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Poly(A)-specific RNase(PARN)generates and regulates miR-125a-5p 3’-isoforms,displaying an altered expression in breast cancer

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Signal Transduction and Targeted Therapy 2024年第5期9卷 1805-1807页

作者： Luisa Tomasello Shoshanah m.Holub Giovanni Nigita Rosario Distefano Carlo m.Croce Department of Cancer Biology and Genetics The Ohio State UniversityColumbusOHUSA Department of Internal medicine Division of HematologyThe Ohio State UniversityColumbusOHUSA

Dear Editor,microRNAs(miRNAs)are small non-coding RNAs crucial for post-transcriptional gene regulation,processed from primary miRNA transcripts by Drosha and Dicer.1 Latest advancements in Next Generation Sequencing highlighted the existence of miRNA isoforms(isomiRs)resulting from alternative processing,RNA editing,or post-transcriptional modifications.

关键词： breast cancer advancement

Dust particle surface potential in an argonhelium plasma using the(r,q)-distribution function

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Communications in Theoretical Physics 2024年第9期76卷 141-148页

作者： Bahaaudin m Raffah A A Abid Abdullah Khan Amin Esmaeili Yas Al-Hadeethi m N S Qureshi Department of Physics Faculty of SciencesKing Abdulaziz UniversityJeddah 21589Saudi Arabia Lithography in Devices Fabrication and Development Research Group Deanship of Scientific ResearchKing Abdulaziz UniversityJeddah 21589Saudi Arabia Joint Laboratory of Plasma Application Technology Institute of Advanced TechnologyUniversity of Science and Technology of ChinaHefei230026China CAS Key Laboratory of Geospace Environment University of Science and Technology of ChinaHefei230026China Department of Physics Zhejiang Normal UniversityJinhua321005China Department of Physics Graduate School of ScienceTokyo Metropolitan UniversityMinami-Osawa 1-1Hachioji City192-0397Japan Department of Physics GC UniversityLahore 54000Pakistan

In this paper,the dust particle surface potential for argon-helium plasma is evaluated analytically and numerically in the context of negatively charged dust particles by employing a power-law(r,q)-distribution *** studies have reported the argon-helium plasma and conducted a brief theoretical and experimental *** deepen our understanding further,this study aims to analyze the argon-helium plasma comprehensively using the same pattern but with the(r,q)-distribution *** this purpose,the current balance equations are derived for electron,helium and argon ions,when these charge species attain the quasineutrality *** numerically examined the currents of plasma species for a broad range of effective distribution function parameters r and *** is revealed that the surface potential of dust particles is significantly affected by the parameters r and q,helium ion-to-electron temperature ratio,argon ion-to-electron temperature ratio,and helium ion to argon ion number density *** incorporating the multi-ion(argon-helium)species,the significance of low-temperature nonmaxwellian dusty(complex)plasma is briefly examined.

关键词： dusty plasma dust charge potential plasma physics helium argon plasma r q distribution function non-maxwellian distribution

Grain refinement of mg-Ca alloys by native mgO particles

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Journal of magnesium and Alloys 2024年第3期12卷 980-996页

作者： Shihao Wang Yun Wang Quentin m.Ramasse Zhongyun Fan Super STEm Laboratory SciTech Daresbury CampusDaresbury WA44ADUK School of Chemical and Process Engineering University of LeedsLeeds LS29JTUK BCAST Brunel University LondonUxbridgeMiddlesex UB83PHUK

