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World Journal of Stem Cells 2016年第2期8卷 32-46页

作者： Gayle F petersen Padraig m Strappe School of Biomedical Sciences Charles Sturt University

A characteristic of neurological disorders is the loss of critical populations of cells that the body is unable to replace,thus there has been much interest in identifying methods of generating clinically relevant numbers of cells to replace those that have been damaged or *** process of neural direct conversion,in which cells of one lineage are converted into cells of a neural lineage without first inducing pluripotency,shows great potential,with evidence of the generation of a range of functional neural cell types both in vitro and in vivo,through viral and non-viral delivery of exogenous factors,as well as chemical induction *** neural cells have been proposed as an attractive alternative to neural cells derived from embryonic or induced pluripotent stem cells,with prospective roles in the investigation of neurological disorders,including neurodegenerative disease modelling,drug screening,and cellular replacement for regenerative medicine applications,however further investigations into improving the efficacy and safety of these methods need to be performed before neural direct conversion becomes a clinically viable *** this review,we describe the generation of diverse neural cell types via direct conversion of somatic cells,with comparison against stem cell-based approaches,as well as discussion of their potential research and clinical applications.

关键词： Adult stem cells Embryonic stem cells Generation of neural cells Induced pluripotent stem cells In vitro differentiation In vivo differentiation Clinical applications Direct conversion Induced neural cells

Biomechanics associated with tibial stress fracture in runners:A systematic review and meta-analysis

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Journal of Sport and Health Science 2023年第3期12卷 333-342页

作者： Clare E.milner Eric Foch Joseph m.Gonzales Drew petersen Department of Physical Therapy and Rehabilitation Sciences Drexel UniversityPhiladelphiaPA 19102USA Department of Health Sciences Central Washington UniversityEllensburgWA 98926USA

Background:Tibial stress fracture(TSF)is an overuse running injury with a long recovery *** many running studies refer to biomechanical risk factors for TSF,only a few have compared biomechanics in runners with TSF to *** aim of this systematic review and meta-analysis was to evaluate biomechanics in runners with TSF compared to ***:Electronic databases Pubmed,Web of Science,SPORTDiscus,Scopus,Cochrane,and CINAHL were *** of bias was assessed and meta-analysis conducted for variables reported in 3 or more ***:The search retrieved 359 unique records,but only the 14 that compared runners with TSF to controls were included in the *** studies were retrospective,2 were prospective,and most had a small sample size(5-30 per group).many variables were not significantly different between ***-analysis of peak impact,active,and braking ground reaction forces found no significant differences between *** studies found larger tibial peak anterior tensile stress,peak posterior compressive stress,peak axial acceleration,peak rearfoot eversion,and hip adduction in the TSF ***:meta-analysis indicated that discrete ground reaction force variables were not statistically significantly different in runners with TSF compared to *** individual included studies,many biomechanical variables were not statistically significantly different between ***,many were reported by only a single study,and sample sizes were *** encourage additional studies with larger sample sizes of runners with TSF and controls and adequate statistical power to confirm or refute these findings.

关键词： Bone stress injury Gait Kinematics Kinetics Tibial acceleration

Association between dairy intake,lipids and vascular structure and function in diabetes

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World Journal of Diabetes 2017年第5期8卷 202-212页

作者： Kristina S petersen Jennifer B Keogh Natalie Lister Jacquelyn m Weir Peter J meikle Peter m Clifton School of Pharmacy and medical Sciences and Sansom Institute for Health Research University of South Australia Baker IDI Heart and Diabetes Institute

