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Arsenic variability and groundwater age in three water supply wells in southeast New Hampshire

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Geoscience Frontiers 2019年第5期10卷 1669-1683页

作者： Joseph p.Levitt James R.Degnan Sarah m.flanagan Bryant C.Jurgens U.S.Geological Survey

Three wells in New Hampshire were sampled bimonthly over three years to evaluate the temporal variability of arsenic concentrations and groundwater *** samples had measurable concentrations of arsenic throughout the entire sampling period and concentrations in individual wells had a mean variation of more than 7 μg/*** time series data from this sampling effort showed that arsenic concentrations ranged from a median of 4 mg/L in a glacial aquifer well (SGW-65) to medians of 19 μg/L and 37 μg/L in wells (SGW-93 and KFW-87) screened in the bedrock aquifer,*** high arsenic concentrations were associated with the consistently high pH (median ≥- 8) and low dissolved oxygen (median mg/L) in the bedrock aquifer wells,which is typical of fractured crystalline bedrock aquifers in New *** from the glacial aquifer often has high dissolved oxygen,but in this case was consistently *** pH also is generally acidic in the glacial aquifer but in this case was slightly alkaline (median =7.5).Also,sorption sites may be more abundant in glacial aquifer deposits than in fractured bedrock which may contribute to lower arsenic *** groundwater ages were less than 50 years old in all three wells and correlated with conservative tracer concentrations,such as chloride;however,mean age was not directly correlated with arsenic *** concentrations at KFW-87 did correlate with water levels,in addition,there was a seasonal pattern,which suggests that either the timing of or multiple sampling efforts may be important to define the full range of arsenic concentrations in domestic bedrock *** geochemically reduced conditions and alkaline pHs are common to both bedrock and glacial aquifer wells in this study,groundwater age correlates less strongly with arsenic concentrations than geochemical *** also is evidence of direct hydraulic connection between the glacial and bedrock aquifers,which can influe

关键词： Arsenic variability Geochemical time series Age tracers Groundwater age modeling

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“Dietary fibre”: moving beyond the “soluble/insoluble” classification for monogastric nutrition, with an emphasis on humans and pigs

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Journal of Animal Science and Biotechnology 2019年第3期10卷 590-600页

作者： Barbara A.Williams Deirdre mikkelsen Bernadine m.flanagan michael J.Gidley The University of Queensland QAAFI Centre for Nutrition and Food SciencesSt. Lucia campus

This review describes dietary fibres originating from a range of foods,particularly in relation to their plant cell *** explores the categorization of dietary fibres into "soluble" or "insoluble".It also emphasizes dietary fibre fermentability,in terms of describing how the gastro-intestinal tract(GIT) microbiota respond to a selection of fibres from these *** is categorized into cereals,legumes,fruits and *** is also made of example whole foods and why differences in physico-chemical characteristics between "purified" and "non-purified"food components are important in terms of ***,recommendations are made as to how dietary fibre could be classified differently,in relation to its functionality in terms of fermentability,rather than only its solubility.

关键词： Cereal grains Dietary fibre Fruits Large intestinal fermentation Legumes microbial activity microbiota plant cell walls Short-chain fatty acids Vegetables

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The development of *** erosion prediction and modeling

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International Soil and Water Conservation Research 2013年第2期1卷 1-11页

作者： John m.Laflen Dennis C.flanagan lowa State U. USDA-ARS National Soil Erosion Research Laboratory West LafayetteIN

Soil erosion prediction technology began over 70 years ago when Austin Zingg published a relationship between soil erosion(by water)and land slope and length,followed shortly by a relationship by Dwight Smith that expanded this equation to include conservation ***,it was nearly 20 years before this work's expansion resulted in the Universal Soil Loss Equation(USLE),perhaps the foremost achievement in soil erosion prediction in the last *** USLE has increased in application and complexity,and its usefulness and limitations have led to the development of additional technologies and new science in soil erosion research and *** among these new technologies is the Water Erosion prediction project(WEpp)model,which has helped to overcome many of the shortcomings of the USLE,and increased the scale over which erosion by water can be *** of application of erosion prediction include almost all land types:urban,rural,cropland,forests,rangeland,and construction *** applications of WEpp include prediction of radioactive material movement with soils at a superfund cleanup site,and near real-time daily estimation of soil erosion for the entire state of Iowa.

关键词： Universal Soil Loss Equation Water Erosion prediction project Soil erosion Erosion prediction History of erosion prediction

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In memoriam:*** ***

International Soil and Water Conservation Research 2021年第4期9卷 485-489页

作者： Dennis C.flanagan Richard m.Cruse James L.Baker paige Chyu USDA-Agricultural Research Service National Soil Erosion Research LaboratoryWest LafayetteINUSA Department of Agronomy Iowa State UniversityAmesIAUSA Department of Agricultural&Biosystems Engineering Iowa State UniversityAmesIAUSA International Research and Training Center on Erosion and Sedimentation BeijingChina

The soil erosion research and soil and water conservation global community lost a treasured member on November 20,2020,when *** matthew Laflen(Fig.1)*** one with a friendly welcoming smile,John had hundreds of friends,both personally and professionally throughout the *** article includes many of his professional and scientific contributions,and impacts from his research and outreach activities.

