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Prospective application of a bleeding and ischemic risks-adjusted antithrombotic protocol in elderly patients revascularized with everolimus-eluting stents:EPIC05-Sierra75 study

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Journal of Geriatric Cardiology 2022年第5期19卷 354-366页

作者： Jose m de la Torre Hernandez Ramon Lopez Palop Jesus m Jimenez mazuecos Pilar Carrillo Sáez Alejandro Gutierez-Barrios Eduardo Pinar Belen Cid Luis Fernandez Tamara Garcia Camarero Cristóbal Urbano-Carrillo Juan F Oteo Dominguez Victor A Jimenez Diaz Antonio EGomez menchero Eladio Galindo Fernández Juan GCórdoba Soriano Raymundo Ocaranza Eduardo ArroyoÚcar Koldobika Garcia San Roman Silvio Leal Ginés martínez Cáceres Jose A Linares Vicente Georgina Fuertes Ferre Xavier Carrillo Juan CRama merchán Catia costa Juan Sanchis Renato Fernandes Alberto Rodrigues Jose m Vegas Valle Hélder Pereira Armando Perez de Prado Cardiology Department Hospital Universitario Marqués de ValdecillaIDIVALSantanderSpain Cardiology Department Hospital Universitario San JuanAlicanteSpain Cardiology Department Complejo Hospitalario Universitario de AlbaceteAlbaceteSpain Cardiology Department Hospital Universitario Puerta del MarCadizSpain Cardiology Department Hospital Clínico Universitario Virgen de la ArrixacaMurciaSpain Cardiology Department Hospital Clinico Universitario de SantiagoCIBERCVSantiago de CompostelaSpain Cardiology Department Hospital Universitario de CrucesBilbaoSpain Cardiology Department Hospital Regional Universitario de MálagaMalagaSpain Cardiology Department Hospital Universitario Puerta de HierroMadridSpain Cardiology Department Hospital Alvaro CunqueiroVigoSpain Cardiology Department Hospital Juan Ramon JimenezHuelvaSpain Cardiology Department Hospital Universitario de BadajozBadajozSpain Cardiology Department Hospital Universitario Lucus AugustiLugoSpain Cardiology Department Hospital de Torrevieja/VinalopóRibera SaludTorreviejaSpain Cardiology Department Hospital Santa CruzLisboaPortugal Cardiology Department Hospital Clínico Universitario Lozano BlesaZaragozaSpain Cardiology Department Hospital Universitario Miguel ServetZaragozaSpain Cardiology Department Hospital Germans Trias i PujolBadalonaSpain Cardiology Department Hospital de MeridaMeridaSpain Cardiology Department Hospital São BernardoSetúbalPortugal Cardiology Department Hospital Clinico Universitario de ValenciaUniversidad de ValenciaCIBERCVValenciaSpain Cardiology Department Hospital do Espirito SantoEvoraPortugal Cardiology Department Centro Hospitalar de Vilanova de GaiaVilanova de GaiaPortugal Cardiology Department Hospital de CabueñesGijonSpain Cardiology Department Hospital Garcia de OrtaAlmadaPortugal Cardiology Department Complejo Asistencial Universitario de LeónLeonSpain

OBJECTIVES Elderly patients show a higher incidence of ischemic and bleeding events after percutaneous transluminal coron-ary intervention(PCI).We sought to investigate outcomes in elderly patients treated with antithrombotic strategy guided by bleeding and ischemic risks after revascularization with last generation everolimus-eluting stent(EES).mETHODS Prospective multicenter registry including patients over 75 years revascularized with EES and antithrombotic ther-apy guided by clinical presentation,PCI complexity and PRECISE DAPT ***-primary safety endpoints were:(1)composite of cardiac death,myocardial infarction and stent thrombosis and;(2)bleeding(BARC 2-5).Primary efficacy endpoint was target lesion revascularization.A matched group of patients revascularized with current drug-eluting stents and no such tailored antith-rombotic therapy was used as *** Finally,1064 patients were included in SIERRA-75 cohort,80.8±4.2 years,36.6%women,71%acute coronary syn-dromes(ACS)and 53.6%complex ***-primary safety endpoint of major adverse cardiovascular events was met in 6.2%,co-primary safety endpoint of bleeding in 7.8%and primary efficacy endpoint of TKLR in 1.5%.The multivariable adjusted model showed no significant association of the prescribed short/long dual antiplatelet therapy(DAPT)durations with any endpoint suggesting a well tailored *** stent thrombosis reported in the subgroup with 1-3 months DAPT *** compared to control group,bleeding BARC 2-5 was significantly lower in SIERRA-75 group(7.4%vs.10.2%,P=0.04)as well as the net safety-efficacy endpoint(14.3%vs.18.5%,P=0.02).CONCLUSIONS In elderly population,the application of this risks-adjusted antithrombotic protocol after revascularization with last generation EES seems to be associated with an improved prognosis in terms of ischemic and bleeding outcomes.

