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中国周刊 2005年第6期 40-41页

作者： michael mann

SOHO, is the abbreviation of’Small Office, Home Office,’ with homes doubling as offices.

关键词： SOHO so good real

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The Boss

英语大王 2013年第5期 4-7页

作者： Becky mann

妈妈生病了,爸爸出门给她买果汁。哥哥、妹妹和我会为妈妈做什么呢?It was Sunday morning. mum was sick* in bed." mum needs someorange juice," Dad said." I’ll go to the store and get some for her. Begood while I’m gone(不... 详细信息

关键词： The Boss

Oxygen radical formation does not have an impact in the treatment of severe acute experimental pancreatitis using free cellular hemoglobin

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World Journal of Gastroenterology 2006年第18期12卷 2914-2918页

作者： Helge Kleinhans Oliver mann Paulus G schurr Jussuf T Kaifi Bente Hansen Jakob R Izbicki Tim Strate Department of General- Visceral- and Thoracic SurgeryUniversity Medical Center Hamburg-EppendorfMartinistrasse 52D-20246 HamburgGermany

AIm： microcirculatory dysfunction and free oxygen radicals are important factors in the pathogenesis of severe acute pancreatitis. Additional oxygen delivery might enhance lipid peroxidation but may also improve pancreatic microcirculation. This study assesses the effect of free cellular bovine hemoglobin on the formation of oxygen radicals and microcirculation in a rodent model of severe acute pancreatitis. mETHODS： Fifteen minutes after induction of acute pancreatitis Wistar rats received either 0.8 mL bovine hemoglobin （HBOC-200）, hydroxyethyl starch （HES） or 2.4 mL of normal saline to ensure normovolemic substitution. After 6 h of examination the pancreas was excised and rapidly processed for indirect measurement of lipid peroxidation products malondialdehyde （mDA） and reduced glutathione （GSH） in pancreatic tissue. RESULTS： The single application of HBOC-200 improved pancreatic microcirculation and reduced histopathological tissue damage significantly. Tissue concentration of mDA did not differ between the groups. Also no differences in GSH levels were detected.CONCLUSION： Though the single application of HBOC-200 and HES improve pancreatic microcirculation, no differences in lipid peroxidation products were detected. The beneficial effect of additional oxygen supply （HBOC-200） does not lead to enhanced lipid peroxidation.

关键词： Hemoglobin-based-oxygen-carrier HBOC Blood substitudes Severe acute pancreatitis Free oxygen radicals Oxidative stress

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阿尔茨海默病患者的脑淀粉样血管病变

中华老年医学杂志 2003年第11期22卷 708-710页

作者：田金洲时晶程龙 David m A mann 北京中医药大学东直门医院老年病科 100700 英国曼彻斯特大学大曼彻斯特神经科学中心

脑淀粉样血管病变(cerebral amyloid angiopathy, CAA)是由淀粉样蛋白在软脑膜及脑皮质血管内沉积所致[1].1975年报道,在尸检的阿尔茨海默病(AD)患者脑内有87% CAA[2].1984年,一种与AD有关的CAA中的β淀粉样蛋白(Aβ)被确认 [1] .Aβ蛋... 详细信息

脑淀粉样血管病变(cerebral amyloid angiopathy, CAA)是由淀粉样蛋白在软脑膜及脑皮质血管内沉积所致[1].1975年报道,在尸检的阿尔茨海默病(AD)患者脑内有87% CAA[2].1984年,一种与AD有关的CAA中的β淀粉样蛋白(Aβ)被确认 [1] .Aβ蛋白由39～42个氨基酸的肽链构成.老年斑(SP)中的Aβ蛋白长臂主要是42～43对碱基,而脑血管性Aβ蛋白则主要为39～40对碱基.Aβ蛋白沉积在大脑实质形成SP或神经炎斑,沉积在血管壁则导致脑淀粉样血管病变.

关键词：阿尔茨海默病脑淀粉样血管病变流行病学神经病理学临床表现

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为什么这些高管注定失败

Some Thoughts on the Going Global Strategy for China's Aerospace Industry

商业评论 2024年第8期 138-143页

作者：金伯利·惠特勒埃德·塔齐亚斯蒂芬·曼徐广彤弗吉尼亚大学达顿商学院 Sycamore and Co. 宝洁校友网络摩根大通集团

C级(C-level)高管的平均任期,为何只有短短5.3年?首席营销官(CmO)和首席信息官(CIO)的平均任职年限,为何很少能超过4年?答案可能就藏在高管猎头用来按图索骥的职位说明书里.本文作者之一(金伯利·惠特勒)曾应邀评估某个CmO职位的吸引力...

C级(C-level)高管的平均任期,为何只有短短5.3年?首席营销官(CmO)和首席信息官(CIO)的平均任职年限,为何很少能超过4年?答案可能就藏在高管猎头用来按图索骥的职位说明书里.本文作者之一(金伯利·惠特勒)曾应邀评估某个CmO职位的吸引力,但在仔细看完这12页职位要求之后,她意识到,自己无法昧着良心推荐任何人来这个职位.从这份文件所描述的职权、工作期望和理想候选人资历条件来看,这个职位的设计存在很大问题.它从设置上就注定了新任的CmO会走向失败.