In mg-Ca alloys the grain refining mechanism,in particular regarding the role of nucleant substrates,remains the object of *** native mgO is being recognised as a nucleating substrate accounting for grain refinement of mg alloys,the possible interactions of mgO with alloying elements that may alter the nucleation potency have not been elucidated ***,we design casting experiments of mg-xCa alloys varied qualitatively in number density of native mgO,which are then comprehensively studied by advanced electron *** results show that grain refinement is enhanced as the particle number density of mgO *** native mgO particles are modified by interfacial layers due to the co-segregation of Ca and N solute atoms at the mgO/mg *** aberration-corrected scanning transmission electron microscopy and electron energy loss spectroscopy,we reveal the nature of these Ca/N interfacial layers at the atomic *** of the crystallographic termination of mgO,Ca and N co-segregate at the mgO/mg interface and occupy mg and O sites,respectively,forming an interfacial structure of a few atomic *** interfacial structure is slightly expanded,less ordered and defective compared to the mgO matrix due to compositional deviations,whereby the mgO substrate is altered as a poorer template to nucleate mg *** solidification in a TP-1 mould,the impotent mgO particles account for the grain refining mechanism,where they are suggested to participate into nucleation and grain initiation processes in an explosive *** work not only reveals the atomic engineering of a substrate through interfacial segregation but also demonstrates the effectiveness of a strategy whereby native mgO particles can be harnessed for grain refinement in mg-Ca alloys.

关键词： mg-Ca alloy Grain refinement mgO Interfacial segregation STEm/EELS Solidification.

A seed and soil model of loneliness in Alzheimer's disease

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Neural Regeneration Research 2024年第12期19卷 2575-2576页

作者： Hannah L.Apostolou Ian m.mcDonough Department of Psychology The University of AlabamaTuscaloosaALUSA Department of Psychology Binghamton UniversityBinghamtonNYUSA

Loneliness is classically defined as a result of perceiving a discrepancy between the desired quantity and quality of one's social life and actual social relationships(Perlman and Peplau,1984).Lifespan research has indicated older adults are among the highest risk for experiencing loneliness because their social network size decreases more frequently than that of younger adults.

关键词： Alzheimer younger soil

Highly toxic Aβ begets more Aβ

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Neural Regeneration Research 2024年第9期19卷 1871-1872页

作者： merc m.Kemeh Noel D.Lazo Gustaf H.Carlson School of Chemistry and Biochemistry Clark UniversityWorcesterMAUSA

Alzheimer’s disease(AD)is the most common form of dementia-the 7th leading cause of death *** the tissue level,AD is characterized by the presence of extracellular amyloid plaques that are comprised primarily of the amyloid-βpeptide(Aβ),and by intraneuronal neurofibrillary tangles composed of *** genetics of early-onset AD and longitudinal brain-imaging studies of late-onset AD indicate that extracellular Aβdeposition,in general,precedes neurofibrillary tangle formation in neurons(Hampel et al.,2021;Young-Pearse et al.,2023).

关键词： Aβ tau Alzheimer death

Neurovascular unit on a chip:the relevance and maturity as an advanced in vitro model

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Neural Regeneration Research 2024年第6期19卷 1165-1166页

作者： Sujey Palma-Florez Anna Lagunas mònica mir Nanobioengineering Group Institute for Bioengineering of Catalonia(IBEC)Barcelona Institute of Science and Technology(BIST)BarcelonaSpain CIBER-BBN ISCIIIMadridSpain Department of Electronics and Biomedical Engineering University of BarcelonaBarcelonaSpain

The brain is a high-energy demanding organ,consuming around 20%of the metabolic energy *** fulfill this demand,cerebral blood flow(CBF)supplies oxygen and glucose continuously through the intricate network of cerebral blood *** for many years brain activity and blood flow were conceived as independent processes,mRI-based functional brain imaging demonstrated that there is a coupling between them.

