip, focusing on primary resonance and subcritical dynamics. The nonlinear governing equations for the FGm pipe are derived by the extended Hamilton's principle, and subsequently discretized through the application of the Galerkin *** direct method of multi-scales is then used to solve the derived equations. A thorough analysis of various parameters, including the clip stiffness, the power-law index, the porosity, and the clip location, is conducted to gain a comprehensive understanding of the system's nonlinear dynamics. Through the analysis of the first natural frequency, the study highlights the influence of the flow velocity and the clip stiffness, while the comparisons with metallic pipes emphasize the role of FGm composition. The examination of the forced response curves reveals saddle-node bifurcations and their dependence on parameters such as the detuning parameter and the power-law index, offering valuable insights into the system's nonlinear resonant behavior. Furthermore, the frequency-response curves illustrate the hardening nonlinearities influenced by factors such as the porosity and the clip stiffness, revealing nuanced effects on the system response and resonance characteristics. This comprehensive analysis enhances the understanding of nonlinear behaviors in FGm porous pipes with a retaining clip, providing key insights for practical engineering applications in system design and optimization.

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Neurogenesis dynamics in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

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Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： moawiah m.Naffaa Department of Psychology and Neuroscience Duke UniversityDurhamNCUSA Department of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and glomerular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit remodeling triggered by memory and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. moreover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory information processing. This adaptive process responds to changes in epithelial composition and contributes to the formation of olfactory memories by modulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions remains a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around mitral and tufted cells. This organizational pattern significantly impacts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and memory. Additionally, this organization is further shaped by axon terminals originating from cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these complex and highly interconnected processes have not been comprehensively studied as a whole. Therefore, this manuscript aims to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These mechanisms are thought to support olfactory learning and memory, potentially through increased

关键词： network adaptability neurogenesis neuronal communication olfactory bulb olfactory learning olfactory memory synaptic plasticity

Chronic low vitamin intake potentiates cisplatin-induced intestinal epithelial cell apoptosis in WNIN rats

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World Journal of Gastroenterology 2006年第7期12卷 1078-1085页

作者： Bodiga vijayalakshmi Boindala Sesikeran Putcha Udaykumar Subramaniam Kalyanasundaram manchala Raghunath Department of Pathology National Institute of NutritionIndian Council of Medical ResearchJamai OsmaniaHyderabad-500 007Andhra PradeshIndia National Center for Laboratory Animal Sciences National Institute of NutritionJamai OsmaniaHyderabad-500 007Andhra PradeshIndia Endocrinology and metabolism Division National Institute of NutritionIndian Council of Medical ResearchJamai OsmaniaHyderabad-500007 Andhra PradeshIndia

AIm： To investigate if cisplatin alters vitamin status and if VR modulates cisplatin induced intestinal apoptosis and oxidative stress in Wistar/NIN （WNIN） male rats.mETHODS： Weanling, WNIN male rats （n = 12 per group） received adlibitum for 17 wk： control diet （20% protein） or the same with 50% vitamin restriction. They were then sub-divided into two groups of six rats each and administered cisplatin （2.61 mg/kg bodyweight） once a week for three wk or PBS （vehicle control）. Intestinal epithelial cell （IEC） apoptosis was monitored by morphometry, Annexin-V binding, m30 cytodeath assay and DNA fragmentation. Structural and functional integrity of the villus were assessed by villus height / crypt depth ratio and activities of alkaline phosphatase, lys, ala-dipeptidyl amino-peptidase, respectively. To assess the probable mechanism（s） of altered apoptosis, oxidative stress parameters, caspase-3 activity, and expression of Bcl-2 and Bax were determined.RESULTS： Cisplatin per se decreased plasma vitamin levels and they were the lowest in VR animals treated with cisplatin. As expected VR increased only villus apoptosis, whereas cisplatin increased stem cell apoptosis in the crypt. However, cisplatin treatment of VR rats increased apoptosis both in villus and crypt regions and was associated with higher levels of TBARS, protein carbonyls and caspase-3 activity, but lower GSH concentrations. VR induced decrease in Bcl-2 expression was further lowered by cisplatin. Bax expression, unaffected by VR was increased on cisplatin treatment. mucosal functional integrity was severely compromised in cisplatin treated VR-rats.CONCLUSION： Low intake of vitamins increases the sensitivity of rats to cisplatin and promotes intestinal epithelial cell apoptosis.

关键词： Apoptosis Cisplatin Intestinal epithelium mucosal integrity Oxidative stress Vitamins,

mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología molecular Severo Ochoa(CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

Transport mechanism in chemically reactive hybrid nanofluid flow containing gyrotactic micro-organisms over a curved oscillatory surface

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Applied mathematics and mechanics(English Edition) 2025年第1期46卷 177-192页

作者： m.NAVEED m.ImRAN T.ASGHAR Z.ABBAS Department of mathematics Division of Science and TechnologyUniversity of Education Department of mathematics The Islamia University of Bahawalpur

This paper examines the transport analysis, including both heat transfer and mass transfer, in hybrid nanofluid flow containing gyrotactic microorganisms towards a curved oscillatory surface. The influence of magnetic fields is also inspected in terms of their physical characteristics. To depict the phenomena of transport, modified versions of both Fick's and Fourier's laws are used. Additionally, the characteristics of both heterogeneous and homogeneous chemical reactions are also incorporated. Utilizing a curvilinear coordinate system, the flow problem is formulated as partial differential equations(PDEs)for momentum, concentration, microorganism field, and energy. An analytical solution to the obtained flow equations is achieved utilizing the homotopy analysis method(HAm).The effects of significant flow parameters on the pressure and microorganism fields, velocity, oscillation velocity, concentration, and temperature distributions are shown via graphs. Furthermore, the variations in skin friction, mass transfer rate, heat transfer rate, and local motile number due to different involved parameters are presented in tables and are analyzed in detail. Graphical results indicate that the curves of velocity and temperature fields are enhanced as the values of the solid volume fraction variables *** is also verified that the concentration rate field decreases as the values of the homogeneous reaction strength parameter and the radius of curvature parameter increase, and it increases with the Schmidt number and the heterogeneous reaction strength *** outcomes show a favorable response of the motile number to advanced values of the Peclet number, the Schmidt number, the microorganism difference parameter, and the bio-convective Lewis number.

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