检索结果-南通市图书馆

Photonics Research 2024年第5期12卷 1078-1092页

作者： RODRIGO mARTIN-HERNANDEZ lorenz GRUNEWALD LUIS SANCHEZ-TEJERINA LUIS PLAJA ENRIQUECONEJERO JARQUE CARLOS HERNANDEZ-GARCIA SEBASTIAN mAI Grupo de Investigacion en Aplicaciones del Laser y Fotonica Departamento de Fisica AplicadaUniversidad de SalamancaE-37008 SalamancaSpain Unidad de Excelencia en Luz y materia Estructuradas(LUmES) Universidad de SalamancaE-37008 SalamancaSpain Institute of Theoretical Chemistry Faculty of ChemistryUniversity of Vienna1090 ViennaAustria Vienna Doctoral School in Chemistry(DoSChem) Faculty of ChemistryUniversity of Vienna1090 ViennaAustria Departamento de Electricidad y Electrónica Universidad de Valladolid47011 ValladolidSpain

*** *** thank Valentina Shumakova,Elizaveta Gangrskaia,Alessandra Bellissimo,Audrius Pugzlys,and Andrius Baltu?ka for fruitful discussions and computational support by the Vienna Scientific Cluster(VSC 4).The authors thankfully acknowledge the computer resources at mareNostrum and SCAYLE,and the technical support provided by Barcelona Supercomputing Center(RES-FI-2022-3-0041).R.m.-H.,L.S.-T.,L.P.,E.C.J.,and C.H.-*** funding from the European Research Council(ERC)under the European Union’s Horizon 2020 research and innovation program(Grant Agreement No.851201)and support from ministerio de Ciencia e Innovación(PID2022-142340NB-I00,PID2019-106910GB-I00).This research was funded in whole or in part by the Austrian Science Fund(FWF)(10.55776/ZK91).For open access purposes,the author has applied a CC BY public copyright license to any author accepted manuscript version arising from this submission.

关键词： metallic polarized discussions

在线全文

学校读者我要写书评

暂无评论

长期区域化疗在转移性肝癌治疗中的地位

德国医学 2000年第2期17卷 67-68页

作者： m.lorenz E.Staib-Sebler C.Gog G.Vetter H.Petrowsky H.-H.mller 吴亚群 Klinik fr Allgemein-und Gefβchirurgie Klinikum der Johann Wolfgang Goethe-UniversittTheodor-Stem-Kai 7D-60590 Frankfurt am MainGermany 同济医科大学附属同济医院

肝转移癌动脉内化疗已有50余年历史,但长期以来仅作为症状治疗。皮下置泵肝动脉插管问题解决后,区域化疗得到重视。氟尿嘧啶脱氧核苷(FUdR)可在肝内维持高浓度,且具良好的溶解性,可经皮下植入泵使用,使病人能在门诊接受2～3周的化疗。... 详细信息

肝转移癌动脉内化疗已有50余年历史,但长期以来仅作为症状治疗。皮下置泵肝动脉插管问题解决后,区域化疗得到重视。氟尿嘧啶脱氧核苷(FUdR)可在肝内维持高浓度,且具良好的溶解性,可经皮下植入泵使用,使病人能在门诊接受2～3周的化疗。其生活质量和有效率(约50％)高于全身化疗组。尽管化学性肝炎、胃十二指肠溃疡、胆管硬化等不良反应只见于动脉内FUdR治疗者,而并不发生于欧洲应用5-氟尿嘧啶(5-Fu)治疗方案者,但肝转移癌的区域治疗还未获公认。

关键词：肝转移瘤药物疗法区域性化疗

在线全文

学校读者我要写书评

暂无评论

mR间接关节造影术诊断肩袖病变

放射学实践 2001年第3期16卷 155-155页

作者： J.Rudolph m.lorenz R.Schroder 汪玲华中科技大学同济医学院附属同济医院

目的：回顾性研究评价肩袖(Rm)病变mR间接关节造影术的价值，并与关节镜检相比较。方法：对疑有肩部病变的63例病人检查：斜冠状位和轴位T1序列平扫、轴位FLASH-2D序列以及斜冠状位T2W和PDW序列。静脉内给予0.1mmol Gd-DTPA/kg体重后，... 详细信息

