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The Physiopathological Crossroads of Aging

Journal of Biosciences and medicines 2019年第6期7卷 102-128页

作者： J.Lasierra-Cirujeda P.Coronel m.J.aza pascual-salcedo m.Gimeno m.m.aza pascual salcedo A.Lasierra-Ibanez C.Lasala-aza logrono(la rioja) spain tedec-meji farma saalcala de henaresmadridspain pharmacy service la rioja health departmentla riojaspain pharmacy service aragon health servicezaragozaspain sciences faculty grade biochemistryuniversity of navarranavarraspain pharmacy faculty university of valenciavalenciaspain

Stress, inflammation and Plasminogen activator inhibitor 1 (PAI-1) are key mechanisms throughout the development of aging, constituting a crossroad in the most frequent pathologies that accompany it. Among metabolic processes, obesity, metabolic syndrome and type 2 diabetes mellitus are included and Alzheimer’s disease among the neurodegenerative processes. Stress is a mechanism of defense of the organism against exogenous and endogenous actions called stressors. In the case of low intensity stimuli, the organism responds with actions aimed at a physiological adaptation (Homeostasis). On the other hand, when a high intensity (experimental level) or chronic stimulus (oxidative stress) is repeated, structural and functional changes are observed in different organs with activation of the hypothalamus-pituitary-adrenal axis, the renin angiotensin system and the sympathetic nervous system, stimulating the production of hormones that release cytokines with proin-flammatory/antiinflammatory properties that play an important role in the previously mentioned pathologies, as well as a marked increase in PAI-1, a gene regulated by stress and by cytokines, with manifest action at the origin of thromboembolic disease, so frequent in aging. The objective of this review is to highlight the importance of the binomial stress and PAI-1 in aging and in the pathologies that accompany it. Because PAI-1 is part of the pathology and complications in aging, some authors suggest the study of PAI-1 inhibitors to achieve its physiological levels, as part of the treatment of these diseases.

关键词： Aging. Oxidative Stress Plasminogen Activator Inhibitor 1 Transforming Growth Factor Beta 1 Glutathione Alzheimer’s Disease

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Sulodexide and Alzheimer’s Disease: A Preliminary Prospective Study

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World Journal of Cardiovascular Diseases 2016年第2期6卷 54-71页

作者： Joaquín Lasierra-Cirujeda maría José aza pascual-salcedo maría mercedes aza pascual-salcedo C. medicine Hematology Logrono Spain The Rioja and Pharmaceutical Act Ministry of Health The Rioja Regional Government Logrono Spain Aragon Health Service Zaragoza Spain

The purpose of this prospective study is to determine the relative incidence of Alzheimer’s disease in patients treated for at least three years, with sulodexide (n = 46, 76.48 ± 7.02 years old) or acenocoumarol (n = 47, 78.21 ± 6.66 years old) in order to prevent primary and secondary venous thromboembolism and atherothrombotic disease. In the sulodexide group, there was an apparent prevention of cognitive and behavioural impairment (relative incidence: 2.02) compared with acenocoumarol group (relative incidence: 4.86). The favourable results in sulodexide group may be related to their pharmacodynamic actions of inhibition of PAI-1, which may interfere with the pathogenesis of Alzheimer’s disease, and to the role of glutathione and PAI-1 in the β-amyloid system in the brain.

