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Journal of energy Chemistry 2024年第10期97卷 438-443页

作者： Lucas Hanssens maarten Houlleberghs C.Vinod Chandran Geert Watson Sambhu Radhakrishnan pascal Van Der Voort Joeri F.m.Denayer Christine e.A.Kirschhock Johan A.martens eric Breynaert Centre for Surface Chemistry and Catalysis-Characterization and Application Team (COK-KAT) NmR/X-Ray platform for Convergence Research (NmRCoRe) Centre for Ordered materials Organometallics and Catalysis (COMOC) Department of Chemistry Ghent University Department of Chemical engineering Vrije Universiteit Brussel

*** circular methane energy systems In recent decades,methane-based energy systems have rapidly gained traction across the globe because of the increasing availability of low-cost methane production ***,fossil methane... 详细信息

关键词： Long duration energy storage Green methane Carbon neutrality Confined clathrate hydrates CH4 /CO2 exchange Direct gas exchange eNeRGY-STORAGe CONFINeD NANOSpACe TO-meTHANe GAS meCHANISmS ADSORpTION HYDROGeN

A novel method for modeling the phase change of iron ore particles in the cohesive zone of a blast furnace

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particuology 2024年第3期86卷 252-261页

作者： Dianyu e Yingming Wen Jiayun Dan Youyuan Jiang Guangchao Wei Jiaxin Cui Jiangxi provincial Key Laboratory for Simulation and modelling of particulate Systems Jiangxi University of Science and TechnologyNanchang330013China International Institute for Innovation Jiangxi University of Science and TechnologyNanchang330013China Ironmaking plant Xiangtan Iron and Steel Corporation of Hunan HualingXiangtan411101China Schoolof Transportation and Vehicle enginering Shandong University of TechnologyZibo255000China

Cohesive zone plays a vital role in the stable operation of a blast furnace(BF),yet the complex phase change process of iron ore particles in this zone is still not well *** this study,a novel one-dimensional(1D)unsteady phase change model was developed to elucidate the heat transfer and melting mechanisms of iron ore *** model validation,the effects of several key operating parameters(e.g.,particle diameter,gas velocity,initial temperature)on the phase change behavior of iron ore particles were analyzed,and the joint effect of multiple parameters was *** results show that larger-sized iron ore particles possess lower specific surface areas,which in turn reduces their convective heat absorption ***,the distance from the solid-liquid phase interface to the particle surface increases,thereby slowing down the movement of the phase interface and pro-longing the melting duration of the *** the gas velocity and the initial temperature does not have a significant impact on reducing the duration of the complete melting *** the specified conditions,it is observed that increasing the gas velocity by 3-fold and 9-fold results in a reduction of the melting duration by 2.4%and 8.3%,*** the initial temperature of iron ore particles results in a decrease in the core-to-surface temperature difference,a slower heating rate,and a shorter duration to achieve *** the factors affecting the melting process,the particle diameter is found to be the most significant in terms of the liquid phase precipitation,mushy zone thickness,and core-to-surface temperature difference of iron ore particles.

关键词： Blast furnace Iron ore melting Cohesive zone Heat transfer phase change

elucidating regulatory processes of intense physical activity by multi-omics analysis

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military medical Research 2024年第4期11卷 479-499页

作者： ernesto S.Nakayasu marina A.Gritsenko Young-mo Kim Jennifer e.Kyle Kelly G.Stratton Carrie D.Nicora Nathalie munoz Kathleen m.Navarro Daniel Claborne Yuqian Gao Karl K.Weitz Vanessa L.paurus Kent J.Bloodsworth Kelsey A.Allen Lisa m.Bramer Fernando montes Kathleen A.Clark Grant Tietje Justin Teeguarden Kristin e.Burnum-Johnson Biological Sciences Division Pacific Northwest National LaboratoryRichlandWA 99352USA environmental and molecular Sciences Division Pacific Northwest National LaboratoryRichlandWA 99352USA Centers for Disease Control and prevention National Institute for Occupational Safety and HealthWestern States DivisionDenverCO 80204USA Computational Analytics Division Pacific Northwest National LaboratoryRichlandWA 99352USA National Security Directorate Pacific Northwest National LaboratoryRichlandWA 99352USA Los Angeles County Fire Department Los AngelesCA 90063USA Centers for Disease Control and prevention National Institute for Occupational Safety and HealthRespiratory Health DivisionMorgantownWV 26505USA environmental and molecular Toxicology Oregon State UniversityCorvallisOR 97331USA