关键词： patients bleeding antithrombotic

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定向凝固单相Sn-2%Sb合金的胞/枝晶转变、枝晶生长和显微硬度（英文）

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Transactions of Nonferrous metals Society of China 2018年第8期28卷 1679-1686页

作者： O.L.ROCHA T.A.costa m.DIAS A.GARCIA Federal hlstitute of Education Science and technology of Para - IFPA 66093-020 Belem-Para Brazil Faculty of mechanical Engineering Federal University of Para - UFPA 66075-110 Belem-Para Brazil Department of manufacturing and materials Engineering University of Campinas-UNICAMP 13083-860 Campinas-Sao Paulo Brazil

采用单相Sn-2%Sb(质量分数)合金进行水平定向凝固实验,分析凝固热参数对显微组织形貌和长度尺度的影响。在凝固过程中,对沿铸坯长度方向的不同部位进行连续温度测量,用这些温度数据来确定凝固热参数,包括生长速率(V_L)和冷却速率(T_R)... 详细信息

采用单相Sn-2%Sb(质量分数)合金进行水平定向凝固实验,分析凝固热参数对显微组织形貌和长度尺度的影响。在凝固过程中,对沿铸坯长度方向的不同部位进行连续温度测量,用这些温度数据来确定凝固热参数,包括生长速率(V_L)和冷却速率(T_R)。高冷却速率的胞晶和枝晶可以表征铸件不同区域的显微组织,当T_R>5.0 K/s时发生枝晶向胞晶的可逆转变。沿定向凝固铸造的长度方向确定胞晶尺寸(λ_c)和一次枝晶间距(λ_1),提出关于λ_c和λ_1与V_L和T_R的实验生长规律,并与垂直向上定向凝固实验结果进行对比分析,并分析显微组织形貌和长度尺度对显微硬度的影响。

关键词： Sn-Sb单相合金定向凝固热参数显微组织胞/枝晶可逆转变

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Curcumin-Loaded Electrospun Fibers: Fluorescence and Antibacterial Activity

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Advanced Fiber materials 2020年第5期2卷 256-264页

作者： mário César Albuquerque de Oliveira Fernando Antonio Gomes da Silva Jr. mateus matiuzzi da costa Nikifor Rakov Helinando Pequeno de Oliveira Institute of materials Science Federal University of Sao Francisco ValleyJuazeiroBA 48920-310Brazil

The health benefits and sensing applications of curcumin-based systems depend on their prevailing photophysical and chemi-cal properties at a specific environment-the characteristic low solubility of curcumin in water hinders high-dosage based *** circumvent this drawback,curcumin has been incorporated in hydrophobic environments in ***,electrospun fibers of Eudragit L100 were loaded with curcumin and applied in fluorescence and antibacterial assays to evaluate prevailing physical and chemical properties in *** characteristic high loading degree of curcumin(250 mg/mL in Eudragit L100 solution)preserves not only the photophysical properties of molecules(such as the intrinsic fluorescence)but also the antibacterial activity of released molecules from electrospun fibers,characterizing an important strategy for improvement in the applicability potential of natural materials.

关键词： Curcumin Fluorescence Electrospinning Hydrophobic core

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Experimental salt cavern in offshore ultra-deep water and well designevaluation for CO_(2) abatement

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International Journal of mining Science and Technology 2019年第5期29卷 641-656页

作者： Alvaro maia da costa Pedro V.m.costa Antonio C.O.miranda mariana B.R.Goulart Okhiria D.Udebhulu Nelson F.F.Ebecken Ricardo C.Azevedo Sérgio m.de Eston Giorgio de Tomi Andre B.mendes Julio R.meneghini Kazuo Nishimoto Claudio mueller Sampaio Camila Brandao Alexandre Breda University of Sao Paulo(USP) Sao Paulo 01000-000Brazil modecom-Technology in Geomechanics and Computing modeling Rio de Janeiro 27570-000Brazil Department of Civil and Environment Engineering University of Brasília(UnB)Brasília 70000-000Brazil COPPE Federal University of Rio de JaneiroRio de Janeiro 27570-000Brazil Technology Division of Shell Shell BrazilRio de Janeiro 27570-000Brazil

