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Pancreatic volume change using three dimensional-computed tomography volumetry and its relationships with diabetes on longterm follow-up in autoimmune pancreatitis

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World Journal of Radiology 2024年第11期16卷 644-656页

作者： Ryuichi Shimada Yasunari Yamada Kazuhisa okamoto Kazunari murakami mitsuteru motomura Hajime Takaki Kengo Fukuzawa Yoshiki Asayama Department of Radiology Oita University Faculty of MedicineYufu 879-5593OitaJapan Department of Radiology Oita Red Cross HospitalOita 870-0033OitaJapan Department of Gastroenterology Oita University Faculty of MedicineYufu 879-5593OitaJapan Department of Hepato-Biliary-Pancreatic Internal medicine Oita Red Cross HospitalOita 870-0033OitaJapan Department of Surgery Oita Red Cross HospitalOita 870-0033OitaJapan

BACKGROUND Several studies found that early pancreatic atrophy detected by computed tomo-graphy(CT)within 6 months was associated with a high incidence of diabetes in patients with type-1 autoimmune pancreatitis(AIP)receiving steroid therapy;however,no long-term follow-up studies have been *** To investigate pancreatic volume(PV)changes using three dimensional(3D)-CT volumetry and their relationship with IgG4 and diabetes in patients with *** This retrospective study included 33 patients with type-1 AIP receiving steroid *** were divided into diffuse(D-type)and mass-forming type(m-type)*** was determined by semi-automated 3D-CT volumetry,and changes between initial and follow-up values were *** relationship between PV and serum IgG4 levels was analyzed by Spearman’s rank *** PV atrophy ratio compared with the presumed normal PV at the time of last follow-up CT and its relationship with diabetes were *** There were 16 D-type and 17 m-type patients with long-term follow-up(mean,95.8 months).The regression curve of mean relative PV change reduced exponentially and rapidly during the first 25 months and then more slowly in both *** overall cumulative pancreas re-enlargement rates at 1,3,5,7 and 10 years were 6.1%,12.2%,29.2%,47.5%and 55.0%,*** was a moderate-to-very strong positive correlation(ρ≥0.4)between PV and serum IgG4 levels in nine(9/13,69.2%)*** 33 patients showed pancreatic atrophy(mean 59.3%)after long-term *** with D-type AIP had a significantly higher atrophy rate and higher incidence of diabetes than m-type patients(Pmore slowly and is considered an important factor associated with *** IgG4 levels were positively correlated with PV during follow-up.

关键词： Autoimmune pancreatitis Computerized tomography volumetry Follow-up study IgG4 Diabetes

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Gastric carcinoma originating from the heterotopic submucosal gastric gland treated by laparoscopy and endoscopy cooperative surgery

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World Journal of Gastrointestinal Oncology 2015年第8期7卷 118-122页

作者： Taisuke Imamura Shuhei Komatsu Daisuke Ichikawa Hiroki Kobayashi mahito miyamae Shoji Hirajima Tsutomu Kawaguchi Takeshi Kubota Toshiyuki Kosuga Kazuma okamoto Hirotaka Konishi Atsushi Shiozaki Hitoshi Fujiwara Kiyoshi Ogiso Nobuaki Yagi Akio Yanagisawa Takashi Ando Eigo Otsuji Division of Digestive Surgery Department of Digestive Surgery Kyoto Prefectural University of Medicine Kyoto 602-8566 Japan Department of molecular Gastroenterology and Hepatology Kyoto Prefectural University of Medicine Kyoto 602-8566 Japan Department of Pathology Kyoto Prefectural University of Medicine Kyoto 602-8566 Japan Department of Gastroenterology and Hepatology Kyoto Kuramaguchi Medical Center Kyoto 603-8151 Japan