目的：回顾性研究评价肩袖(Rm)病变mR间接关节造影术的价值，并与关节镜检相比较。方法：对疑有肩部病变的63例病人检查：斜冠状位和轴位T1序列平扫、轴位FLASH-2D序列以及斜冠状位T2W和PDW序列。静脉内给予0.1mmol Gd-DTPA/kg体重后，肩部主动活动和重复T1序列，借助感兴趣区(ROI)技术定量测量肌腱内的信号强度(SI)和衡量对比剂增强CE。在32例病人其结果经关节镜证实。结果：冈上肌腱的平均信号强度(SI)，在给对比剂前后，在各种病变(退化、撞击、不完全撕裂和完全撕裂)明显高于正常结果(P＜0.05)。同样，按百分比计算的对比增强(CE)也是如此(P＜0.05)。检出了9例完全撕裂和3例撞击综合征患者(平扫/增强后二者敏感性100％)。诊断了6例不完全破裂，其中3例假阳性，1例假阴性；敏感性75％，特异性50％。结论：mR间接关节造影术改善了Rm病变的影像表现。然而用它探查不完全撕裂也有欠缺，因为要确切区分肌腱的退变与不完全撕裂还很困难。华中科技大学同济医学院附属同济医院汪玲译胡国栋校摘自 Fortschr Rontgenstr 2000,172:686-691

关键词：肩袖病变 mR间接关节造影术诊断

Predicting the next move: tracking the complexity of lung cancer evolution and metastasis

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2023年第9期8卷 3885-3887页

作者： Carina lorenz Axel m.Hillmer Johannes Brägelmann University of Cologne Faculty of Medicine and University Hospital CologneDepartment of Translational GenomicsCologneGermany University of Cologne Faculty of Medicine and University Hospital CologneMildred Scheel School of Oncology CologneCologneGermany University of Cologne Faculty of Medicine and University Hospital CologneCenter for Molecular Medicine CologneCologneGermany University of Cologne Faculty of Medicine and University Hospital CologneInstitute of PathologyCologneGermany

In a series of seven papers in Nature and Nature medicine,the TRACERx study group presents multi-omic analyses of 421 non-small cell lung cancer(NSCLC)patients,which have yielded a comprehensive map of intratumor heterogeneity(ITH)and lung cancer evolutionary trajectories at an unprecedented level of detail.1–7 The in-depth molecular data,and their subsequent integrated analyses,hold the potential to not only shine light on lung cancer progression but also influence a broad spectrum of scientific disciplines,research fields,and clinical oncology,thereby enhancing our understanding of cancer in general.

关键词： lung cancer metastasis

The effect of temperature on ionic liquid modified Fe-N-C catalysts for alkaline oxygen reduction reaction

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2022年第5期31卷 324-329页

作者： Thomas Wolker Kai Brunnengräber Ioanna martinaiou Nick lorenz Gui-Rong Zhang Ulrike I.Kramm Bastian J.m.Etzold Department of Chemistry Ernst-Berl-Institut für Technische und Makromolekulare ChemieTechnical University of Darmstadt64287 DarmstadtGermany Department of Chemistry Catalysts and Electrocatalysts GroupTechnical University of Darmstadt64287 DarmstadtGermany Graduate School of Excellence Energy Science and Engineering Technical University of Darmstadt64287 DarmstadtGermany Department of materials and Earth Sciences Technical University of Darmstadt64287 DarmstadtGermany School of Chemical Engineering and Technology Tiangong UniversityTianjin 300387China

modifying solid catalysts with an ionic liquid layer is an effective approach for boosting the performance of both Pt-based and non-precious metal catalysts toward the oxygen reduction reaction. While most studies operated at room temperature it remains unclear whether the IL-associated boosting effect can be maintained at elevated temperature, which is of high relevance for practical applications in low temperature fuel cells. Herein, Fe-N-C catalysts were modified by introducing small amounts of hydrophobic ionic liquid, resulting in boosted electrocatalytic activity towards the alkaline oxygen reduction reaction at room temperature. It is demonstrated that the boosting effect can be maintained and even strengthened when increasing the electrolyte temperature up to 70℃. These findings show for the first time that the incorporation of ionic liquid is a suited method to obtain advanced noble metal-free electrocatalysts that can be applied at operating temperature condition.