Background:physiological and biochemical processes across tissues of the body are regulated in response to the high demands of intense physical activity in several occupations,such as firefighting,law enforcement,military,and sports.A better understanding of such processes can ultimately help improve human performance and prevent illnesses in the work ***:To study regulatory processes in intense physical activity simulating real-life conditions,we performed a multi-omics analysis of 3 biofluids(blood plasma,urine,and saliva)collected from 11 wildland firefighters before and after a 45 min,intense exercise *** profiles ***-exercise were compared by Student’s t-test followed by pathway analysis and comparison between the different omics ***:Our multi-omics analysis identified and quantified 3835 proteins,730 lipids and 182 metabolites combining the 3 different types of *** blood plasma analysis revealed signatures of tissue damage and acute repair response accompanied by enhanced carbon metabolism to meet energy *** urine analysis showed a strong,concomitant regulation of 6 out of 8 identified proteins from the renin-angiotensin system supporting increased excretion of catabolites,reabsorption of nutrients and maintenance of fluid *** saliva,we observed a decrease in 3 pro-inflammatory cytokines and an increase in 8 antimicrobial peptides.A systematic literature review identified 6 papers that support an altered susceptibility to respiratory ***:This study shows simultaneous regulatory signatures in biofluids indicative of homeostatic maintenance during intense physical activity with possible effects on increased infection susceptibility,suggesting that caution against respiratory diseases could benefit workers on highly physical demanding jobs.

关键词： multi-omics analysis Intense exercise Human performance Biofluids metabolism Immunity

COVID-19 vaccination produces exercise-responsive SARS-CoV-2 specific T-cells regardless of infection history

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Journal of Sport and Health Science 2024年第1期13卷 99-107页

作者： Kyle A.Smith Tiffany m.Zúñiga Forrest L.Baker Helena Batatinha Charles R.pedlar Shane C.Burgess michael p.Gustafson emmanuel Katsanis Richard J.Simpson School of Nutritional Sciences and Wellness The University of ArizonaTucsonAZ 85721USA Department of pediatrics The University of ArizonaTucsonAZ 85724USA Faculty of Sport Allied Health and Performance ScienceSt.Mary's UniversityTwickenham TW14SXUK Institute of Sport exercise and Health University College LondonLondon WC1E 7HUUK Department of Animal and Comparative Biomedical Sciences The University of ArizonaTucsonAZ 85721USA The University of Arizona Cancer Center The University of ArizonaTucsonAZ 85719USA Laboratory medicine and pathology Mayo Clinic ArizonaPhoenixAZ 85054USA Department of Immunobiology The University of ArizonaTucsonAZ 85724USA Department of medicine The University of ArizonaTucsonAZ 85724USA Department of pathology The University of ArizonaTucsonAZ 85724USA

Background:The mobilization and redistribution of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)specific T-cells and neutralizing antibodies(nAbs)during exercise is purported to increase immune surveillance and protect against severe coronavirus disease 2019(COVID-19).We sought to determine if COVID-19 vaccination would elicit exercise-responsive SARS-CoV-2 T-cells and transiently alter nAb ***:eighteen healthy participants completed a 20-min bout of graded cycling exercise before and/or after receiving a COVID-19 *** major leukocyte subtypes were enumerated before,during,and after exercise by flow cytometry,and immune responses to SARS-CoV-2 were determined using whole blood peptide stimulation assays,T-cell receptor(TCR)-βsequencing,and SARS-CoV-2 nAb ***:COVID-19 vaccination had no effect on the mobilization or egress of major leukocyte subsets in response to intensity-controlled graded ***,non-infected participants had a significantly reduced mobilization of CD4+and CD8+naive T-cells,as well as CD4+central memory T-cells,after vaccination(synthetic immunity group);this was not seen after vaccination in those with prior SARS-CoV-2 infection(hybrid immunity group).Acute exercise after vaccination robustly mobilized SARS-CoV-2 specific T-cells to blood in an intensity-dependent *** groups mobilized T-cells that reacted to spike protein;however,only the hybrid immunity group mobilized T-cells that reacted to membrane and nucleocapsid *** increased significantly during exercise only in the hybrid immunity ***:These data indicate that acute exercise mobilizes SARS-CoV-2 specific T-cells that recognize spike protein and increases the redistribution of nAbs in individuals with hybrid immunity.