关键词： Sulodexide Alzheimer’s Disease Glutathione t-PA PAI-1 Plasminogen Plasmin

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Aging: Thromboembolic Disease, metabolic Syndrome, Type 2 Diabetes mellitus, and Alzheimer’s Disease

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Journal of Biosciences and medicines 2016年第5期4卷 1-20页

作者： Joaquín Lasierra-Cirujeda maría José aza pascual-salcedo Alicia Lasierra-Ibañez Carmen Lasala aza maría mercedes aza pascual-salcedo Centro médico Hematológico Logrono Spain Pharmaceutical Act ministry of Health La Rioja Regional Government Logrono Spain Aragon Health Service Zaragoza Spain

Aging can be interpreted as an unavoidable process whose end point is the death. Aging entails, in the hemostasis field, some changes that favour blood hypercoagulability. Both the plasminogen activator inhibitor (PAI-1), specific inhibitor of the tissue plasminogen activator (t-PA), accompanied by the oxidative stress and the marked decrease of the main antioxidant—glutathione are fundamental in the bases of elderly pathologies which can cause death. There is some scientific evidence of the relationship between aging, neuro-degenerative diseases, an excessive production of reactive oxygen species and the decrease of proteolysis in brain. The cerebral plasminogen/plasmin system represents the essential proteolytic mechanism that degrades amyloid peptides (β-amyloidosis) for action of plasmin with effectiveness. This physiologic process is being considered as a preventive neurodegenerative mechanism. At the same time, the decrease of glutathione levels in aging entails a decrease of cerebral plasmin activity and a progressive descent of t-PA activity due to a descent in t-PA expression and an increase in PAI production. All of them entail an increment of amyloid beta peptides (Aβ) production and a lower level of their clearance. Both mechanisms, oxidative stress, direct consequence of the oxygenate metabolism of aerobics cells, and changes in the systemic fibrinolysis and cerebral b-amyloidolytic activity, play a very important role in thromboembolic disease, metabolic syndrome—obesity, insulin resistance, hyperglycemia—, type 2 Diabetes mellitus and Alzheimer’s disease, clinical processes that accompany the aging. In this revision we show the importance of the interaction between glutathione, proteolytic t-PA/plasminogen/plasmin system, and the inhibitor PAI-1 in aging physiopathology, whose results suggest the hypothesis of the importance of a therapeutic strategy using the inhibition of PAI-1 as a goal, because it is increased in the different aging pathologic pro

关键词： Aging Alzheimer’s Disease T2Dm PAI-1 Glutathione

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An Iterative Domain Decomposition Algorithm for the Grad(div)Operator

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Communications in Computational Physics 2009年第2期5卷 391-397页

作者： E.Ahusborde m.azaıez m.O.Deville E.H.mund TREFLE (UMR CNRS 8505)Ecole Nationale Superieure de Chimie et de Physique de BordeauxPessacFrance Laboratory of Computational Engineering Ecole Polytechnique Federale de Lausanne1015 LausanneSwitzerland Unite de Thermodynamique UCL1348 Louvain-La-NeuveBelgium

This paper describes an iterative solution technique for partial differential equations involving the grad(div)operator,based on a domain *** are performed to solve the solution on the *** identify the transmission relationships through the *** relate the approach to a Steklov-Poincare operator,and we illustrate the performance of technique through some numerical experiments.

关键词： Domain decomposition grad(div)operator stable approximation iterative substructuring method Steklov-Poincar´e operator

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Surveillance and diagnosis of hepatocellular carcinoma: A systematic review

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World Journal of Clinical Cases 2019年第16期7卷 2269-2286页

作者： Sonia pascual Cayetano miralles Juan m Bernabé Javier Irurzun mariana Planells Liver Unit Hospital General Universitario de AlicanteAlicante 03010Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBEREHDAlicante 03010Spain Radiology Department Hospital General Universitario de AlicanteAlicante 03010Spain