关键词： soil hundreds professional

performance evaluation of a water erosion tracer using plot-scale experiments and process-based modeling

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International Soil and Water Conservation Research 2023年第4期11卷 622-632页

作者： João m.Villela Jamil A.A.Anache Alex m.Watanabe Dennis C.flanagan Edson C.Wendland Silvio Crestana EmBRApA-Brazilian Agricultural Research Corporation LNNA-National Laboratory of Nanotechnology for AgrobusinessSt.XV de NovembroSão CarlosSP13560-970Brazil University of São paulo(USp) São Carlos School of Engineering.Graduate Program in Environmental Engineering Sciences(PPG-SEA)Av.Trabalhador São-CarlenseCxP.359São CarlosSP13566590Brazil Department of Hydraulics and Sanitation São Carlos School of Engineering(EESC)University of São Paulo(USP)CxP.359São CarlosSP13566-590Brazil Federal University of mato Grosso Do Sul CxP.549Campo Grande.MS.79070-900Brazil USDA-Agricultural Research Service National Soil Erosion Research Laboratory275 S.Russell StWest LafayetteIN47907USA

Socioeconomic and environmental losses caused by water erosion have highlighted the importance of quantifying and understanding the dynamics of soil redistribution in the landscape to develop effective soil management *** methods are applied to estimate erosion/deposition rates and identify sources of sediments,among them,the one that uses rare earth elements(REE)as a tracer stands ***,an alternative not yet explored that can benefit the accuracy of the estimates provided by the method is using a tracer containing a chemical signature composed of more than one *** present study aimed to evaluate the performance of a new water erosion tracer based on montmoril-lonite labeled with rare earth elements(La40-mmT).The innovative aspects of this La40-mmT tracer include its highly stable multi-chemical signature(Nd^(3+),La^(3+),and pr^(3+)),which enhances tracer detection in the environment,and its low production cost due to the use of an industrial residue in the synthesis *** tracer was evaluated for a typical soil of the Cerrado biome,using a natural rainfall field-scale plot-NRFp(5 m × 20 m)and a physical predictive erosion model(WEpp).The results showed that the La40-mmT tracer could be used to estimate erosion/deposition rates,with agreement between the values observed with the tracer and the WEpp ***,this study confirmed the great potential of La40-mmT as a tool to identify patterns of soil redistribution at the field scale and aid in the validation of erosion models.

关键词： Soil erosion Tracer Rare earth elements Deposition Sediment source WEpp model

Reversal of maternal obesity attenuates hypoxia and improves placental development in the preeclamptic-like BpH/5 mouse model

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BIOCELL 2023年第9期47卷 2051-2058页

作者： DANIELLA m.ADAmS KALIE F.BECKERS JULIET p.flanagan VIVIANE C.L.GOmES CHIN-CHI LIU JENNY L.SONES Veterinary Clinical Sciences School of Veterinary MedicineLouisiana State UniversityBaton RougeLAUSA pennington Biomedical Research Center Louisiana State UniversityBaton RougeLAUSA Small Animal Clinical Sciences College of Veterinary MedicineMichigan State UniversityEast LansingMIUSA

Background:Women with obesity have higher risk of adverse pregnancy outcomes,including preeclampsia(pE).Late-gestational hypertension,aberrant fetoplacental development,and fetal growth restriction(FGR),hallmarks of pE,are observed spontaneously in BpH/5 *** to obese preeclamptic women,BpH/5 mice have higher visceral white adipose tissue(WAT)and circulating *** hypothesized that attenuation of maternal obesity and serum leptin in pregnant BpH/5 mice will improve fetoplacental development by decreasing hypoxia markers and leptin expression at the maternal-fetal ***:To test this hypothesis,BpH/5 mice were fed ad libitum(lib)and pair-fed(pF)to C57 ad lib controls beginning at embryonic day(e)***-related genes,hypoxia inducible factor(Hif)1α,stem cell factor(Scf),heme oxygenase-1(Ho-1),leptin(Lep),and leptin receptor(LepR)were assessed in e7.5 implantation ***:BpH/5 ad lib had 1.5 to 2-fold increase in Hif1α,Scf,and Ho-1 mRNA and a greater than 3-fold increase in leptin mRNA vs.C57 that was attenuated with *** leptin promoted Hif1αand Ho-1 mRNA expression in e7.5 decidua in *** hypoxic conditions in vitro did not change decidual leptin ***,BpH/5 pF mice demonstrated improved fetal and placental outcomes later in gestation,with greater placental vascular area by e18.5 and attenuation of ***:In conclusion,pair-feeding BpH/5 mice beginning at conception may improve placental vasculature formation via decreased leptin and hypoxia-associated markers in this *** investigations are needed to better determine the effect of hypoxia and leptin on pregnancy outcomes in obese pregnant women.