关键词： Anti-viral COVID-19 exercise immunology SARS-CoV-2 T-Cells Vaccine

Anti-obesity effects of fucoidan from Sargassum thunbergii in adipocytes and high fat diet induced obese mice through inhibiting adipogenic specific transcription factor

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Food Science and Human Wellness 2024年第3期13卷 1608-1616页

作者： Hyo-Geun Lee H.H.A.C.K.Jayawardhana Fengqi Yang D.p.Nagahawaththa N.m.Liyanage Kyung-mo Song Yun-Sang Choi Seung-Hong Lee You-Jin Jeon min-Cheol Kang Department of marine Life Sciences Jeju National UniversityJeju 63243Republic of Korea marine Science Institute Jeju National UniversityJeju 63333Republic of Korea Research Group of Food processing Korea Food Research InstituteWanju 55365Republic of Korea Department of pharmoceutical engineering Soonchunhyang UniversityAsan 31538Republic of Korea

The prevalence of obesity has increased and is a health concern *** to the concerns regarding synthetic anti-obesity treatments,nowadays natural products become a *** studies proved that there is a potential to use marine algae as anti-obesity ***,in this study,the lipid inhibitory effect of crude polysaccharide of amyloglucosidase-assisted hydrolysate from Sargassum thunbergii(STAC)and its fucoidan fractions(STAFs)on 3T3-L1 cells and high-fat diet(HFD)-induced obese mice were *** to the results,the STAF3,showed the highest xylose content and exhibited significant inhibitory effects on lipid accumulation by downregulating adipogenic and lipogenic proteins in 3T3-L1 ***,oral supplementation with STAC significantly declined gain in body weight and fat weight,and serum lipid contents in an HFD-induced obesity mouse *** and chemical characterizations demonstrated that puritied STAF3 has consistent surface morphology and small particle size,with similar structural characteristics as commercial ***,these results indicate that STAC and purified STAF3 from Sargassum thunbergia is a potent source to develop as ananti-obesity agents or functional food products to counter obesity.

关键词： Sargassum thunbergii Fucoidan Anti-obesity Anti-steatosis

An Adaptive Hate Speech Detection Approach Using Neutrosophic Neural Networks for Social media Forensics

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Computers, materials & Continua 2024年第4期79卷 243-262页

作者： Yasmine m.Ibrahim Reem essameldin Saad m.Darwish Department of Information Technology Institute of Graduate Studies and ResearchAlexandria UniversityAlexandria21526Egypt Faculty of Computers and Information Technology Egyptian E-Learning University(EELU)Giza12611Egypt Faculty of Computers and Data Science Alexandria UniversityAlexandria21554Egypt

Detecting hate speech automatically in social media forensics has emerged as a highly challenging task due tothe complex nature of language used in such platforms. Currently, several methods exist for classifying hatespeech, but they still suffer from ambiguity when differentiating between hateful and offensive content and theyalso lack accuracy. The work suggested in this paper uses a combination of the Whale Optimization Algorithm(WOA) and particle Swarm Optimization (pSO) to adjust the weights of two multi-Layer perceptron (mLps)for neutrosophic sets classification. During the training process of the mLp, the WOA is employed to exploreand determine the optimal set of weights. The pSO algorithm adjusts the weights to optimize the performanceof the mLp as fine-tuning. Additionally, in this approach, two separate mLp models are employed. One mLpis dedicated to predicting degrees of truth membership, while the other mLp focuses on predicting degrees offalse membership. The difference between these memberships quantifies uncertainty, indicating the degree ofindeterminacy in predictions. The experimental results indicate the superior performance of our model comparedto previous work when evaluated on the Davidson dataset.

关键词： Hate speech detection whale optimization neutrosophic sets social media forensics

Factors that influence the results of indirect decompression employing oblique lumbar interbody fusion

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World Journal of Orthopedics 2024年第8期15卷 734-743页

作者： Andrey e Bokov Svetlana Y Kalinina mingiyan I Khaltyrov Alexandr p Saifullin Anatoliy A Bulkin Department of Neurosurgery Institute of Traumatology and OrthopedicsPrivolzhsky Research Medical UniversityNizhny Novgorod603005Russia Department of Traumatology Orthopedics and NeurosurgeryPrivolzhsky Research Medical UniversityNizhny Novgorod603005Russia