关键词： Oxygen reduction reaction Non-precious metal catalyst Ionic liquid Fe-N-C catalyst Temperature effect

Treatment of biliary tract cancer with NVP-AEW541:mechanisms of action and resistance

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2010年第2期16卷 156-166页

作者： Samuel Wolf Jana lorenz Joachim mssner marcus Wiedmann Department of Internal medicineⅡ University of Leipzig Department of Internal medicineⅠ St. Mary's Hospital

AIm:To investigate in vitro treatment with NVPAEW541,a small molecule inhibitor of insulin-like growth factor-1 receptor(IGF-1R),in biliary tract cancer (BTC),since this disease is associated with a poor prognosis due to wide resistance to chemotherapeutic agents and ***:Cell growth inhibition by NVP-AEW541 was studied in vitro in 7 human BTC cell lines by automated cell *** addition,the anti-tumoral mechanism of NVP-AEW541 was studied by Western blotting,cell cycle analysis and reverse transcription-polymerase chain reaction(RT-PCR).Anti-tumoral drug effect in combination with gemcitabine,5-fluorouracil(5-FU)and Polo-like kinase 1 inhibitor BI2536 was also studied. RESULTS:In vitro treatment with NVP-AEW541 suppressed growth in all human BTC cell lines,however response was lower in gallbladder *** withNVP-AEW541 was associated with dephosphorylation of IGF-1R and *** contrast,phosphorylation of p42/p44 and Stat3 and expression of Bcl-xL were inconsistently *** addition,treated cells showed cell cycle arrest at the G1/S-checkpoint and an increase in sub-G1 ***,IGF-1R and its ligands IGF-1 and IGF-2 were co-expressed in RT-PCR,suggesting an autocrine loop of tumor cell *** with gemcitabine,NVP-AEW541 exerted synergistic effects, particularly at low concentrations,while effects of combination with 5-FU or BI 2536 were only additive. CONCLUSION:Our findings suggest that NVP-AEW541 is active against BTC in vitro and potentiates the efficacy of gemcitabine.

关键词： Tyrosine kinase inhibitor Cholangiocarcinoma Gemcitabine NVP-AEW541

Improving interruption performance of mechanical circuit breakers by controlling pre-current-zero wave shape

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

High Voltage 2019年第2期4卷 122-129页

作者： Tim Schultz Benjamin Hammerich lorenz Bort Christian m.Franck High Voltage Laboratory ETH ZurichPhysikstrasse 38092 ZurichSwitzerland

mechanical circuit breakers(mCBs)are the limiting component for current injection HVDC circuit *** their interruption performance reduces requirements for capacitance and inductance needed in the injection circuit and thus space use and *** performance can be achieved by creating a period of low current gradient before zero crossing in the mCB,*** using a saturable inductor(SI).In this paper,the impact of duration and steepness during the low current-gradient phase is linked to arc parameters of the investigated model gas circuit *** is shown in a scaled experimental setup that an optimum design of the SI can be derived from arc time constant and interruption limits for constant current *** optimisation results in a considerable increase of interruption *** feasibility of implementing an SI in a full-scale HVDC circuit breaker is demonstrated using *** an improved injection scheme,the stresses for the mCB can be reduced ***,the injection circuit components can be scaled down,making the topology more *** reduced interruption requirements might also make it possible to use a single gas interrupter instead of a series connection of vacuum interrupters,reducing the complexity of the mechanical switch.

关键词： performance capacitance wave

Synthetic biology identifies the minimal gene set required for paclitaxel biosynthesis in a plant chassis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

molecular Plant 2023年第12期16卷 1951-1961页

作者： Youjun Zhang lorenz Wiese Hao Fang Saleh Alseekh Leonardo Perez de Souza Federico Scossa John molloy mathias Christmann Alisdair R.Fernie max-Planck-Institut fur molekulare Pflanzenphysiologie Am Muhlenberg 114476 Potsdam-GolmGermany Center of Plant Systems Biology and Biotechnology 4000 PlovdivBulgaria Institute of Chemistry and Biochemistry Freie Universitat BerlinTakustraBe 314195 BerlinGermany Department of Biomolecular Systems Max Planck Institute of Colloids and Interfaces14476 PotsdamGermany Research Center for Genomics and Bioinformatics(CREA-GB) Via Ardeatina 54600178 RomeItaly