Gastric carcinoma is derived from epithelial cells in the gastric mucosa. We reported an extremely rare case of submucosal gastric carcinoma originating from the heterotopic submucosal gastric gland(HSG) that was safely diagnosed by laparoscopy and endoscopy cooperative surgery(LECS). A 66-year-old man underwent gastrointestinal endoscopy, which detected a submucosal tumor(SmT) of 1.5 cm in diameter on the lesser-anterior wall of the upper gastric body. The tumor could not be diagnosed histologically, even by endoscopic ultrasound-guided fine-needle aspiration biopsy. Local resection by LECS was performed to confirm a diagnosis. Pathologically, the tumor was an intra-submucosal well differentiated adenocarcinoma invading 5000 μm intothe submucosal layer. The resected tumor had negative lateral and vertical margins. Based on the Japanese treatment guidelines, additional laparoscopic proximal gastrectomy was curatively performed. LECS is a less invasive and safer approach for the diagnosis of SmT, even in submucosal gastric carcinoma originating from the HSG.

关键词： Heterotopic submucosal gland Laparoscopyand endoscopy cooperative surgery Gastric carcinoma Gastric submucosal tumor Less invasive treatment

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直径9.8mm的超细型结肠镜进行全结肠检查

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世界核心医学期刊文摘（胃肠病学分册） 2005年第12期1卷 43-44页

作者： okamoto m. Kawabe T. Kato J. 赵菊辉 Department of Gastroenterology Faculty of Medicine University of Tokyo 7- 3- 1Hongo Bunkyo- ku Tokyo 113- 8655 Japan Dr.

Background: The pediatric colonoscope is superior to the standard colonoscope in some patients with a fixed,angulated colon. A colonoscope thinner than the pediatric one is thought to out- perform even the pediatric colonoscope in such cases. This study was conducted to assess the efficacy of an ultrathin colonoscope, 9.8 mm in diameter, comparing it with pediatric and standard colonoscopes. methods: Three types of colonoscopes were used: ultrathin, pediatric, and standard. A total of 287 consecutive patients were assigned to three groups: ultrathin (n = 94), pediatric (n = 98), and standard (n = 95). First assessment was the ratio of cecal intubation and the reasons for unsuccessful colonoscopy. The second was the time to cecal intubation. Results: Cecal intubation rates were not different among three groups (96% in each). The main reasons for failed colonoscopy were looping in the ultrathin group, and angulation or stricture in the pediatric and standard groups. mean time to the cecum was slightly longer in the ultrathin group (6.5 minutes) than the pediatric group (5.6 minutes) and standard group (6.1 minutes), but there were no significant differences among three groups. Conclusion: Colonoscopy with the ultrathin colono- scope was as successful as with the pediatric and standard colonoscopes. The advantage of the ultrathin colonoscope might be notable in cases with stricture or severe angulation.

关键词：结肠镜检全结肠肠腔狭窄次要指标肠狭窄评价指标

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老年患者右侧结肠易发扁平型早期结肠直肠癌

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世界核心医学期刊文摘（胃肠病学分册） 2005年第10期1卷 17-18页

作者： okamoto m. Kawabe T. Yamaji Y. 赵天智 Department of Gastroenterology Faculty of Medicine University of Tokyo 7-3-1 Hongo Bunkyo-ku 113-8655 Tokyo Japan Dr.

BACKGROUND: Flat-type colorectal cancer is frequently reported in Japan and Europe, but its clinical features remain obscure. Thus, we investigated the clinical features of flat-type early colorectal cancer with respect to tumor location and patient age and compared them with those of polypoid-type early and advanced cancer. mETHODS: Between January 1999 and June 2001, total colonoscopy was performed in 6,178 patients (mean age, 61 years; 4,290 males and 1,888 females). Of these patients, 402 patients with 429 colorectal cancers were found: 202 at advanced stage (invading beyond muscularis propria) and 227 at early stage (carcinoma in situ or invading within submucosa). Early-stage cancer was classified into two macroscopic subgroups: flat-type and polypoid-type. RESULTS: Out of 227 early cancers, 44 were flat type and 183 were polypoid. Flat-type early cancer was more frequently located in the right colon (57 percent, 25/44) than polypoid-type cancer (19 percent, 35/183; P matous component in flat-type early cancer was less frequent than in polypoid-type cancer (23 percent vs. 92 percent, P minimal change (16 percent, 18 percent, and 25 percent, respectively). An increase in the proportion of right-sided colon with age was also found in advanced cancer (20 percent, 38 percent, and 52 percent, respectively). CONCLUSION: The incidence of flat-type early cancer in right-sided colon increased with age, similar to the pattern of advanced cancer. This suggests that flat-type early cancer may be a precursor of advanced cancer in the right colon, especially in older people.