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Aerospace China 2011年第4期12卷 19-20页

作者： Ji mann

In light of economic globalization and the international economic landscape that has been changed by the global financial crisis,China's economy has already been completely integrated into the global *** Chinese enterprises face fierce competition not only internationally as they pursue a "going global" strategy,but also in the domestic market from foreign ***,to make their business operations international is not an option,but a *** must cultivate international strategic thinking and an international vision,learn to use international resourcrs and markets,optimize resource distribution,develop advantages,and raise their core competiveness.

关键词： In Some Thoughts on the Going Global Strategy for China’s Aerospace Industry

China Still Undergoing Transformation

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International Understanding 2016年第1期 62-64页

作者： Holger mann

What is China today,where is the most populous country on earth headed-and where does it want to go?During an International Exchange Programme from September 8 to 17,I had the chance to gather impressions on this ***

关键词： Transformation headed chance Still today Together gather politics innovative considerably

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灵活多面体搜索算法在多聚焦成像技术中应用

天然气工业 2004年第11期24卷 38-41页

作者：罗银河 Jürgen mann 董桥梁中国地质大学 University of Karlsruhe Geophysical Insititute.Karlsruhe Germany 中国石化中原油田物探研究院

在现代地震数据处理中,叠加是改善资料质量最重要的一步。在叠加过程中,时差校正就成为了至关重要的算子。为了得到高质量的叠加剖面,精确的时差校正公式就显得尤为重要。多聚焦技术利用波场综合的聚焦参数的更新代替了传统的速度更新,... 详细信息

在现代地震数据处理中,叠加是改善资料质量最重要的一步。在叠加过程中,时差校正就成为了至关重要的算子。为了得到高质量的叠加剖面,精确的时差校正公式就显得尤为重要。多聚焦技术利用波场综合的聚焦参数的更新代替了传统的速度更新,从而实现了多聚焦叠加并生成拟自激自收剖面。多聚焦时差校正公式在独立于地质构造模型和采集系统的情况下推导出来,其核心是选择合适的最优化方法。近年来,灵活多面体搜索技术(FPS)被应用到多聚焦参数最优化中,虽然是比较稳健的搜索方法,但将其应用到多聚焦技术最优化问题中去,还需要进行相应的改进。基于此,文章将多聚焦参数对转换到多面体空间并线性化使之适应数值计算,并提出了初始值的获取方法以及算法终止的判别标准。实测数据的叠加结果表明:FPS很好地实现了多聚焦参数的最优化,较好地实现了共中心点(CmP)的"同相叠加"。

关键词：叠加时差自激自收地震数据处理聚焦剖面波场多面体参数最优化

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胍乙啶作用机制的研究

华中科技大学学报(医学版) 1963年第1期 90-99页

作者： Kroneberg G. schümann H.J 赵国举

[2—(Oktahydre-1-azocinyl)-athyl]-Guanidinsulfat即胍乙啶(Guaneth-idin),乃新型有效降血压药,用于高血压病治疗。此药的降血压作用在于长时持续地对肾上腺素能神经传递介质的抑制。用药后电刺激颈交感节后纤维不再引起瞬膜收缩,大量也

关键词：大白鼠家鼠属心耳儿茶酚胺苯胺

Acrylamide fragment inhibitors that induce unprecedented conformational distortions in enterovirus 713C and SARS-CoV-2 main protease

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Acta Pharmaceutica Sinica B 2022年第10期12卷 3924-3933页

作者： Bo Qin Gregory B.Craven Pengjiao Hou Julian Chesti Xinran Lu Emma S.Child Rhodri m.L.morgan Wenchao Niu Lina Zhao Alan Armstrong David J.mann Sheng Cui NHC Key Laboratory of Systems Biology of Pathogens Institute of Pathogen BiologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100076China Department of Life Sciences Imperial College LondonSouth Kensington CampusLondon SW72AZUK Department of Chemistry Imperial College LondonMolecular Sciences Research HubWhite City CampusWood LaneLondon W120BZUK CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety Institute of High Energy PhysicsUniversity of Chinese Academy of SciencesBeijing 100049China

RNA viruses are critically dependent upon virally encoded proteases to cleave the viral polyproteins into functional *** of these proteases exhibit a similar fold and contain an essential catalytic cysteine,offering the opportunity to inhibit these enzymes with electrophilic small *** we describe the successful application of quantitative irreversible tethering(qIT)to identify acrylamide fragments that target the active site cysteine of the 3C protease(3Cpro)of Enterovirus 71,the causative agent of hand,foot and mouth disease in humans,altering the substrate binding ***,we re-purpose these hits towards the main protease(mpro)of SARS-CoV-2 which shares the 3C-like fold and a similar active *** hit fragments covalently link to the catalytic cysteine of mpro to inhibit its *** demonstrate that targeting the active site cysteine of mpro can have profound allosteric effects,distorting secondary structures to disrupt the active dimeric unit.

关键词： SARS-CoV-2 Protease inhibitors Covalent fragments Allosteric inhibition EV71