The diterpenoid paclitaxel(Taxol)is a chemotherapy medication widely used as a first-line treatment against several types of solid *** supply of paclitaxel from natural sources is ***,missing knowledge about the genes involved in several specific metabolic steps of paclitaxel biosynthesis has rendered it difficult to engineer the full *** this study,we used a combination of transcriptomics,cell biology,metabolomics,and pathway reconstitution to identify the complete gene set required for the heterologous production of *** identified the missing steps from the current model of paclitaxel biosynthesis and confirmed the activity of most of the missing enzymes via heterologous expression in Nicotiana ***,we identified a new C4β-C20 epoxidase that could overcome the first bottleneck of metabolic *** used both previously characterized and newly identified oxomutases/epoxidases,taxane 1β-hydroxylase,taxane 9aα-hydroxylase,taxane 9α-dioxygenase,and phenylalanine-CoA ligase,to successfully biosynthesize the key intermediate baccatin Ill and to convert baccatin Ill into paclitaxel in *** combination,these approaches establisha metabolic route to taxoidbiosynthesis and provide insights into the unique chemistry that plants use to generate complex bioactive metabolites.

关键词： paclitaxel biosynthesis synthetic biology baccatin Ill biosynthesis Taxus

Effect of processing parameters on in situ screen printing-assisted synthesis and electrical properties of Ti3SiC2-based structures

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Advanced Ceramics 2021年第1期10卷 129-138页

作者： mylena lorenz Nahum TRAVITZKY Carlos R.RAmBO Department of materials Science University of Erlangen-Nuremberg91058 ErlangenGermany Tomsk Polytechnic University 634050 TomskRussia Departm ent of Electrical and Electronic Engineering Federal University of Santa Catarina88040-900 FlorianopolisBrazil

This work reports on the development of pastes containing Ti,TiC,Si,and C elementary powders for in situ synthesis of Ti3SiC2 via screen *** paste compositions were manufactured using two powder mixtures(Ti/Si/C and Ti/TiC/Si/C)with different *** pastes were screen printed onto Al2O3 substrates and sintered at 1400℃in argon varying the dwell time from 1 to 5 *** printed pastes containing TiC and excess of Si exhibited the lowest surface roughness and after 5 h sintering comprised of Ti3SiC2 as the majority *** electrical conductivity of this sample was found to range from 4.63×10^(4)to 2.57×10^(5)S·m^(-1)in a temperature range of 25-400℃.

关键词： mAX phases Ti3SiC2 screen printing in situ synthesis electrical conductivity

Hybrid multimode - multicore fibre based holographic endoscope for deep-tissue neurophotonics

在线全文

学校读者我要写书评

暂无评论

Light(Advanced manufacturing) 2022年第3期3卷 84-92页

作者： Yang Du Sergey Turtaev Ivo T Leite Adrian lorenz Jens Kobelke Katrin Wondraczek Tomas Cizmar Leibniz Institute of Photonic Technology Albert-Einstein-Straβe 9Jena07745Germany Institute of Scientific Instruments of CAS Kralovopolska 147Brno61264Czechia Institute of Applied Optics Friedrich Schiller University JenaFrobelstieg 107743 JenaGermany

In-vivo microendoscopy in animal models became a groundbreaking technique in neuroscience that rapidly expands our understanding of the *** hair-thin endoscopes based on multimode fibres are now opening up the prospect of ultra-minimally invasive neuroimaging of deeply located brain *** these advancements with methods of functional imaging and optogenetics,as well as extending its applicability to awake and motile animals constitute the most pressing challenges for this *** we demonstrate a novel fibre design capable of both,high-resolution imaging in immobilised animals and bending-resilient optical addressing of neurons in motile *** optimised refractive index profile and the probe structure allowed reaching a spatial resolution of 2μm across a 230μm field of view for the initial layout of the ***,the fibre exhibits negligible cross-talk between individual inner-cores during fibre *** work provides a technological solution for imaging-assisted spatially selective photo-activation and activity monitoring in awake and freely moving animal models.

关键词： multimode fibre multicore fibre Fibre-based imaging microendoscopy Endomicroscopy Holographic endoscopy