关键词：结肠直肠癌扁平型早期癌息肉型固有肌层原位癌肿瘤位置全结肠内镜检查黏膜下层

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电炉底吹EF—KGC工艺

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涟钢科技与管理 1995年第3期 56-61页

作者： N. mimura H. Washio m. Usuzaka T. okamoto H. Toritani 李洁

1 概述在现代炼钢业中,转炉(BOF)主要目标是通过钢水搅拌的冶金反应来提高效率,直到最近,电炉炼钢集中重点放在通过采用大容量变压器、大容量炉子、废钢予热器和富氧燃烧器来提高冶炼能力。然而,从搅拌钢水的冶金反应方面来看,则几乎没... 详细信息

1 概述在现代炼钢业中,转炉(BOF)主要目标是通过钢水搅拌的冶金反应来提高效率,直到最近,电炉炼钢集中重点放在通过采用大容量变压器、大容量炉子、废钢予热器和富氧燃烧器来提高冶炼能力。然而,从搅拌钢水的冶金反应方面来看,则几乎没有取得什么改进。

关键词：耐火材料电炉炼钢电弧炉喷嘴底吹冶金反应钢水搅拌单位电耗冶金效果水模型试验

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采后光照条件对白凤桃果实品质和挥发性香气物质形成的影响(英文)

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植物生理与分子生物学学报 2007年第3期33卷 205-212页

作者：李斌贾惠娟冈本五郎浙江大学园艺系冈山大学大学院自然科学研究科

研究了白凤桃果实贮藏过程中光照条件对果实成熟的影响。在7月12日(未熟期)和7月16日(硬熟期)采收果实,分别贮藏在光条件(白色荧光灯照明,果顶部光强为80μmol m^(-2)s^(-1))和暗条件中,室温均为25℃。硬熟期采收果实贮藏在光条件下,达... 详细信息

研究了白凤桃果实贮藏过程中光照条件对果实成熟的影响。在7月12日(未熟期)和7月16日(硬熟期)采收果实,分别贮藏在光条件(白色荧光灯照明,果顶部光强为80μmol m^(-2)s^(-1))和暗条件中,室温均为25℃。硬熟期采收果实贮藏在光条件下,达到完熟期时,乙烯生成量较低。果肉的硬度在各个采收期,各种贮藏条件下均没有差别。光条件贮藏果实中花青苷含量较高。未熟期采收果实贮藏在光条件下时,可溶性固形物含量增加较多。光条件贮藏果实中天冬酰胺的下降比暗贮藏果实中更多。各时期采收的果实中,在光下贮藏时,果肉和果皮γ-癸内酯和γ-十二内酯的含量都明显增加。以上结果表明,白凤桃果实采收后在光下贮藏,可以明显改善果实的品质。

关键词：挥发性香气光照桃采后品质

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multicenter cooperative observational study of idiopathic pulmonary fibrosis with non-small cell lung cancer

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World Journal of Respirology 2016年第1期6卷 42-48页

作者： Noriyuki Ebi Shoji Tokunaga Kazunobu Itoh Isamu okamoto Nobutaka Edakuni Shinji Fujii Kentaro Watanabe Shinichiro Hayashi Takashige maeyama Yoichi Nakanishi Department of Respiratory Oncology Iizuka Hospital Department of medical Informatics Kyushu University Hospital Division of Respiratory medicine Shinbeppu Hospital Research Institute for Diseases of the Chest Graduate School of Medical SciencesKyushu University Division of Respirology Neurology and Rheumatology Department of Medicine Kurume University School of Medicine Division of Respiratory Disease Kumamoto Regional Medical Center Department of Respiratory medicine Fukuoka University Hospital Department of Internal medicine Faculty of MedicineSaga University