关键词： cerebral maturity consuming

Hydroxytyrosol and Parkinson's disease:protective actions against alpha-synuclein toxicity

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Neural Regeneration Research 2024年第7期19卷 1427-1428页

作者： Ruth Hornedo-Ortega Ana m.Espinosa-Oliva Departamento de Nutrición y Bromatología Toxicología y Medicina LegalFacultad de FarmaciaUniversidad de SevillaSevilleSpain Instituto de Biomedicina de Sevilla IBiS/Hospital Universitario Virgen del Rocío/CSIC/Universidad de SevillaSevillaSpain Departamento de Bioquímica y Biología molecular Facultad de FarmaciaUniversidad de SevillaSevillaSpain

Parkinson’s disease:Parkinson’s disease(PD) is the second most prevalent neurodegenerative disease,after Alzheimer’s disease,affecting 1%of the general population over the age of *** to data from the World Health Organization(WHO),its prevalence has doubled in the past 25 *** 2019,global estimates indicated over 8.5 million individuals with PD and it is suggested that PD caused 329000 deaths,an increase of over 100% since 2000(WHO,2022).

关键词： protective Alzheimer prevalence

Clinical implications of reconsideration of enthesitis/enthesopathy/enthesial erosion,as tendon attachmentlocalized avulsions and stress fracture equivalents

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World Journal of Orthopedics 2024年第10期15卷 902-907页

作者： Bruce m Rothschild Department of medicine Indiana University Ball Memorial HospitalMuncieIN 47303United States

Recognizing the mechanical origin of enthesitis/enthesopathy and the avulsion-nature of what had previously been considered erosions,it seems inappropriate to attribute it to stresses related to a person’s normal ***,sudden or unconditioned repetitive stresses appears the more likely *** of enthesial reaction have lacked standardization as to findings present among individuals who appear to be *** evaluation by palpation and mani-pulation may be as effective as application of radiologic *** of the mechanical nature of the disease,including individuals with inflammatory arthritis suggests prescription of mechanical solutions that reduce stresses across the involved enthesis.

关键词： Enthesitis Epicondylitis Erosion Avulsion Clinical examination

Assessment of spongy moth infestation impacts on forest productivity and carbon loss using the Sentinel-2 satellite remote sensing and eddy covariance flux data

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Ecological Processes 2024年第2期13卷 231-245页

作者： Nur Hussain Alemu Gonsamo Shusen Wang m.Altaf Arain School of Earth Environment and Society and McMaster Centre for Climate Change Mc Master University Canada Centre for Remote Sensing Natural Resources Canada

Background Deciduous forests in eastern North America experienced a widespread and intense spongy moth（Lymantria dispar） infestation in 2021. This study quantified the impact of this spongy moth infestation on carbon（C） cycle in forests across the Great Lakes region in Canada, utilizing high-resolution（10 × 10 m2） Sentinel-2 satellite remote sensing images and eddy covariance（EC） flux data. Study results showed a significant reduction in leaf area index（LAI） and gross primary productivity（GPP） values in deciduous and mixed forests in the region in *** Remote sensing derived, growing season mean LAI values of deciduous（mixed） forests were 3.66（3.18）, 2.74（2.64）, and 3.53（2.94） m2m-2in 2020, 2021 and 2022, respectively, indicating about 24（14）% reduction in LAI, as compared to pre-and post-infestation years. Similarly, growing season GPP values in deciduous（mixed） forests were 1338（1208）, 868（932）, and 1367（1175） g C m-2, respectively in 2020, 2021 and 2022, showing about 35（22）% reduction in GPP in 2021 as compared to pre-and post-infestation years. This infestation induced reduction in GPP of deciduous and mixed forests, when upscaled to whole study area（178,000 km2）, resulted in 21.1（21.4） mt of C loss as compared to 2020（2022）, respectively. It shows the large scale of C losses caused by this infestation in Canadian Great Lakes *** The methods developed in this study offer valuable tools to assess and quantify natural disturbance impacts on the regional C balance of forest ecosystems by integrating field observations, high-resolution remote sensing data and models. Study results will also help in developing sustainable forest management practices to achieve net-zero C emission goals through nature-based climate change solutions.

关键词： Spongy moth Infestation Carbon Gross ecosystem productivity Leaf area index Temperate forest Remote sensing Sentinel-2 Eddy covariance