This paper presents a proposal for an experimental salt cavern in offshore ultra-deep water for CO2 abatement,including the instrumentation plan and well conceptual design evaluated for carbon capture and storage(CCS)*** studies are based on applied computational mechanics associated with field experimentation that has contributed to the technical feasibility of the underground potash mine at the State of Sergipe in *** knowhow allowed the stability analysis of several salt caverns for brine production at the State of Alagoas in Brazil and to the drilling through stratified thick layers of salt of the pre-salt reservoirs in Santos ***,this knowledge has been applied in the design of onshore and offshore salt caverns opened by dissolution for storage of natural gas and *** geomechanical study,through the application of computational mechanics,of offshore giant salt caverns of 450 m high by 150 m in diameter,shows that one cavern can store about 4 billion Sm3 or 7.2 million tons of *** the construction of the giant cavern,which will be the first gas storage offshore in the world,it has been decided to develop an experimental one,with smaller size,to obtained field *** experimental cavern will allow the calibration of parameters to be used in the structural integrity analysis of the cavern and well for storage of natural gas which is rich in CO2 under high pressure.

关键词： Salt cavern Pre-salt reservoir Geomechanical study Carbon capture and storage

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Colorful Insights： Advances in Imaging Drive Nove 3reakthroughs in Ca^2＋ Signaling

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molecular Plant 2015年第3期8卷 352-355页

作者： Alex costa Jorg Kudla Dipartimento di Bioacienze Università degli Studi di Milano Via G. Celoria 26 20133 Milan Italy Istituto di Biofisica Consiglio Nazionale delle Ricerche Via G. Celoria 26 20133 Milan Italy Institut für Biologie und Biotechnologie der Pflanzen Universitat Münster Schlossplatz 4 48149 Münster Germany

In plants, Ca^2＋ signals occur in response to both environmental and developmental stimuli. These signals involve increases in [Ca^2＋] in compartments such as the cytoplasm, nucleus, and mitochondria, and can display multiple shapes ranging from sin- gle transients to repetitive Ca^2＋ oscillations. Generation and shaping of stimulus specific [Ca^2＋] signatures depends on Ca^2＋ influxes and effluxes occurring at both the plasma membrane （Pm） and membranes of the different subcellular compartments.

关键词： @@

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Assessing potential protection effects on commercial fish species in a Cuban mPA

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Aquaculture and Fisheries 2020年第5期5卷 234-244页

作者： Barbara Horta e costa Jorge Angulo-Valdés Jorge m.S.Gonçalves Pedro Barros Center of marine Sciences CCMARUniversity of AlgarveCampus de GambelasFaro8005-139Portugal Centro de Investigaciones marinas Universidad de La HabanaCalle 16 No.114PayaLa HabanaCP 11300Cuba School of Natural Resources and Environment University of FloridaUnited States of America103 Black HallGainesvilleFL32611USA Centre for marine and Environmental Research(CImA) University of AlgarveCampus de GambelasFaro8005-139Portugal Food and Agriculture Organization(FAO) Fisheries and Aquaculture Department Marine and Inland Fisheries Branch(FIRF)Rome00153Italy

Cuba has been leading marine protected area(mPA)designation in the Caribbean region to ensure conservation of its valuable marine ***,an efficient monitoring program for mPAs is still to be implemented and will benefit from pre-existing *** highly regulated mPA of Punta Francés National Park is one of the first Cuban mPAs and was established mainly to protect species and ecosystems for tourism *** of protection effects on commercial fish species was lacking in this *** study aimed at increasing local scientific knowledge by providing a baseline study about the most commercially fished families(Haemulidae,Lutjanidae and Serranidae)around Punta Francés *** collected represent only a limited period but can be used as a base point to support future *** abundance in number and biomass,and size were collected to test for differences between inside and adjacent areas outside the Punta Francés mPA,in different coral reef *** main result of this study was the significantly larger size and biomass of snappers and groupers outside the mPA where intense fisheries *** observation consistent with a large spawning aggregation was also recorded outside the *** with a limited set of data,these results suggest that,at least temporarily,the most targeted species[and sizes]are still highly vulnerable to *** habitats in the adjacent area,that are apparently missing within the mPA,may support some of the results *** the limits of the Punta Francés mPA to include those habitats outside may be critical to ensure the effectiveness of this mPA in contributing to protect the most commercial species of the *** should be done together with efficient fisheries management measures in the region,such as the significantly increase of minimum legal sizes and temporal closures during spawning migrations.

