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Glia-to-neuron reprogramming to the rescue?

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Neural Regeneration Research 2025年第5期20卷 1395-1396页

作者： Jack W.Hickmott Cindi m.morshead Department of surgery University of TorontoTorontoONCanada Donnelly Centre for Cellular and Biomolecular Research TorontoONCanada Institute of Biomedical Engineering University of TorontoTorontoONCanada The KITE Research Institute Toronto Rehabilitation InstituteUniversity Health NetworkTorontoONCanada

Over the last two decades,the dogma that cell fate is immutable has been increasingly challenged,with important implications for regenerative *** brea kth rough discovery that induced pluripotent stem cells could be generated from adult mouse fibroblasts is powerful proof that cell fate can be *** exciting extension of the discovery of cell fate impermanence is the direct cellular reprogram ming hypothesis-that terminally differentiated cells can be reprogrammed into other adult cell fates without first passing through a stem cell state.

关键词： programming passing proof

Daily variation of radon gas and its short-lived progeny concentration near ground level and estimation of aerosol residence time

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Chinese Physics B 2016年第5期25卷 111-118页

作者： m mohery A m Abdallah A Ali s s Baz Physics Department Faculty of Science University of Jeddah Physics Department Faculty of Science Sohag University Astronomy Department Faculty of Science King Abdulaziz University Astronomy Department Faculty of Science Cairo University Physics Department Girls Faculty of Science King Abdulaziz University

Atmospheric concentrations of radon（^（222）Rn） gas and its short-lived progenies^（218）Po,^（214）Pb, and^（214）Po were continuously monitored every four hours at the ground level in Jeddah city, Kingdom of saudi Arabia. The measurements were performed three times every week, starting from November 2014 to October 2015. A method of electrostatic precipitation of positively charged^（218）Po and ^（214）Po by a positive voltage was applied for determining^（222）Rn gas concentration. The short-lived^（222）Rn progeny concentration was determined by using a filter holder connected with the alpha-spectrometric technique. The meteorological parameters（relative air humidity, air temperature, and wind speed） were determined during the measurements of^（222）Rn and its progeny concentrations.^（222）Rn gas as well as its short-lived progeny concentration display a daily and seasonal variation with high values in the night and early morning hours as compared to low values at noon and in the afternoon. The observed monthly atmospheric concentrations showed a seasonal trend with the highest values in the autumn/winter season and the lowest values in the spring/summer season. moreover, and in parallel with alphaspectrometric measurements, a single filter-holder was used to collect air samples. The deposited activities of^（214）Pb and the long-lived^（222）Rn daughter ^（210）Pb on the filter were measured with the gamma spectrometric technique. The measured activity concentrations of^（214）Pb by both techniques were found to be relatively equal largely. The highest mean seasonally activity concentrations of ^（210）Pb were observed in the autumn/winter season while the lowest mean were observed in the spring/summer season. The mean residence time（mRT） of aerosol particles in the atmospheric air could be estimated from the activity ratios of ^（210）Pb/^（214）Pb.

关键词： daily variation radon progeny concentration meteorological variables

Effect of Colouring Process on Pitting susceptibility of Austenitic stainless steel

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Journal of materials science & Technology 2008年第3期24卷 400-406页

作者： s.s.mahmoud m.m.Ahmed Chemistry Department University College of Girls for ArtsScience and EducationAin Shams University

Colouring of the austenitic stainless steel alloy （20.45% Cr, 8.57% Ni） was carried out in NaNO3-KNO3 eutectic melt without and with additions of Na2O2, NaCl and their mixtures at different temperatures ranging from 400-600℃, under open-circuit and galvanostatic anodic polarization conditions. The produced colours greatly depend on the thickness of oxide films, which in turn depends on the composition of the molten bath and its temperature. The more attractive, bright, adherent and uniform coloured oxide films can be obtained at 400, 450 and 500℃ in molten nitrate bath containing NaCl and Na2O2 mixtures. The pitting corrosion susceptibility of the coloured oxide films was tested in FeCl3 and NaCl as corrosive media. The obtained results indicate that the pitting corrosion susceptibility of the coloured oxide films greatly depends on the previous operating conditions of the colouring process of the stainless steel specimens such as the composition of molten bath, temperature and technique of colouring process.