BACKGROUND Indirect decompression is one of the potential benefits of anterior reconstruction in patients with spinal *** the other hand,the reported rate of revision surgery after indirect decompression highlights the necessity of working out prediction models for the radiographic results of indirect decompression with assessing their clinical *** To assess factors that influence radiographic and clinical results of the indirect decompression in patients with stenosis of the lumbar *** This study is a single-center cross-sectional evaluation of 80 consecutive patients(17 males and 63 females)with lumbar spinal stenosis combined with the instability of the lumbar spinal *** underwent single level or bisegmental spinal instrumentation employing oblique lumbar interbody fusion(OLIF)with percutaneous pedicle screw *** results of the indirect decompression were assessed using computerized tomography,while macNab scale was used to assess clinical *** After indirect decompression employing anterior reconstruction using OLIF,the statistically significant increase in the disc space height,vertebral canal square,right and left lateral canal depth were detected(Рe median(m)relative vertebral canal square increase came toМ=24.5%with 25%-75%quartile border(16.3%;33.3%)if indirect decompression was achieved by restoration of the segment *** patients with the reduction of the upper vertebrae slip,the median of the relative increase in vertebral canal square accounted for 49.5%with 25%-75%quartile border(2.35;99.75).Six out of 80 patients(7.5%)presented with unsatisfactory results because of residual nerve root *** critical values for lateral recess depth and vertebral canal square that were associated with indirect decompression failure were 3 mm and 80 mm2 *** Indirect decompression employing anterior reconstruction is achieved by the increase in disc height al

关键词： Indirect decompression Anterior reconstruction Central lumbar spinal stenosis Degenerative spondylolisthesis Lateral recess stenosis Spinal instability Oblique lateral interbody fusion

exosomes derived from tumor adjacent fibroblasts efficiently target pancreatic tumors

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Acta pharmaceutica Sinica B 2024年第7期14卷 3009-3026页

作者： Saini Setua Shabia Shabir poornima Shaji Ana martinez Bulnes Anupam Dhasmana Swathi Holla Nivesh K.mittal Nirakar Sahoo Tripti Saini Francesco Giorgianni mohammad Sikander Andrew e.massey Bilal B.Hafeez manish K.Tripathi Vincent p.Diego meena Jaggi Junming Yue Nadeem Zafar murali m.Yallapu Stephen W.Behrman Sheema Khan Subhash C.Chauhan Department of pharmaceutical Sciences College of Pharmacyand College of MedicineUniversity of Tennessee Health Science Center(UTHSC)MemphisTN 36163USA Department of Computer Science Islamic University of Science and TechnologyAwantiporaJ&K 192122India Department of Immunology and microbiology School of MedicineUniversity of Texas Rio Grande ValleyMcAllenTX 78504USA South Texas Center of excellence in Cancer Research School of Medicinethe University of Texas Rio Grande ValleyMcAllenTX 78504USA Himalayan School of Biosciences and Cancer Research Institute Himalayan Institute of Medical SciencesSwami Rama Himalayan UniversityDehradun 248016India plough Center for Sterile Drug Delivery Solutions UTHSCMemphisTN 38104USA Department of Biology College of SciencesUTRGVMcAllenTX 78539USA National Institute of Biomedical Imaging and Bioengineering(NIBIB) National Institutes of HealthBethesdaMD 20892USA South Texas Diabetes and Obesity Institute UTRGVMcAllenTX 78504USA Dept.of Laboratory medicine&pathology University of WashingtonSeattleWA 98195USA Department of Surgery Baptist Memorial Medical EducationBaptist Memorial HospitalMemphisTN 38120USA Baptist Health Sciences University MemphisTN 38104USA

The application of extracellular vesicles,particularly exosomes(eXs),is rapidly expanding in the field of medicine,owing to their remarkable properties as natural carriers of biological *** study investigates utilization of exosomes derived from stromal cells of tumor adjacent normal tissues(NAF-eXs)for personalized medicine,which can be derived at the time of diagnosis by endoscopic ***,we show that exosomes(eXs)derived from NAFs demonstrate differential bio-physical characteristics,efficient cellular internalization,drug loading efficiency,pancreatic tumor targeting and delivery of ***-derived eXs(NAF-eXs)were used for loading ormeloxifene(ORm),a potent anti-cancer and desmoplasia inhibitor as a model *** found that ORm maintains normal fibroblast cell phenotype and renders them incompatible to be triggered for a CAF-like phenotype,which may be due to regulation of Ca^(2+) influx in fibroblast ***-eXs-ORm effectively blocked oncogenic signaling pathways involved in desmoplasia and epithelial mesenchymal transition(emT)and repressed tumor growth in xenograft mouse *** conclusion,our data suggests preferential tropism of NAF-eXs for pDAC tumors,thus imply feasibility of developing a novel personalized medicine for pDAC patients using autologous NAF-eXs for improved therapeutic outcome of anti-cancer ***,it provides the opportunity of utilizing this biological scaffold for effective therapeutics in combination with standard therapeutic regimen.