关键词： Cuba marine protected areas Commercial fish species Spawning aggregations Artisanal fisheries Coral reefs

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Biochar influences the cane fields’microbiota and the development of pre-sprouted sugarcane seedlings

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Waste Disposal and Sustainable Energy 2023年第1期5卷 75-88页

作者： Bruna Cristina Pinto Adriana Barboza Alves Osania Emerenciano Ferreira Gustavo Henrique Gravatim costa magno Andréde Oliveira Augusto Cesar da Silva Bezerra Alan Rodrigues Teixeira machado Postgraduate Program in Environmental Sciences State University of Minas GeraisFrutal UnityFrutalMinas Gerais38202-436Brazil Department of Agricultural and Biological Sciences State University of Minas GeraisFrutal UnityFrutalMinas Gerais38208-436Brazil Postgraduate Program in Geotechnical Engineering Federal University of Ouro PretoOuro PretoMinas Gerais35400-000Brazil Department of Transport Engineering Federal Center for Technological Education of Minas GeraisBelo HorizonteMinas Gerais30421-169Brazil Department of Exact Sciences State University of Minas GeraisJoão Monlevade UnityJoão MonlevadeMinas Gerais35930-314Brazil

This research investigates the soil conditioning effect of sugar cane fields with biochar produced from sugarcane *** influence on the physicochemical and microbiological conditions of the soil and the agronomic performance of sugarcane seedlings was *** this end,the biochar from sugarcane bagasse was produced by pyrolysis in a double drum oven and mixed with soil at rates of 0,1%,3%,and 5%(in weight).The experiment was installed in a greenhouse with two evaluation periods(30 days and 60 days)and five *** pot received a pre-sprouted cane seedling,and the analysis of colony-forming units(bacteria and fungi),physicochemical characteristics of the soil,and growth and development of sugarcane were performed per *** biochar showed a high fixed carbon content(72%)and a specific surface area estimated by the adsorption of methylene blue of 50 m2 g−***,its structure is porous and contains important nutrients(e.g.,CaO,K2O,and P2O5).In the periods evaluated,the applications of the 3%and 5%(in weight)rates of biochar reduced most of the soil fertility ***,the chemical analyses indicated that the sugarcane field soil collected already possessed high *** microbiota was influenced,but only the application of the 3%(in weight)rate at 60 days after planting showed a significant positive effect on the number of bacteria forming units,with an increase of approximately 385%.On the other hand,no significant positive effect on sugarcane development was ***,biochar application in high-fertility sugarcane plantation soil did not result in gains for sugarcane development in the periods evaluated.

关键词： Soil Biometry microbiology Double drum oven Biochar

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Phylogenetic Analysis of RhoGAP Domain-Containing Proteins

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Genomics, Proteomics & Bioinformatics 2006年第3期4卷 182-188页

作者： marcelo m. Brando Karina L. Silva-Brando Fernando F. costa Sara T.O. Saad Hematology and Hemotherapy Center State University of Campinas 13083-970 Campinas SP Brazil Department of Zoology Institute of Biology State University of Campinas 13083-970 Campinas SP Brazil.

Proteins containing an Rho GTPase-activating protein （RhoGAP） domain work as molecular switches involved in the regulation of diverse cellular functions. The ability of these GTPases to regulate a wide number of cellular processes comes from their interactions with multiple effectors and inhibitors, including the RhoGAP family, which stimulates their intrinsic GTPase activity. Here, a phylogenetic approach was applied to study the evolutionary relationship among 59 RhoGAP domain-containing proteins. The sequences were aligned by their RhoGAP domains and the phylogenetic hypotheses were generated using maximum Parsimony and Bayesian analyses. The character tracing of two traits, GTPase activity and presence of other domains, indicated a significant phylogenetic signal for both of them.

关键词： Bayesian analysis character tracing parsimony phylogenomics protein domain,RhoGAP

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Is there a window of opportunity to optimize trastuzumab cardiac monitoring?