关键词： stainless steel alloy Pitting corrosion Colouring processes

Vascular endothelial growth factor:a double-edged sword in the development of white matter lesions

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Neural Regeneration Research 2025年第1期20卷 191-192页

作者： Narek manukjan Daniel Fulton Zubair Ahmed Wmatthijs Blankesteijn sébastien Foulquier Department of Pharmacology and Toxicology Maastricht UniversityMaastrichtThe Netherlands CARIm-school for Cardiovascular Diseases Maastricht UniversityMaastrichtThe Netherlands Neuroscience and Ophthalmology Institute of Inflammation and AgeingUniversity of BirminghamEdgbastonBirminghamUK Centre for Trauma sciences Research University of BirminghamEdgbastonBirminghamUK mHeNs-school for mental Health and Neuroscience Maastricht UniversityMaastrichtThe Netherlands Department of Neurology Maastricht University Medical CenterMaastrichtThe Netherlands

As the population ages,the burden of age-related diseases becomes ***,over 55 million people suffer from dementia worldwide,with Alzheimer’s disease being the most common ***,it is becoming clearer that underlying vascular pathology such as cerebral small vessel disease(csVD)may be a more detrimental cause for dementia(Cuadrado-Godia et al.,2018).It is estimated that 10%-30%of the elderly population and 35%-90%of all dementia patients exhibit signs of *** term csVD refers to pathology affecting the small vessels of the brain,which can lead to lacunar cerebral infarcts,enlarged perivascular spaces,and cortical hemorrhages(Cuadrado-Godia et al.,2018).CsVD is often associated with cognitive decline,gait problems,and dementia(Cuadrado-Godia et al.,2018).

关键词： pathology becoming white

Advancing healthcare through laboratory on a chip technology:Transforming microorganism identification and diagnostics

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World Journal of Clinical Cases 2025年第3期13卷 9-19页

作者： Carlos m Ardila Department of Basic sciences Biomedical Stomatology Research GroupUniversidad de Antioquia U de AMedellín 0057Colombia

In a recent case report in the World Journal of Clinical Cases,emphasized the crucial role of rapidly and accurately identifying pathogens to optimize patient treatment ***-on-a-chip(LOC)technology has emerged as a transformative tool in health care,offering rapid,sensitive,and specific identification of *** editorial provides a comprehensive overview of LOC technology,highlighting its principles,advantages,applications,challenges,and future *** studies from the field have demonstrated the practical benefits of LOC devices in clinical diagnostics,epidemiology,and food *** studies have underscored the superiority of LOC technology over traditional methods,showcasing improvements in speed,accuracy,and *** future integration of LOC with biosensors,artificial intelligence,and data analytics promises further innovation and *** call to action emphasizes the importance of continued research,investment,and adoption to realize the full potential of LOC technology in improving healthcare outcomes worldwide.

关键词： Laboratory-on-a-chip microorganism identification Diagnostics Point-ofcare testing Biosensors

Prediction of Typhoon Tracks Using Dynamic Linear models

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Advances in Atmospheric sciences 2003年第3期20卷 379-384页

作者： Keon-Tae sOHN H.Joe KWON Ae-sook suh Pusan KongjuMeteorological Research Institute//KMA National UniversityPusan609-735KoreaNational UniversityKonju314-701KoreaSeoul156-010Korea

This paper presents a study on the statistical forecasts of typhoon tracks. Numerical models have their own systematic errors, like a bias. In order to improve the accuracy of track forecasting, a statistical model called DLm (dynamic linear model) is applied to remove the systematic error. In the analysis of typhoons occurring over the western North Pacific in 1997 and 2000, DLm is useful as an adaptive model for the prediction of typhoon tracks.

关键词： typhoon track forecast systematic error dynamic linear model

Prognostic value of changes in serum carcinoembryonic antigen levels for preoperative chemoradiotherapy response in locally advanced rectal cancer

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World Journal of Gastroenterology 2020年第44期26卷 7022-7035页

作者： Chinock Cheong Jun sang shin Kwang Wook suh Department of surgery Ajou University School of MedicineSuwon 16499Gyeonggi-doSouth Korea