关键词： pancreatic cancer Tumor adjacent normal tissue fibroblasts(NAF) Desmoplasia extracellular vesicles exosomes Tumor targeting Ormeloxifene personalized medicine

prompt neutron emission in ^(250)No spontaneous fission associated with ground and isomeric state decays

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Chinese physics C 2024年第6期48卷 112-117页

作者： R.S.mukhin A.V.Isaev A.V.Andreev m.L.Chelnokov V.I.Chepigin H.m.Devaraja I.N.Izosimov A.A.Kuznetsova O.N.malyshev A.G.popeko Yu.A.popov A.Rahmatinejad B.Sailaubekov T.m.Shneidman e.A.Sokol A.I.Svirikhin m.S.Tezekbayeva m.A.Bychkov A.V.Yeremin O.Dorvaux B.Gall K.Kessaci K.Hauschild A.Lopez-martens Joint Institute for Nuclear Research Dubna141980Russia Dubna State University Dubna141982Russia Institute of Nuclear physics Almaty050032Kazakhstan L.N.Gumilyov eurasian National University Astana010008Kazakhstan Kazan Federal University Kazan420008Russia Universitéde Strasbourg CNRSStrasbourg67000France IJCLab IN2P3-CNRSUniversitéParis-SaclayOrsay91400France

The complete-fusion reaction^(204)pb(^(48)Ca,2n)^(250)No was used to study two activities of^(250)No with distinct half-lives.A total of 1357 events were observed in the SFiNx neutron detection *** average number of neutrons emitted per spontaneous fission of^(250)No was determined to be(4.1±0.1).The unusually symmetrical shape of the prompt neutron multiplicity distribution was restored and presented for the first *** tests were performed to compare the prompt neutron multiplicity distributions associated with the ground state and K-isomer state decays.

关键词： spontaneous fission prompt neutrons actinide

增材制造Ti6Al4V合金的闪速等离子体电解氧化与在生理介质中的电化学行为

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Transactions of Nonferrous metals Society of China 2024年第4期34卷 1150-1166页

作者： H.mORA-SANCHeZ C.RAmOS m.mOHeDANO B.TORReS R.ARRABAL e.mATYKINA Departamento de Ingeniería Química y de materiales Facultad de Ciencias QuímicasUniversidad Complutense de Madrid28040 MadridSpain CIDeTeC Basque Research and Technology Alliance(BRTA)Po.Miramón 19620014 Donostia-San SebastiánSpain Departamento matemática Aplicada Ciencia e Ingeniería de Materiales y Tecnología ElectrónicaUniversidad Rey Juan CarlosC/Tulipán s/nMóstoles 28933MadridSpain

研究激光粉末床熔融增材制造(Am)(又称直接金属激光烧结)技术制备的Ti6Al4V合金等离子体电解氧化(peO)处理及其电化学行为。通过短时间(<120 s)peO处理(也称闪速peO),在Am合金和传统合金表面制备了3~10μm厚、含Ca和p的涂层。然后在改... 详细信息

研究激光粉末床熔融增材制造(Am)(又称直接金属激光烧结)技术制备的Ti6Al4V合金等离子体电解氧化(peO)处理及其电化学行为。通过短时间(peO处理(也称闪速peO),在Am合金和传统合金表面制备了3~10μm厚、含Ca和p的涂层。然后在改良的α-mem溶液中,通过动电位极化曲线和电化学阻抗谱(eIS)评估了合金的电化学行为。与传统合金相比,Am合金中形成了细小的层片状α显微组织和层间小尺寸的β相颗粒,这促使了火花的产生,从而促进了peO涂层的生长。闪速peO涂层提高了传统合金和Am合金的耐腐蚀性,最薄的涂层(m)提供了高达3倍的保护。Am Ti6Al4V由于其高的晶界密度,易受局部缝隙腐蚀的影响。而即使短至35 s的闪速peO处理也足以成功避免这种情况。

关键词：增材制造激光粉末床熔融等离子体电解氧化闪速peO 钛缝隙腐蚀 α-mem

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