BACKGROUND Hepatocellular carcinoma (HCC) appears in most of cases in patients with advanced liver disease and is currently the primary cause of death in this *** of HCC has been proposed and recommended in clinical guidelines to obtain earlier diagnosis,but it is still controversial and is not accepted *** To review the actual evidence to support the surveillance programs in patients with cirrhosis as well as the diagnosis *** Systematic review of recent literature of surveillance (tools,interval,cost-benefit,target population) and the role of imaging diagnosis (radiological non-invasive diagnosis,optimal modality and agents) of *** The benefits of surveillance of HCC,mainly with ultrasonography,have been assessed in several prospective and retrospective analysis,although the percentage of patients diagnosed in surveillance programs is still *** of HCC permits diagnosis in early stages allows better access to curative treatment and increases life expectancy in patients with *** is a tumor with special radiological characteristics in computed tomography and magnetic resonance imaging,which allows highly accurate diagnosis without routine biopsy *** actual recommendation is to perform biopsy only in indeterminate *** The evidence supports the recommendation of performing surveillance of HCC in patients with cirrhosis susceptible of treatment,using ultrasonography every 6 *** diagnosis evaluation of HCC can be established based on noninvasive imaging criteria in patients with cirrhosis.

关键词： Surveillance Hepatocellular carcinoma Ultrasonography Cirrhosis Imaging diagnosis

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Optimizing Electroless Plating of Ni-mo-P Coatings Toward Functional Ceramics

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Acta metallurgica Sinica(English Letters) 2020年第3期33卷 437-445页

作者： N.ma.Rosas-Laverde A.Pruna J.Cembrero m.pascual J.Orozco-messana Department of materials and mechanical Engineering Universitat Politecnica de ValenciaValenciaSpain Department of materials Escuela Politecnica NacionalQuitoEcuador Center for Surface Science and Nanotechnology Polytechnic University of BucharestBucharestRomania Instituto de Tecnologia de materiales Universitat Politecnica de ValenciaValenciaSpain

Ni-mo-P coatings are obtained at the surface of ceramic substrate by electroless deposition using palladium as a surface *** influence of catalyst activation conditions on coatings’ properties was assessed by structural,morphological,electrical,mechanical measurements and adhesion strength by using X-ray diffraction,field emission scanning electron microscopy,atomic force microscopy,Hall effect and nanoindentation techniques,*** results indicated the formation of dense,continuous and uniform coatings consisting mainly of *** coatings obtained at 300℃for 12 h exhibited the best electrical properties,namely resistivity of 9.32 μΩ cm,smaller roughness(Ra 0.090 μm) and average mechanical *** adhesion tests showed a firm adherence of the Ni-mo-P coatings to the ceramic *** results of this study could offer an approach for obtaining conducting ceramic substrates in order to be employed in photovoltaic *** performance of demonstrative heterojunction solar cell obtained with such metallized ceramic is indicative of the high potential of the Ni-mo-P electroless coatings for functional ceramics.

关键词： Electroless plating Ni-mo-P Ceramic Solar cell

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Effect of the dietary supplementation with extracts of chestnut wood and grape pomace on performance and jejunum response in female and male broiler chickens at different ages

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Journal of Animal Science and Biotechnology 2023年第1期14卷 212-228页

作者： A.pascual m.Pauletto A.Trocino m.Birolo m.Dacasto m.Giantin F.Bordignon C.Ballarin m.Bortoletti G.Pillan G.Xiccato Department of Agronomy FoodNatural ResourcesAnimal and Environment(DAFNAE)University of PadovaViale dell’Universita 1635020 PadovaLegnaroItaly. Department of Comparative Biomedicine and Food Science(BCA) University of PadovaViale dell’Universita 1635020 PadovaLegnaroItaly.