AIm To determine lipid species that change in response to a change in dairy consumption. In addition, to investigate whether dairy associated lipid species are correlated with changes in measures of vascular structure and *** A 12-mo randomised controlled trial was conducted to determine the effect of increased consumption of fruit, vegetables and dairy, compared to usual diet, on measures of vascular structure and function in adults with type 1 and type 2 diabetes(n = 108). Thispaper comprises post-hoc analyses investigating the relationship between dairy intake, serum lipid species and vascular health. Central and peripheral blood pressure, carotid femoral pulse wave velocity, augmentation index, serum lipid species and dietary intake were measured at baseline and 3-mo. Common carotid artery intima media thickness was measured at baseline and *** Serum lipid species [lysophosphatidylcholine(LPC) 14:0, LPC 15:0, LPC 16:1, phosphatidylcholine(PC) 29:0 PC 30:0, PC 31:0 and cholesterol ester(CE) 14:0] were associated with the change in full fat dairy consumption(rho 0.19-0.25; P mo change in some lipids was positively associated with the 3-mo change in central systolic [LPC 14:0(rho 0.30; P = 0.007), PC 30:0(rho 0.28; P = 0.010)] and diastolic blood pressure [LPC 14:0(rho 0.32; P = 0.004), LPC 15:0(rho 0.23; P = 0.04), LPC 16:1(rho 0.23; P = 0.035), PC 29:0(rho 0.28; P = 0.01), PC 30:0(rho 0.36; P = 0.001), PC 31:0(rho 0.30; P = 0.007)] and 12-mo change in common carotid artery intimal medial thickness [CE 14:0(rho 0.22; P = 0.02)]. Pulse wave velocity and augmentation index were unrelated to dairy and lipid *** An increase in dairy associated lipids appears to be associated with an increase in blood pressure and common carotid intimal medial thickness.

关键词： Lipids Phospholipids Atherosclerosis Dairy Lysophosphatidylcholine Lipidomics Carotid intima media thickness Pulse wave velocity Diabetes

Sclerotherapy as a primary or salvage procedure for aneurysmal bone cysts:A single-center experience

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世界骨科杂志:英文版 2023年第9期14卷 698-706页

作者： Kolja Sebastian Weber Claus Lindkær Jensen michael mørk petersen Department of Orthopedic Surgery RigshospitaletCopenhagen 2100Denmark

BACKGROUND Aneurysmal bone cysts(ABC)are benign cystic bone tumors of an osteolytic and locally aggressive *** an alternative to the primary treatment of choice,which consists of curettage with bone grafting,alternative treatment methods with promising results have been *** our department,we have,in recent years,used percutaneous sclerotherapy with *** objective of this study was to identify the healing rate and safety of sclerotherapy with *** To identify the efficacy and safety of sclerotherapy with polidocanol in primary and recurrent *** Twenty-two consecutive patients(median age 12.5 years;range 1-27)with 23 ABCs treated with sclerotherapy with polidocanol from 2016-2021 were included *** patients(48%)had undergone different forms of previous treatment with *** general anesthesia and fluoroscopic guidance,repeated percutaneous injections of 4mg polidocanol/kg body weight were *** review of the electronic medical records,the following were identified:healing and recurrence rate,number of treatments,gender,age,comorbidity,location of the tumor and side effects/complications,as well as any previous surgery for *** median length of radiographic follow-up was 19.5 *** All ABCs except one(96%)showed healing or stable disease after a median of 4(range 1-8)*** clinical and radiographic healing was observed in 16 cysts(70%),while partial radiographic healing with resolution of pain was seen in 6 cases(26%)and considered as stable *** cyst that failed to heal had previously undergone curettage twice with *** patient with a large pelvic ABC experienced,right after two injections,a sudden drop in blood pressure,which could quickly be *** patient with a juxtaphyseal ABC in the femoral neck showed a minor limb length discrepancy because of *** that,no complications were *** Percutaneous sclerotherapy

关键词： Aneurysmal bone cyst Bone tumor Sclerotherapy Polidocanol Healing rate Complications

more abundant and healthier meat:will the mSTN editing epitome empower the commercialization of gene editing in livestock?