AIm: To research the natural course of idiopathic pulmonary fibrosis(IPF) with advanced non-small cell lung cancer(NSCLC) and the association between acutemETHODS: From may 2007 through April 2011, 17 CT naive patients with IPF and advanced NSCLC were enrolled. Patients were classified into best supportive care(BSC) group or CT group based on the patient's preference. Patients in the CT group received carboplatin(CBDCA)(AUC 5-6) plus paclitaxel(PTX)(175-200 mg/m2) on day 1 of each 21-d cycle as first-line ***: All patients but one chose the CT group. In the CT group, the objective response rate was 38%. The most frequent toxicity ≥ grade 3 was neutropenia(88%). Two patients(12.5%) developed AE-IPF. The median progression-free survival, the median survival time and the 1-year survival rate were 4.1 mo, 8.7 mo and 35%, respectively. Second-line CT-related AE and CT-unrelated AE occurred in 2 and 3 patients(1: BSC group; 2: CT group), respectively. Seven(41%) of all patients developed AE-IPF throughout the clinical course, and 6 of 7 patients with AE-IPF died within one ***: The incidence of AE-IPF was higher among IPF patients with advanced NSCLC than among those without NSCLC. CBDCA plus PTX regimen was tolerable and effective. However, AE-IPF has a fatal toxicity with or without CT in IPF patients with advanced NSCLC.

关键词： Non-small cell lung cancer Chemotherapy Idiopathic pulmonary fibrosis Acute exacerbation Best supportive care

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IgG3抗体与线粒体主要自身抗原决定簇及乳酸杆菌抗原位点的交叉反应是原发胆汁性肝硬化的特征

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世界核心医学期刊文摘（胃肠病学分册） 2005年第11期1卷 50-51页

作者： Bogdanos D.-P. Baum H. okamoto m. D. Vergani 徐瑞 Institute of Liver Studies King's College Hospital Denmark Hill London SES 9RS United KingdomProf.

The serological hallmark of primary biliary cirrhosis (PBC) is the presence of pyruvate dehydrogenase complex E2 subunit (PDC-E2) antimitochondrial antibodies (AmAs). Anti- PDC-E2 antibodies cross-react specifically with mycobacterial hsp65, and we have demonstrated that the motif SxGDL[ILV]- AE shared by PDC- E2212- 226 and hsp’s is a cross-reactive target. Having found that this same motif is present only in β -galactosidase of Lactobacillus delbrueckii (BGAL LACDE), we hypothesized that this homology would also lead to cross-reactivity. The mimics were tested via ELISA for reactivity and competitive cross-reactivity using sera from100 AmA-positive and 23 AmA-negative PBC patients and 190 controls. An Escherichia colt (ECOLI) PDC-E2 mimic that has been pathogenetically linked to PBC but lacks this motif has been also tested. Anti-BGAL266-280 LACDE antibodies were restricted to AmA-positive patients (54 of 95, 57% ) and belonged to immunoglobulin (Ig) G3. Of the 190 controls, 22 (12% ; P mainly of the IgG4 subclass. ECOLI PDC-E2 reactivity was virtually absent. BGAL266- 280/PDC- E2212- 226 reactivity of the IgG3 isotype was found in 52 (52% ) AmA-positive PBC patients but in only 1 of the controls (P med via competition *** affinity for BGAL266- 280 was greater than for PDC- E2 mimics. Preincubation of a multireactive serum with BGAL266- 280 reduced the inhibition of enzymatic activity by 40% , while marginal effect (12% ) or no effect (2% ) was observed in human or ECOLIPDC-E2 mimics. In conclusion, IgG3 antibodies to BGAL LACDE cross-react with the major mitochondrial autoepitope and are characteristic of PBC.