Background:Recently,interest in the use of herbs and phytogenic compounds has grown because of their potential role in the production and health of livestock *** these compounds,several tannins have been tested in poultry,but those from chestnut wood and grape-industry byproducts have attracted remarkable ***,the present study aimed to gain further insights into the mechanisms involved in the response to the dietary supplementation with extracts of chestnut wood or grape *** this purpose,864 broiler chickens were fed a control diet(C)or the same diet supplemented 0.2%chestnut wood(CN)extract or 0.2%grape pomace(GP)extract from hatching until commercial slaughtering(at 45 days of age)to assess their effects on performance,meat quality,jejunum immune response and whole-transcriptome profiling in both sexes at different ages(15 and 35 d).Results:Final live weight and daily weight gain significantly increased(Pmpared to CN and C *** villi height was lower in chickens fed the CN diet than in those fed the C diet(Pmoreover,a lower density of CD45~+cells was observed in chickens fed the CN diet(Pmpared to those fed the C and GP *** involved in either pro-or anti-inflammatory response pathways,and antimicrobial and antioxidant responses were affected by GP and CN *** was no effect of the dietary treatment on meat *** sex,in addition to a lower growth performance,females showed a lower occurrence of wooden breast(16.7%vs.55.6%;Pmeat(48.6%vs.4.17%;Pmajor muscles after slaughtering than those in *** on the results of whole-transcriptome profiling,a significant activation of some molecular pathways related to immunity was observed in males compared with those of ***:The GP supplementation improved chicken performance and promoted immune responses in the intestinal mucosa;moreover,a

关键词： Growth Immunohistochemistry meat quality Tannins Transcriptome

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Effect of dietary supplementation with yeast cell wall extracts on performance and gut response in broiler chickens

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Journal of Animal Science and Biotechnology 2020年第3期11卷 736-746页

作者： A.pascual m.Pauletto m.Giantin G.Radaelli C.Ballarin m.Birolo C.Zomeño m.Dacasto m.Bortoletti m.Vascellari G.Xiccato A.Trocino Department of Comparative Biomedicine and Food Science(BCA) University of PadovaViale dell’Università16I-35020 LegnaroPadovaItaly department of agronomy foodnatural resourcesanimaland environment(dafnae)university of padovaviale dell’università16i-35020 legnaropadovaitaly histopathology department istituto zooprofilattico sperimentale delle venezieviale dell’università10i-35020 legnaropadovaitaly

Background:The dietary supplementation of yeast cell wall extracts(YCW)has been found to reduce pathogenic bacteria load,promote immunoglobulin production,prevent diseases by pro-inflammatory responses,and alter gut microbiota *** study evaluated growth and slaughter results,health,gut morphology,immune status and gut transcriptome of 576 male chickens fed two diets,i.e.C(control)or Y(with 250–500 g/t of YCW fractions according to the growth period).At 21 and 42 d the jejunum of 12 chickens per diet were sampled and stained with hematoxylin/eosin for morphometric evaluation,with Alcian-PAS for goblet cells,and antibodies against CD3+intraepithelial T-cells and CD45+intraepithelial *** jejunum sampled at 42 d were also used for wholetranscriptome ***:Dietary YCW supplementation did not affect final live weight,whereas it decreased feed intake(114 to 111 g/d;P≤0.10)and improved feed conversion(1.74 to 1.70;P≤0.01).Regarding the gut,YCW supplementation tended to increase villi height(P=0.07);it also increased the number of goblet cells and reduced the density of CD45+cells compared to diet C(Pme,four genes were expressed more in broilers fed diet Y compared to diet C,*** P450,family 2,subfamily C,polypeptide 23b(CYP2C23B),tetratricopeptide repeat domain 9(TTC9),basic helix-loop-helix family member e41(BHLHE41),and the metalloreductase *** one gene set(HES_PATHWAY)was significantly enriched among the transcripts more expressed in broilers fed diet ***,a total of 41 gene sets were significantly over-represented among genes up-regulated in control ***,several enriched gene sets are implicated in immune functions and related to NF-κB signaling,apoptosis,and interferon ***:The dietary YCW supplementation improved broiler growth performance,increased gut glycoconjugate secretion and reduced the inflammatory status together with differences in the gut tran

关键词： Gut morphometry Immuno-histochemistry Saccharomyces cerevisiae Transcriptomic analysis

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A regionalized IO-model to value seasonal recreational ecosystem services in a mountain National Park in Spain

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Journal of mountain Science 2022年第1期19卷 211-227页