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World Journal of Cardiology 2022年第7期14卷 403-410页

作者： Bruno Henrique Rala de Paula maria Eduarda Teixeira Ferro costa Carlos Augusto moreira de Sousa JoséBines Sarah Cannon Research Institute London W1G 6ADUnited Kingdom Department of Cardiology Hospital do Câncer III-Instituto Nacional de CâncerRio de Janeiro 20560-121Brazil Departamento de Tecnologias da Informação e Educação em Saúde(DTIES) da Faculdade de Ciências Médicas(FCM)na Universidade do Estado do Rio de Janeiro(UERJ)Rio de Janeiro 20550-170Brazil Department of medical Oncology Instituto Nacional de CâncerRio de Janeiro 20560-121Brazil

BACKGROUND It remains unclear whether the current arbitrary screening recommendations of trastuzumab-related cardiotoxicity provides an adequate balance between preventing heart damage and curtailing a curative *** To determine the incidence rate and consequences of trastuzumab-induced cardiotoxicity as adjuvant treatment in a real-world *** We present a retrospective analysis of cardiac function measured by echocardiogram at baseline and every 3 mo during trastuzumab *** was defined as a drop in left ventricular ejection fraction(LVEF)≥10%from baseline and/or any dropmber 2014,407 patients were ***(93.6%)were treated with an anthracycline followed by a taxane-based regimen and trastuzumab for 12 *** patients(9.8%)had *** of them were symptomatic,and 28(72.5%)completely recovered *** happened early as shown by LVEF measured on echocardiogram 2 to 4 as compared to 5 to 7(odds ratio=2.47,95%confidence interval:1.09,5.63,P=0.024).There were 54 deaths(13.3%)during the 70-mo follow-up period;1(0.2%)was attributed to late cardiotoxicity(4 years after treatment).The absence of symptomatic cardiotoxicity during trastuzumab treatment and moreover the early occurrence on the treatment period may translate into a strategy to evaluate less *** We observed a 10%rate of asymptomatic cardiotoxicity,which mirrors the results from the large adjuvant *** being transient,an LVEF drop led to frequent treatment delays and *** remains unclear whether LVEF decline is predictive of late cardiotoxicity,and treatment efficacy is compromised.

关键词： Cardiac toxicity Ventricular Dysfunction Heart failure Trastuzumab Breast cancer

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Use of butyrate or glutamine in enema solution reduces inflammation and fibrosis in experimental diversion colitis

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World Journal of Gastroenterology 2012年第32期18卷 4278-4287页

作者： Rodrigo Goulart Pacheco Christiano costa Esposito Lucas Cm müller morgana TL Castelo-Branco Leonardo Pereira Quintella Vera Lucia A Chagas Heitor Siffert P de Souza Alberto Schanaider Department of Surgery Experimental Surgery CenterSurgical Sciences Postgraduate ProgramMedical SchoolFederal University of Rio de JaneiroRio de JaneiroRJ 21941-913Brazil Laboratory of Cellular Immunology Department of Histology and EmbryologyInstitute of Biomedical SciencesFederal University of Rio de JaneiroRio de JaneiroRJ 21941-913Brazil Department of Pathology Medical SchoolFederal University of Rio de JaneiroRio de JaneiroRJ 21941-913Brazil Department of Internal medicine Hospital Universitario Clementino Fraga FilhoFederal University of Rio de JaneiroRio de JaneiroRJ 21941-913Brazil

AIm:To investigate whether butyrate or glutamine enemas could diminish inflammation in experimental diversion ***:Wistar specific pathogen-free rats were submitted to a Hartmann's end colostomy and treated with enemas containing glutamine,butyrate,or *** were administered twice a week in the excluded segment of the colon from 4 to 12 wk after the surgical ***-up colonoscopy was performed every 4 wk for 12 *** effect of treatment was evaluated using video-endoscopic and histologic scores and measuring interleukin-1β,tumor necrosis factor-alpha,and transforming growth factor beta production in organ cultures by enzyme linked immunosorbent ***:Colonoscopies of the diverted segment showed mucosa with hyperemia,increased number of vessels,bleeding and mucus *** with either glutamine or butyrate induced significant reductions in both colonoscopic(P mber of goblet cells(P = 0.021;P = 0.029),and the rate of apoptosis within the epithelium(P = 0.043;P = 0.011) to normal *** high levels of cytokines in colon explants from rats with diversion colitis significantly decreased to normal values after treatment with butyrate or ***:The improvement of experimental diversion colitis following glutamine or butyrate enemas highlights the importance of specific luminal nutrients in the homeostasis of the colonic mucosa and supports their utilization for the treatment of human diversion colitis.

关键词：结肠炎丁酸引水实验炎症酶联免疫吸附试验纤维化谷氨酸

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