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Science China(Life Sciences) 2022年第2期65卷 448-450页

作者： Xiaolong Wang Björn petersen Key Laboratory of Animal Genetics Breeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F UniversityYangling 712110China Institute of Farm Animal Genetics Friedrich-Loeffler-Institute(FLI)Mariensee 31535Germany

In recent years,various gene-edited crops and livestock have been developed to find rapid and unconventional solutions to boost agriculture,animal breeding,environmental sustain-ability,and animal *** the animal production field,significant gene-edited livestock with economic beneficial traits,like the mSTN-edited double muscles,can be com.m.rcialized on a large scale to benefit more people with real *** demand for animal proteins increases an-nually with improvement of living conditions in modern societies and developing ***,the number of people with special needs for healthier meat(with high-protein and low-fat)is growing(e.g.,elderly patients with cardio/cerebrovascular diseases).With steady global en-vironmental deterioration,increasing human population,growing food demand,continuous disease outbreaks,and concerns regarding animal welfare。

关键词： abundant crops breeding

Clinical and dietary predictors of common carotid artery intima media thickness in a population with type 1 and type 2 diabetes: A cross-sectional study

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World Journal of Diabetes 2017年第1期8卷 18-27页

作者： Kristina S petersen Jennifer B Keogh Peter J meikle manohar L Garg Peter m Clifton School of Pharmacy and medical Sciences University of South Australia Baker IDI Heart and Diabetes Institute Nutraceuticals Research Group University of NewcastleCallaghan

AIm To determine the clinical and dietary predictors of common carotid artery intima media thickness(CCA ImT) in a cohort of subjects with type 1 and type 2 diabetes. mETHODS Participants with type 1(n = 23) and type 2 diabetes(n = 127) had mean and mean maxim.m.CCA ImT measured using B mode ultrasound. Dietary intake was measured using a food frequency questionnaire. Clinical and dietary predictors of mean and mean maxim.m.CCA ImT were determined using linear regression analysis adjusted for potential confounders. RESULTS The main predictors of mean and mean maxim.m.CCA ImT were age and weight. After multivariate adjustment there were no dietary predictors of CCA ImT. However,in subjects that were not prescribed a lipid lowering medication alcohol consumption was positively associated with CCA ImT after multivariate adjustment. No difference existed in CCA ImT between subjects with type 1 or type 2 diabetes once age was adjusted for. CONCLUSION CCA ImT was predominantly predicted by age and weight in these subjects with diabetes. The finding that CCA ImT was not different between people with type 1 and type 2 diabetes warrants further investigation in a larger cohort.

关键词： Diabetes Carotid intima media thickness Arterial structure Diet Lipidomics Carotenoids

Observational study of a new modular femoral revision system

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World Journal of Orthopedics 2020年第3期11卷 167-176页

作者： Karen Dyreborg michael mørk petersen Sidse Schwartz Balle Anne Grete Kjersgaard Søren Solgaard Department of Orthopaedic Surgery Herlev-Gentofte Hospital2900 HellerupDenmark Department of Orthopaedic Surgery Rigshospitalet2100 KøbenhavnDenmark Department of Diagnostic Radiology Herlev-Gentofte Hospital2900 HellerupDenmark

BACKGROUND The uncemented ArcosTm.m.dular Femoral Revision System(ARCOS)is a new comprehensive,press-fit revision *** modular design offers a wide range of possible combinations to accommodate different variations of anatomy and bone *** ARCOS is made by a proximal body and a distal *** probably the only ones worldwide we predominantly use a combination of body and stem which supports proximal fixation and load,since this m.m.cs the concept of the primary total hip arthroplasty with proximal weight-bearing,leading to bone stock preservation and no stress shielding or thigh *** To evaluate the early results after femoral revision in a consecutive series of patients undergoing surgery over 3 *** We included 116 patients in the *** were operated in the period August 2011 to December 2014 and we got a clinical mean observation time of 4(0.5-6)*** and radiographical follow-up included present function of the hip assessed by Harris Hip Score,Oxford Hip Score,and EQ5D(measure of health outcome).Of the 116 patients,17 died in the interim and were consequently included only in the implant survivorship analysis;46 patients attended the follow-up *** In total 6(5%)hips were re-revised due to infection(n=3),fracture(n=2)or subsidence(n=1).No patient was re-revised due to aseptic *** 1-,2-and 5-year probability of implant survival(95%CI)were 97%(93%-100%),97%(93%-100%)and 96%(92%-99%),*** this cohort 95 patients received a combination of a proximal broach and a distal curved and slotted stem(BS),aiming for proximal fixation and load bearing;21 patients received a different *** comparing these two groups the BS-group had a 5-year implant survival probability(95%CI)of 97%(93%-100%)compared with the group of other combinations with a 5-year implant survival probability(95%CI)of 90%(78%-100%)(P=0.3).Our regression analysis showed that periprosthetic fracture as an indication for the ARCO