关键词：胆汁性肝硬化 IgG3 抗线粒体抗体抗原决定簇抗原位点交叉反应亚单位血清学特异性抗原共有序列

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measurement of prostaglandin metabolites is useful in diagnosis of small bowel ulcerations

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World Journal of Gastroenterology 2019年第14期25卷 1753-1763页

作者： Yuichi matsuno Junji Umeno motohiro Esaki Yoichiro Hirakawa Yuta Fuyuno Yasuharu okamoto Atsushi Hirano Shigeyoshi Yasukawa Fumihito Hirai Toshiyuki matsui Shuhei Hosomi Kenji Watanabe Naoki Hosoe Haruhiko Ogata Tadakazu Hisamatsu Shunichi Yanai Shuji Kochi Koichi Kurahara Tsuneyoshi Yao Takehiro Torisu Takanari Kitazono Takayuki matsumoto Department of medicine and Clinical Science Graduate School of Medical Sciences Kyushu University Department of Endoscopic Diagnostics and Therapeutic Saga University Hospital Department of Epidemiology and Public Health Graduate School of Medical Sciences Kyushu University Department of Gastroenterology Fukuoka University Chikushi Hospital Department of Gastroenterology Osaka City University Graduate School of Medicine Department of Intestinal Inflammation Research Hyogo College of Medicine Center for Diagnostic and Therapeutic Endoscopy School of Medicine Keio University the Third Department of Internal medicine Kyorin University School of Medicine Division of Gastroenterology Department of Internal Medicine Iwate Medical University Division of Gastroenterology Matsuyama Red Cross Hospital Department of Gastroenterology Sada Hospital

BACKGROUND We recently reported on a hereditary enteropathy associated with a gene encoding a prostaglandin transporter and referred to as chronic enteropathy associated with SLCO2 A1 gene(CEAS). Crohn's disease(CD) is a major differential diagnosis of CEAS, because these diseases share some clinical features. Therefore, there is a need to develop a convenient screening test to distinguish CEAS from *** To examine whether prostaglandin E major urinary metabolites(PGE-mUm) can serve as a biomarker to distinguish CEAS from *** This was a transactional study of 20 patients with CEAS and 98 patients with *** was diagnosed by the confirmation of homozygous or compound heterozygous mutation of SLCO2 A1. We measured the concentration of PGEmUm in spot urine by radioimmunoassay, and the concentration was compared between the two groups of patients. We also determined the optimal cut-off value of PGE-mUm to distinguish CEAS from CD by receiver operating characteristic(ROC) curve *** Twenty Japanese patients with CEAS and 98 patients with CD were ***-mUm concentration in patients with CEAS was significantly higher than that in patients with CD(median 102.7 vs 27.9 μg/g × Cre, P mUm contributed to 7.3 increase in the likelihood for the diagnosis of CEAS [95% confidence interval(CI) 3.2-16.7]. A logistic regression analysis revealed that the association was significant even after adjusting confounding factors(adjusted odds ratio 29.6, 95%CI 4.7-185.7). ROC curve analysis revealed the optimal PGE-mUm cut-off value for the distinction of CEAS from CD to be 48.9 μg/g × Cre with 95.0% sensitivity and 79.6% *** PGE-mUm measurement is a convenient, non-invasive and useful test for the distinction of CEAS from CD.

关键词： Chronic enteropathy associated with SLCO2A1 gene Prostaglandin E major urinary metabolites Chronic nonspecific multiple ulcers of the small intestine Crohn's disease Small intestine

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新型2.0L高效柴油机的开发

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汽车与新动力 2013年第6期45卷 26-32页

作者： Chisaki J Yoshijima K Kikuchi T morinaka S Yamada K okamoto m Oda T manabe K 闫红梅

丰田汽车公司致力于应用高可靠、低成本的基础技术来开发兼具驾驶乐趣和高燃油效率的车辆。开发侧重于燃烧特性和摩擦的逐步改进,最大限度地利用新型2.0 L高效柴油机的最大潜力。自2011年11月以来,这种新型发动机已在世界各地的市场推出... 详细信息

丰田汽车公司致力于应用高可靠、低成本的基础技术来开发兼具驾驶乐趣和高燃油效率的车辆。开发侧重于燃烧特性和摩擦的逐步改进,最大限度地利用新型2.0 L高效柴油机的最大潜力。自2011年11月以来,这种新型发动机已在世界各地的市场推出,被用于Avensis、Auris、RAV4和Verso等车型。概述了新型发动机及其技术要点。

关键词：柴油机燃油效率电控可变机油泵双室油底壳

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