关键词： preeclampsia BpH/5 Leptin Hypoxia

Escherichia coli-host macrophage interactions in the pathogenesis of inflammatory bowel disease

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World Journal of Gastroenterology 2014年第27期20卷 8751-8763页

作者： Ahmed Tawfik paul K flanagan Barry J Campbell Department of Gastroenterology Institute of Translational Medicine University of Liverpool

multiple studies have demonstrated alterations in the intestinal microbial community (termed the microbiome) in Crohn’s disease (CD) and several lines of evidence suggest these changes may have a significant role in disease pathogenesis. In active and quiescent disease, both the faecal and mucosa-associated microbiome are discordant with matched controls with reduced biodiversity, changes in dominant organisms and increased temporal variation described. mucosa-associated adherent, invasive Escherichia coli (E. coli) (AIEC), pro-inflammatory and resistant to killing by mucosal macrophages, appear to be particularly important. AIEC possess several virulence factors which may confer pathogenic potential in CD. Type-1 pili (FimH) allow adherence to intestinal cells via cell-surface carcinoembryonic antigen-related cell adhesion molecules and possession of long polar fimbrae promotes translocation across the intestinal mucosa via microfold (m)-cells of the follicle-associated epithelium. Resistance to stress genes (htrA, dsbA and hfq) and tolerance of an acidic pH may contribute to survival within the phagolysosomal environment. Here we review the current understanding of the role of mucosa-associated E. coli in Crohn’s pathogenesis, the role of the innate immune system, factors which may contribute to prolonged bacterial survival and therapeutic strategies to target intracellular E. coli.

关键词： Crohn's disease Inflammatory bowel disease Escherichia coli Intra-macrophage survival and replication phagolysosome Autophagy

pancreatic intraductal papillary mucinous neoplasm in a patient with Lynch syndrome

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World Journal of Gastroenterology 2015年第9期21卷 2820-2825页

作者： meghan R flanagan Arjun Jayaraj Wei Xiong matthew m Yeh Wendy H Raskind Venu G pillarisetty Department of Surgery University of Washington Medical Center University of Washington SeattleWA 98195United States Department of pathology and Laboratory medicine University of British ColumbiaVancouverBritish ColumbiaVancouverBC V6Z 1Y6Canada Department of pathology University of Washington Medical Center Departments of medicine/medical Genetics and pyschiatry and Behavioral Sciences University of Washington Medical Center

Intraductal papillary mucinous neoplasm(IpmN) is a mucin-producing epithelial neoplasm that carries a risk of progression to invasive pancreatic ductal *** syndrome is an autosomal dominant condition caused by germline mutations in mismatch repair genes such as mSH2 that lead to microsatellite instability and increased risk of tumor *** families with Lynch syndrome have an increased risk of pancreatic cancer, a clear connection between Lynch syndrome and IpmN has not been *** present a report of a 58 year-old Caucasian woman with multiple cancers and a germline mutation of mSH2 consistent with Lynch syndrome.A screening abdominal computed tomography scan revealed a dilated main pancreatic duct and cystic ductular structure in the uncinate process that were consistent with IpmN of the main pancreatic duct on *** and polymerase chain reaction of the patient's pancreas specimen did not reveal microsatellite instability or mismatch repair gene loss of expression or *** findings may be explained by the fact that loss of mismatch repair function and microsatellite instability is a late event in neoplastic *** the relative rarity of main duct IpmN, its appearance in the setting of somatic mSH2 mutation suggests that IpmN may fit into the constellation of Lynch syndrome related malignancies.

关键词： Intraductal papillary mucinous neoplasm pancreatic

Hydrogen absorption properties of amorphous(Ni0.6Nb0.4-yTay)100-xZrx membranes

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progress in Natural Science:materials International 2017年第1期27卷 126-131页

作者： O.palumbo F.Trequattrini N.pal m.Hulyalkar S.Sarker D.Chandra T.flanagan m.Dolan A.paolone CNR-ISC U.O.S. La Sapienza Department of physics Sapienza University of Rome Department of Chemical and materials Engineering University of Nevada Department of Chemistry University of Vermont CSIRO QCAT Energy 1 Technology CourtPullenvale

Ni based amorphous materials have great potential as hydrogen purification membranes. In the present work the melt spun(Ni0.6Nb0.4-yTay)100-xZrxwith y=0, 0.1 and x=20, 30 was studied. The result of X-ray diffraction spectra of the ribbons showed an amorphous nature of the alloys. Heating these ribbons below T mosphere（1-10 bar）, the amorphous structure was retained. The crystallization process was characterized by differential thermal analysis and the activation energy of such process was obtained. The hydrogen absorption properties of the samples in their amorphous state were studied by the volumetric method,and the results showed that the addition of Ta did not significantly influence the absorption properties, a clear change of the hydrogen solubility was observed with the variation of the Zr content. The values of the hydrogenation enthalpy changed from37 k J/mol for x=30 to9k J/mol for x=20. The analysis of the volumetric data provides the indications about the hydrogen occupation sites during hydrogenation, suggesting that at the beginning of the absorption process the deepest energy levels are occupied, while only shallower energy levels are available at higher hydrogen content, with the available interstitial sites forming a continuum of energy levels.

关键词： Amorphous Ni based alloy ribbons High temperature X-ray diffraction DTA Activation energy Crystallization temperature Hydrogen solubility