作者： Víctor mARTIN BARROSO mónica de CASTRO-PARDO pascual FERNÁNDEZ mARTÍNEZ João C.AZEVEDO Department of Applied Economics I and history and economic institutions Faculty of Law and Social SciencesUniversidad Rey Juan CarlosCampus of VicálvaroTulipanMóstoles 28933Spain Department of Financial and Actuarial Economics and Statistics-Statistics and Operational Research Complutense University of MadridCampus of SomosaguasPozuelo de Alarcon 28223Spain Centro de Investigação de montanha Instituto Politécnico de BragançaCampus de Santa ApolóniaBragança 5300-253Portugal

Recreational Ecosystem Services(RES)are among the most frequently evaluated ecosystem *** are seen as a major opportunity for sustainable development in areas of high ecological value resulting from the presence of emblematic species,habitats or scenery,often integrated in conservation areas,in particular in mountain areas affected by depopulation,rising environmental risks and ***,the assessment of RES has been based on Contingent Valuation and Choice Experiments,methods with limitations related to their ***,Input-Output(IO)models provide a very accurate and effective way of valuation of RES with regional information regarding interindustry *** data on nature tourist expenditure may be only available annually,tourism inflows have a strong seasonal behavior,which impacts the profitability of several local economic *** this paper,we firstly constructed a novel regionalized IO-model based on Cross-Industry Location Quotients using employment data and,secondly,based on monte Carlo simulation,we estimated nature tourist expenditure monthly using data on nature tourism *** method allowed for a more precise RES evaluation,estimating direct,indirect and induced monthly economic impacts of nature-based *** method was applied to the Ordesa and monte Perdido(OmP)National Park in the Spanish *** estimate the average tourist expenditure,we collected and analyzed spending on commerce,hospitality and restaurants,leisure,and transport of 385 *** suggest that using a regionalized IO model leads to a considerable reduction of over-estimation of the economic impact of tourist expenditure estimated by conventional *** into consideration the direct,indirect and induced effects of tourist expenditure in 2016-2018,the total annual output effect in the OmP National Park amounted to€208.8 million,while the total income effect amounted to€86.29 ***,a total of

关键词： Input-Output monte Carlo Simulation Location quotients Recreational Ecosystem Services Nature tourism Sustainable mountain development

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A socioeconomic approach to the profile of microcredit holders from the Hispanic minority in the USA

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Financial Innovation 2023年第1期9卷 484-508页

作者： Salvador Cruz Rambaud Joaquín López pascual Emilio m.Santandreu Departamento de Economía y Empresa Universidad de Almería04120 AlmeríaSpain Departamento de Economía de la Empresa Universidad Rey Juan Carlos28032 VicálvaroMadridSpain OUR microlending LLC MiamiFL 33145USA

The subject of this study is the microcredit market in the USA,more specifically in *** justification for choosing this specific state is the massive presence of the Hispanic *** will facilitate a generalization of the obtained results to the microcredit market in Latin American ***,the objective of this study is to analyze the profile of microcredit holders and their companies from socioeconomic and financial points of *** our data also consider the degree of repayment of the microloans included in the sample,the clients’profile is related to the punctuality or default of their corresponding loan repayments using the methodology of multi-nomial logit *** variables used in this study refer to personal information concerning borrowers(gender,age,education level,and marital status),the economic situation of their respective companies(closeness to the lender,number of workers,and revenues),and the characteristics of granted loans(principal,term,and purpose).However,the results of the regression show that only two variables are significant at the 5%significance level:the borrower’s age,which has a positive effect on repay-ment punctuality,and the loan term,which exhibits a negative *** findings of this study have clear implications,as they can help lenders design suitable microloans adjusted to customer ***,future research should include other demograph-ics and characteristics of affected companies.

关键词： microcredit Customer profile Socioeconomic factors multinomial logit regression Repayment microentrepreneurship

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