BACKGROUND Preoperative chemoradiotherapy(CRT)is a standard treatment modality for locally advanced rectal ***,CRT alone cannot improve overall *** 20%of patients with CRT-resistant tumors show disease ***,predictive factors for treatment response are needed to identify patients who will benefit from *** theorized that the prognosis may vary if patients are classified according to pre-to post-CRT changes in carcinoembryonic antigen(CEA)*** To identify patients with locally advanced rectal cancer for preoperative chemoradiotherapy based on carcinoembryonic antigen *** We retrospectively included locally advanced rectal cancer patients who underwent preoperative CRT and curative resection between 2011 and *** were assigned to groups A,B,and C based on pre-and post-CRT serum CEA levels:Both>5;pre>5 and post≤5;and both≤5 ng/mL,*** compared the response to CRT based on changes in serum CEA *** operating characteristic curve analysis was performed to determine optimal cutoff for neutrophil–lymphocyte ratio and platelet–lymphocyte *** logistic regression analysis was used to evaluate the prognostic factors for pathologic complete response(pCR)/good *** The cohort comprised 145 patients;of them,27,43,and 65 belonged to groups A,B,and C,respectively,according to changes in serum CEA levels before and after ***-(Pst-CRT(Ps and the ratio of downstaging(P=0.013)were higher in Groups B and C than in Group *** ratio of pathologic tumor regression grade 0/1 significantly differed among the groups(P=0.003).Group C had the highest number of patients showing pCR(Pmost patients with pCR showed pre-and post-CRT CEA levelsmL(Pst-CRT CEA levels were important risk factors for pCR(OR=18.71;95%CI:4.62–129.51,Psponse(OR=5.07;95%CI:1.92–14.83,P=0.002),***-CRT

关键词： Rectal cancer Neoadjuvant chemoradiation therapy Carcinoembryonic antigen levels Prognostic factor Change in serum carcinoembryonic antigen Response of chemoradiotherapy

Effect of Al addition on corrosion behavior of high-purity mg in terms of processing history

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Journal of magnesium and Alloys 2023年第3期11卷 851-868页

作者： sang Kyu Woo Byeong-Chan suh Ha sik Kim Chang Dong Yim Helmholtz Zentrum Hereon Max-Planck-Straße 1Geesthacht D-21502Germany Korea Institute of materials science 797 Changwondae-roSeongsan-guChangwonGyeongnam 51508Republic of Korea University of science and Technology 217 Gajeong-roYuseong-guDaejeon 34113Republic of Korea

In this study,the effects of Al addition on the corrosion behavior of pure mg with controlled impurity contents were systematically analyzed according to the processing *** results revealed that the corrosion behavior of high-purity mg-Al alloys is strongly related to changes in the microstructure,including theβphase and Al-mn or Al-Fe phases,and the protectiveness of the surface film according to the Al content and processing *** the as-cast alloys,the corrosion rate increased due to the increase ofβphase as the Al content increased,but in the as-extruded alloys,the corrosion rate,which was high due to intermetallic compounds caused by impurities in the low Al alloy,decreased as the Al content increased,and then increased *** is due to the combined effect of the increase of theβphase and decrease of the impurity effect,and the increase of the dissolved Al *** results suggest that it is necessary to analyze the effect of alloying elements on the corrosion behavior of pure mg with information concerning the impurity content and processing history.

关键词： mg High purity mg-Al alloys Processing history micro-galvanic surface film

A Tailored Finite Point method for solving steady mHD Duct Flow Problems with Boundary Layers

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Communications in Computational Physics 2011年第6期10卷 161-182页

作者： Po-Wen Hsieh Yintzer shih suh-Yuh Yang Department of mathematics National Central UniversityJhongli CityTaoyuan County 32001Taiwan Department of Applied mathematics National Chung Hsing UniversityTaichung 40227Taiwan.

In this paper we propose a development of the finite difference method,called the tailored finite point method,for solving steady magnetohydrodynamic(mHD)duct flow problems with a high Hartmann *** the Hartmann number is large,the mHD duct flow is convection-dominated and thus its solution may exhibit localized phenomena such as the boundary *** conventional numerical methods can not efficiently solve the layer problem because they are lacking in either stability or ***,the proposed tailored finite point method is capable of resolving high gradients near the layer regions without refining the ***,we devise the tailored finite point method for the scalar inhomogeneous convectiondiffusion problem,and then extend it to the mHD duct flow which consists of a coupled system of convection-diffusion *** each interior grid point of a given rectangular mesh,we construct a finite-point difference operator at that point with some nearby grid points,where the coefficients of the difference operator are tailored to some particular properties of the *** examples are provided to show the high performance of the proposed method.

关键词： magnetohydrodynamic equations Hartmann numbers convection-dominated problems boundary layers tailored finite point methods finite difference methods