关键词： Hip prosthesis Arthroplasty Implantation Replacement arthroplasty Total hip replacements modular femoral stem

mobilization of hematopoietic progenitor cells in patients with liver cirrhosis

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World Journal of Gastroenterology 2010年第2期16卷 217-224页

作者： Ursula m Gehling marc Willems Kathleen Schlagner Ralf A Benndorf maura Dandri Jrg petersen martina Sterneck Joerg-matthias Pollok Dieter K Hossfeld Xavier Rogiers Department of Hepatobiliary Surgery and Transplant Surgery University Hospital Hamburg-Eppendorf20246 HamburgGermany Department of medicine University Hospital Hamburg-Eppendorf20246 HamburgGermany Institute of Experimental and Clinical Pharmacology and Toxicology University Hospital Hamburg-Eppendorf20246 HamburgGermany Gent University Hospital and medical School 9000 GentBelgium

AIm:To test the hypothesis that liver cirrhosis is associated with mobilization of hematopoietic progenitor cells. mETHODS:Peripheral blood samples from 72 patients with liver cirrhosis of varying etiology were analyzed by flow *** progenitor cell subsets were immunoselected and used for functional assays in vitro. Plasma levels of stromal cell-derived factor-1(SDF-1) were measured using an enzyme linked immunosorbent ***:Progenitor cells with a CD133 + /CD45 + CD14 + phenotype were observed in 61%of th *** 1%and 26%of the peripheral bloo mononuclear cells(mNCs)displayed this phenotype Furthermore,a distinct population of c-kit + progenito cells(between 1%and 38%of the mNCs)could b detected in 91%of the ***,18% of the patients showed a population of progenito cells(between 1%and 68%of the mNCs)that wa characterized by expression of breast cancer resistanc *** phenotypic analysis disclosed tha the circulating precursors expressed CXC chemokin receptor 4,the receptor for *** line with thi finding,elevated plasma levels of SDF-1 were presen in all patients and were found to correlate with th number of mobilized CD133 + progenitor cells.

关键词： CD133 antigen CD14 antigen c-kit protein Breast cancer resistance protein-1 protein Progenitor cells CXC chemokine receptor 4 Stromal cell-derived factor-1 Liver cirrhosis

Non-Viral Deoxyribonucleoside Kinases——Diversity and Practical Use

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Journal of Genetics and Genomics 2015年第5期42卷 235-248页

作者： Louise Slot Christiansen Birgitte munch-petersen Wolfgang Knecht Department of Biology Lund University Department of Science Systems and ModelsRoskilde University Lund Protein Production Platform Lund University

Deoxyribonucleoside kinases （dNKs） phosphorylate deoxyribonucleosides to their corresponding monophosphate compounds, dNks also phosphorylate deoxyribonucleoside analogues that are used in the treatment of cancer or viral infections. The study of the m.m.alian dNKs has therefore always been of great medical interest. However, during the last 20 years, research on dNKs has gone into non- m.m.alian organisms. In this review, we focus on non-viral dNKs, in particular their diversity and their practical applications. The diversity of this enzyme family in different organisms has proven to be valuable in studying the evolution of enzymes. Some of these newly discovered enzymes have been useful in numerous practical applications in medicine and biotechnology, and have contributed to our understanding of the structural basis of nucleoside and nucleoside analogue activation.

关键词： Nucleosides Nucleotides Nucleoside salvage pathway Evolution Suicide gene therapy Deoxynucleosides Deoxynucleotides Deoxy-nucleoside kinases